Detection module and detection system

Abstract

The embodiment of the utility model provides a detection module and a detection system, the detection module can comprise a detection module main body, the detection module main body comprises a base part and a covering part, and the covering part covers the base part to form a micro-channel structure; the micro-channel structure comprises a first micro-flow section and a second micro-flow section, the first micro-flow section and the second micro-flow section are spirally arranged in the same rotating direction, and the inner end of the first micro-flow section is connected with the inner end of the second micro-flow section; the waveguide is used for conducting light wave conduction and is arranged on the inner side of the micro-channel structure based on spiral matching of the micro-channel structure. The first micro-flow section and the second micro-flow section are spirally arranged, so that the distance of a to-be-detected substance flowing through the micro-flow channel structure can be increased, and the waveguide is spirally matched based on the micro-flow channel structure, so that the interaction distance between the to-be-detected substance and the waveguide can be increased; therefore, the absorption effect of the substance to be detected on the frequency doubling of the near infrared spectrum can be improved.

Description

Technical Field

[0001] The present application relates to the field of microfluidics technology, and in particular to a detection module and a detection system. Background Art

[0002] Near infrared spectroscopy (800-2500nm) is extremely important in qualitative detection and quantitative analysis of substances. In near infrared spectroscopy, the molecular vibration energy state transitions between one or several energy levels, and the molecular vibration absorption mode is double frequency absorption and combined frequency absorption. The determination of double frequency absorption peaks is extremely common. For example, the characteristic absorption peaks of hydrogen-containing substances (such as substances containing -CH, -NH, -OH and -SH) in the near infrared can be used to identify the functional group category of organic matter.

[0003] However, the near-infrared double frequency absorption is much smaller than the mid-infrared fundamental frequency absorption, and is easily masked by background noise or other irrelevant absorption. When using some existing detection instruments to perform near-infrared double frequency analysis on some substances, these detection instruments find it difficult to allow the substances to fully absorb the near-infrared double frequency, making the near-infrared spectrum double frequency unclear on the spectrum, making it difficult to obtain relevant information about the substance, affecting the diagnosis of near-infrared spectrum double frequency absorption. Utility Model Content

[0004] In view of the deficiencies of the prior art, the present application proposes a detection module and a detection system, which are intended to improve the degree of near-infrared spectrum double frequency absorption of the substance to be tested.

[0005] To achieve the above objectives, on the one hand, the present application provides a detection module, including:

[0006] The detection module body comprises a base and a covering portion, wherein the covering portion covers the base to form a microfluidic structure; the microfluidic structure comprises a first microfluidic segment and a second microfluidic segment, wherein the first microfluidic segment and the second microfluidic segment are spirally arranged with the same rotation direction, and the inner end of the first microfluidic segment is connected to the inner end of the second microfluidic segment;

[0007] A waveguide is arranged on the inner side of the microfluidic channel structure based on the spiral matching of the microfluidic channel structure, and the waveguide is used for conducting light waves.

[0008] In some possible embodiments, the covering portion includes:

[0009] A first microfluidic channel groove is arranged based on the spiral matching of the microfluidic channel structure;

[0010] The waveguide is arranged on the covered surface of the base portion, and is used to cooperate with the first microchannel groove to form the microchannel structure when the covering portion covers the base portion.

[0011] In some possible embodiments, a plurality of the waveguides are provided, and a plurality of the plurality of the waveguides are respectively provided at one of a plurality of inner sides of the first micro-channel grooves.

[0012] In some possible embodiments, the waveguide is disposed on the covered surface of the base portion by one of the following methods:

[0013] The waveguide is convexly arranged on the covered surface of the base, and the convex height of the waveguide is smaller than the depth of the first microchannel groove; or,

[0014] The waveguide is embedded in the covered surface of the base.

[0015] In some possible embodiments, the covering portion includes:

[0016] A microfluidic channel protrusion is arranged based on the spiral matching of the microfluidic channel structure;

[0017] The base portion comprises:

[0018] The second microfluidic channel groove is arranged based on the spiral matching of the microfluidic channel structure, the waveguide is arranged at the bottom of the second microfluidic channel groove, and the distance from the waveguide surface to the surface covered by the base is greater than the protrusion height of the microfluidic channel protrusion.

[0019] In some possible embodiments, the waveguide is provided in plurality, at least one of the plurality of waveguides is provided on the surface of the microchannel protrusion, and the distance between the waveguide provided on the surface of the microchannel protrusion and the waveguide provided on the bottom of the second microchannel groove is not 0.

[0020] In some possible embodiments, the waveguide is disposed at the bottom of the second microchannel groove in one of the following ways:

[0021] The waveguide is arranged on the bottom surface of the second microchannel groove; or,

[0022] The waveguide is embedded in the bottom surface of the second microchannel groove.

[0023] In some possible embodiments, the waveguide is disposed on the covered surface of the base;

[0024] The base portion comprises:

[0025] A base protrusion is arranged on the covered surface of the base part, and the base protrusion is located between the setting position of the first microfluidic segment and the setting position of the second microfluidic segment;

[0026] The covering portion comprises:

[0027] The third micro-channel groove is used to cooperate with the base protrusion to form the micro-channel structure when the covering portion covers the base portion.

[0028] In some possible embodiments, the waveguide is disposed on the covered surface of the base by one of the following methods:

[0029] The waveguide is convexly arranged on the covered surface of the base portion, and the convex height of the waveguide is smaller than the height of the convex portion of the base; or,

[0030] The waveguide is embedded in the covered surface of the base. On the other hand, the present application provides a detection system, including a coupling optical fiber, a coupling optical fiber and a detection module as described in the above aspects, wherein the coupling optical fiber and the coupling optical fiber are coupled and connected to the waveguide in the detection module respectively.

[0031] The embodiment of the present application provides a detection module and a detection system, wherein the detection module may include a detection module body, including a base and a cover, wherein the cover covers the base to form a microfluidic structure; the microfluidic structure includes a first microfluidic segment and a second microfluidic segment, wherein the first microfluidic segment and the second microfluidic segment are spirally arranged with the same rotation direction, and the inner end of the first microfluidic segment is connected to the inner end of the second microfluidic segment; a waveguide is arranged on the inner side of the microfluidic structure based on the spiral matching of the microfluidic structure, and the waveguide is used for conducting light waves. By spirally arranging the first microfluidic segment and the second microfluidic segment, the distance that the substance to be tested flows through the microfluidic structure can be increased, and since the waveguide is arranged based on the spiral matching of the microfluidic structure, the interaction distance between the substance to be tested and the waveguide can be increased, so that the substance to be tested can have a longer distance to absorb the near-infrared spectrum double frequency of the light wave in the waveguide, thereby improving the absorption effect of the substance to be tested on the near-infrared spectrum double frequency. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 is a schematic diagram of a detection module provided by an embodiment of the present application;

[0033] Figure 2 is a partial cross-sectional schematic diagram of a detection module provided in a specific embodiment of the present application;

[0034] Figure 3 is a partial cross-sectional schematic diagram of a detection module provided in another specific embodiment of the present application;

[0035] Figure 4 is a partial cross-sectional schematic diagram of a detection module provided in another specific embodiment of the present application;

[0036] Figure 5 is a partial cross-sectional schematic diagram of a detection module provided in another specific embodiment of the present application;

[0037] Figure 6 is a partial cross-sectional schematic diagram of a detection module provided in another specific embodiment of the present application;

[0038] Figure 7 is a partial cross-sectional schematic diagram of a detection module provided in another specific embodiment of the present application;

[0039] Figure 8 is a partial cross-sectional schematic diagram of a detection module provided in another specific embodiment of the present application;

[0040] Fig. 9 It is a schematic diagram of a detection system provided by an embodiment of the present application.

[0041] Reference numerals:

[0042] Detection module 1, detection module body 11, base 111, second microchannel groove 1111, base protrusion 1112, covering part 112, first microchannel groove 1121, microchannel protrusion 1122, third microchannel groove 1123, microchannel structure 113, first microfluidic segment 12, second microfluidic segment 13, waveguide 14, detection system 2, coupling optical fiber 21, and coupling optical fiber 22. DETAILED DESCRIPTION

[0043] In order to make the purpose, technical solution and advantages of the present application more clearly understood, the present application is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.

[0044] It should be noted that, unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which this application belongs. The terms used herein are only for the purpose of describing the embodiments of this application and are not intended to limit this application.

[0045] Before further describing the embodiments of the present application in detail, the nouns and terms involved in the embodiments of the present application are explained. The nouns and terms involved in the embodiments of the present application are subject to the following interpretations.

[0046] Evanescent waves are attenuated waves generated at the interface of media. When a beam of light is incident from a denser medium to a less dense medium at a certain angle of incidence and undergoes total reflection, the refracted beam disappears, and the beam propagates only in the direction of the reflected beam, while an evanescent wave propagating along the interface is generated in the direction of the less dense medium. This wave is generated by the interference effect between the reflected wave and the transmitted wave. The characteristic of the evanescent wave is that its amplitude decreases rapidly with the distance from the interface and eventually disappears, and its intensity decays exponentially with distance. Due to these characteristics of the evanescent wave, its propagation distance near the medium interface is very short, but the amplitude changes greatly.

[0047] At present, when some existing detection instruments perform near-infrared frequency doublet analysis on some substances, it is difficult for these detection instruments to make the substances to be tested fully absorb the near-infrared frequency doublets, making the near-infrared spectrum frequency doublets on the spectrum not obvious, making it difficult to obtain relevant information of the substance, affecting the diagnosis of near-infrared spectrum frequency doublet absorption.

[0048] In order to improve the degree of absorption of near-infrared spectrum double frequency by the substance to be tested, the embodiment of the present application provides a detection module and a detection system, the detection module may include a detection module body, including a base and a cover, the cover covers the base to form a microfluidic structure; the microfluidic structure includes a first microfluidic segment and a second microfluidic segment, the first microfluidic segment and the second microfluidic segment are spirally arranged with the same rotation direction, and the inner end of the first microfluidic segment is connected to the inner end of the second microfluidic segment; a waveguide is arranged on the inner side of the microfluidic structure based on the spiral matching of the microfluidic structure, and the waveguide is used for light wave conduction. By spirally arranging the first microfluidic segment and the second microfluidic segment, the distance that the substance to be tested flows through the microfluidic structure can be increased, and because the waveguide is arranged based on the spiral matching of the microfluidic structure, the interaction distance between the substance to be tested and the waveguide can be increased, so that the substance to be tested can have a longer distance to absorb the near-infrared spectrum double frequency of the light wave in the waveguide, thereby improving the absorption effect of the substance to be tested on the near-infrared spectrum double frequency.

[0049] It should be noted that in order to distinguish the base and the covering part in the present application, there will be a gap between the base and the covering part to indicate the difference. In actual use, the covering part will tightly cover the base, and the substance to be tested cannot flow out from the gap shown in the accompanying drawings.

[0050] Reference Figure 1 As shown, Figure 1 The external structure of the detection module is shown in Figure 1In the detection module 1 shown, the detection module 1 may include, but is not limited to, a detection module body 11 and a waveguide 14. The detection module body 11 may include, but is not limited to, a base portion 111 and a cover portion 112. The microfluidic structure 113 may include, but is not limited to, a first microfluidic segment 12 and a second microfluidic segment 13, wherein the first microfluidic segment 12 and the second microfluidic segment 13 are spirally arranged with the same rotation direction, and the inner end of the first microfluidic segment 12 is connected to the inner end of the second microfluidic segment 13 ( Figure 1 The first microfluidic segment 12 and the second microfluidic segment 13 are separated by a dotted line in the figure), and the waveguide 14 is arranged on the inner side of the microfluidic structure 113 based on the spiral matching of the microfluidic structure 113, and the waveguide 14 can be used for light wave conduction. Among them, the inner end of the first microfluidic segment 12 refers to the end of the first microfluidic segment 12 that is completely spiraled inwards, and relatively speaking, the outer end of the first microfluidic segment 12 refers to the end of the first microfluidic segment 12 outside the spiral. In addition, the inner end of the second microfluidic segment 13 refers to the end of the second microfluidic segment 13 that is completely spiraled inwards, and relatively speaking, the outer end of the second microfluidic segment 13 refers to the end of the second microfluidic segment 13 outside the spiral.

[0051] In one embodiment, the detection module body 11 can be a fixed body or a detachable body, etc., which is not specifically limited here. For example, after the assembly of other structures such as the waveguide 14 is completed, the base 111 and the covering part 112 can be fixedly connected to form an integrated detection module body 11; for another example, after the assembly of other structures such as the waveguide 14 is completed, the base 111 and the covering part 112 may not be fixedly connected. When the technician needs to use the detection module 1 to perform material detection, the technician can form a microfluidic structure 113 by covering the covering part 112 to the base 111. When the technician needs to clean the microfluidic structure 113, the technician can easily remove the covering part 112, thereby making the use of the detection module 1 more convenient and user-friendly.

[0052] In one embodiment, the handedness here can be as follows Figure 1 The counterclockwise direction shown may also be clockwise direction, which is not specifically limited here.

[0053] In one embodiment, the distance between the first micro-fluidic segment 12 and the second micro-fluidic segment 13 may be various, such as 0.01 mm, 0.02 mm, etc., which is not specifically limited here.

[0054] In one embodiment, the first micro-flow segment 12 can be in a fully curved state or in a spiral state. Figure 1 The partially bent and partially straightened states shown are not specifically limited here.

[0055] In one embodiment, the second micro-flow segment 13 can be in a fully curved state or in a spiral state. Figure 1 The partially bent and partially straightened states shown are not specifically limited here. Among them, for the waveguide portion in the bent state, this portion of the waveguide can be set with a larger radius or a smaller radius. When the waveguide portion in the bent state is set with a larger radius, the bending loss of the waveguide can be effectively reduced.

[0056] In one embodiment, the first microfluidic segment 12 can be symmetrical or asymmetrical with the second microfluidic segment 13, which is not specifically limited here. Figure 1 As shown, the first microfluidic segment 12 can be symmetrical with the second microfluidic segment 13, and both microfluidic segments are partially bent and partially straightened, and the corresponding bent portions are symmetrical to each other. For another example, the first microfluidic segment 12 can be asymmetrical with the second microfluidic segment 13, and the first microfluidic segment 12 can be in a fully bent state, and the second microfluidic segment 13 can be in a partially bent and partially straightened state.

[0057] In one embodiment, the conduction direction of the light wave in the waveguide 14 can be the same as the flow direction of the substance to be tested in the microfluidic structure 113 (that is, the direction in which the light wave is coupled into the waveguide 14 is the same as the injection direction of the substance to be tested into the microfluidic structure), or it can be opposite to the flow direction of the substance to be tested in the microfluidic structure 113 (that is, the direction in which the light wave is coupled into the waveguide 14 is opposite to the injection direction of the substance to be tested into the microfluidic structure), which is not specifically limited here.

[0058] In one embodiment, the waveguide 14 may be a ridge waveguide or a strip waveguide, etc., which is not specifically limited here.

[0059] In one embodiment, the cross section of the microchannel structure can be a triangle, a quadrilateral, etc., which is not specifically limited here. On this basis, the waveguide 14 can be arranged on any one of the multiple inner sides of the microchannel structure 113, which is not specifically limited here.

[0060] In one embodiment, the base 111 of the present application can be a silicon-on-insulator (SOI) substrate structure, which can specifically include a silicon substrate and a silicon oxide film layer, and the cover 112 in the present application can be made of materials such as polydimethylsiloxane (PDMS), which is not specifically limited here. Specifically, the waveguide 14 of the present application can be epitaxially grown on the upper surface of the silicon substrate by the silicon oxide film layer, and the waveguide 14 material can be epitaxially grown on the upper surface of the silicon oxide film layer. It should be noted that those skilled in the art can perform etching on the base 111 or the waveguide 14 according to needs, which is not specifically limited here. It should be noted that in the embodiments appearing below, when the cover 112 is provided with a waveguide 14, those skilled in the art can set a certain base material on the surface of the position where the waveguide 14 is set in the cover 112 as the base of the waveguide 14, which is not specifically limited here.

[0061] Specifically, in Figure 1 In the detection module shown, the outer end of one of the first microfluidic segment 12 and the second microfluidic segment 13 can be used to inject the substance to be detected, and the outer end of the other can be used to flow out the substance to be detected after being acted upon by light waves. Assuming that the first microfluidic segment 12 is used to inject the substance to be detected, when the substance to be detected enters the microchannel structure 113 from the outer end of the first microfluidic segment 12, the substance to be detected will first flow in the first microfluidic segment 12 along the rotation direction of the first microfluidic segment 12. Since the first microfluidic segment 12 is arranged in a spiral shape, the length of the first microfluidic segment 12 can be extended in a spiral manner. Therefore, for a unit volume of the substance to be detected, a unit volume of the substance to be detected requires a longer time to completely flow through the first microfluidic segment 12.

[0062] After a unit volume of the substance to be tested flows out of the first microfluidic segment 12, it will flow into the second microfluidic segment 13. Since the second microfluidic segment 13 is also arranged in a spiral shape, and the second microfluidic segment 13 has the same rotation direction as the first microfluidic segment 12, the unit volume of the substance to be tested can flow in the second microfluidic segment 13 along the reverse rotation direction. Similarly, the length of the second microfluidic segment 13 can also be extended in a spiral manner. Therefore, for a unit volume of the substance to be tested, these substances to be tested also need a longer time to completely flow through the second microfluidic segment 13.

[0063] On this basis, since the waveguide 14 is arranged on the inner side of the microfluidic structure 113, the substance to be tested can contact the waveguide 14 when flowing in the microfluidic structure 113. The waveguide 14 can couple light waves through an external optical fiber to detect the substance to be tested. In the process of the waveguide 14 conducting the coupled light waves, when the light waves contact the surface of the waveguide 14 in contact with the substance to be tested, the light waves can generate evanescent waves on the surface of the waveguide 14 in contact with the substance to be tested through the interference effect, and the evanescent waves will be transmitted to the substance to be tested. At this time, some hydrogen-containing groups in the substance to be tested will absorb the near-infrared light doubled frequency in the evanescent wave, and the evanescent wave of the absorbed near-infrared light doubled frequency will be converted back into light waves as the microfluidic substance flows out, and is coupled into the waveguide 14, and combined with the light waves conducted in the waveguide 14. Since the near-infrared light doubled in the light wave re-coupled into the waveguide 14 is absorbed, the light wave transmitted in the waveguide 14 can carry the spectral information of the substance to be measured and couple the spectral information out of the waveguide.

[0064] On this basis, since the waveguide 14 is matched and arranged based on the spiral shape of the microfluidic structure 113, the transmission distance of the light wave of the waveguide 14 is the sum of the lengths of the first microfluidic segment 12 and the second microfluidic segment 13. Since the light wave of the waveguide 14 will continuously generate evanescent waves during the transmission process, and the unit volume of the substance to be tested needs to complete the flow through the first microfluidic segment 12 and the second microfluidic segment 13, the distance of the interaction between the evanescent wave and the unit volume of the substance to be tested is extended. Therefore, the unit volume of the substance to be tested will undergo multiple near-infrared light double frequency absorption during this process, so that the near-infrared absorption effect of the substance to be tested in the microfluidic structure is enhanced, so that the near-infrared double frequency absorption information in the light wave transmitted in the waveguide 14 can be made more obvious, thereby improving the detection accuracy and detection effect of the substance to be tested.

[0065] Reference Figure 2 As shown, Figure 2A partial cross section of a detection module provided by a specific embodiment is shown. In one embodiment, the covering portion 112 may include, but is not limited to, a first microfluidic groove 1121, which is arranged based on the spiral matching of the microfluidic structure 113, and the waveguide 14 is arranged on the surface of the base 111 to be covered, and the waveguide 14 can be used to cooperate with the first microfluidic groove 1121 to form the microfluidic structure 113 when the covering portion 112 covers the base 111. By arranging the first microfluidic groove in the covering portion, the microfluidic structure can form a larger flow channel cross section, and the microfluidic structure can flow more substances to be tested per unit time, thereby improving the near-infrared absorption effect of the substances to be tested in the dimension flow structure while improving the detection efficiency of the microfluidic structure for the substances to be tested. In addition, since the waveguide is arranged on the surface of the base to be covered, when the waveguide is made on the surface of the base to be covered, the required number of epitaxy and etching times can be reduced, thereby reducing the production cost of the detection module.

[0066] In one embodiment, a plurality of waveguides 14 disposed on the inner side of the microchannel structure 113 may be provided, and a plurality of the plurality of waveguides 14 are respectively disposed on one of the plurality of inner sides of the first microchannel groove 1121. By providing a plurality of waveguides, the microchannel structure can obtain more evanescent waves to interact with the substance to be detected, thereby better improving the near-infrared absorption effect of the substance to be detected.

[0067] The plurality of the plurality of waveguides 14 refers to the plurality of waveguides 14 other than the waveguide 14 disposed on the surface covered by the base portion 111. In addition, the inner side of the first microfluidic channel groove 1121 refers to any one of the three surfaces of the groove bottom surface and the two side surfaces relative to the groove bottom surface of the first microfluidic channel groove 1121. In addition, the waveguides 14 may be provided with 2, 3, 4, etc., which are not specifically limited here. For example, refer to Figure 3 As shown, when the number of the waveguides 14 is 2, another waveguide 14 other than the waveguide 14 disposed on the covered surface of the base portion 111 may be disposed on the bottom surface of the first microchannel groove 1121 .

[0068] In one embodiment, the waveguide 14 is embedded in the covered surface of the base 111. The waveguide 14 may be embedded in the covered surface of the base 111 in the following manners: the waveguide 14 is partially embedded in the covered surface of the base 111, and the waveguide 14 is completely embedded in the covered surface of the base 111. When the waveguide 14 is completely embedded in the covered surface of the base 111, the surface of the waveguide 14 may be flush with the covered surface of the base 111, so that the microchannel structure can form a larger flow channel cross section, thereby enabling the microchannel to flow more test substances per unit time.

[0069] Reference Figure 4 As shown, in one embodiment, the waveguide 14 is convexly arranged on the covered surface of the base 111, and the convex height of the waveguide 14 is less than the depth of the first microchannel groove 1121. Specifically, since the waveguide 14 is convex, when the covering portion 112 covers the surface of the base 111, the waveguide 14 will occupy a certain amount of the groove space of the first microchannel groove 1121, and since the convex height of the waveguide 14 is less than the depth of the first microchannel groove 1121, a certain amount of groove space will remain in the first microchannel groove 1121 for the flow of the substance to be tested. At this time, since the space for the flow of the substance to be tested is occupied, the flow channel cross-section of the microchannel structure is reduced, which can make the unit volume of the substance to be tested interact with more evanescent waves, thereby better improving the near-infrared absorption effect of the substance to be tested.

[0070] Reference Figure 5 As shown, Figure 5 A partial cross section of a detection module provided by another specific embodiment is shown. In one embodiment, the covering portion 112 may include but is not limited to a microchannel protrusion 1122, and the base portion 111 may include but is not limited to a second microchannel groove 1111. The microchannel protrusion 1122 is arranged based on the spiral matching of the microchannel structure 113, and the second microchannel groove 1111 is arranged based on the spiral matching of the microchannel structure 113. The waveguide 14 is arranged at the bottom of the second microchannel groove 1111, and the distance from the surface of the waveguide 14 to the covered surface of the base portion 111 is greater than the protrusion height of the microchannel protrusion 1122. Figure 4 The structure of the detection module 1 shown is similar. Figure 5 For the detection module 1 shown, when the covering portion 112 covers the surface of the base 111, the microchannel protrusion 1122 will occupy the groove space of the second microchannel groove 1111 to a certain extent, and because the distance from the surface of the waveguide 14 to the surface covered by the base 111 is greater than the protrusion height of the microchannel protrusion 1122, there will be a certain amount of groove space left in the second microchannel groove 1111 for the flow of the substance to be tested. At this time, since the space for the flow of the substance to be tested is occupied, the flow channel cross-section of the microchannel structure is reduced, thereby reducing the substance to be tested that flows through the microchannel structure per unit time, and on the contrary, the substance to be tested per unit volume can fully interact with the evanescent wave in the microchannel structure, thereby better improving the near-infrared absorption effect of the substance to be tested. Among them, the number of waveguides 14 can be 1 or more, which is not specifically limited here. In addition, when the number of waveguides 14 is more than one, those skilled in the art can determine the position of each waveguide 14 according to actual conditions, which is not specifically limited here.

[0071] Reference Figure 6As shown, in one embodiment, a plurality of waveguides 14 are provided on the inner side of the microchannel structure 113, at least one of the plurality of waveguides 14 is provided on the surface of the microchannel protrusion 1122, and the distance between the waveguide 14 provided on the surface of the microchannel protrusion and the waveguide 14 provided at the bottom of the second microchannel groove 1111 is not 0. By providing a waveguide on the surface of the microchannel protrusion, the flow channel cross section of the microchannel structure can be further reduced, so that the remaining groove space of the second microchannel groove can be further compressed, and the flow rate of the substance to be tested in the microchannel structure per unit time can be reduced. In addition, by providing a plurality of waveguides, the microchannel structure can obtain more evanescent waves, and then the substance to be tested per unit volume can interact with more evanescent waves, so that the substance to be tested per unit volume can be more fully absorbed by near-infrared double frequency.

[0072] When the number of waveguides 14 is two, the configuration can be as follows: Figure 6 As shown; when the number of waveguides 14 is greater than 2, the waveguides 14 among the multiple waveguides 14, except for the waveguide 14 arranged on the surface of the microchannel protrusion 1122 and the waveguide 14 arranged at the bottom of the second microchannel groove 1111, can be arranged on the side wall opposite to the bottom surface of the second microchannel groove 1111.

[0073] In one embodiment, the waveguide 14 may be disposed on the bottom surface of the second microchannel groove 1111 (ie Figure 6 The waveguide 14 may be embedded in the bottom surface of the second microchannel groove 1111. The waveguide 14 embedded in the bottom surface of the second microchannel groove 1111 includes: the waveguide 14 is partially embedded in the bottom surface of the second microchannel groove 1111, and the waveguide 14 is completely embedded in the bottom surface of the second microchannel groove 1111. When the waveguide 14 is completely embedded in the covered surface of the base 111, the surface of the waveguide 14 can be flush with the covered surface of the base 111, so that the microchannel structure can form a larger flow channel cross-section, so that the microchannel can flow more test substances per unit time.

[0074] Reference Figure 7As shown, in one embodiment, the base portion 111 may include but is not limited to a base protrusion 1112, and the cover portion 112 may include but is not limited to a third microchannel groove 1123. The waveguide 14 is arranged on the covered surface of the base portion 111, the base protrusion 1112 is arranged on the covered surface of the base portion 111, the base protrusion 1112 is located between the setting position of the first microfluidic segment 12 and the setting position of the second microfluidic segment 13, and the third microchannel groove 1123 can be used to cooperate with the base protrusion 1112 to form a microchannel structure 113 when the cover portion 112 covers the base portion 111. By arranging the base protrusion on the base and the third microchannel groove on the cover portion, a microchannel structure with a larger flow channel cross section can be formed, and the microchannel structure can flow more substances to be tested in a unit time, so that the near-infrared absorption effect of the substances to be tested in the flow structure can be improved, and the detection efficiency of the microchannel structure on the substances to be tested can be improved.

[0075] Reference Figure 8 As shown, in one embodiment, the waveguide 14 is convexly arranged on the surface of the base 111 covered, and the convex height of the waveguide 14 is less than the height of the base convex portion. When the covering portion 112 covers the surface of the base 111, the waveguide 14 will occupy a certain amount of the groove space formed by the third microchannel groove 1123 and the base convex portion 1112, and since the convex height of the waveguide 14 is less than the height of the base convex portion 1112, a certain amount of space will remain in the groove space formed by the third microchannel groove 1123 and the base convex portion 1112 for the flow of the substance to be tested. At this time, since the space for the flow of the substance to be tested is occupied, the flow channel cross-section of the microchannel structure is reduced, which can make the unit volume of the substance to be tested interact with more evanescent waves, thereby better improving the near-infrared absorption effect of the substance to be tested.

[0076] In one embodiment, the waveguide 14 is embedded in the covered surface of the base 111. The waveguide 14 is embedded in the covered surface of the base 111, including: the waveguide 14 is partially embedded in the covered surface of the base 111, and the waveguide 14 is completely embedded in the covered surface of the base 111. When the waveguide 14 is completely embedded in the covered surface of the base 111, the surface of the waveguide 14 can be flush with the covered surface of the base 111, so that the microchannel structure can form a larger flow channel cross-section, so that the microchannel can flow more test substances per unit time.

[0077] Reference Fig. 9As shown, the embodiment of the present application also provides a detection system 2, which may include but is not limited to a coupling optical fiber, a coupling optical fiber and a detection module 1 as provided in the above embodiments, the coupling optical fiber 21 and the coupling optical fiber 22 are coupled and connected to the waveguide in the detection module 1 respectively, and the implementation principles and effects of various detection modules 1 can refer to the above content and will not be elaborated here.

[0078] The technical features of the above embodiments may be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0079] In the embodiments of the present application, "at least one" refers to one or more, and "more than one" refers to two or more. "And / or" describes the association relationship of associated objects, indicating that three relationships may exist. For example, A and / or B can represent the situation where A exists alone, A and B exist at the same time, and B exists alone. Among them, A and B can be singular or plural. The character " / " generally indicates that the objects associated before and after are in an "or" relationship. "At least one of the following" and similar expressions refer to any combination of these items, including any combination of singular or plural items. For example, at least one of a, b and c can mean: a exists alone, b exists alone, c exists alone, a and b exist at the same time, a and c exist at the same time, b and c exist at the same time, or a, b and c exist at the same time, wherein a, b, c can be single or multiple.

[0080] In the embodiments of the present application, "indication" may include direct indication and indirect indication, and may also include explicit indication and implicit indication. The information indicated by a certain information is called information to be indicated. In the specific implementation process, there may be many ways to indicate the information to be indicated, such as but not limited to, the information to be indicated may be directly indicated, such as indicating the information to be indicated itself or the index of the information to be indicated. The information to be indicated may also be indirectly indicated by indicating other information, wherein the other information has an association relationship with the information to be indicated. It is also possible to indicate only a part of the information to be indicated, while the other parts of the information to be indicated are known or agreed in advance. For example, the indication of specific information may also be achieved by means of the arrangement order of each information agreed in advance (for example, specified by the protocol), thereby reducing the indication overhead to a certain extent.

[0081] In the embodiments of the present application, each term and English abbreviation is provided for the convenience of description and shall not constitute any limitation to the present application. The present application does not exclude the possibility of defining other terms that can achieve the same or similar functions in existing or future protocols.

[0082] In the embodiments of the present application, the terms "first", "second", and "third" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, a feature defined as "first", "second", and "third" may explicitly or implicitly include one or more of the features.

[0083] The above-mentioned embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the present application. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application.

Claims

1. A detection module, characterized in that: include: The detection module body comprises a base and a covering portion, wherein the covering portion covers the base to form a microfluidic structure; the microfluidic structure comprises a first microfluidic segment and a second microfluidic segment, wherein the first microfluidic segment and the second microfluidic segment are spirally arranged with the same rotation direction, and the inner end of the first microfluidic segment is connected to the inner end of the second microfluidic segment; A waveguide is arranged on the inner side of the microfluidic channel structure based on the spiral matching of the microfluidic channel structure, and the waveguide is used for conducting light waves.

2. The module according to claim 1, characterized in that The covering portion comprises: A first microfluidic channel groove is arranged based on the spiral matching of the microfluidic channel structure; The waveguide is arranged on the covered surface of the base portion, and is used to cooperate with the first microchannel groove to form the microchannel structure when the covering portion covers the base portion.

3. The module according to claim 2, characterized in that There are a plurality of waveguides disposed on the inner side of the microchannel structure, and a plurality of the plurality of waveguides are disposed correspondingly on one of the plurality of inner sides of the first microchannel grooves.

4. The module according to claim 2, characterized in that The waveguide is arranged on the covered surface of the base by one of the following methods: The waveguide is convexly arranged on the covered surface of the base, and the convex height of the waveguide is smaller than the depth of the first microchannel groove; or, The waveguide is embedded in the covered surface of the base.

5. The module according to claim 1, characterized in that The covering portion comprises: A microfluidic channel protrusion is arranged based on the spiral matching of the microfluidic channel structure; The base portion comprises: The second microfluidic channel groove is arranged based on the spiral matching of the microfluidic channel structure, the waveguide is arranged at the bottom of the second microfluidic channel groove, and the distance from the waveguide surface to the surface covered by the base is greater than the protrusion height of the microfluidic channel protrusion.

6. The module according to claim 5, characterized in that There are multiple waveguides arranged on the inner side of the microfluidic structure, at least one of the multiple waveguides is arranged on the surface of the microfluidic protrusion, and the distance between the waveguide arranged on the surface of the microfluidic protrusion and the waveguide arranged at the bottom of the second microfluidic groove is not 0.

7. The module according to claim 5, characterized in that The waveguide is disposed at the bottom of the second microchannel groove in one of the following ways: The waveguide is arranged on the bottom surface of the second microchannel groove; or, The waveguide is embedded in the bottom surface of the second microchannel groove.

8. The module according to claim 1, characterized in that The waveguide is arranged on the covered surface of the base; The base portion comprises: A base protrusion is arranged on the covered surface of the base part, and the base protrusion is located between the setting position of the first microfluidic segment and the setting position of the second microfluidic segment; The covering portion comprises: The third micro-channel groove is used to cooperate with the base protrusion to form the micro-channel structure when the covering portion covers the base portion.

9. The module according to claim 8, characterized in that The waveguide is arranged on the surface covered by the base by one of the following methods: The waveguide is convexly arranged on the covered surface of the base portion, and the convex height of the waveguide is smaller than the height of the convex portion of the base; or, The waveguide is embedded in the covered surface of the base.

10. A detection system, characterized in that: It comprises a coupling-in optical fiber, a coupling-out optical fiber and a detection module as claimed in any one of claims 1 to 9, wherein the coupling-in optical fiber and the coupling-out optical fiber are coupled and connected to a waveguide in the detection module respectively.

Images