Blue copper peptide release characteristic simulation device

Abstract

The blue copper peptide release characteristic simulation device mainly comprises a test box, a liquid dropping tank and a liquid receiving cup, the test box is provided with a liquid inlet pipe, an inner cavity and a liquid outlet pipe which are communicated, the bottom of the inner cavity is coated with blue copper peptide slow-release gel, and a sponge block is placed on the upper part of the blue copper peptide slow-release gel; the liquid dropping tank is located above the test box, a throttle valve is arranged at the bottom of the liquid dropping tank, and the throttle valve is connected with a liquid inlet pipe of the test box through a hose; the liquid receiving cup is located below the test box liquid outlet pipe and used for containing liquid flowing out of the test box liquid outlet pipe. The blue copper peptide release characteristic simulation device can simulate the subcutaneous tissue environment of a human body, and performs simulation test on the release characteristic of blue copper peptide to obtain a blue copper peptide release amount curve corresponding to time. The blue-copper peptide release characteristic simulation device is beneficial to mastering the dynamic process of blue-copper peptide release and the biological activity and the treatment effect of blue-copper peptide slow-release gel.

Description

Technical Field

[0001] The utility model relates to the technical field of blue copper peptides, in particular to a blue copper peptide release characteristic simulation device. Background Art

[0002] Blue copper peptide is a powerful skin regeneration agent, which is very effective in treating skin damage. It can not only reduce the formation of scar tissue, but also stimulate the skin to heal itself. However, blue copper peptide has poor hydrophilicity and is difficult to be directly absorbed by the skin. Moreover, blue copper peptide is easily affected by temperature and pH value and denatured and inactivated, making it difficult to exert its efficacy. The latest technology is to embed blue copper peptide into the gel network of poloxamer through cross-linking technology to form a sustained-release gel containing blue copper peptide. The gel structure not only serves as a delivery carrier for blue copper peptide, but also provides a three-dimensional scaffold that can promote the attachment and proliferation of skin cells on the three-dimensional scaffold, supporting the reconstruction and repair of skin tissue.

[0003] The sustained-release system not only affects the dynamic process of drug release, but is also directly related to the biological activity and therapeutic effect of the drug. In the development of the blue copper peptide sustained-release gel, the release characteristics of the blue copper peptide need to be tested and evaluated. Since this test cannot be used for human experiments, it is necessary to design a blue copper peptide release characteristic simulation device for the blue copper peptide sustained-release gel. Utility Model Content

[0004] In order to overcome the shortcomings of the background technology, the utility model discloses a blue copper peptide release characteristic simulation device, which adopts the following technical solutions:

[0005] A blue copper peptide release characteristic simulation device, comprising:

[0006] The test box has a connected liquid inlet pipe, an inner cavity and a liquid outlet pipe, a blue copper peptide sustained-release gel is smeared on the bottom of the inner cavity, and a sponge block is placed on the upper part of the blue copper peptide sustained-release gel;

[0007] The dripping tank is located above the test box, and a throttle valve is provided at the bottom of the dripping tank, and the throttle valve is connected to the liquid inlet pipe of the test box through a hose;

[0008] The liquid receiving cup is used to receive the liquid flowing out of the liquid outlet pipe of the test box.

[0009] To further improve the technical solution, 0.9% saline solution is placed in the drip tank, and the temperature of the saline solution is 35-37°C.

[0010] To further improve the technical solution, a constant temperature heating tube is provided in the drip tank, and the constant temperature heating tube is used to heat the physiological saline at a constant temperature.

[0011] To further improve the technical solution, the dripping tank is a glass tank, a neck is provided at the mouth of the dripping tank, and scale lines are marked on the neck.

[0012] To further improve the technical solution, the test box is composed of a square glass box body and a glass box cover, and a sealing ring is arranged between the glass box cover and the glass box body.

[0013] To further improve the technical solution, the test box is placed horizontally, and the liquid outlet tube has a bend opening downward.

[0014] After implementing the above technical solution, compared with the background technology, the beneficial effects produced by the utility model are:

[0015] The blue copper peptide release characteristics simulation device is mainly composed of a test box, a drip tank and a liquid receiving cup, which can simulate the subcutaneous tissue environment of the human body, simulate the release characteristics of the blue copper peptide, and obtain a blue copper peptide release amount curve corresponding to time.

[0016] The blue copper peptide release characteristic simulation device is helpful to grasp the dynamic process of blue copper peptide release, as well as the biological activity and therapeutic effect of blue copper peptide sustained-release gel. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Attached Figure 1 Shown is a schematic diagram of the overall structure of the blue copper peptide release characteristics simulation device.

[0018] Attached Figure 2 Shown is a schematic diagram of the structure of the test box.

[0019] Attached Figure 3 Shown is a top view of the glass box.

[0020] In the attached figure: 1. test box; 11. glass box body; 12. glass box cover; 13. sealing ring; 2. drip tank; 3. throttle valve; 4. hose; 5. liquid receiving cup; 6. blue copper peptide sustained-release gel; 7. sponge block; 8. physiological saline; 9. constant temperature heating tube. DETAILED DESCRIPTION

[0021] The preferred embodiments of the present invention are described below with reference to the accompanying drawings. It should be understood by those skilled in the art that these embodiments are only used to explain the technical principles of the present invention and are not intended to limit the scope of protection of the present invention. It should be noted that in the description of the present invention, the terms "front", "rear", "up", "down", "left", "right", "vertical", "horizontal", "inside", "outside" and the like indicating directions or positional relationships are based on the directions or positional relationships shown in the accompanying drawings, which are only for the convenience of description, rather than indicating or implying that the device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation of the present invention. It should also be noted that in the description of the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected" and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected, or indirectly connected through an intermediate medium, or the internal connection of two components. For those skilled in the art, the specific meanings of the above terms in the present invention can be understood according to the specific circumstances.

[0022] As attached Figure 1 As shown, a blue copper peptide release characteristic simulation device is mainly composed of a test box 1, a drip tank 2 and a liquid receiving cup 5. The structure and function thereof are described in detail below.

[0023] The test box 1 is placed horizontally, and has a connected liquid inlet pipe, an inner cavity and a liquid outlet pipe, and the liquid outlet pipe has a downwardly opened elbow. The dripping tank 2 is located above the test box 1, and a throttle valve 3 is provided at the bottom of the dripping tank 2, and the throttle valve 3 is connected to the liquid inlet pipe of the test box 1 through a hose 4. The liquid receiving cup 5 is located below the liquid outlet pipe of the test box 1, and the liquid receiving cup 5 is used to hold the liquid flowing out of the liquid outlet pipe of the test box 1.

[0024] Specifically, the dripping tank 2 is a glass tank, and a neck is provided at the mouth of the dripping tank 2, and a scale line is marked on the neck. A certain volume of 0.9% saline 8 is placed in the dripping tank 2, and the temperature of the saline 8 is 35-37°C. Since the test process is long, in order to prevent the temperature of the saline 8 from decreasing during the test process, a constant temperature heating tube 9 is provided in the dripping tank 2, and the constant temperature heating tube 9 can heat the saline 8 at a constant temperature, so that the temperature of the saline 8 is kept constant at 35-37°C.

[0025] See attached Figure 2 and attached Figure 3The test box 1 is composed of a square glass box body 11 and a glass box cover 12, and a sealing ring 13 is arranged between the glass box cover 12 and the glass box body 11. The bottom of the inner cavity of the test box 1 is coated with a blue copper peptide sustained-release gel 6, and a sponge block 7 is placed on the top of the blue copper peptide sustained-release gel 6. The glass box cover 12 is used to seal the glass box body 11, and the sponge block 7 can be placed in the glass box cover 12 by opening it.

[0026] The physiological saline 8 at 35-37°C is used to simulate the body fluid environment of the human body, and the sponge block 7 is provided to simulate the subcutaneous tissue of the human body. The throttle valve 3 is provided, and the drip tank 2 is arranged above the test box 1 to give the physiological saline 8 a certain pressure and fluidity, simulating the flow amount and flow speed of body fluid in the subcutaneous tissue of the human body.

[0027] Working process:

[0028] See attached Figure 1 First, a certain volume of physiological saline 8 at a temperature of 35-37°C is poured into the drip tank 2, and then the dripping speed and dripping amount of the physiological saline 8 are adjusted through the throttle valve 3 to allow the physiological saline 8 to enter the test box 1. After the blue copper peptide sustained-release gel 6 is soaked in the physiological saline 8, part of the blue copper peptide is released in the physiological saline 8 and brought into the liquid receiving cup 5 by the physiological saline 8 until the physiological saline 8 in the drip tank 2 is completely emptied. At this time, the timing is started, and the blue copper peptide in the liquid receiving cup 5 is subjected to spectral analysis to obtain the release amount of the blue copper peptide.

[0029] The same volume of physiological saline 8 is refilled into the drip tank 2, and the above test is repeated to obtain a blue copper peptide release characteristic curve corresponding to time.

[0030] From the above, it can be seen that the blue copper peptide release characteristic simulation device can simulate the human subcutaneous tissue environment, perform simulation test on the release characteristics of the blue copper peptide, and obtain the blue copper peptide release amount curve corresponding to time.

[0031] Although the embodiments of the present invention have been shown and described, it is understood by those skilled in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention, and the protection scope of the present invention is defined by the attached claims and their equivalents.

Claims

1. A blue copper peptide release characteristics simulation device, characterized in that: include: The test box has a connected liquid inlet pipe, an inner cavity and a liquid outlet pipe, the bottom of the inner cavity is coated with a blue copper peptide sustained-release gel, and a sponge block is placed on the upper part of the blue copper peptide sustained-release gel; The dripping tank is located above the test box, and a throttle valve is provided at the bottom of the dripping tank, and the throttle valve is connected to the liquid inlet pipe of the test box through a hose; The liquid receiving cup is used to receive the liquid flowing out of the liquid outlet pipe of the test box.

2. A blue copper peptide release characteristics simulation device as claimed in claim 1, characterized in that: The drip tank contains 0.9% normal saline solution, and the temperature of the normal saline solution is 35-37°C.

3. A blue copper peptide release characteristics simulation device as claimed in claim 2, characterized in that: A constant temperature heating tube is arranged in the drip tank, and the constant temperature heating tube is used for heating the physiological saline at a constant temperature.

4. A blue copper peptide release characteristics simulation device as claimed in claim 1, characterized in that: The dripping jar is a glass jar, a neck is arranged at the mouth of the dripping jar, and scale lines are marked on the neck.

5. A blue copper peptide release characteristics simulation device as claimed in claim 1, characterized in that: The test box consists of a square glass box body and a glass box cover, and a sealing ring is arranged between the glass box cover and the glass box body.

6. A blue copper peptide release characteristics simulation device as claimed in claim 1, characterized in that: The test box is placed horizontally, and the liquid outlet pipe has a bend opening downward.

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