In-vitro irradiation experiment device

Abstract

The utility model relates to the technical field of radiation medical experiment instruments, in particular to an in-vitro irradiation experiment device. Comprising one or more in-vitro irradiation experiment units, each in-vitro irradiation experiment unit comprises a particle source placement model and a culture dish, and the culture dish is located above the particle source placement model and is coaxial with the particle source placement model; the particle source placement model is in a spherical crown shape, the height of the spherical crown is smaller than the radius of a sphere where the spherical crown is located, P particle sub-sources are arranged on the particle source placement model, P-1 particle sub-sources are consistent in activity and evenly placed on the maximum circumference of the upper bottom face of the particle source placement model, and the initial apparent activity of the other particle sub-source is larger than that of the P-1 particle sub-sources. The particle source is called as a central particle source, and the central particle source is placed on the vertex of the particle source placement model. According to the utility model, the radiation dose of the particle source on the particle source placement model on the cancer cell plane at the bottom of the culture dish is uniformly distributed.

Description

Technical Field

[0001] The utility model relates to the technical field of radiation medical experimental instruments, in particular to an in vitro irradiation experimental device. Background Art

[0002] The characteristic of low-dose rate brachytherapy (LDR-BT) is that a particle source carrying radioactive isotopes (referred to as particle source) is directly placed at the lesion, which can continuously irradiate the lesion for a long time to provide a higher cumulative dose, while ensuring low-dose radiation to the patient's normal organs and tissues. This makes LDR-BT have a high local control rate of tumors and a low incidence of postoperative complications, significantly prolonging the patient's survival time.

[0003] Low-dose-rate brachytherapy requires an in vitro irradiation experiment to determine the initial activity and irradiation time of the particle source. Existing in vitro experimental devices also include particle source placement models and culture sensitivities. In ordinary models, according to the actual dose requirements and dose uniformity requirements, the placement of particle sources is usually based on the Manchester system principle, that is, evenly distributed on the maximum circumference of the template; or a particle source accounting for 5% of the total radiation intensity is placed at the center of the disk; or a placement mode of two rings plus one center point is required, which depends on the ratio of the plane disk diameter and the distance between the plane disk and the culture dish. However, in actual irradiation experiments, this placement of particle sources still needs to improve the uniformity of irradiation dose distribution on the culture dish plane (that is, cancer cells are evenly spread in the culture dish). Utility Model Content

[0004] The technical problem to be solved by the utility model is to provide an in vitro irradiation experimental device, so that the particle source placed on the particle source model irradiates the cancer cell plane at the bottom of the culture dish with uniform dose distribution.

[0005] In order to solve the technical problem, the technical solution adopted by the utility model is: an in vitro irradiation experimental device, including one or more in vitro irradiation experimental units, each of which includes a particle source placement model and a culture dish, the culture dish is located above the particle source placement model and is coaxially arranged with the particle source placement model; the particle source placement model is in the shape of a spherical crown, the height of the spherical crown is less than the radius of the sphere in which it is located, and P particle sub-sources are arranged on the particle source placement model, among which the P-1 particle sub-sources have the same activity and are evenly placed on the maximum circumference of the bottom surface of the particle source placement model, and another particle source has an initial apparent activity greater than the initial apparent activity of the P-1 particle sub-source, which is called a central particle source, and the central particle source is placed at the vertex of the particle source placement model.

[0006] Furthermore, 13 particle sources with an initial apparent activity of 1 mCi are evenly placed on the maximum circumference of the upper bottom surface of the particle source placement model, and a central particle source with an initial apparent activity of 3.7 mCi is placed at the vertex of the particle source placement model.

[0007] Furthermore, the height of the particle source placement model is 5-5.5 mm, the diameter of the upper bottom surface of the particle source placement model is 35-36.5 mm, the radius of the sphere where the particle source placement model is located is 33-34 mm, and the distance between the upper bottom surface of the particle source placement model and the bottom surface of the culture dish is 8-8.5 mm.

[0008] Furthermore, the multiple in vitro irradiation experiment units are installed in a box body with a cover, the multiple in vitro irradiation experiment units are separated by partitions, and side panels are arranged on the outer sides of the multiple in vitro irradiation experiment units.

[0009] Furthermore, the culture dish is carried by a transparent polystyrene plate, the transparent polystyrene plate is a hollow cylinder, and the bottom of the transparent polystyrene plate is transitionally connected to the top plate outwards, and the culture dish is located on the hollow cylinder.

[0010] Furthermore, grooves are provided on the upper bottom surface and the vertices of the particle source placement model, and the particle source is located in the grooves.

[0011] Furthermore, a particle source placement model is opened on the bottom plate of the box body.

[0012] Furthermore, the box body, partitions and side panels are all made of lead.

[0013] Furthermore, six in vitro irradiation experimental units arranged in a 2*3 rectangular matrix are arranged in the box with a cover.

[0014] Furthermore, the thickness of the partition plate and the side plate is 5 mm.

[0015] The beneficial effects of the utility model are as follows: the utility model changes the particle source placement model into a spherical crown shape, the height of the spherical crown is less than the radius of the sphere in which it is located, and a P particle source is arranged on the particle source placement model, wherein the P-1 particle source has the same activity and is evenly placed on the maximum circumference of the bottom surface of the particle source placement model, and another particle source has an initial apparent activity greater than the initial apparent activity of the P-1 particle source, which is called the central particle source, and is placed at the vertex of the particle source placement model. With such an arrangement, the particle source on the particle source placement model can make the dose distribution of the plane irradiation of the cancer cells at the bottom of the culture dish uniform. Multiple in vitro irradiation experimental units are installed in the box body, and multiple in vitro irradiation experiments can be carried out simultaneously, thereby improving the experimental efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 This is a schematic diagram of the in vitro irradiation experimental device described in Example 1;

[0017] Figure 2 This is a schematic diagram of the in vitro irradiation experimental device described in Example 1 with the cover opened;

[0018] Figure 3 This is a schematic diagram of the in vitro irradiation experimental device described in Example 2;

[0019] Figure 4 This is a schematic diagram of the in vitro irradiation experimental device described in Example 2 with the cover opened;

[0020] In the figure: 1. box cover, 2. bottom plate, 3. side plate, 4. partition, 5. top plate, 6. cylindrical pit, 7. particle source placement model, 8. groove, 9. particle source. DETAILED DESCRIPTION

[0021] The utility model is further described below in conjunction with the accompanying drawings and specific embodiments.

[0022] Example 1

[0023] This embodiment discloses an in vitro irradiation experimental device, such as Figure 1 , 2 As shown, it includes an in vitro irradiation experimental unit, which includes a particle source placement model 7 and a culture dish. The culture dish is located above the particle source placement model 7 and is coaxially arranged with the particle source placement model; the particle source placement model 7 is in the shape of a spherical crown, and the height of the spherical crown is less than the radius of the sphere in which it is located. There are 14 particle sources 9 on the particle source placement model 7, among which 13 particle sources have the same activity and are evenly placed on the maximum circumference of the bottom surface of the particle source placement model 7. The initial apparent activity of another particle source is greater than the initial apparent activity of the 13 particle sources, which is called the central particle source. The central particle source 9 is placed on the vertex of the particle source placement model 7.

[0024] In this embodiment, 13 particle sources with an initial apparent activity of 1 mCi are evenly placed on the maximum circumference of the upper bottom surface of the particle source placement model 7, and a central particle source with an initial apparent activity of 3.7 mCi is placed on the vertex of the particle source placement model.

[0025] In this embodiment, the height of the particle source placement model is 5 mm, the diameter of the upper bottom surface of the particle source placement model is 36 mm, the radius of the sphere where the particle source placement model is located is 3 mm, and the distance between the upper bottom surface of the particle source placement model and the bottom surface of the culture dish is 8 mm. This size is the optimal size obtained through optimization, which can make the particle source on the particle source placement model irradiate the cancer cell plane at the bottom of the culture dish with uniform dose distribution

[0026] In this embodiment, the in vitro irradiation experimental unit is installed in a box body, which includes a box cover 1 and a bottom plate 2. The particle source placement model 7 is opened on the bottom plate 2 of the box body, and a side plate 3 is provided on the outside of the in vitro irradiation experimental unit.

[0027] In this embodiment, the culture dish is carried by a transparent polystyrene plate, the transparent polystyrene plate is a hollow cylinder, and the bottom of the transparent polystyrene plate is transitionally connected to the top plate 5 outwards, and the culture dish is located on the hollow cylinder.

[0028] In this embodiment, grooves 8 are formed on the upper bottom surface and the top of the particle source placement model 7 , and the particle source 9 is located in the grooves 8 .

[0029] In this embodiment, the material of the box cover 1, the bottom plate 2 and the side plate 3 are all lead.

[0030] Example 2

[0031] This embodiment discloses an in vitro irradiation experimental device, such as Figure 3 , 4 As shown, it includes a box body and 6 in vitro irradiation experimental units arranged in a 2*3 rectangular matrix in the box body. The box body includes a box cover 1 and a bottom plate 2. The 6 in vitro irradiation experimental units are separated by a partition 4, and the 6 in vitro irradiation experimental units are provided with side panels 3 on the outside, and a top plate 5 is provided above the in vitro irradiation experimental units.

[0032] The six in vitro irradiation experimental units have the same structure, and all include a particle source placement model 7 and a culture dish. The culture dish is located above the particle source placement model 7 and is coaxially arranged with the particle source placement model. The particle source placement model 7 is in the shape of a spherical crown, and the height of the spherical crown is less than the radius of the sphere in which it is located. There are 14 particle sources 9 on the particle source placement model 7, among which 13 particle sources have the same activity and are evenly placed on the maximum circumference of the bottom surface of the particle source placement model 7. Another particle source has an initial apparent activity greater than the initial apparent activity of the 13 particle sources, and is called a central particle source. The central particle source 9 is placed on the vertex of the particle source placement model 7.

[0033] In this embodiment, 13 particle sources with an initial apparent activity of 1 mCi are evenly placed on the maximum circumference of the upper bottom surface of the particle source placement model 7, and a central particle source with an initial apparent activity of 3.7 mCi is placed on the vertex of the particle source placement model.

[0034] In this embodiment, the height of the particle source placement model is 5 mm, the diameter of the upper bottom surface of the particle source placement model is 36 mm, the radius of the sphere where the particle source placement model is located is 3 mm, and the distance between the upper bottom surface of the particle source placement model and the bottom surface of the culture dish is 8 mm. This size is the optimal size obtained through optimization, which can make the particle source on the particle source placement model irradiate the cancer cell plane at the bottom of the culture dish with uniform dose distribution

[0035] In this embodiment, the culture dish is carried by a transparent polystyrene plate, the transparent polystyrene plate is a hollow cylinder, and the bottom of the transparent polystyrene plate is transitionally connected to the top plate 5 outwards, and the culture dish is located on the hollow cylinder.

[0036] In this embodiment, grooves 8 are formed on the upper bottom surface and the top of the particle source placement model 7 , and the particle source 9 is located in the grooves 8 .

[0037] In this embodiment, the material of the box cover 1, the bottom plate 2, the partition plate 4 and the side plate 3 are all lead.

[0038] The culture dish is carried by a transparent polystyrene plate, which is in the shape of a hollow cylinder, and the bottom of the transparent polystyrene plate transitions inwardly into an arc to form an arc pit, and the culture dish is located on the arc pit.

[0039] In this embodiment, the particle source placement model 7 is opened on the bottom plate 2 of the box body.

[0040] In this embodiment, the thickness of the partition plate and the side plate is 5 mm.

[0041] The above description is only the basic principle and preferred embodiments of the present invention. Improvements and substitutions made by those skilled in the art based on the present invention belong to the protection scope of the present invention.

Claims

1. An in vitro irradiation experimental device, characterized in that: The invention comprises one or more in vitro irradiation experimental units, each of which comprises a particle source placement model and a culture dish, wherein the culture dish is located above the particle source placement model and is coaxially arranged with the particle source placement model; the particle source placement model is in the shape of a spherical crown, wherein the height of the spherical crown is less than the radius of the sphere in which it is located; a P particle source is arranged on the particle source placement model, wherein the P-1 particle source has the same activity and is evenly placed on the maximum circumference of the bottom surface of the particle source placement model; another particle source has an initial apparent activity greater than the initial apparent activity of the P-1 particle source, and is called a central particle source, and the central particle source is placed on the vertex of the particle source placement model.

2. The in vitro irradiation experimental device according to claim 1, characterized in that: Thirteen particle sources with an initial apparent activity of 1 mCi are evenly placed on the largest circumference of the upper bottom surface of the particle source placement model, and a central particle source with an initial apparent activity of 3.7 mCi is placed at the vertex of the particle source placement model.

3. The in vitro irradiation experimental device according to claim 1, characterized in that: The height of the particle source placement model is 5-5.5 mm, the diameter of the upper bottom surface of the particle source placement model is 35-36.5 mm, the radius of the sphere where the particle source placement model is located is 33-34 mm, and the distance between the upper bottom surface of the particle source placement model and the bottom surface of the culture dish is 8-8.5 mm.

4. The in vitro irradiation experimental device according to claim 1, characterized in that: A plurality of in vitro irradiation experimental units are installed in a box body with a cover, the plurality of in vitro irradiation experimental units are separated by partitions and side panels are arranged outside the plurality of in vitro irradiation experimental units.

5. The in vitro irradiation experimental device according to claim 1 or 4, characterized in that: The culture dish is carried by a transparent polystyrene plate, which is in the shape of a hollow cylinder, and the bottom of the transparent polystyrene plate is transitionally connected to the top plate outwards, and the culture dish is located on the hollow cylinder.

6. The in vitro irradiation experimental device according to claim 1 or 4, characterized in that: There are grooves on the upper bottom surface and the vertex of the particle source placement model, and the particle source is located in the grooves.

7. The in vitro irradiation experimental device according to claim 4, characterized in that: The particle source placement model is opened on the bottom plate of the box.

8. The in vitro irradiation experimental device according to claim 4, characterized in that: The box body, partitions and side panels are all made of lead.

9. The in vitro irradiation experimental device according to claim 4, characterized in that: Six in vitro irradiation experimental units arranged in a 2*3 rectangular matrix are arranged in the box with a cover.

10. The in vitro irradiation experimental device according to claim 4, characterized in that: The thickness of the partitions and side panels is 5 mm.

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