Liquid chromatographic analysis device for chemical pharmacy

Abstract

The utility model discloses a liquid chromatographic analysis device for chemical pharmacy, and relates to the technical field of chromatographic analyzers. The analyzer comprises a fixed box, a water tank, an electric push rod and an analyzer body, the analyzer body is arranged on one side of the fixed box, the water tank is fixed to the side, close to the analyzer body, of the inner wall of the upper portion of the fixed box, and a plurality of transverse parallel cooling fins are fixed to the side, away from the analyzer body, of the rear portion of the water tank. Fans are fixed at two corners, far away from the side surface of the analyzer main body, of the water tank in front of the cooling fins; electric push rods are symmetrically fixed at the bottom of the water tank along a transverse center line. According to the utility model, the fixed box, the water tank, the electric push rod and the analyzer main body are arranged, so that the problems that the heat dissipation efficiency is relatively low after a liquid chromatographic analysis device is used for exhausting and heating a solvent, and gas in the solvent is not thoroughly removed are solved.

Description

Technical Field

[0001] The utility model belongs to the technical field of chromatographic analyzers, in particular to a liquid chromatographic analysis device for chemical and pharmaceutical use. Background Art

[0002] Liquid chromatography is frequently used in biology, medicine, pharmacy, food science and other fields. It is mainly used to separate, analyze and isolate samples. When liquid chromatography analysis is performed, a liquid chromatography analysis device is required. In chemical pharmaceutical production, liquid chromatography analysis is required to determine the properties and content of the effective components in the prepared drugs. However, it still has the following disadvantages in actual use:

[0003] When a liquid chromatography analysis device performs chromatographic analysis of drugs, in order to reduce errors and interferences during chromatographic analysis, the gas in the solvent is removed by vacuuming or heating. In the process of removing the gas by heating, heating the solvent will cause the temperature of the solvent to rise. After the temperature of the solvent rises, it is cooled to a temperature suitable for use by natural heat dissipation. The waiting time is long, which affects the efficiency of the chromatographic analysis. In addition, the gas in the solvent is removed by only one method, and the gas removal is not thorough enough. Utility Model Content

[0004] The utility model aims to provide a liquid chromatography analysis device for chemical and pharmaceutical use, which solves the problems of low heat dissipation efficiency and insufficient removal of gas in the solvent after the liquid chromatography analysis device performs solvent exhaust heating by arranging a fixed box, a water tank, an electric push rod and an analyzer body.

[0005] In order to solve the above technical problems, the utility model is achieved through the following technical solutions:

[0006] The utility model is a liquid chromatography analysis device for chemical and pharmaceutical use, comprising a fixed box, a water tank, an electric push rod and an analyzer body. The analyzer body is arranged on one side of the fixed box, the water tank is fixed on the side of the upper inner wall of the fixed box close to the analyzer body, a plurality of heat sinks parallel to each other are fixed on the side of the rear of the water tank away from the analyzer body, fans are fixed at two corners of the water tank in front of the heat sink away from the side of the analyzer body, the electric push rod is symmetrically fixed along the horizontal center line at the bottom of the water tank, when working, the water tank is fixed in it through the fixed box, the heat of the solvent in the water tank is assisted by the heat sink to dissipate the heat, the fan blows air to further dissipate the heat, the square piston driven by the electric push rod pushes the solvent in the water tank to lift and output, and after the solvent enters the analyzer body, the chromatographic analysis is performed.

[0007] Furthermore, a front door is hinged on the front side of the fixed box, and ventilation holes are provided through the front door and the rear side of the fixed box. The ventilation holes correspond to the positions of the heat sinks. The fixed box shields its front side through the front door and ventilates through the ventilation holes.

[0008] Furthermore, the telescopic end of the electric push rod is movably connected to the bottom of the water tank, a square piston is fixed on the telescopic ends of the two electric push rods, the square piston is movably connected in the water tank, a ceramic heating plate is fixed on the top of the square piston, and the electric push rod drives the square piston to rise and fall, thereby pushing the solvent in the water tank to be transported through the connecting pipe.

[0009] Furthermore, a thermometer is fixedly connected through the top of the water tank near the front, two electric-controlled valves are fixedly connected to the top of the water tank behind the thermometer, an infusion tube is fixedly connected to the top of the electric-controlled valve near the front, and a vacuum pump is fixedly connected to the top of the electric-controlled valve near the rear. The temperature of the water tank is measured by the thermometer, and the gas precipitated in the solvent in the water tank is extracted by the vacuum pump.

[0010] Furthermore, the output end of the vacuum pump is fixedly connected to an air outlet pipe, and the air outlet pipe is fixed on the top of the fixed box. The top ends of the infusion tube and the air outlet pipe are fixedly connected to connectors, and the vacuum pump outputs the pumped gas to the processing equipment through the air outlet pipe.

[0011] Furthermore, a fixed sleeve is fixedly connected to the top of the analyzer body, a connecting pipe is fixedly connected to one side of the top of the water tank, the connecting pipe is fixed through the top of the fixed box, one end of the connecting pipe away from the water tank is fixed in the fixed sleeve, and the analyzer body fixes the end of the connecting pipe through the fixed sleeve, so that the solvent transported in the connecting pipe is input into it.

[0012] The utility model has the following beneficial effects:

[0013] 1. The utility model solves the problem of low heat dissipation efficiency of the liquid chromatography analysis device after exhausting and heating the solvent by setting a fixed box and a water tank. After the solvent is degassed, the fan is started to blow air to the heat sink on the water tank, so that the temperature of the solvent in the water tank drops to a temperature that can be used for chromatographic analysis, so that the heat dissipation efficiency of the liquid chromatography analysis device after exhausting and heating the solvent is higher.

[0014] 2. The utility model solves the problem of insufficient removal of gas from the solvent when the liquid chromatography analysis device performs solvent exhaust by arranging a fixed box, a water tank, an electric push rod and an analyzer body. When the ceramic heating plate heats the solvent in the water tank, the gas dissolved in the solvent is precipitated, and at the same time, the electric control valve under the vacuum pump is started, and the vacuum pump is started. The vacuum pump pumps the gas precipitated in the water tank into the air outlet pipe, and transports it to the exhaust device through the air outlet pipe, so that the content of dissolved gas in the solvent in the water tank is greatly reduced, so that the gas in the solvent is removed more thoroughly when the liquid chromatography analysis device performs solvent exhaust. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is a three-dimensional diagram of the assembly structure of a liquid chromatography analysis device for chemical and pharmaceutical use;

[0016] Figure 2 It is a three-dimensional diagram of the fixed box structure;

[0017] Figure 3 It is a three-dimensional diagram of the water tank structure;

[0018] Figure 4 It is a three-dimensional diagram of the electric push rod structure;

[0019] Figure 5 This is a three-dimensional diagram of the main structure of the analyzer.

[0020] Reference numerals:

[0021] 1. Fixed box; 101. Front door; 102. Air vent; 2. Water tank; 201. Fan; 202. Heat sink; 203. Thermometer; 204. Electric control valve; 205. Infusion tube; 206. Vacuum pump; 207. Exhaust pipe; 208. Connector; 209. Connecting pipe; 3. Electric push rod; 301. Square piston; 302. Ceramic heating plate; 4. Analyzer body; 401. Fixed sleeve. DETAILED DESCRIPTION

[0022] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model. Specific embodiment 1

[0024] See also Figure 1-5The utility model is a liquid chromatography analysis device for chemical and pharmaceutical use, comprising a fixed box 1, a water tank 2, an electric push rod 3 and an analyzer body 4. The analyzer body 4 is arranged on one side of the fixed box 1, and the fixed box 1 fixes the water tank 2 therein, and provides chromatographic analysis of the sample through the analyzer body 4. The water tank 2 is fixed on the side of the upper inner wall of the fixed box 1 close to the analyzer body 4, and the chromatographic analysis solvent is contained in the water tank 2. A plurality of heat sinks 202 are fixed on the side of the rear of the water tank 2 away from the analyzer body 4, and fans 201 are fixed at the two corners of the side of the water tank 2 away from the analyzer body 4 in front of the heat sink 202. The air is sucked in from the air vents 102 on the front door 101 through the fan 201, and output through the air vents 102 on the fixed box 1. The bottom of the water tank 2 is symmetrically fixed with electric push rods 3 along the horizontal center line, and the square piston 301 is driven to rise and fall in the water tank 2 by the electric push rods 3.

[0025] Specifically, a front door 101 is hinged on the front side of the fixed box 1, and air holes 102 are provided through the front door 101 and the rear side of the fixed box 1. The air holes 102 correspond to the positions of the heat sink 202. The front of the fixed box 1 is covered by the front door 101, and the air holes 102 provide the function of inlet and outlet of heat dissipation air.

[0026] Furthermore, the telescopic end of the electric push rod 3 is movably connected to the bottom of the water tank 2, and a square piston 301 is fixed on the telescopic ends of the two electric push rods 3. The square piston 301 is movably connected in the water tank 2, and a ceramic heating plate 302 is fixed on the top of the square piston 301. When the electric push rod 3 is working, it drives the square piston 301 to rise in the water tank 2. When the square piston 301 rises, it pushes the solvent in the water tank 2 to be transported to the connecting pipe 209, and then transported to the analyzer body 4 through the connecting pipe 209.

[0027] The operation process of this embodiment is as follows: during operation, after a suitable amount of solvent is loaded into the water tank 2, the ceramic heating plate 302 is started to allow the gas dissolved in the solvent in the water tank 2 to be initially precipitated. After the solvent is degassed, the fan 201 is started to blow air onto the heat sink 202 on the water tank 2, so that the temperature of the solvent in the water tank 2 drops to a temperature at which chromatographic analysis can be performed. The electric push rod 3 is then started to drive the square piston 301 to rise in the water tank 2. When the square piston 301 rises, the solvent in the water tank 2 is pushed to be transported to the connecting pipe 209, and then transported to the analyzer body 4 through the connecting pipe 209. Specific embodiment 2

[0029] See also Figure 1 , 3, 4, 5. On the basis of the specific embodiment 1, a thermometer 203 is fixed through the top of the water tank 2 near the front, and the thermometer 203 measures the temperature in the water tank 2. Two electrically controlled valves 204 are fixedly connected to the top of the water tank 2 behind the thermometer 203. A liquid infusion tube 205 is fixedly connected to the top of the electrically controlled valve 204 near the front, and a vacuum pump 206 is fixedly connected to the top of the electrically controlled valve 204 near the rear. The water tank 2 is connected to the liquid infusion tube 205 and the vacuum pump 206 through the electrically controlled valve 204. When the vacuum pump 206 is working, the gas in the water tank 2 is extracted therefrom, so that a negative pressure is maintained in the water tank 2, and the gas precipitated from the solvent in the water tank 2 is discharged. The water tank 2 transports the solvent for liquid phase mass spectrometry analysis to the electrically controlled valve 204 through the infusion tube 205, and then the infusion tube 205 is controlled to be on and off by the electrically controlled valve 204.

[0030] Specifically, the output end of the vacuum pump 206 is fixedly connected to an outlet pipe 207, and the outlet pipe 207 is fixed on the top of the fixed box 1. The tops of the infusion tube 205 and the outlet pipe 207 are fixedly connected to a connector 208. The connector 208 at the top of the infusion tube 205 is connected to the pipe joint for conveying the solvent, and the connector 208 at the top of the outlet pipe 207 is connected to the input end of the equipment for treating waste gas. The outlet pipe 207 at the output end of the vacuum pump 206 conveys the pumped gas therein to the waste gas treating equipment.

[0031] Furthermore, the top of the analyzer body 4 is fixedly connected to a fixed sleeve 401, and one side of the top of the water tank 2 is fixedly connected to a connecting pipe 209. The connecting pipe 209 is fixed on the top of the fixed box 1, and one end of the connecting pipe 209 away from the water tank 2 is fixed in the fixed sleeve 401. The analyzer body 4 fixes the connecting pipe 209 through the fixed sleeve 401, so that the solvent transported in the connecting pipe 209 is transported to the analyzer body 4 for operation.

[0032] The operation process of this embodiment is: when the ceramic heating plate 302 heats the solvent in the water tank 2, the gas dissolved in the solvent is precipitated, and at the same time, the electric control valve 204 below the vacuum pump 206 is started, and the vacuum pump 206 is started. The vacuum pump 206 pumps the gas precipitated in the water tank 2 into the outlet pipe 207, and transports it to the exhaust equipment through the outlet pipe 207, so that the gas content dissolved in the solvent in the water tank 2 is greatly reduced.

[0033] In the description of this specification, the description with reference to the terms "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the utility model. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0034] The preferred embodiments of the utility model disclosed above are only used to help explain the utility model. The preferred embodiments do not describe all the details in detail, nor do they limit the utility model to the specific implementation methods described. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the utility model, so that technicians in the relevant technical field can well understand and use the utility model. The utility model is limited only by the claims and their full scope and equivalents.

Claims

1. A liquid chromatography analysis device for chemical and pharmaceutical use, comprising a fixed box (1), a water tank (2), an electric push rod (3) and an analyzer body (4), characterized in that: An analyzer body (4) is arranged on one side of the fixed box (1); a water tank (2) is fixed on the side of the upper inner wall of the fixed box (1) close to the analyzer body (4); a plurality of heat sinks (202) parallel to each other are fixed on the rear side of the water tank (2) away from the analyzer body (4); fans (201) are fixed at two corners of the side of the water tank (2) away from the analyzer body (4) in front of the heat sink (202); and electric push rods (3) are fixed symmetrically along the horizontal center line at the bottom of the water tank (2).

2. A liquid chromatography analysis device for chemical and pharmaceutical use according to claim 1, characterized in that: The front side of the fixed box (1) is hinged with a front door (101), and both the front door (101) and the rear side of the fixed box (1) are provided with ventilation holes (102), and the positions of the ventilation holes (102) correspond to those of the heat sink (202).

3. A liquid chromatography analysis device for chemical and pharmaceutical use according to claim 1, characterized in that: The telescopic end of the electric push rod (3) is movably connected to the bottom of the water tank (2), a square piston (301) is fixed on the telescopic ends of the two electric push rods (3), the square piston (301) is movably connected in the water tank (2), and a ceramic heating plate (302) is fixed on the top of the square piston (301).

4. A liquid chromatography analysis device for chemical and pharmaceutical use according to claim 1, characterized in that: A thermometer (203) is fixedly connected through the top of the water tank (2) near the front, and two electric control valves (204) are fixedly connected to the top of the water tank (2) behind the thermometer (203). A liquid infusion tube (205) is fixedly connected to the top of the electric control valve (204) near the front, and a vacuum pump (206) is fixedly connected to the top of the electric control valve (204) near the rear.

5. A liquid chromatography analysis device for chemical and pharmaceutical use according to claim 4, characterized in that: The output end of the vacuum pump (206) is fixedly connected to an air outlet pipe (207), and the air outlet pipe (207) is fixedly connected to the top of the fixed box (1). The top ends of the infusion tube (205) and the air outlet pipe (207) are both fixedly connected to a connector (208).

6. A liquid chromatography analysis device for chemical and pharmaceutical use according to claim 1, characterized in that: The top of the analyzer body (4) is fixedly connected to a fixed sleeve (401), and one side of the top of the water tank (2) is fixedly connected to a connecting pipe (209), the connecting pipe (209) is fixed through the top of the fixed box (1), and one end of the connecting pipe (209) away from the water tank (2) is fixed in the fixing sleeve (401).

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