Control system for measuring integrity and sterility of rotating bowl for continuous flow centrifugal machine in real time

Abstract

The utility model relates to a control system for measuring integrity and sterility of a rotating bowl for a continuous flow centrifugal machine in real time, and relates to the field of continuous flow centrifugal machines, the control system comprises a centrifugal machine body, the continuous flow bowl and a pressurizing pipe, the centrifugal machine body comprises an outer barrel, a sealing cover and a power shaft, and the sealing cover is rotationally connected to the outer barrel; the sealing cover is used for covering the outer barrel and is in sealing connection with the outer barrel, the power shaft is rotationally connected to the inner bottom of the outer barrel, the continuous circulation bowl is connected to the power shaft and is used for rotating in the outer barrel, and the pressurizing pipe penetrates through the outer barrel and is in sealing connection with the outer barrel, and is used for introducing positive-pressure sterile gas into the outer barrel. The rotary bowl has the effect of reducing the material loss cost caused by the reduction of the sealing performance of the rotary bowl.

Description

Technical Field

[0001] The present application relates to the field of continuous flow centrifuges, and in particular to a control system for real-time measurement of bowl integrity and sterility of a continuous flow centrifuge. Background Art

[0002] Continuous centrifuge is a vertical centrifuge that can continuously perform processes such as material feeding, separation and slag unloading, and is widely used in fields such as biotechnology.

[0003] The utility model patent with publication number CN218031415U discloses a centrifuge bowl sealing structure, which includes a material cover and a bowl, the material cover is rotatably fixed at the opening of the bowl, and also includes an annular sealing sleeve and a sealing ring, the inner ring of the sealing sleeve is fixed on the material cover, the outer ring of the sealing sleeve is fixed on the sealing ring, and a plurality of elastic members are arranged along the circumferential direction on the side of the sealing ring close to the material cover, and the two ends of the elastic member respectively abut the material cover and the sealing ring and press the sealing ring to seal on the bowl. The present application arranges elastic members, and uses multiple elastic members to press the sealing ring to seal on the bowl. Even if the sealing ring is excessively worn, the sealing ring is still pressed on the bowl by the elastic member, which can improve the sealing effect of the sealing ring.

[0004] The above-mentioned related technical solutions have the following defects: during the operation of the centrifuge, if the sealing effect of the material cover decreases, it is difficult for the user to immediately discover and perform maintenance, so that outside air can enter the material cover to react with the material or contaminate the material. Utility Model Content

[0005] In order to reduce the material loss cost caused by the decline in the sealing performance of the rotating bowl, the present application provides a real-time measurement of the integrity and sterility control system of the rotating bowl for a continuous flow centrifuge.

[0006] The present application provides a real-time measurement of the bowl integrity and sterility control system for a continuous flow centrifuge, which adopts the following technical solutions:

[0007] A real-time measurement of the integrity and aseptic control system of a rotating bowl for a continuous flow centrifuge comprises a centrifuge body, a continuous flow rotating bowl and a pressurizing tube. The centrifuge body comprises an outer barrel, a sealing cover and a power shaft. The sealing cover is rotatably connected to the outer barrel. The sealing cover is used to cover the outer barrel and is sealed with the outer barrel. The power shaft is rotatably connected to the inner bottom of the outer barrel. The continuous flow rotating bowl is connected to the power shaft. The continuous flow rotating bowl is used to rotate in the outer barrel. The pressurizing tube runs through the outer barrel and is sealed with the outer barrel. The pressurizing tube is used to introduce positive pressure sterile gas into the outer barrel.

[0008] By adopting the above technical solution, a power shaft is arranged in the centrifuge body so that the power shaft can drive the continuous flow bowl to rotate in the centrifuge body. A user can achieve the effect of separating the materials by placing a test tube containing materials into the continuous flow bowl. A pressure tube is arranged in the outer barrel so that the pressure tube can pass positive pressure gas into the outer barrel. When a leak occurs at the connection between the sealing cover and the outer barrel, the positive pressure sterile gas escapes from the outer barrel, thereby reducing the air containing bacteria and microorganisms outside the centrifuge body from entering the centrifuge body, thereby reducing the probability of the materials being contaminated. Even if a leak occurs on the centrifuge body, the user can recover the materials in the centrifuge body.

[0009] Optionally, an air pressure sensor is provided in the centrifuge body, and the air pressure sensor is used to detect the air pressure in the centrifuge body.

[0010] By adopting the above technical solution, an air pressure sensor is arranged in the centrifuge body, so that the air pressure sensor can detect the air pressure in the centrifuge body. When a leak occurs in the centrifuge body, the gas in the centrifuge body escapes, causing the air pressure in the centrifuge body to decrease. After the user fills the gas into the centrifuge body through the pressurized pipe, the air pressure sensor can be used to check the sealing of the centrifuge body. When a leak occurs in the centrifuge body, the user can quickly discover and repair it through the air pressure sensor.

[0011] Optionally, the continuous flow bowl includes a bottom plate and a side wall, the bottom plate and the side wall are connected to form a barrel structure, the bottom plate is used to be connected to the power shaft, and a plurality of sieve holes are opened on the side wall.

[0012] By adopting the above technical solution, by opening a plurality of sieve holes on the side wall, when the material rotates in the continuous flow bowl, the liquid or particles with smaller particle size in the material can pass through the sieve holes into between the side wall and the outer barrel, thereby completing the separation of the material. The user can achieve the effect of separating the material by separately recovering the material in the continuous flow bowl and the outer barrel.

[0013] Optionally, a feed pipe is provided on the sealing cover, the feed pipe passes through the sealing cover and is sealed with the sealing cover, and a one-way valve is provided on the feed pipe, the one-way valve is used to allow the fluid to flow unidirectionally from the outside of the centrifuge body to the inside of the centrifuge body.

[0014] By adopting the above technical solution, a feed pipe is arranged on the sealing cover, so that the user can inject materials into the continuous flow bowl through the feed pipe. By arranging a one-way valve in the feed pipe, it is difficult for the air in the centrifuge body to flow out of the centrifuge body through the feed pipe. When the pressurizing pipe injects positive pressure gas into the centrifuge body, a high-pressure environment can be maintained in the centrifuge body.

[0015] Optionally, the outer barrel is provided with a discharge pipe, which passes through the outer barrel and is sealed with the outer barrel, and a second one-way valve is provided on the discharge pipe, which is used to allow the fluid to flow unidirectionally from the inside of the centrifuge body to the outside of the centrifuge body.

[0016] By adopting the above technical solution, a discharge pipe is provided on the outer barrel, so that the separated material in the outer barrel can be discharged to the outside of the centrifuge body through the discharge pipe, and a second one-way valve is provided on the discharge pipe, so that it is difficult for the air outside the centrifuge body to enter the centrifuge body through the discharge pipe. When the material is discharged from the discharge pipe, the air pressure in the centrifuge body decreases, and the user can continue to fill the centrifuge body with gas through the pressure pipe until the reading of the air pressure sensor changes to be greater than the atmospheric pressure.

[0017] Optionally, a sterile control valve is provided on the pressurized pipe, and the sterile control valve is used to reduce the probability of sterile air being contaminated.

[0018] By adopting the above technical solution, a sterile control valve is arranged on the pressurized pipe, so that the sterile control valve controls the on-off of the pressurized pipe through a thin film, thereby reducing the probability of the sterile control valve contaminating the sterile gas in the pressurized pipe. After the user introduces gas into the centrifuge body through the pressurized pipe, the sterile control valve is closed, so that the interior of the centrifuge body can be kept airtight, and the air pressure sensor can monitor the leakage of the centrifuge body.

[0019] Optionally, a pressure regulating valve is provided on the pressurizing pipe, and the pressure regulating valve is used to maintain the air pressure in the pressurizing pipe at a level slightly higher than the atmospheric pressure.

[0020] By adopting the above technical solution, a pressure regulating valve is arranged on the pressurized pipe, and the pressure regulating valve can set the flow rate according to the design. Under the action of the fluid, the valve automatically eliminates the residual pressure in the pipeline, so that the pressure of the positive pressure gas filled into the centrifuge body from the pressurized pipe is relatively small, thereby reducing the probability of explosion caused by excessive pressure in the centrifuge body.

[0021] Optionally, the power shaft is detachably connected to the continuous flow bowl.

[0022] By adopting the above technical solution, by making the power shaft and the continuous flow bowl detachably connected, the user can remove the continuous flow bowl from the power shaft and transfer the material in the continuous flow bowl after finishing separating the materials, which is convenient for use.

[0023] In summary, the beneficial technical effects of this application are:

[0024] 1. By arranging a power shaft in the centrifuge body, the power shaft can drive the continuous flow bowl to rotate in the centrifuge body. The user can achieve the effect of separating the materials by placing the test tube containing the materials into the continuous flow bowl. By arranging a pressure tube in the outer barrel, the pressure tube can pass positive pressure gas into the outer barrel. When the connection between the sealing cover and the outer barrel leaks, the positive pressure sterile gas escapes from the outer barrel, thereby reducing the air containing bacteria and microorganisms outside the centrifuge body from entering the centrifuge body, which can reduce the probability of material contamination. Even if there is a leak on the centrifuge body, the user can recover the materials in the centrifuge body;

[0025] 2. By arranging an air pressure sensor in the centrifuge body, the air pressure sensor can detect the air pressure in the centrifuge body. When a leak occurs in the centrifuge body, the gas in the centrifuge body will escape, causing the air pressure in the centrifuge body to decrease. After the user fills the gas into the centrifuge body through the pressure pipe, the air pressure sensor can be used to check the sealing of the centrifuge body. When a leak occurs in the centrifuge body, the user can quickly discover and repair it through the air pressure sensor.

[0026] 3. By arranging a sterile control valve on the pressurized pipe, the sterile control valve controls the on-off of the pressurized pipe through a thin film, thereby reducing the probability of the sterile control valve contaminating the sterile gas in the pressurized pipe. After the user introduces gas into the centrifuge body through the pressurized pipe and closes the sterile control valve, the inside of the centrifuge body can be kept airtight, so that the air pressure sensor can monitor the leakage of the centrifuge body. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 It is a schematic diagram of the overall structure of Example 1 of the present application.

[0028] Figure 2 It is a schematic diagram of the continuous flow bowl structure of Example 2 of the present application.

[0029] Figure 3 It is a schematic diagram of the continuous flow bowl structure of Example 1 of the present application.

[0030] Figure numerals: 1. Centrifuge body; 11. Outer barrel; 12. Sealing cover; 13. Power shaft; 2. Continuous flow bowl; 21. Bottom plate; 22. Side wall; 221. Sieve hole; 3. Feed pipe; 31. One-way valve 1; 4. Discharge pipe; 41. One-way valve 2; 5. Pressurizing pipe; 51. Aseptic control valve; 52. Pressure regulating valve; 6. Air pressure sensor. DETAILED DESCRIPTION

[0031] The present application is further described in detail below in conjunction with the accompanying drawings.

[0032] Example 1

[0033] The present application embodiment discloses a real-time measurement of the bowl integrity and sterility control system for a continuous flow centrifuge, referring to Figure 1 and Figure 2 , including a centrifuge body 1, a continuous flow bowl 2 and a pressurizing tube 5. The centrifuge body 1 includes an outer barrel 11, a sealing cover 12 and a power shaft 13. The outer barrel 11 is a cylindrical barrel structure with an opening. The outer barrel 11 is vertically arranged. The power shaft 13 is vertically arranged in the outer barrel 11. The lower end of the power shaft 13 is rotatably connected to the bottom of the outer barrel 11 and is coaxially arranged relative to the outer barrel 11. The sealing cover 12 is rotatably connected to the outer barrel 11. The sealing cover 12 is used to cover the opening of the outer barrel 11 and make the outer barrel 11 airtight. The continuous flow bowl 2 is detachably connected to the power shaft 13. The power shaft 13 can drive the continuous flow bowl 2 to rotate in the outer barrel 11. The user can place the material in the continuous flow bowl 2, so that the continuous flow bowl 2 can drive the material to rotate, thereby achieving the effect of separating materials of different properties mixed in the material.

[0034] Reference Figure 2 and Figure 3 The continuous flow bowl 2 is a cylindrical structure with an opening, and includes a bottom plate 21 and a side wall 22, wherein the bottom plate 21 is fixed to one end of the side wall 22. A through hole is provided at the center of the bottom plate 21, and the power shaft 13 is inserted into the through hole. The user can detachably connect the continuous flow bowl 2 to the power shaft 13 by setting bolts on the power shaft 13. The user can place a sealed container such as a test tube in the continuous flow bowl 2, and the continuous flow bowl 2 drives the test tube to rotate, thereby centrifugally stratifying the material in the test tube.

[0035] Reference Figure 1 and Figure 2 In order to reduce the probability of the material being contaminated in the centrifuge body 1, the user can cover the sealing cover 12 on the outer barrel 11 and perform centrifugal work. The sealing cover 12 is provided with a rubber strip, which abuts against the outer barrel 11, so that the outer barrel 11 is sealed, thereby reducing the probability of external air entering the outer barrel 11 and reacting with the material, and can reduce the probability of material deterioration.

[0036] Reference Figure 1 and Figure 2, the pressurizing tube 5 is arranged on the outer barrel 11, the pressurizing tube 5 passes through the outer barrel 11 and is fixed on the outer barrel 11, and the outer wall of the pressurizing tube 5 is sealed and connected to the outer barrel 11. The air pressure sensor 6 is arranged on the sealing cover 12, the air pressure sensor 6 passes through the sealing cover 12 and is sealed and connected to the sealing cover 12, and the air pressure sensor 6 is provided with an electric wire, which is used to power the air pressure sensor 6 and transmit an electric signal. The pressurizing tube 5 is used to fill the outer barrel 11 with gas whose air pressure is higher than the atmospheric pressure. Before the user performs the centrifugal work of the material, he first sets the sealing cover 12 on the outer barrel 11, and injects high-pressure gas into the outer barrel 11 through the pressurizing tube 5, so that there is a micro-positive pressure environment of 1-2kpa inside the centrifuge body 1, and the air pressure sensor 6 can detect the air pressure in the outer barrel 11 and output an electric signal. The user can determine the change of the air pressure in the outer barrel 11 by checking the change of the electrical signal output by the air pressure sensor 6, so as to facilitate the user to determine the airtightness of the centrifuge body 1. When the user finds that the reading of the air pressure sensor 6 changes quickly, it means that the airtightness of the centrifuge body 1 is poor. The user can inspect and repair the centrifuge body 1, thereby ensuring the production quality of the material after centrifugation, reducing the probability of material contamination or deterioration, and improving production efficiency.

[0037] Reference Figure 1 and Figure 2 The sealing cover 12 is provided with a feed pipe 3, which is vertically arranged and penetrates the sealing cover 12. The feed pipe 3 is sealed and connected to the sealing cover 12. The feed pipe 3 is inserted into the continuous flow bowl 2. The user can continuously inject materials into the continuous flow bowl 2 through the feed pipe 3 during the rotation of the continuous flow bowl 2, so that the centrifuge body 1 can continuously perform material separation work. A one-way valve 31 is provided on the feed pipe 3. The one-way valve 31 allows the fluid to flow in one direction in the feed pipe 3. The material can enter the centrifuge body 1 through the one-way valve 31. The high-pressure gas in the centrifuge body 1 is difficult to be discharged to the outside of the centrifuge body 1 through the one-way valve 31. When the pressure pipe 5 injects high-pressure gas into the outer barrel 11, the outer barrel 11 can maintain a closed environment.

[0038] Reference Figure 2 A sterile control valve 51 is provided on the pressurizing pipe 5. The sterile control valve 51 can be a diaphragm valve. The diaphragm valve uses a diaphragm as an opening and closing member to close the flow channel and cut off the fluid, which can reduce the pollution to the air. When the sterile air is filled into the centrifuge body 1 from the pressurizing pipe 5, the pollution of the pressurized air to the material can be reduced.

[0039] Reference Figure 2 A pressure regulating valve 52 is provided on the pressurizing pipe 5, and the pressure regulating valve 52 is configured as an overflow valve. The overflow valve limits the pressure of the sterile air in the pressurizing pipe 5 to a lower range, thereby reducing the probability of excessive air being injected into the centrifuge body 1, causing an accident due to excessive pressure in the outer barrel 11.

[0040] The implementation principle of the embodiment of the present application is as follows: by arranging a pressurized tube 5 on the centrifuge body 1 and arranging an air pressure sensor 6 in the outer barrel 11, before performing centrifugal work, the user first places the sealing cover 12 on the outer barrel 11, fills the pressurized sterile air into the sealed outer barrel 11, and detects the air pressure change in the outer barrel 11 through the air pressure sensor 6, so as to determine the airtightness of the centrifuge body 1. When the user opens the sealing cover 12, the centrifuge body 1 is filled with positive pressure gas, and it is difficult for outside air to enter the outer barrel 11, thereby reducing the probability of the material in the continuous flow bowl 2 being contaminated by the outside air.

[0041] Example 2

[0042] The present application embodiment discloses a real-time measurement of the bowl integrity and sterility control system for a continuous flow centrifuge, referring to Figure 2 , which is different from the embodiment in that a plurality of sieve holes 221 are provided on the side wall 22. When the material falls into the continuous flow bowl 2 and rotates, the liquid or small solid particles in the material can pass through the sieve holes 221 and fall into the space between the outer barrel 11 and the side wall 22, thereby achieving the effect of separating the material. When the sieve holes 221 are provided on the continuous flow bowl 2, the top of the side wall 22 of the continuous flow bowl 2 abuts against the sealing cover 12, thereby reducing the probability of unscreened material entering the gap between the outer barrel 11 and the side wall 22 from between the side wall 22 and the sealing cover 12, thereby improving the screening quality of the centrifuge body 1.

[0043] Reference Figure 2 The outer barrel 11 is provided with a discharge pipe 4, which penetrates the outer barrel 11 and is sealed with the outer barrel 11. The discharge pipe 4 is provided with a check valve 2 41, which is used to make the fluid flow in the discharge pipe 4 in one direction, so that the fluid between the outer barrel 11 and the side wall 22 can be discharged outside the centrifuge body 1 through the discharge pipe 4, and it is difficult for the outside air to enter the centrifuge body 1 through the discharge pipe 4, thereby reducing the probability of material deterioration in the centrifuge body 1.

[0044] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. A real-time measurement of bowl integrity and sterility control system for a continuous flow centrifuge, characterized in that: The centrifuge body (1) comprises a centrifuge body (1), a continuous flow bowl (2) and a pressurizing tube (5). The centrifuge body (1) comprises an outer barrel (11), a sealing cover (12) and a power shaft (13). The sealing cover (12) is rotatably connected to the outer barrel (11). The sealing cover (12) is used to cover the outer barrel (11) and is sealed to the outer barrel (11). The power shaft (13) is rotatably connected to the inner bottom of the outer barrel (11). The continuous flow bowl (2) is connected to the power shaft (13). The continuous flow bowl (2) is used to rotate in the outer barrel (11). The pressurizing tube (5) passes through the outer barrel (11) and is sealed to the outer barrel (11). The pressurizing tube (5) is used to introduce positive pressure sterile gas into the outer barrel (11).

2. A real-time measurement of bowl integrity and sterility control system for a continuous flow centrifuge according to claim 1, characterized in that: An air pressure sensor (6) is provided in the centrifuge body (1), and the air pressure sensor (6) is used to detect the air pressure in the centrifuge body (1).

3. A real-time measurement of bowl integrity and sterility control system for a continuous flow centrifuge according to claim 2, characterized in that: The continuous flow bowl (2) comprises a bottom plate (21) and a side wall (22), wherein the bottom plate (21) and the side wall (22) are connected to form a cylindrical structure, the bottom plate (21) is used to be connected to the power shaft (13), and a plurality of sieve holes (221) are provided on the side wall (22).

4. A real-time measurement of bowl integrity and sterility control system for a continuous flow centrifuge according to claim 3, characterized in that: The sealing cover (12) is provided with a feed pipe (3), the feed pipe (3) passes through the sealing cover (12) and is sealedly connected to the sealing cover (12), and the feed pipe (3) is provided with a one-way valve (31), the one-way valve (31) is used to allow a fluid to flow from the outside of the centrifuge body (1) to the inside of the centrifuge body (1) in a one-way direction.

5. A real-time measurement of bowl integrity and sterility control system for a continuous flow centrifuge according to claim 4, characterized in that: The outer barrel (11) is provided with a discharge pipe (4), which passes through the outer barrel (11) and is sealed with the outer barrel (11), and a second one-way valve (41) is provided on the discharge pipe (4), which is used to allow the fluid to flow from the inside of the centrifuge body (1) to the outside of the centrifuge body (1) in a one-way manner.

6. A real-time measurement of bowl integrity and sterility control system for a continuous flow centrifuge according to claim 1, characterized in that: The pressurizing pipe (5) is provided with a sterile control valve (51), and the sterile control valve (51) is used to reduce the probability of sterile air being contaminated.

7. A real-time measurement of bowl integrity and sterility control system for a continuous flow centrifuge according to claim 6, characterized in that: The pressurizing pipe (5) is provided with a pressure regulating valve (52), and the pressure regulating valve (52) is used to maintain the air pressure in the pressurizing pipe (5) at a level slightly higher than the atmospheric pressure.

8. A real-time measurement of bowl integrity and sterility control system for a continuous flow centrifuge according to claim 1, characterized in that: The power shaft (13) is detachably connected to the continuous flow bowl (2).

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