Liquid transfer device and liquid transfer tip removal device

Abstract

The present application relates to the field of medical equipment technology, and in particular to a liquid transfer device and a liquid transfer tip removal device. The liquid transfer tip removal device includes a frame, a first drive guide mechanism, a mounting plate, a second drive guide mechanism, a trigger assembly, a tip mounting tube and a sleeve; the first drive guide mechanism is arranged on the frame and connected to the mounting plate, and can drive the mounting plate to move in the first position and the second position; the second drive guide mechanism is fixed to the mounting plate and connected to the trigger assembly, and can drive the trigger assembly to switch between the reset state and the trigger state; the tip mounting tube is connected to the mounting plate and is used to install the liquid transfer tip, and the sleeve is slidably sleeved on the outer periphery of the tip mounting tube; the mounting plate is in the first position to drive the tip mounting tube to retract the frame, and in the second position to drive the tip mounting tube to extend out of the frame; the trigger assembly switches to the trigger state to drive the sleeve to slide toward the end of the tip mounting tube to remove the liquid transfer tip. The liquid transfer tip removal device can complete the automatic replacement of the liquid transfer tip and improve the liquid transfer efficiency.

Description

Technical Field

[0001] The present application relates to the technical field of medical equipment, and in particular to a liquid transfer device and a liquid transfer tip removal device. Background Art

[0002] A pipette, also called a pipette gun, is a measuring tool that transfers liquid from the original container to another container within a certain range. It is widely used in biochemical and medical fields.

[0003] Due to the harmfulness of the liquid being transferred, the difficulty in cleaning, or the lack of convenience, some pipettes often use disposable tips that can be discarded. This type of tip is generally made of plastic and is inserted into the tip holder of the pipette during use. The tip needs to be removed from the pipette after use. This type of pipette requires frequent replacement of pipette tips. In order to quickly replace the tip, some pipettes are equipped with a tip removal device, but there may be deviations during operation, causing damage to the pipette and affecting the service life of the pipette. More importantly, the tip removal device can only remove the tip from the pipette, but cannot install the pipette tip to the pipette, which is inconvenient and affects the efficiency of pipetting. Utility Model Content

[0004] The present application provides a pipetting device and a pipetting tip removal device, which can realize automatic replacement of the pipetting tip by the pipetting device and improve the pipetting efficiency.

[0005] In a first aspect, the present application provides a device for removing and removing a pipette tip, comprising: a frame, a first drive guide mechanism, a mounting plate, a second drive guide mechanism, a trigger assembly, a pipette tip mounting tube, and a sleeve;

[0006] The first driving guide mechanism is disposed on the frame and connected to the mounting plate, and is used to drive the mounting plate to move between a first position and a second position relative to the frame;

[0007] The second driving guide mechanism is fixed to the mounting plate and connected to the trigger assembly, and is used to drive the trigger assembly to switch between a reset state and a trigger state;

[0008] The pipette tip mounting tube is connected to the mounting plate and is used to mount the pipette tip, and the sleeve is slidably sleeved on the outer circumference of the pipette tip mounting tube;

[0009] When the mounting plate is in the first position, it drives the tip mounting tube to be retracted into the frame, and when the mounting plate is in the second position, it drives the tip mounting tube to be extended out of the frame; when the trigger assembly is in the reset state, the pipette tip can be mounted on the tip mounting tube; during the switching process of the trigger assembly to the trigger state, the sleeve is driven to slide toward the end of the tip mounting tube to remove the pipette tip from the tip mounting tube.

[0010] In some embodiments, the frame includes a top plate and a bottom plate arranged parallel to each other, and a side plate connected between the top plate and the first end of the bottom plate;

[0011] The first driving guide mechanism comprises:

[0012] A guide rail is fixed to the side plate, and the mounting plate is parallel to the top plate and the bottom plate and is slidably connected to the guide rail;

[0013] A first driving motor is fixed to the top plate or the bottom plate;

[0014] The first screw rod assembly is connected to the first driving motor and the mounting plate, and is used to drive the mounting plate to move between a first position and a second position.

[0015] In some embodiments, the first driving guide mechanism further includes a first guide rod, the first guide rod is connected between the second ends of the top plate and the bottom plate, and one end of the mounting plate away from the guide rail is slidably connected to the first guide rod.

[0016] In some embodiments, the second driving guide mechanism comprises:

[0017] A second driving motor is fixed to the mounting plate;

[0018] A second screw rod assembly connected to the second drive motor;

[0019] A second guide rod fixed to the mounting plate;

[0020] The trigger component comprises:

[0021] A head removal plate is slidably connected to the second guide rod, the head removal plate is connected to the second screw rod assembly and moves parallel to or away from the mounting plate under the drive of the second screw rod assembly;

[0022] A head removal guide rod, slidably connected to the mounting plate;

[0023] When the trigger assembly moves to a reset state, it drives the head removal plate to separate from the head removal guide rod; when the trigger assembly moves to a trigger state, the head removal plate abuts and drives the head removal guide rod to slide, and the head removal guide rod drives the sleeve to slide to the end of the suction head mounting tube.

[0024] In some embodiments, the unloading head guide rods are provided in two groups.

[0025] In some embodiments, the pipette tip removal device includes a limit block, which is concave and snap-fitted to the mounting plate, and the tip mounting tube corresponds to the groove of the limit block and passes through the limit block; the sleeve is provided with a second limit boss which is locked in the groove of the limit block, and the head removal guide rod is arranged corresponding to the second limit boss.

[0026] In some embodiments, the suction head mounting tube is provided with a first limiting boss that is clamped on the mounting plate, and a return spring is provided between the first limiting boss and the second limiting boss.

[0027] In some embodiments, the pipette tip removal device satisfies at least any one of the following:

[0028] The frame is provided with a first position sensor for detecting whether the mounting plate reaches the first position;

[0029] The mounting plate is provided with a second position sensor for detecting whether the trigger assembly has returned to a reset state;

[0030] A third position sensor for detecting the position of the sleeve is also included.

[0031] In some embodiments, at least one of the first position sensor, the second position sensor, and the third position sensor is a photocoupler sensor.

[0032] In a second aspect, the present application provides a pipetting device, comprising a plunger pump, a connecting hose, a connecting head and a pipette tip removal device as described in any of the above items, wherein the plunger pump is connected to the connecting hose, and the connecting head connects the connecting hose and the tip mounting tube.

[0033] Compared with the prior art, the above technical solution provided by the embodiment of the present application has the following advantages: the pipette tip can be installed or removed relative to the tip mounting tube, which prevents the operator from contacting toxic substances or contaminating the sample liquid, and improves the efficiency of pipette tip replacement and pipetting efficiency. The working process is as follows:

[0034] Tip mounting tube reset: the first drive guide mechanism drives the mounting plate to move to the first position, and the tip mounting tube connected to the mounting plate is retracted into the frame to complete the reset. At the same time, the second drive guide mechanism drives the trigger assembly to switch to the reset state to prevent the trigger assembly from affecting the installation of the pipette tip;

[0035] When the pipette tip needs to be installed, the tip installation tube is aligned with the pipette tip on the pipette tip holder, and the first driving guide mechanism drives the mounting plate to move from the first position to the second position, driving the tip installation tube to extend out of the frame and be plugged and fixed with the pipette tip, thereby completing the installation of the pipette tip through the tip installation tube;

[0036] When the pipette tip needs to be removed, the second drive guide mechanism drives the trigger assembly to switch from the reset state to the trigger state, thereby driving the sleeve to slide toward the end of the tip mounting tube. The sleeve abuts the end of the pipette tip, and the pipette tip connected to the end of the tip mounting tube is removed from the tip mounting tube.

[0037] The above-mentioned pipette tip removal device can realize automatic installation and removal of pipette tips, and installation and removal are convenient and quick, which improves the efficiency of tip replacement and pipetting. The operator only needs to align the pipette tip holder with the tip mounting tube during installation, and avoids contact with the pipette tip or the tip mounting tube during the whole process, reducing the risk of contact with toxic substances and the risk of contaminating the sample liquid. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the present application and, together with the description, serve to explain the principles of the present application.

[0039] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, for ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative labor.

[0040] One or more embodiments are exemplarily described by pictures in the corresponding drawings, and these exemplified descriptions do not constitute limitations on the embodiments. Elements with the same reference numerals in the drawings represent similar elements, and unless otherwise stated, the figures in the drawings do not constitute proportional limitations.

[0041] Figure 1 A schematic diagram of a liquid transfer device using a liquid transfer tip removal device provided in an embodiment of the present application;

[0042] Figure 2 for Figure 1 A front view of

[0043] Figure 3 for Figure 1 Left view of .

[0044] Figure 4 for Figure 2 AA section view;

[0045] Figure 5 for Figure 3 BB cross-sectional view;

[0046] Figure 6 for Figure 5 A partial enlarged view of part I in the middle.

[0047] Description of reference numerals:

[0048] 1-first drive motor; 2-second drive motor; 3-plunger pump; 4-guide rail; 5-frame; 501-top plate; 502-side plate; 503-bottom plate; 6-mounting plate; 7-first position sensor; 8-first baffle; 9-head removal plate; 10-first guide rod; 11-pipette tip; 12-second position sensor; 13-tip mounting tube; 1301-first limit boss; 14-sleeve; 1401-second limit boss; 15-third position sensor; 16-reset spring; 17-limit block; 18-connecting head; 19-second guide rod; 20-head removal guide rod; 21-connecting hose. DETAILED DESCRIPTION

[0049] In order to make the purpose, technical solution and advantages of the embodiments of the present application clearer, the technical solution in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of this application.

[0050] The disclosure below provides many different embodiments or examples to realize the different structures of the present application. In order to simplify the disclosure of the present application, the parts and settings of specific examples are described below. Of course, they are only examples, and the purpose is not to limit the present application. In addition, the present application can repeat reference numbers and / or letters in different examples. This repetition is for the purpose of simplification and clarity, and does not itself indicate the relationship between the various embodiments and / or settings discussed.

[0051] For ease of description, spatial relative terms may be used herein to describe the relative positional relationship or movement of one element or feature relative to another element or feature as shown in the figure, such as "inside", "outside", "inner side", "outer side", "below", "below", "above", "above", "front", "back", etc. Such spatial relative terms are intended to include different orientations of the device in use or operation in addition to the orientation depicted in the figure. For example, if the device in the figure undergoes a position flip or a posture change or a motion state change, then these directional indications also change accordingly, for example: an element described as "below other elements or features" or "below other elements or features" will subsequently be oriented as "above other elements or features" or "above other elements or features". Therefore, the example term "below..." may include both upper and lower orientations. The device may be otherwise oriented (rotated 90 degrees or in other directions) and the spatial relative descriptors used herein are interpreted accordingly.

[0052] In order to solve the problem in the prior art that the pipette cannot automatically replace the pipette tip 11 and affects the pipetting efficiency, the present application provides a pipette device and a pipette tip removal device, which can enable the operator to automatically replace the pipette tip 11 without contact, thereby improving the tip replacement efficiency and the pipetting efficiency; at the same time, it prevents the operator from contacting toxic substances and contaminated sample liquid.

[0053] See also Figure 1 and Figure 2 , an embodiment of the present application provides a device for removing and removing a pipette tip, which can realize automatic installation and removal of a pipette tip 11. The device for removing and removing a pipette tip includes a frame 5, a first drive guide mechanism, a mounting plate 6, a second drive guide mechanism, a trigger assembly, a tip mounting tube 13 and a sleeve 14. Among them, the first drive guide mechanism is installed on the frame 5, and the mounting plate 6 is connected to the output end of the first drive guide mechanism, and can move between a first position and a second position relative to the frame 5 under the drive of the first drive guide mechanism. The second drive guide mechanism is installed on the mounting plate 6, and the trigger assembly is connected to the output end of the second drive guide mechanism, and can switch between a reset state and a trigger state under the drive of the second drive guide mechanism.

[0054] The tip mounting tube 13 is connected to the mounting plate 6 and is used for the pipette tip 11 to be sleeved at its end. The sleeve 14 is slidably sleeved on the outer periphery of the tip mounting tube 13. When the tip mounting tube 13 is inserted into the pipette tip 11, the pipette tip 11 abuts against and drives the sleeve 14 to slide in a direction away from the end of the tip mounting tube 13; when the sleeve 14 is driven by the trigger assembly to slide in the direction toward the end of the tip mounting tube 13, it abuts against the end of the pipette tip 11, and the pipette tip 11 sleeved at the end of the tip mounting tube 13 is removed from the tip mounting tube 13.

[0055] When the mounting plate 6 is driven to the first position by the first driving guide mechanism, the mounting tube 13 is retracted relative to the frame 5; when the mounting plate 6 is driven to the second position by the first driving guide mechanism, the mounting tube 13 is extended relative to the frame 5. When the trigger assembly is driven to the reset state by the second driving guide mechanism, the trigger assembly is disengaged from the limit of the sleeve 14, and the sleeve 14 can slide in a direction away from the end of the tip mounting tube 13, so that the pipette tip 11 can squeeze the sleeve 14 from the end of the tip mounting tube 13 to be sleeved and installed at the end of the tip mounting tube 13; when the trigger assembly is driven to the trigger state by the second driving guide mechanism, the trigger assembly drives the sleeve 14 to slide toward the end of the tip mounting tube 13, and the pipette tip 11 sleeved and installed at the end of the tip mounting tube 13 is removed.

[0056] The reset process of the tip mounting tube 13: the first driving guide mechanism drives the mounting plate 6 to move to the first position, and the tip mounting tube 13 connected to the mounting plate 6 is retracted into the frame 5 to complete the reset. At the same time, the second driving guide mechanism drives the trigger component to switch to the reset state to prevent the trigger component from affecting the installation of the pipette tip 11.

[0057] During the installation process of the pipette tip 11, the trigger assembly remains in the reset state, and the first drive guide mechanism drives the mounting plate 6 to move from the first position to the second position, driving the tip mounting tube 13 to extend relative to the frame 5. The tip mounting tube 13 is inserted into the pipette tip 11 during the extension process, so that the pipette tip 11 is sleeved and installed at the end of the tip mounting tube 13.

[0058] During the removal process of the pipette tip 11, the second driving guide mechanism drives the trigger assembly to switch from the reset state to the trigger state, and at the same time drives the sleeve 14 to slide toward the end of the tip mounting tube 13. The sleeve 14 abuts and pushes the end of the pipette tip 11, and the pipette tip 11 connected to the end of the tip mounting tube 13 is removed from the tip mounting tube 13.

[0059] It should be noted that the first drive guide mechanism and the second drive guide mechanism usually include a drive part and a guide part, which are respectively used to drive the corresponding components such as the mounting plate 6 to reciprocate along the set direction. The trigger assembly is essentially a group of transmission components arranged between the second drive guide mechanism and the sleeve 14, and the movement of the second drive guide mechanism drives the trigger assembly to switch between the reset state and the trigger state. The trigger assembly can be fixedly connected to the sleeve 14, or it can have no direct connection relationship with the sleeve 14, and can only abut the drive sleeve 14 to slide toward the end direction of the suction head mounting tube 13 in the trigger state.

[0060] In one embodiment provided in this application, continue to refer to Figure 1 and Figure 2, the frame 5 includes a top plate 501, a bottom plate 503 and a side plate 502, the top plate 501 and the bottom plate 503 are arranged parallel to each other at a set interval, and the side plate 502 is vertically connected between the first ends of the top plate 501 and the bottom plate 503. The first drive guide mechanism includes a guide assembly, a first drive motor 1 and a first screw assembly. Exemplarily, the guide assembly can be a guide rail 4 installed and fixed on the inner side of the side plate 502, the mounting plate 6 is arranged parallel to the top plate 501 and the bottom plate 503, and the first end of the mounting plate 6 is slidably connected to the guide rail 4. The first drive motor 1 is fixed on the top plate 501 or the bottom plate 503, and the accompanying drawings use the first drive motor 1 to be fixed on the top plate 501, and the first screw assembly is connected between the output shaft of the first drive motor 1 and the mounting plate 6, and the mounting plate 6 is driven to move between the top plate 501 and the bottom plate 503 by the forward and reverse rotation of the first drive motor 1. The first position refers to the position where the mounting plate 6 is close to the top plate 501 by a preset distance, and the second position refers to the position where the mounting plate 6 is close to the bottom plate 503 by a preset distance. The suction head mounting tube 13 is connected to the mounting plate 6, and a hole is opened at a corresponding position of the bottom plate 503 for the suction head mounting tube 13 to extend or retract into the rack 5.

[0061] Furthermore, in order to ensure that the mounting plate 6 slides smoothly between the top plate 501 and the bottom plate 503 along the guide rail 4, the first driving guide mechanism also includes a first guide rod 10, and the first guide rod 10 is vertically connected to the second end of the top plate 501 and the bottom plate 503. The second end of the mounting plate 6 is provided with a sliding guide hole that cooperates with the first guide rod 10. With the help of the first guide rod 10 and the guide rail 4, the movement of the mounting plate 6 is guided by the mounting plate 6 respectively, so as to ensure the stability and accuracy of the movement of the mounting plate 6.

[0062] In some embodiments, a first position sensor 7 may be provided on the frame 5 as required, and the first position sensor 7 may be used to detect the position of the mounting plate 6 to determine whether the mounting plate 6 has reached the first position. Specifically, the first position sensor 7 may be an optical coupling sensor installed at a corresponding position of the side plate 502, the optical coupling sensor including a transmitting end and a receiving end relatively arranged, and a first baffle 8 is provided at the first end of the mounting plate 6. When the first baffle 8 moves between the transmitting end and the receiving end of the optical coupling sensor, the infrared rays emitted by the transmitting end are blocked, and the receiving end cannot receive the infrared signal. The first position sensor 7 and the first drive guide mechanism may be used in combination to improve the reliability of the first drive guide mechanism driving the mounting plate 6 to move. The first position sensor 7 may also be a proximity switch, etc., which will not be elaborated in detail here.

[0063] The setting of the second driving guide mechanism can also refer to Figure 1 and Figure 2In this embodiment, the second driving guide mechanism includes a second driving motor 2, a second screw assembly and a second guide rod 19. The second driving motor 2 is fixed to the side of the mounting plate 6 facing the bottom plate 503, the second screw assembly penetrates the mounting plate 6 and extends to the side of the mounting plate 6 facing the top plate 501, the second screw assembly is connected to the output shaft of the second driving motor 2, and the other end is used to connect and drive the trigger assembly to move; the second guide rod 19 is vertically fixed to the side of the mounting plate 6 facing the top plate 501. Correspondingly, the trigger assembly includes a head removal plate 9 and a head removal guide rod 20, the head removal plate 9 is arranged parallel to the mounting plate 6, and the head removal plate 9 is slidably sleeved on the second guide rod 19, and can slide toward or away from the mounting plate 6 in a state parallel to the mounting plate 6 under the guidance of the second guide rod 19. The second screw assembly is connected to the head removal plate 9, and the head removal plate 9 is driven to move toward or away from the mounting plate 6 by the forward and reverse rotation of the second driving motor 2 and the second screw assembly, and the head removal guide rod 20 penetrates the mounting plate 6 and is slidably connected to the mounting plate 6.

[0064] When the second drive motor 2 and the second screw assembly drive the trigger assembly to switch to the reset state, the head unloading plate 9 is driven to move away from the mounting plate 6 toward the top plate 501, and the head unloading plate 9 and the head unloading guide rod 20 are disengaged, and the limit on the head unloading guide rod 20 is released. The head unloading guide rod 20 can slide toward the top plate 501, so that the sleeve 14 can slide upward relative to the suction tip mounting tube 13 without affecting the pipette nozzle being sleeved and installed on the end of the suction tip mounting tube 13.

[0065] The second drive motor 2 and the second screw assembly drive the trigger assembly to switch to the trigger state, driving the head unloading plate 9 to move toward the mounting plate 6. The bottom surface of the head unloading plate 9 contacts the head unloading guide rod 20 and drives the head unloading guide rod 20 to move downward. The head unloading guide rod 20 abuts against the driving sleeve 14 to move relative to the tip mounting tube 13 toward the end of the tip mounting tube 13. If the end of the tip mounting tube 13 is sleeved with a pipette tip 11, the sliding of the sleeve 14 can remove the pipette tip 11 from the tip mounting tube 13.

[0066] Specifically, two or more groups of head removal guide rods 20 can be provided. Taking two groups as an example, the two groups of head removal guide rods 20 are symmetrically arranged about the axis of the sleeve 14, and the head removal guide rods 20 are located at the periphery of the suction head mounting tube 13, so as to facilitate relatively balanced driving of the sleeve 14. Correspondingly, the head removal plate 9 can be provided with a avoidance groove so that the head removal plate 9 can extend to the periphery of the suction head mounting tube 13, and abut against the head removal guide rods 20 when moving toward the mounting plate 6, so that the head removal guide rods 20 abut against the driving sleeve 14 to move toward the end of the suction head mounting tube 13.

[0067] In some embodiments, in conjunction with Figures 2 to 6In order to limit the position of the sliding sleeve 14 and prevent the sliding sleeve 14 from falling off relative to the tip mounting tube 13, the pipette tip removal device provided in the embodiment of the present application also includes a limit block 17, which is concavely snap-fitted to the lower side of the mounting plate 6, that is, the side facing the bottom plate 503. The tip mounting tube 13 and the sleeve 14 both correspond to the groove of the limit block 17 and penetrate the limit block 17 so as to pass through the opening of the bottom plate 503. The top end of the sleeve 14 is located in the groove of the limit block 17, and the head removal guide rod 20 penetrates from the upper end surface of the mounting plate 6 to the lower end surface and extends into the groove of the limit block 17. The top of the sleeve 14 is provided with a second limiting boss 1401, the size of which is larger than the size of the hole on the limiting block 17 through which the sleeve 14 passes. When the second limiting boss 1401 abuts against the bottom of the groove, the bottom end of the sleeve 14 is flush with the bottom end of the tip mounting tube 13, ensuring that the sleeve 14 can remove the pipette tip 11 on the tip mounting tube 13. In the illustrated embodiment, the head removal guide rod 20 and the second limiting boss 1401 are connected by fastening screws, so that the head removal guide rod 20 and the mounting plate 6 cooperate to play a certain guiding role in the sliding of the sleeve 14 relative to the tip mounting tube 13.

[0068] The top end of the pipette tip mounting tube 13 penetrates the upper end surface of the mounting plate 6 so as to be connected to the connecting hose 21 through the connector 18. In order to ensure that the pipette tip mounting tube 13 does not slide upward relative to the mounting plate 6 when the mounting plate 6 drives the pipette tip mounting tube 13 to move downward to be connected to the pipette tip 11, the portion of the pipette tip mounting tube 13 located at the lower side of the mounting plate 6, i.e., the portion located in the groove of the limiting block 17, is provided with a first limiting boss 1301, the size of the first limiting boss 1301 is larger than the size of the hole on the mounting plate 6 through which the pipette tip mounting tube 13 passes upward, so that the first limiting boss 1301 is clamped on the lower side of the mounting plate 6.

[0069] Furthermore, the part of the tip mounting tube 13 located in the groove of the limit block 17 is sleeved with a return spring 16, and the two ends of the return spring 16 respectively abut between the first limit boss 1301 and the second limit boss 1401, providing an upward elastic force for the tip mounting tube 13 and a downward elastic force for the sleeve 14, so as to keep the tip mounting tube 13 and the mounting plate 6 in a relatively close state. It should be noted that the elastic force provided by the return spring 16 is less than the connection force between the end of the pipette tip 11 and the tip mounting tube 13, that is, when the pipette tip 11 is connected by the tip mounting tube 13 and drives the sleeve 14 to move upward to compress the return spring 16, the elastic force generated by the return spring 16 cannot separate the tip mounting tube 13 from the pipette tip 11, and the head removal plate 9 needs to press down the head removal guide rod 20, and the head removal guide rod 20 abuts downward to drive the sleeve 14 to move downward to separate the pipette tip 11 from the tip mounting tube 13.

[0070] On the basis of the above-mentioned embodiments, the pipette tip removal device provided in the present application may also be provided with a second position sensor 12 and a third position sensor 15 as needed. Among them, the second position sensor 12 may be provided at the mounting plate 6 to detect the position of a trigger assembly such as the head removal plate 9. Exemplarily, the second position sensor 12 adopts an optical coupling sensor and is installed at a preset height on the upper surface of the mounting plate 6, and a second baffle is provided at the corresponding position of the head removal plate 9. When the head removal plate 9 is driven by the second drive motor 2 and the second screw assembly to move upward until the second baffle is detected by the optical coupling sensor, the head removal plate 9 and the head removal guide rod 20 are completely disengaged and no longer abut against the head removal guide rod 20, and the sleeve 14 can drive the head removal guide rod 20 to move upward without being limited by the abutment of the head removal plate 9, that is, the trigger assembly is in a reset state, and at this time the pipette tip 11 can be installed on the tip mounting tube 13.

[0071] The third position sensor 15 can be arranged in the limit block 17 to detect the position of the second limit boss 1401, that is, the sleeve 14. When the second limit boss 1401 moves upward to a state close to the first limit boss 1301 and compresses the reset spring 16, the third position sensor 15 can detect the second limit boss 1401. At this time, the sleeve 14 is in a state away from the end of the tip mounting tube 13, that is, the bottom end, indicating that the pipette tip 11 is installed and connected to the tip mounting tube 13. When the third position sensor 15 fails to detect the second limit boss 1401, the second limit boss 1401 is in a state away from the first limit boss 1301, and the sleeve 14 is in a position close to the end of the tip mounting tube 13, indicating that the pipette tip 11 is not installed on the tip mounting tube 13. The third position sensor 15 can confirm whether the pipette tip 11 is installed on the tip mounting tube 13 by detecting the position of the sleeve 14. The third position sensor 15 can also be an optical coupling sensor or a proximity switch.

[0072] The embodiment of the present application also provides a liquid transfer device, including a plunger pump 3, a connecting hose 21, a connector 18, and a liquid transfer tip removal device provided in the above embodiment, wherein the connector 18 is connected to the top of the tip mounting tube 13, and the connecting hose 21 is connected between the connector 18 and the plunger pump 3. When a liquid transfer tip 11 is connected to the end of the tip mounting tube 13 and liquid needs to be transferred, the plunger pump 3 is operated in a first direction to transfer liquid; when liquid needs to be discharged, the plunger pump 3 is driven to operate in a second direction to discharge liquid, and the first direction and the second direction are opposite, and liquid transfer is achieved by driving the plunger pump 3 to reciprocate.

[0073] It should be understood that the terms used herein are only for the purpose of describing specific example embodiments and are not intended to be limiting. Unless the context clearly indicates otherwise, the singular forms "one", "an" and "said" as used herein may also be meant to include plural forms. The terms "include", "comprise", "contain", and "have" are inclusive, and therefore specify the existence of stated features, steps, operations, elements and / or parts, but do not exclude the existence or addition of one or more other features, steps, operations, elements, parts, and / or combinations thereof. The method steps, processes, and operations described herein are not interpreted as necessarily requiring them to be performed in the specific order described or illustrated, unless the execution order is clearly indicated. It should also be understood that additional or alternative steps may be used.

[0074] Although the terms first, second, third, etc. can be used in the text to describe multiple elements, components, regions, layers and / or sections, these elements, components, regions, layers and / or sections should not be limited by these terms. These terms can only be used to distinguish an element, component, region, layer or section from another region, layer or section. Unless the context clearly indicates, terms such as "first", "second" and other numerical terms do not imply order or sequence when used in the text. Therefore, the first element, component, region, layer or section discussed below can be referred to as the second element, component, region, layer or section without departing from the teaching of the example embodiments.

[0075] The above description is only a specific implementation of the present application, so that those skilled in the art can understand or implement the present application. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present application. Therefore, the present application will not be limited to the embodiments shown herein, but will conform to the widest range consistent with the principles and novel features applied for herein.

Claims

1. A device for removing and removing a pipette tip, characterized in that: include: A frame, a first drive guide mechanism, a mounting plate, a second drive guide mechanism, a trigger assembly, a suction head mounting tube and a sleeve; The first driving guide mechanism is disposed on the frame and connected to the mounting plate, and is used to drive the mounting plate to move between a first position and a second position relative to the frame; The second driving guide mechanism is fixed to the mounting plate and connected to the trigger assembly, and is used to drive the trigger assembly to switch between a reset state and a trigger state; The pipette tip mounting tube is connected to the mounting plate and is used to mount the pipette tip, and the sleeve is slidably sleeved on the outer circumference of the pipette tip mounting tube; When the mounting plate is in the first position, the pipette tip mounting tube is driven to be retracted into the frame, and when the mounting plate is in the second position, the pipette tip mounting tube is driven to be extended out of the frame; The trigger assembly is in a reset state, and the pipette tip can squeeze the sleeve to be installed on the tip mounting tube; during the switching process of the trigger assembly to the trigger state, the sleeve is driven to slide toward the end of the tip mounting tube to remove the pipette tip from the tip mounting tube.

2. The device for removing and removing the pipette tip according to claim 1, characterized in that: The frame includes a top plate and a bottom plate arranged parallel to each other, and a side plate connected between the top plate and the first end of the bottom plate; The first driving guide mechanism comprises: A guide rail is fixed to the side plate, and the mounting plate is parallel to the top plate and the bottom plate and is slidably connected to the guide rail; A first driving motor is fixed to the top plate or the bottom plate; The first screw rod assembly is connected to the first driving motor and the mounting plate, and is used to drive the mounting plate to move between a first position and a second position.

3. The device for removing and removing the pipette tip according to claim 2, characterized in that: The first driving guide mechanism further comprises a first guide rod, the first guide rod is connected between the second ends of the top plate and the bottom plate, and one end of the mounting plate away from the guide rail is slidably connected to the first guide rod.

4. The device for removing and removing the pipette tip according to claim 1, characterized in that: The second driving guide mechanism comprises: A second driving motor is fixed to the mounting plate; A second screw rod assembly connected to the second drive motor; A second guide rod fixed to the mounting plate; The trigger component comprises: A head removal plate is slidably connected to the second guide rod, the head removal plate is connected to the second screw rod assembly and moves parallel to or away from the mounting plate under the drive of the second screw rod assembly; A head removal guide rod, slidably connected to the mounting plate; When the trigger assembly moves to a reset state, it drives the head removal plate to separate from the head removal guide rod; when the trigger assembly moves to a trigger state, the head removal plate abuts and drives the head removal guide rod to slide, and the head removal guide rod drives the sleeve to slide to the end of the suction head mounting tube.

5. The device for removing and removing the pipette tip according to claim 4, characterized in that: The unloading head guide rods are arranged in two groups.

6. The device for removing and removing the pipette tip according to claim 4, characterized in that: The pipette tip removal device includes a limit block, which is concave and snap-fitted to the mounting plate; the tip mounting tube corresponds to the groove of the limit block and passes through the limit block; the sleeve is provided with a second limit boss which is locked in the groove of the limit block; the tip removal guide rod is arranged corresponding to the second limit boss.

7. The device for removing and removing the pipette tip according to claim 6, characterized in that: The suction head mounting tube is provided with a first limiting boss that is clamped on the mounting plate, and a return spring is provided between the first limiting boss and the second limiting boss.

8. The device for removing and removing a pipette tip according to any one of claims 1 to 7, characterized in that: The pipette tip removal device at least meets any one of the following requirements: The frame is provided with a first position sensor for detecting whether the mounting plate reaches the first position; The mounting plate is provided with a second position sensor for detecting whether the trigger assembly has returned to a reset state; A third position sensor for detecting the position of the sleeve is also included.

9. The device for removing and removing the pipette tip according to claim 8, characterized in that: At least one of the first position sensor, the second position sensor, and the third position sensor is a photocoupler sensor.

10. A liquid transfer device, characterized in that: It comprises a plunger pump, a connecting hose, a connecting head and the pipette tip removal device according to any one of claims 1 to 9, wherein the plunger pump is connected to the connecting hose, and the connecting head connects the connecting hose and the pipette tip mounting tube.

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