Smear fixing and staining device

Abstract

The utility model discloses a smear fixing and dyeing device, including a heating mechanism for fixing a sample on a smear, a moving mechanism for moving the smear to different liquid adding positions, a dripping mechanism for dripping dye, a liquid storage mechanism for supplying dye to the dripping mechanism, and a main body mechanism for fixing the above mechanisms; the main body mechanism includes a shell and a base, the shell is fixedly connected to the base; the shell covers at least one of the moving mechanism, the heating mechanism and the dripping mechanism; the moving mechanism is movably arranged above the base, the dripping mechanism is fixedly arranged above the moving mechanism, and the heating mechanism is arranged above the dripping mechanism; the liquid storage mechanism is fixedly arranged on the side of the shell. The utility model can realize one-stop fixing and dyeing of smears, greatly improves the operating efficiency of morphological examination, and effectively reduces the risk of sample contamination of smears, and has a simple structure and is easy to manufacture.

Description

Technical Field

[0001] The utility model relates to the technical field of smears, in particular to a smear fixing and dyeing device. Background Art

[0002] In recent years, with the development of intelligent technology, although intelligent diagnosis has made significant progress, it has also brought many problems, such as the accuracy of diagnostic results. Morphological examination, as the gold standard for laboratory diagnosis, has gradually gained attention in the field of medical diagnosis. However, morphological examination has some inherent defects, which need to be overcome to meet the needs of modern large-scale sample inspection. At present, there are mainly the following problems in morphological examination: ① The operation process of morphological staining inspection is too cumbersome, the inspection efficiency is low, and it cannot meet the needs of existing large-scale sample inspection; ② Existing semi-automatic equipment often manually drips the staining solution, and the consistency of the staining solution dripping position and dripping amount is poor; ③ Sample fixation requires independent equipment, which further reduces the efficiency of morphological examination and increases the risk of sample contamination. Utility Model Content

[0003] The technical problem to be solved by the utility model is to provide a smear fixing and staining device, which can realize one-stop fixing and staining of smears, greatly improve the operational efficiency of morphological examination, and effectively reduce the contamination risk of the smear sample staining process.

[0004] In order to solve one or more of the above technical problems, the technical solutions adopted by the present utility model are as follows:

[0005] The utility model discloses a smear fixing and dyeing device, comprising a heating mechanism for fixing a sample on a smear, a moving mechanism for moving the smear to different liquid adding positions, a dripping mechanism for dripping dyeing liquid, a liquid storage mechanism for supplying dyeing liquid to the dripping mechanism, and a main body mechanism for fixing the above-mentioned mechanisms; the main body mechanism comprises a shell and a base, the shell is fixedly connected to the base; the shell covers at least one of the moving mechanism, the heating mechanism and the dripping mechanism; the moving mechanism is movably arranged above the base, the dripping mechanism is fixedly arranged above the moving mechanism, and the heating mechanism is arranged above the dripping mechanism; the liquid storage mechanism is fixedly arranged on the side of the shell.

[0006] Furthermore, the moving mechanism includes a sliding groove provided on the base, a sliding block movable back and forth along the sliding groove, and a fixed plate for fixing the smear; the sliding block is fixedly connected to the fixed plate to drive the fixed plate to move back and forth along the sliding groove.

[0007] Furthermore, the sliding groove is formed by connecting a first sliding groove, a second sliding groove, a third sliding groove and a fourth sliding groove in sequence, the first sliding groove and the third sliding groove have the same inclination angle, and the second sliding groove and the fourth sliding groove have the same inclination angle; the end face of the sliding block contacting the sliding groove is composed of a first plane and a second plane, the inclination angle of the first plane is the same as the inclination angle of the first sliding groove, and the inclination angle of the second plane is the same as the second sliding groove.

[0008] Furthermore, a slot for fixing the smear is provided on the fixing plate, and the slot is used to fix the smear.

[0009] Furthermore, a fixing mechanism for fixing the smear is provided at one end of the card slot, and the fixing mechanism comprises a fixing hole opened on the fixing plate and a fixing rod passing through the fixing hole, and the fixing rod fixes or releases the smear by approaching or moving away from the smear.

[0010] Furthermore, the dripping mechanism includes a control device for controlling the dripping amount and dripping time of the dye solution and a dripping pipe for dripping the dye solution onto the smear, and the control device is fixedly arranged between the heating mechanism and the dripping pipe.

[0011] Furthermore, the liquid storage mechanism is provided with a plurality of liquid storage units, the liquid storage units are used to store dye solutions with different purposes or functions, and the liquid storage units are respectively connected to the dripping mechanisms.

[0012] Preferably, the number of the moving mechanisms can be set to be multiple, so as to realize the simultaneous moving operation of multiple smears; the number of the dripping mechanisms can be set to be multiple, so as to realize the operation of dripping dye solution to multiple smears.

[0013] Preferably, it also includes a cover body that can be sealed with the main body mechanism, and the cover body is used to isolate external pollutants during the smear fixing and staining process.

[0014] Preferably, it also includes an operating host for convenient input of operating instructions to realize digital control of the smear fixing and staining device. The operating host is fixedly arranged on one side of the base. The operating host includes a touch screen for convenient human-computer interaction and a host for receiving input instructions and issuing control instructions.

[0015] Compared with the prior art, the technical solution provided by the utility model has the following advantages and beneficial effects:

[0016] (1) The smear fixing and staining device provided by the utility model has a simple structure and is easy to operate, which effectively improves the fixing and staining efficiency of the smear and greatly improves the uniformity of the staining results;

[0017] (2) By setting an inclined angle on the sliding groove and the sliding block, the horizontal surface further improves the stability of the dye solution when the dye solution is dripped, and the inclined surface improves the wettability of the dye solution to the sample, thereby improving the dyeing effect;

[0018] (3) By providing a card slot on the fixed plate, the stability of the smear during movement is improved, and the uniformity of smear staining is further improved;

[0019] (4) A fixing mechanism is provided on the card slot to improve the stability of the smear movement process and facilitate the placement and removal of the smear through the movement of the fixing mechanism;

[0020] (5) By setting up a control device, the automation transformation of dye liquid dripping is improved, and it is convenient to control the dripping mechanism to drip the dye liquid by operating the host. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative labor.

[0022] Figure 1 It is a schematic diagram of the overall structure of Example 1;

[0023] Figure 2 It is a partial structural schematic diagram of Example 1;

[0024] Figure 3 for Figure 2 Enlarged structural diagram at A in the middle.

[0025] In the figure: 1-main unit; 2-touch screen; 3-base; 4 shell; 5-heating mechanism; 6-control device; 7-first dripping pipe; 8-second dripping pipe; 9-third dripping pipe; 10-fixed plate; 11-card slot; 12-smear; 13-first sliding groove; 14-second sliding groove; 15-third sliding groove; 16-fourth sliding groove; 17-sliding block; 18-fixing hole; 19-fixing rod; 20-fixing rod; 21-liquid storage mechanism; 22-cover body. DETAILED DESCRIPTION

[0026] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0027] In the description of the present invention, it should be noted that the terms "upper", "lower", "horizontal", "left", "right", "front", "rear", etc. indicating directions or positional relationships are based on the directions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as limiting the present invention. In addition, the terms "first" and "second" are only used for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0028] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "connection" and "installation" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0029] Example

[0030] like Figure 1-3 As shown, this embodiment provides a smear fixing and staining device, including an operation host for conveniently inputting operation instructions to realize digital control of the smear fixing and staining device, the operation host is fixedly arranged on the left side of the base 3, and the operation host includes a host 1 for receiving input instructions and issuing control instructions and a touch screen 2 for convenient human-computer interaction;

[0031] The smear fixing and staining device also includes a heating mechanism 5 for fixing the sample on the smear, a moving mechanism for moving the smear to different liquid adding positions, a dripping mechanism for dripping dye, a liquid storage mechanism for supplying dye to the dripping mechanism, and a main mechanism for fixing the aforementioned mechanisms; the main mechanism includes a shell 4 and a base 3, and the shell 4 is fixedly connected to the base 3; the shell 4 covers the moving mechanism, the heating mechanism 5 and the dripping mechanism to protect the moving mechanism, the heating mechanism 5 and the dripping mechanism to prevent external impurities from entering and affecting the fixation and staining of the smear; the moving mechanism is movably arranged above the base 3; the dripping mechanism is fixedly arranged above the moving mechanism, and the heating mechanism 5 is arranged above the dripping mechanism; the liquid storage mechanism 21 is fixedly arranged on the side of the shell 4.

[0032] The moving mechanism includes a sliding groove provided on the base 3, a sliding block 17 that can move back and forth along the sliding groove, and a fixed plate 10 for fixing the smear; the upper end of the sliding block 17 is fixedly connected to the fixed plate 10, so that the fixed plate 10 drives the sliding block 17 to move back and forth along the sliding groove. When the moving mechanism is working, the fixed plate 10 drives the sliding block 17 to move back and forth along the sliding groove when moving, so as to achieve staining of different sample areas of the smear.

[0033] To improve the accuracy of the dripping mechanism in dripping dye, the dripping mechanism includes a control device 6 for controlling the dripping amount and dripping time of the dye and a dripping pipe for dripping the dye onto the smear. The control device 6 is fixedly arranged between the heating mechanism 5 and the dripping pipe.

[0034] The sliding groove is formed by connecting the first sliding groove 13, the second sliding groove 14, the third sliding groove 15 and the fourth sliding groove 16 in sequence, wherein the first sliding groove 13 and the third sliding groove 15 have the same inclination angle and are both horizontal planes, the second sliding groove 14 and the fourth sliding groove 16 have the same inclination angle and form a certain angle with the horizontal plane; the end face of the sliding block 17 contacting the sliding groove is composed of a first plane and a second plane (not shown in the figure), the inclination angle of the first plane is the same as the inclination angle of the first sliding groove 13, and the inclination angle of the second plane is the same as the inclination angle of the second sliding groove 14. When the fixed plate 10 drives the sliding block 17 to move, the sliding block 17 first enters the first sliding groove 13 to slide, and when entering the second sliding groove 14 from the first sliding groove 13, the bottom plane of the sliding block 17 contacts with the plane of the second sliding groove 14 to generate a first resistance signal, and the control device 6 receives the first resistance signal, and then sends a first control signal to control the dripping mechanism to drip dye to the smear for primary dyeing; when the sliding block 17 continues to move forward and enters the third sliding groove 15 from the second sliding groove 14, the bottom inclined surface of the sliding block 17 contacts with the inclined surface of the third sliding groove 15 to generate a second resistance signal, and the control device 6 receives the second resistance signal, and then sends a second control signal to control the dripping mechanism to drip rinse liquid to the smear for rinse operation; when the sliding block 17 moves from the third sliding groove 15 to the fourth sliding groove 16, a third resistance signal is generated, and the control device 6 receives the third resistance signal, and then sends a third control signal to control the dripping mechanism to drip dye to the smear for a second time for re-dyeing.

[0035] In order to further improve the stability of the smear when the dye is dripped, a slot 11 for fixing the smear is provided on the fixing plate 10. A fixing mechanism for fixing the smear is provided at the left end of the slot 11, and the fixing mechanism includes a fixing hole 18 opened on the fixing plate 10 and a fixing rod 19 passing through the fixing hole 18. The fixing rod 19 fixes or releases the smear by approaching or moving away from the smear.

[0036] In order to meet the needs of the smear staining and fixing device for staining different types of samples, a plurality of liquid storage units are arranged in the liquid storage mechanism 21. The liquid storage units are used to store dye solutions with different purposes or functions. The liquid storage units are respectively connected to corresponding dripping mechanisms to achieve staining of different samples.

[0037] In order to meet the fixed dyeing efficiency of the smear fixing and dyeing device and realize the operation of dripping dye solution to multiple smears, the number of dripping mechanisms is set as three in this embodiment, namely the first dripping pipe 7, the second dripping pipe 8 and the third dripping pipe 9, which can realize the primary dyeing, rinsing and re-dyeing of the sample at the same time, greatly improving the dyeing efficiency; the number of moving mechanisms and the corresponding slides can also be set to multiple to realize the simultaneous movement operation of multiple smears. In this embodiment, three are set, and three smears can be moved at the same time to complete the dyeing of multiple pictures.

[0038] In order to further improve the sealing performance of the smear fixing and staining device, it also includes a cover body 22 that can be sealed with the main body mechanism. The cover body 22 is used to isolate external pollutants during the smear fixing and staining process, which can effectively improve the trouble of external impurities during the fixing and staining process and improve the success rate of smear fixing and staining.

[0039] When staining is required, first, open the cover 22, place the three sample smears in the corresponding slots 11 on the fixing plate 10, rotate the fixing rod 19 to move it to the right along the fixing hole 18 to fix the sample smears, close the cover 22, and prepare to start sample fixation and staining; adjust the heating device to a suitable heating temperature to heat and fix the sample smears; then start the staining mode through the touch screen, the control device 6 outputs a control signal, and controls the driving device to drive the fixing plate 10 to drive the sliding block 17 to move forward along the corresponding sliding groove, and the sliding block 17 first Enter the first sliding groove 13 to slide, when the sliding block 17 enters the second sliding groove 14 from the first sliding groove 13, the sample smear is just below the first dripping pipe 7, and the bottom plane of the sliding block 17 contacts the plane of the second sliding groove 14 to generate a first resistance signal (the specific control circuit is not shown), the control device 6 receives the first resistance signal, and then sends a first control signal to control the dripping mechanism to absorb the dye liquid of the corresponding liquid storage unit in the liquid storage mechanism 21 and drip the dye liquid (for example, fluorescent dye liquid or GMS dye liquid) to the sample smear through the first dripping pipe 7, so as to realize the initial dyeing of the sample smear;

[0040] When the sliding block 17 continues to move forward and enters the third sliding groove 15 from the second sliding groove 14, the initially stained sample smear is just below the second dripping pipe 8. When the bottom inclined surface of the sliding block 17 contacts the inclined surface of the third sliding groove 15, a second resistance signal is generated. The control device 6 receives the second resistance signal and then sends a second control signal to control the dripping mechanism to absorb the dye solution of the corresponding liquid storage unit in the liquid storage mechanism 21 and drip the cleaning solution (such as water or PBS buffer) to the sample smear through the second dripping pipe 8, so as to clean the sample smear.

[0041] When the sliding block 17 continues to move forward from the third sliding groove 15 to the fourth sliding groove 16, the initially stained sample smear is just below the third dripping pipe 9. When the bottom plane of the sliding block 17 contacts the plane of the fourth sliding groove 16, a third resistance signal is generated. The control device 6 receives the third resistance signal and then sends a third control signal to control the third dripping pipe 9 of the dripping mechanism to drip dye to the smear for a second time for re-dyeing (the re-dyeing liquid can be a safflower dye or a safranin dye), thereby completing the sample smear dyeing.

[0042] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A smear fixing and staining device, characterized in that: The invention comprises a heating mechanism for fixing a sample on a smear, a moving mechanism for moving the smear to different liquid adding positions, a dripping mechanism for dripping dye, a liquid storage mechanism for supplying dye to the dripping mechanism and a main body mechanism for fixing the above-mentioned mechanisms; the main body mechanism comprises a shell and a base, the shell is fixedly connected to the base; the shell covers at least one of the moving mechanism, the heating mechanism and the dripping mechanism; the moving mechanism is movably arranged above the base, the dripping mechanism is fixedly arranged above the moving mechanism, and the heating mechanism is arranged above the dripping mechanism; the liquid storage mechanism is fixedly arranged on the side of the shell.

2. The smear fixing and dyeing device according to claim 1, characterized in that: The moving mechanism comprises a sliding groove provided on the base, a sliding block movable back and forth along the sliding groove and a fixed plate for fixing the smear; the sliding block is fixedly connected to the fixed plate to drive the fixed plate to move back and forth along the sliding groove.

3. The smear fixing and dyeing device according to claim 2, characterized in that: The sliding groove is formed by the first sliding groove, the second sliding groove, the third sliding groove and the fourth sliding groove being connected in sequence, the first sliding groove and the third sliding groove have the same inclination angle, and the second sliding groove and the fourth sliding groove have the same inclination angle; the end face of the sliding block contacting the sliding groove is composed of a first plane and a second plane, the inclination angle of the first plane is the same as the inclination angle of the first sliding groove, and the inclination angle of the second plane is the same as the second sliding groove.

4. The smear fixing and dyeing device according to claim 3, characterized in that: The fixing plate is provided with a slot for fixing the smear.

5. The smear fixing and dyeing device according to claim 4, characterized in that: One end of the card slot is provided with a fixing mechanism for fixing the smear, and the fixing mechanism comprises a fixing hole opened on the fixing plate and a fixing rod passing through the fixing hole, and the fixing rod fixes or releases the smear by approaching or moving away from the smear.

6. The smear fixing and dyeing device according to any one of claims 1 to 5, characterized in that: The dripping mechanism comprises a control device for controlling the dripping amount and dripping time of the dye solution and a dripping pipe for dripping the dye solution onto the smear, and the control device is fixedly arranged between the heating mechanism and the dripping pipe.

7. The smear fixing and dyeing device according to any one of claims 1 to 5, characterized in that: The liquid storage mechanism is provided with a plurality of liquid storage units, and the liquid storage units are used to store dye solutions with different purposes or functions, and the liquid storage units are respectively connected to the dripping mechanisms.

8. The smear fixing and dyeing device according to claim 5, characterized in that: The number of the dripping mechanisms can be multiple to achieve the operation of dripping dye solution on multiple smears; the number of the moving mechanisms can be multiple to achieve the simultaneous movement operation of multiple smears.

9. The smear fixing and dyeing device according to claim 1, characterized in that: It also includes a cover body that can be sealed with the main body mechanism, and the cover body is used to isolate external pollutants during the smear fixing and staining process.

10. The smear fixing and dyeing device according to claim 1, characterized in that: It also includes an operating host for convenient input of operating instructions to achieve digital control of the smear fixing and staining device. The operating host is fixedly arranged on one side of the base. The operating host includes a touch screen for convenient human-computer interaction and a host for receiving input instructions and issuing control instructions.

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