Lactobacillus oral microparticles capable of reducing heavy metal residues
By covering the multi-layer structures outside the Lactobacillus granules, including the heat-resistant layer, plant extraction layer, gel layer and anti-adhesion layer, the shortcomings of existing Lactobacillus oral particles in reducing heavy metal residues are solved, and effective heavy metal dissolution and shelf life are achieved.
Patent Information
- Application Number
- CN202420517638.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-03-18
- Publication Date
- 2025-03-28
- Estimated Expiration
- 2034-03-18
AI Technical Summary
The existing oral microparticles of Lactobacillus have shortcomings in reducing heavy metal residues, and cannot effectively cooperate with Lactobacillus granules to achieve the effect of heavy metal discharge.
By covering the anti-thermal layer, plant extraction layer, gel layer and anti-adhesion layer outside the Lactobacillus granules, a multi-layered oral particles are formed. The heat-resistant layer improves the stability of Lactobacillus granules, the plant extraction layer strengthens the ability to relieve heavy metals, the gel layer helps Lactobacillus eliminate toxin substances, prevents the absorption of heavy metals, and prevents the particles from sticking to each other.
It has achieved effective reduction of heavy metal residues under the conditions of ensuring a long shelf life, enhanced the ability of Lactobacillus to relieve heavy metal toxins, and prevented the human body from absorbing heavy metals such as lead and cadmium.
Smart Images
Figure CN222676875U_ABST
Abstract
Description
Technical Field
[0001] The present application relates to the field of oral particles, and in particular to a Lactobacillus oral microparticle capable of reducing heavy metal residues. Background Art
[0002] Heavy metals are usually defined as having a density greater than 4.5 g / cm 2 The main toxicity of metals comes from the interaction between heavy metal ions and various enzymes in the human body, which affects the human metabolism. This is because most heavy metals are transition metal elements and tend to form complexes. Human proteins contain amino groups, sulfhydryl groups, etc., which have strong binding forces with heavy metals. The active centers of many enzymes can form stereo-coordinated chelates. The central elements can easily be replaced by heavy metal elements with stronger binding forces, causing the enzyme to lose its activity. The human body itself contains heavy metal substances, some of which are essential trace elements, such as copper, zinc, and selenium, which is very popular in certain health products, etc. They often constitute the active centers of enzymes.
[0003] When heavy metals are ingested, they first combine with proteins and polypeptides in food and digestive juices, or react with anions to form precipitates, depending on their chemical properties. Most of them are excreted in the feces and are not absorbed. Some of them are absorbed by the human body and combine with plasma proteins, some are detoxified in the liver and excreted in the bile, and some are captured by the renal tubules and excreted in the urine. However, heavy metals that enter the blood cannot be completely metabolized. During their movement in the blood circulation, they often combine with their target organs. For example, organic mercury is lipophilic and often accumulates in fat and the brain. Cadmium ions are fond of bones and deposited in bones. Chronic poisoning leads to the famous "Itai-itai disease"; mercury ions are fond of renal tubules, and poisoning often causes acute renal failure. Lead ions are also fond of bones, and so on. Once heavy metals are bound to target organs, they are often difficult to excrete, and they can accumulate over a long period of time to cause chronic poisoning. For example, patients with Minamata disease have organic mercury accumulated in the brain for more than 20 years before causing obvious poisoning reactions.
[0004] Recent studies have found that Lactobacillus has the ability to reduce heavy metal residues. People who are poisoned by heavy metals can eliminate them from their bodies by taking Lactobacillus. In order to ensure its effectiveness, Lactobacillus needs to be highly active. The existing technology uses a layered particle structure.
[0005] For example, in the prior art, application number: 2017211301162, "Oral microparticles for maintaining high activity and stability of Lactobacillus", comprises a lactobacillus particle, an anti-dehydration layer coated on the outside of the lactobacillus particle, an anti-damage layer coated on the outside of the anti-dehydration layer, an antioxidant layer coated on the outside of the anti-damage layer, an oligosaccharide layer coated on the outside of the antioxidant layer, and a polysaccharide layer coated on the outside of the oligosaccharide layer. In this application, a multi-layered embedding structure is used to isolate external moisture, air and high temperature, so that the lactobacillus particles have high survival rate, activity and stability, can reach the user's intestines and be absorbed, so as to improve their biological absorption utilization rate; however, the various layer settings of this application cannot cooperate with the lactobacillus particles to achieve the effect of excreting heavy metals.
[0006] Therefore, it is necessary to provide a new technical solution to solve the above technical problems. Utility Model Content
[0007] The present application provides a Lactobacillus oral microparticle for reducing heavy metal residues, comprising Lactobacillus particles, wherein the outer side of the Lactobacillus particles is coated with a heat-resistant layer, the outer side of the heat-resistant layer is coated with a plant extract layer, the outer side of the plant extract layer is coated with a gel layer, and the outer side of the gel layer is coated with an anti-adhesion layer.
[0008] As a preferred embodiment, the heat-resistant layer is made of one of lecithin, soybean oil, coconut oil, olive oil, linseed oil, sesame oil, inca inchi oil, camellia oil, brown rice oil, canola oil, sunflower oil, peanut oil and avocado oil.
[0009] As a preferred embodiment, the plant extract layer adopts one of glutathione, vitamin C, tomato extract, carrot extract, garlic extract, mung bean extract, cauliflower extract and coriander extract.
[0010] As a preferred solution, the gel layer is made of one of alginate, agar, pumpkin pectin, wood ear plant gel, seaweed gel, carageenan and guanyin.
[0011] As a preferred embodiment, the anti-sticking layer is made of one of amylose, microcrystalline cellulose, resistant dextrin, oat fiber, citrus fiber, inulin fiber, and an anti-caking agent.
[0012] The heat-resistant layer in the present application can improve the stability of the lactobacillus particles, thereby increasing their shelf life in the increasingly common high temperature weather; the plant extract layer ensures that after consumption, it can cooperate with the lactobacillus to strengthen the elimination of various heavy metal poisons, such as chromium, aluminum, lead, mercury, etc., thereby achieving the purpose of reducing heavy metal residues; the gel layer ensures that a gel-like substance can be formed in the intestine after consumption, which helps the lactobacillus to eliminate toxic substances, prevents the human body from absorbing heavy metals such as lead and cadmium, and eliminates radioactive elements in the body; the gel layer prevents the lactobacillus particles from sticking to each other during the subsequent processing steps, which is not conducive to product design and consumption; under the condition of ensuring a longer shelf life, the present application can strengthen the elimination of various heavy metal poisons, help the lactobacillus to eliminate toxic substances, prevent the human body from absorbing heavy metals such as lead and cadmium, and achieve the purpose of reducing heavy metal residues through the provision of the plant extract layer and the gel layer. BRIEF DESCRIPTION OF THE DRAWINGS
[0013] Figure 1 It is a schematic diagram of the structure of this application;
[0014] Figure 2 It is a comparison chart of experimental data of this application;
[0015] 110, lactobacillus particles 120, heat-resistant layer 130, plant extract layer 140, gel layer
[0016] 150. Anti-stick layer. DETAILED DESCRIPTION
[0017] The specific implementation of the present invention is described in detail below in conjunction with the accompanying drawings. It should be noted that the specific implementation described here is only used to illustrate and explain the present invention, and is not used to limit the present invention.
[0018] The present application provides an oral Lactobacillus microparticle for reducing heavy metal residues, including Lactobacillus microparticles 110, wherein the Lactobacillus microparticles 110 are obtained by centrifugation and concentration after fermentation and cultivation of Lactobacillus having the effect of enhancing the metabolism of heavy metals; the outer side of the Lactobacillus microparticles is coated with a heat-resistant layer 120, and the heat-resistant layer 120 covers the outside of the Lactobacillus microparticles 110 in order to enhance the stability of the Lactobacillus microparticles 110 and to increase the shelf life in view of the increasingly common high temperatures in daily climate; preferably, the heat-resistant layer 120 is composed of one or more of lecithin, soybean oil, coconut oil, olive oil, linseed oil, sesame oil, inca inchi oil, camellia oil, brown rice oil, canola oil, sunflower oil, peanut oil, and avocado oil.
[0019] The outer side of the heat-resistant layer 120 is coated with a plant extract layer 130. The plant extract layer 130 is designed to cooperate with the lactobacillus particles 110 to strengthen the elimination of various heavy metal toxins, such as chromium, aluminum, lead, mercury, etc. after being eaten. The vitamin C, anthocyanins, and flavonoids in the extract of the plant extract layer 130 have good antioxidant capacity and can combine with toxic substances to reduce the heavy metal content in the body, thereby achieving the purpose of reducing heavy metal residues. Preferably, the plant extract layer 130 uses one or more of glutathione, vitamin C, tomato extract, carrot extract, garlic extract, mung bean extract, cauliflower extract, and coriander extract.
[0020] The outer side of the plant extract layer 130 is coated with a gel layer 140. The gel layer 140 is to ensure that a gel-like substance can be formed in the intestine after consumption, so as to help lactobacilli eliminate toxins, prevent the human body from absorbing heavy metals such as lead and cadmium, and eliminate radioactive elements in the body. Preferably, the gel layer 140 is selected from any one or more substances, including but not limited to: alginate, agar, pumpkin pectin, fungus plant gum, seaweed, carageenan, guanyin or a group consisting of any combination of the above.
[0021] The outside of the gel layer 140 is coated with an anti-adhesion layer 150, which prevents the lactobacillus particles 110 from adhering to each other during the subsequent processing steps, which is not conducive to product design and consumption; preferably, the ingredients of the anti-adhesion layer 150 are selected from any one or more substances, including but not limited to: amylose, microcrystalline cellulose, resistant dextrin, oat fiber, citrus fiber, inulin fiber, anti-caking agent or any combination of the above.
[0022] The present application provides an experimental method and experimental results of Lactobacillus granules 110 being able to increase the discharge of heavy metals in mice as follows: Lactobacillus granules 110 take Lactobacillus paracasei P as an example:
[0023] Experimental methods: 8-week-old C57 BL / 6 male mice were randomly divided into 5 groups, including control group (sterile water), heavy metal group (Pb), Pb+Lactobacillus paracasei P oral microparticle group, Pb+Lactobacillus fermentum F oral microparticle group, and Pb+Lactobacillus casei C oral microparticle group, with 5 mice in each group. The experimental process was to feed the mice with sterile water or different lactobacilli (1.64X10 7 cfu / mouse), five days a week, for a total of 4 weeks; during the experiment, the mice drank sterile water or 1000 ppm [Pb] heavy metal solution normally. At the end of the fourth week of the experiment, the mouse feces were collected for quantitative analysis of heavy metals.
[0024] After the mouse feces were weighed, they were ground and digested with aqua regia. The supernatant was centrifuged and filtered through a 0.22um filter. The Pb concentration was quantified by atomic absorption spectrophotometry. The heavy metal content of the specimen was expressed as ppm / g of feces wet weight.
[0025] Experimental results: Figure 2 As shown, after mice consumed Lactobacillus casei C for 4 weeks, the heavy metal Pb content in their feces increased, indicating that Lactobacillus can reduce the accumulation of heavy metals in the body by increasing the excretion of heavy metals.
[0026] The heat-resistant layer in the present application can improve the stability of the lactobacillus particles, thereby increasing their shelf life in the increasingly common high temperature weather; the plant extract layer ensures that after consumption, it can cooperate with the lactobacillus to strengthen the elimination of various heavy metal poisons, such as chromium, aluminum, lead, mercury, etc., thereby achieving the purpose of reducing heavy metal residues; the gel layer ensures that a gel-like substance can be formed in the intestine after consumption, which helps the lactobacillus to eliminate toxic substances, prevents the human body from absorbing heavy metals such as lead and cadmium, and eliminates radioactive elements in the body; the gel layer prevents the lactobacillus particles from sticking to each other during the subsequent processing steps, which is not conducive to product design and consumption; under the condition of ensuring a longer shelf life, the present application can strengthen the elimination of various heavy metal poisons, help the lactobacillus to eliminate toxic substances, prevent the human body from absorbing heavy metals such as lead and cadmium, and achieve the purpose of reducing heavy metal residues through the provision of the plant extract layer and the gel layer.
[0027] The present invention has been described through the above-mentioned relevant embodiments, however, the above-mentioned embodiments are only examples for implementing the present invention; it must be pointed out that the disclosed embodiments do not limit the scope of the present invention. On the contrary, modifications and equivalent settings contained in the spirit and scope of the claims are all included in the scope of the present invention.
Claims
1. A Lactobacillus oral microparticle for reducing heavy metal residues, comprising Lactobacillus microparticles (110), characterized in that: The outer side of the lactobacillus particles (110) is coated with a heat-resistant layer (120), the outer side of the heat-resistant layer (120) is coated with a plant extract layer (130), the outer side of the plant extract layer (130) is coated with a gel layer (140), and the outer side of the gel layer (140) is coated with an anti-adhesion layer (150).
2. The Lactobacillus oral microparticles for reducing heavy metal residues according to claim 1, characterized in that: The heat-resistant layer (120) is made of one of lecithin, soybean oil, coconut oil, olive oil, linseed oil, sesame oil, inca inchi oil, camellia oil, brown rice oil, canola oil, sunflower oil, peanut oil, and avocado oil.
3. The Lactobacillus oral microparticles for reducing heavy metal residues according to claim 1, characterized in that: The plant extract layer (130) uses one of glutathione, vitamin C, tomato extract, carrot extract, garlic extract, mung bean extract, cauliflower extract and coriander extract.
4. The Lactobacillus oral microparticles for reducing heavy metal residues according to claim 1, characterized in that: The gel layer (140) is made of one of alginate, agar, pumpkin pectin, wood ear plant gum, seaweed, carrageenan, and guanyin.
5. The Lactobacillus oral microparticles for reducing heavy metal residues according to claim 1, characterized in that: The anti-adhesion layer (150) is made of one of amylose, microcrystalline cellulose, resistant dextrin, oat fiber, citrus fiber, inulin fiber, and an anti-caking agent.