A dissolving device for detecting rosuvastatin

Abstract

The utility model discloses a dissolving device for detecting rosuvastatin, comprising a heating box, a dissolving box is arranged in the heating box, a heating chamber is formed between the heating box and the dissolving box, a heating component is arranged in the heating chamber, a box cover is arranged on the heating box, a feeding port is arranged on the box cover, a screen is arranged in the feeding port, a feeding screening bin is arranged on the feeding port, a circulating extrusion mechanism is arranged in the feeding screening bin, the circulating extrusion mechanism comprises a cam and an operating rod, a crushing tooth plate is arranged at one end of the operating rod, a spring is arranged at the outer ring of the operating rod, an abutting slide is arranged at the other end of the operating rod, and the abutting slide abuts against the cam. The utility model performs water bath heating on the dissolving box through the heating component, so as to improve the dissolving efficiency of the dissolving box, and the size of the material entering the dissolving box is fixed through the arrangement of the screen, and then the staggered stirring long leaves and the stirring short leaves are driven by the rotating shaft to stir, so that the stirring is more uniform, the heating is more uniform, and the dissolving efficiency is further improved.

Description

Technical Field

[0001] The utility model relates to the technical field of dissolution for rosuvastatin analysis, in particular to a dissolution device for rosuvastatin detection. Background Art

[0002] There are many ways to test drugs. For soluble drugs, the dissolved drugs are often tested in the form of solutions to more accurately test the physical and chemical parameters of the drugs. Currently, dissolution is a very common processing operation in the testing of rosuvastatin, the purpose of which is to change the product's form for easier testing.

[0003] However, the dissolution rate of the existing drug dissolving device still needs to be improved. In order to improve the dissolution efficiency, stirring blades are generally used to disperse the materials and stir the solvent to dissolve; however, since the stirring blades are constantly stirring drug raw materials of different sizes during the dissolution process, long-term use can easily cause wear to the stirring blades, thereby affecting the dispersion effect and efficiency, reducing the service life, and thus affecting the dissolution efficiency. Utility Model Content

[0004] The utility model aims to solve the technical problems existing in the prior art and provide a dissolving device for detecting rosuvastatin.

[0005] To achieve the above-mentioned purpose, the technical solution provided by the utility model is: a dissolution device for detecting rosuvastatin, comprising a heating box, a dissolution box is arranged in the heating box, a heating chamber is formed between the heating box and the dissolution box, a heating component is arranged in the heating chamber, a detachable box cover is arranged on the heating box, a feeding port connected with the dissolution box is arranged on the box cover, a screen is arranged in the feeding port, a feed screening bin is arranged on the feeding port, a circulating extrusion mechanism in the feed screening bin, the circulating extrusion mechanism comprises a cam and an operating rod, a crushing tooth plate is arranged at one end of the operating rod, a spring is arranged on the outer ring of the operating rod, two ends of the spring are respectively connected with the crushing tooth plate and the inner wall of the feed screening bin, and a contact slide is arranged at the other end of the operating rod, and the contact slide contacts the cam.

[0006] Preferably, a rotating shaft is provided in the dissolving box, and long stirring blades and short stirring blades are alternately provided on the rotating shaft. A motor is provided at the bottom of the heating box, and the motor is connected to the rotating shaft.

[0007] Preferably, the heating chamber is provided with a liquid inlet pipe and a drain pipe, and the liquid inlet pipe and the drain pipe are both provided with electric valves. The heating assembly includes an electric heating plate and a temperature sensor arranged in the heating chamber, and the electric heating plate is electrically connected to the temperature sensor and an external controller.

[0008] Preferably, a water tank is provided on the box cover, and the water tank is located on both sides of the feed screening bin. A water inlet pipe is provided on the water tank, and the water inlet pipe passes through the box cover and is connected to the dissolution box.

[0009] Preferably, a driving motor is arranged outside the water tank, an output end of the driving motor is connected to a camshaft, and the camshaft is connected to the cam.

[0010] Preferably, a feed port is provided on the feed screening bin, and crushing teeth are provided on the crushing tooth plate.

[0011] Preferably, a discharge pipe is provided at the bottom of the dissolving box, and the discharge pipe extends out of the heating box and is provided with an electric valve.

[0012] Beneficial effects of the utility model:

[0013] 1. When the utility model is in use, the dissolution box is heated in a water bath by a heating component to improve the dissolution efficiency of the dissolution box, and the size of the material entering the dissolution box is fixed by the setting of the screen, and then the motor drives the rotating shaft to rotate, and the rotating shaft drives the staggered long stirring blades and the short stirring blades to stir, so that rosuvastatin is stirred more evenly and heated more evenly, further improving the dissolution efficiency.

[0014] 2. In the utility model, since the working environment of the long stirring blades and the short stirring blades in the dissolution box is to stir the pharmaceutical particles of the same size, the wear of the long stirring blades and the short stirring blades is reduced, so that the long stirring blades and the short stirring blades will not affect the stirring effect when used for a long time, thereby improving the dissolution efficiency in the dissolution box. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] The drawings described herein are used to provide a further understanding of the present invention and constitute a part of the present invention. The illustrative embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation on the present invention.

[0016] Figure 1 It is a schematic diagram of the overall structure of a preferred embodiment of the utility model.

[0017] Figure annotation:

[0018] 1-heating box 2-dissolving box 3-liquid inlet pipe 4-box cover 5-water tank 6-feed screening bin 7-feeding port 8-crushing teeth 9-crushing tooth plate 10-spring 11-operating lever 12-abutting slide plate 13-camshaft 14-cam 15-water inlet pipe 16-feeding port 17-stirring short blades 18-stirring long blades 19-electric heating plate 20-temperature sensor 21-discharge pipe 22-rotating shaft 23-motor 24-drain pipe 25-screen. DETAILED DESCRIPTION

[0019] This section will describe in detail the specific embodiments of the utility model. The preferred embodiments of the utility model are shown in the accompanying drawings. The purpose of the accompanying drawings is to supplement the description of the text part of the specification with graphics, so that people can intuitively and vividly understand each technical feature and the overall technical solution of the utility model, but it cannot be understood as a limitation on the protection scope of the utility model.

[0020] In the description of the present invention, it should be understood that descriptions involving orientation, such as up, down, front, back, left, right, etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0021] In the description of the present utility model, "several" means one or more, "more" means more than two, "greater than", "less than", "exceed" etc. are understood to exclude the number itself, and "above", "below", "within" etc. are understood to include the number itself. If there is a description of "first" or "second", it is only used for the purpose of distinguishing the technical features, and cannot be understood as indicating or implying the relative importance or implicitly indicating the number of the indicated technical features or implicitly indicating the order of the indicated technical features.

[0022] In the description of the present invention, unless otherwise clearly defined, terms such as setting, installing, connecting, etc. should be understood in a broad sense, and technicians in the relevant technical field can reasonably determine the specific meanings of the above terms in the present invention based on the specific content of the technical solution.

[0023] Example 1

[0024] Reference Figure 1 A preferred embodiment of the utility model is a dissolution device for detecting rosuvastatin, comprising a heating box 1, a dissolution box 2 is arranged in the heating box 1, a detachable box cover 4 is arranged on the heating box 1, a feeding port 16 connected to the dissolution box 2 is arranged on the box cover 4, a screen 25 is arranged in the feeding port 16, a feed screening bin 6 is arranged on the feeding port 16, a circulating extrusion mechanism is arranged in the feed screening bin 6, and the circulating extrusion mechanism comprises a cam 14 and an operating rod 11, a crushing tooth plate 9 is arranged at one end of the operating rod 11, a spring 10 is arranged on the outer ring of the operating rod 11, and the two ends of the spring 10 are respectively connected to the crushing tooth plate 9 and the inner wall of the feed screening bin 6, and the other end of the operating rod 11 is provided with an abutting slide plate 12, and the abutting slide plate 12 abuts against the cam 14.

[0025] Furthermore, a water tank 5 is provided on the box cover 4 , and the water tank 5 is located on both sides of the feed screening bin 6 . A water inlet pipe 15 is provided on the water tank 5 , and the water inlet pipe 15 passes through the box cover 4 and is connected with the dissolution box 2 .

[0026] A driving motor is disposed outside the water tank 5 , and an output end of the driving motor is connected to a camshaft 13 , and the camshaft 13 is connected to the cam 14 .

[0027] The feed screening bin 6 is provided with a feed port 7 , and the crushing tooth plate 9 is provided with crushing teeth 8 .

[0028] Specifically, when in use, rosuvastatin is introduced into the feed screening bin 6 through the feed port 7, and the driving motor outside the water tank 5 is started. The cam shaft 13 is driven to rotate by the driving motor, thereby driving the cam 14 to rotate. The cam 14 pushes the contact slide plate 12 to move in the horizontal direction, thereby driving the operating rod 11 to move. The operating rod 11 drives the crushing tooth plate 9 to move. When the crushing tooth plate 9 on the left moves to the right, the spring 10 will be stretched. As the cam 14 rotates, the spring 10 will gradually reset. Therefore, under the setting of the cam 14 and the spring 10, the cyclic reciprocating motion of the crushing tooth plate 9 in the horizontal direction can be achieved. Circulating extrusion mechanisms are provided on both sides of the feed screening bin 6, so It can drive the crushing tooth plates 9 on the left and right sides to perform relative cyclic reciprocating motion, thereby realizing the extrusion and crushing of rosuvastatin. The crushed rosuvastatin is screened out through the screen 25 to obtain rosuvastatin of a size matching the screen aperture, so that the rosuvastatin transferred from the feed screening bin 6 to the dissolution box 2 will not exceed a fixed size of material, so that the working environment of the long stirring blade 18 and the short stirring blade 17 in the dissolution box 2 is to stir the drug particles of the same size, reducing the wear of the long stirring blade 18 and the short stirring blade 17, so that the long stirring blade 18 and the short stirring blade 17 will not affect the stirring effect when used for a long time, thereby improving the dissolution efficiency in the dissolution box 2.

[0029] Example 2

[0030] A heating chamber is formed between the heating box 1 and the dissolving box 2, and a heating component is arranged in the heating chamber. A liquid inlet pipe 3 and a drain pipe 24 are arranged on the heating chamber. Electric valves are arranged on the liquid inlet pipe 3 and the drain pipe 24. The heating component includes an electric heating plate 19 and a temperature sensor 20 arranged in the heating chamber. The electric heating plate 19 and the temperature sensor 20 are electrically connected to an external controller.

[0031] Specifically, during use, when dissolving in the dissolution box 2, water is added to the heating chamber through the liquid inlet pipe 3, and then the electric heating plate 19 is controlled to start heating, and the water temperature in the heating chamber (a maximum water temperature value can be preset) is detected in real time through the temperature sensor 20. When the water temperature reaches the preset maximum value, the signal is transmitted to the external controller to control the electric heating plate 19 to stop heating, thereby avoiding the destruction of the medicinal properties of the drug due to excessive water temperature and affecting the later test results. The dissolution box 2 improves the dissolution rate and effect of rosuvastatin by heating the water bath in the heating chamber.

[0032] Example 3

[0033] The dissolving box 2 is provided with a rotating shaft 22, on which long stirring blades 18 and short stirring blades 17 are staggered, and a motor 23 is provided at the bottom of the heating box 1, and the motor 23 is connected to the rotating shaft 22. A discharge pipe 21 is provided at the bottom of the dissolving box 2 (preferably, a guide platform is provided at the bottom of the dissolving box 2), and the discharge pipe 21 extends out of the heating box 1 and is provided with an electric valve.

[0034] Specifically, during use, when rosuvastatin material enters the dissolution box 2, the water in the water tank 5 flows into the dissolution box 2 through the water inlet pipe 15, and the motor 23 drives the rotating shaft 22 to rotate, thereby driving the long stirring blade 18 and the short stirring blade 17 to stir, so that the rosuvastatin is dissolved more evenly and heated more evenly.

[0035] To sum up, when the utility model is in use, the dissolution box 2 is heated in a water bath by the heating component to improve the dissolution efficiency of the dissolution box 2, and the size of the material entering the dissolution box 2 is fixed by the setting of the screen 25, and then the motor 23 drives the rotating shaft 22 to rotate, and the rotating shaft 22 drives the staggered long stirring blades 18 and the short stirring blades 17 to stir, so that the rosuvastatin is stirred more evenly and heated more evenly, thereby further improving the dissolution efficiency; and because the working environment of the long stirring blades 18 and the short stirring blades 17 in the dissolution box 2 is to stir the drug particles of the same size, the wear of the long stirring blades 18 and the short stirring blades 17 is reduced, so that the long stirring blades 18 and the short stirring blades 17 will not affect the stirring effect when used for a long time, thereby improving the dissolution efficiency in the dissolution box 2.

[0036] Under the premise that no conflict occurs, those skilled in the art may freely combine and superimpose the above-mentioned additional technical features.

[0037] The above description is only a preferred implementation mode of the present utility model. Any technical solution that achieves the purpose of the present utility model by basically the same means belongs to the protection scope of the present utility model.

Claims

1. A dissolution device for detecting rosuvastatin, characterized in that: The invention comprises a heating box (1), wherein a dissolving box (2) is arranged in the heating box (1), a heating chamber is formed between the heating box (1) and the dissolving box (2), a heating component is arranged in the heating chamber, a detachable box cover (4) is arranged on the heating box (1), a feeding port (16) connected to the dissolving box (2) is arranged on the box cover (4), a screen (25) is arranged in the feeding port (16), a feeding screening bin (6) is arranged on the feeding port (16), and the feeding A circulating extrusion mechanism is arranged in the screening bin (6), and the circulating extrusion mechanism comprises a cam (14) and an operating rod (11). A crushing tooth plate (9) is arranged at one end of the operating rod (11), and a spring (10) is arranged on the outer ring of the operating rod (11). The two ends of the spring (10) are respectively connected to the crushing tooth plate (9) and the inner wall of the feed screening bin (6). The other end of the operating rod (11) is arranged with an abutting slide plate (12), and the abutting slide plate (12) abuts against the cam (14).

2. A dissolution device for detecting rosuvastatin according to claim 1, characterized in that: A rotating shaft (22) is arranged in the dissolving box (2), and long stirring blades (18) and short stirring blades (17) are arranged alternately on the rotating shaft (22). A motor (23) is arranged at the bottom of the heating box (1), and the motor (23) is connected to the rotating shaft (22).

3. A dissolution device for detecting rosuvastatin according to claim 1, characterized in that: The heating chamber is provided with a liquid inlet pipe (3) and a drain pipe (24), and both the liquid inlet pipe (3) and the drain pipe (24) are provided with electric valves. The heating component comprises an electric heating plate (19) and a temperature sensor (20) arranged in the heating chamber, and the electric heating plate (19) and the temperature sensor (20) are electrically connected to an external controller.

4. A dissolution device for detecting rosuvastatin according to claim 1, characterized in that: A water tank (5) is provided on the box cover (4), and the water tank (5) is located on both sides of the feed screening bin (6). A water inlet pipe (15) is provided on the water tank (5), and the water inlet pipe (15) passes through the box cover (4) and is connected to the dissolution box (2).

5. A dissolution device for detecting rosuvastatin according to claim 4, characterized in that: A driving motor is arranged outside the water tank (5), an output end of the driving motor is connected to a camshaft (13), and the camshaft (13) is connected to the cam (14).

6. A dissolution device for detecting rosuvastatin according to claim 1, characterized in that: The feed screening bin (6) is provided with a feed port (7), and the crushing tooth plate (9) is provided with crushing teeth (8).

7. A dissolution device for detecting rosuvastatin according to claim 1, characterized in that: A discharge pipe (21) is provided at the bottom of the dissolving box (2), and the discharge pipe (21) extends out of the heating box (1) and is provided with an electric valve.

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