Continuous dialysis device

Abstract

The utility model discloses a continuous dialysis device which comprises a dialysis bag, a dialysis barrel, a liquid storage barrel, a first liquid inlet pipeline, a second liquid inlet pipeline, a first liquid outlet pipeline and a second liquid outlet pipeline. The first dialysis membrane layer of the dialysis bag forms a first liquid storage space, and a second liquid storage space is formed between the second dialysis membrane layer and the first dialysis membrane layer of the dialysis bag; the dialysis bag is contained in the dialysis barrel, and a third liquid storage space is formed between the dialysis bag and the dialysis barrel; the first liquid inlet pipeline is communicated with the liquid storage barrel and the first liquid storage space; the first liquid outlet pipeline is communicated with the first liquid storage space; the second liquid inlet pipeline is communicated with the liquid storage barrel and the third liquid storage space; one end of the second liquid outlet pipeline is positioned in the liquid storage barrel. According to the continuous dialysis device, the buffer solution is conveyed in a flowing manner, so that dialysis pollution caused by manual contact is avoided. By introducing the flowing buffer solution, double-side dialysis of the dialysate in the second liquid storage space can be realized, and meanwhile, the design that the buffer solution is introduced into the two sides respectively can enlarge the dialysis area and improve the dialysis speed.

Description

Technical Field

[0001] The utility model relates to the technical field of dialysis equipment, in particular to a continuous dialysis device. Background Art

[0002] In the process of natural material extraction, dialysis is a common way to remove salt, remove small molecular organic substances and concentrate samples. The dialysis process relies on the selective permeability of the semipermeable membrane, that is, substances below the calibrated molecular weight can freely enter and exit the semipermeable membrane driven by the concentration difference on both sides of the membrane. Now dialysis has become one of the simplest technologies for biochemical experiments, industrial extraction and purification of natural macromolecules.

[0003] The common process of dialysis at present includes: putting the dialyzed solution into a semipermeable membrane dialysis bag and sealing it, and then putting the dialysis bag into a buffer solution, which is generally deionized water or saline. After a certain period of dialysis, the water is replaced successively until the dialysis is completed.

[0004] Frequent water changes in this dialysis method may cause artificial contamination of the dialysis bag, and untimely water changes will also lead to unsatisfactory dialysis effects within the specified time. At the same time, only one-sided dialysis is achieved through the outer side of the semipermeable membrane dialysis bag, and the dialysis speed is slow; and the prior art uses a method of bundling the dialysis bag to reduce the contact area between the dialyzate and the buffer solution, which slows down the dialysis speed. Utility Model Content

[0005] The utility model aims at overcoming at least one of the above problems and provides a continuous dialysis device.

[0006] The technical solution adopted by the utility model is as follows:

[0007] The present application provides a continuous dialysis device, comprising a dialysis bag, a dialysis bucket, a liquid storage bucket, a first liquid inlet pipeline, a second liquid inlet pipeline, a first liquid outlet pipeline, and a second liquid outlet pipeline;

[0008] The dialysis bag comprises a first dialysis membrane layer and a second dialysis membrane layer coated on the outside of the first dialysis membrane layer, wherein the first dialysis membrane layer forms a first liquid storage space inwardly, and a second liquid storage space is formed between the first dialysis membrane layer and the second dialysis membrane layer, and the second liquid storage space is used to store dialysis fluid;

[0009] The liquid storage barrel is used for storing buffer solution;

[0010] The dialysis bag is accommodated in the dialysis bucket, and a third liquid storage space is formed between the second dialysis membrane layer and the dialysis bucket;

[0011] One end of the first liquid inlet pipeline is located in the liquid storage barrel, and the other end is connected to the first liquid storage space of the dialysis bag;

[0012] One end of the first liquid outlet pipeline is connected to the first liquid storage space of the dialysis bag, and the other end is located outside the dialysis bucket;

[0013] One end of the second liquid inlet pipeline is located in the liquid storage barrel, and the other end is connected to the third liquid storage space;

[0014] One end of the second liquid outlet pipeline is located in the liquid storage barrel, and the other end is located outside the dialysis barrel.

[0015] The continuous dialysis device provided by the present application delivers buffer solution in a flowing manner through the inlet and outlet pipelines during the dialysis process without the need for manual intermittent water changes, thereby avoiding dialysis contamination caused by manual contact. By separately introducing buffer solution into the first liquid storage space formed by the first dialysis membrane layer and the third liquid storage space formed between the second dialysis membrane layer and the dialysis barrel, the dialysate in the second liquid storage space can be subjected to bilateral dialysis. At the same time, the design of introducing the flowing buffer solution into the two sides can increase the dialysis area and improve the dialysis speed. By controlling the flow rate of the first inlet pipeline and the first outlet pipeline, the dialysis effect of the second dialysis membrane layer inside the dialysis bag can be improved.

[0016] In actual use, by increasing the liquid flow rate in the first liquid storage space, a dialysis rate similar to that of the outer side with a large surface area can be achieved by realizing a larger interface concentration difference and a larger permeability under a smaller surface area on the inner side, thereby realizing real-time multi-directional diffusion of the dialysate salt component and improving the dialysis rate.

[0017] Furthermore, the continuous dialysis device also includes a first pump and a second pump, the first pump and the second pump are respectively arranged on the first liquid inlet pipeline and the second liquid inlet pipeline, and the first pump and the second pump are used to pump liquid to the first liquid storage space and the third liquid storage space respectively.

[0018] The flow dialysis of the buffer solution is achieved by pumping the buffer solution. This dialysis method keeps the concentration difference on both sides of the dialysis membrane at a high value at all times, which can increase the dialysis speed.

[0019] Furthermore, the first pump and the second pump are both submersible water pumps, and the first pump and the second pump are both arranged inside the liquid storage barrel and are respectively connected to the ends of the first liquid inlet pipeline and the second liquid inlet pipeline.

[0020] Compared with ordinary water pumps, submersible water pumps have lower power, higher efficiency and more stable operation.

[0021] Furthermore, the continuous dialysis device further comprises a flow meter, and the flow meter comprises at least two flow meters, and the two flow meters are respectively arranged on the first liquid inlet pipeline and the second liquid inlet pipeline;

[0022] The flow meter is used to cooperate with the first pump or the second pump to achieve the purpose of detecting and controlling the liquid flow rate or the liquid intake amount.

[0023] During the dialysis process, it is only necessary to use a flow meter to adjust the flow rate of the inlet and outlet pipes to achieve continuous dialysis. The overall operation is simple and convenient.

[0024] Furthermore, the flow meter is arranged on the first liquid inlet pipeline and the second liquid inlet pipeline between the outside of the dialysis bucket and the outside of the liquid storage bucket.

[0025] Furthermore, the flow meter is also respectively provided on the first liquid outlet pipeline and the second liquid outlet pipeline outside the dialysis bucket.

[0026] Furthermore, an inlet and an outlet respectively connected to the first liquid storage space are formed on the second dialysis membrane layer of the dialysis bag, and the inlet and the outlet are respectively penetrated on the second liquid storage space, so that the first liquid storage space is connected to the outside.

[0027] Furthermore, the continuous dialysis device also includes a connecting piece, which has a through hole. The connecting piece is arranged on the dialysis bag, and the through hole is arranged corresponding to the inlet or outlet. The first liquid inlet pipeline and the first liquid outlet pipeline are respectively arranged on the through hole and are connected to the first liquid storage space through the connecting piece.

[0028] Furthermore, the connecting piece is bonded to the dialysis bag.

[0029] Furthermore, the first dialysis membrane layer and the second dialysis membrane layer are concentrically arranged.

[0030] In the present application, the concentric arrangement refers to the concentric arrangement of the second liquid storage space and the first liquid storage space, that is, the distance from the first dialysis membrane layer to the second dialysis membrane layer is uniform. Such an arrangement can also increase the contact area between the dialysate and the buffer solution, maintain a high concentration difference between the internal dialysis solution and the buffer solution, and improve the efficiency of dialysis; it can also make the dialysate in the second liquid storage space evenly permeate toward the side close to the first dialysis membrane layer and the side close to the second dialysis membrane layer, further improving the dialysis efficiency.

[0031] Furthermore, it also includes a buffer recovery barrel, and one end of the first liquid outlet pipeline and the second liquid outlet pipeline located outside the dialysis barrel are respectively connected to the buffer recovery barrel;

[0032] The buffer recovery bucket is used to receive the dialyzed buffer discharged from the first liquid storage space and the third liquid storage space.

[0033] The beneficial effects of the utility model are:

[0034] (1) The continuous dialysis device provided by the present application delivers buffer solution in a flowing manner through the inlet and outlet pipelines during the dialysis process without the need for manual intermittent water changes, thereby avoiding dialysis contamination caused by manual contact. By separately introducing flowing buffer solution into the first liquid storage space and the third liquid storage space, the dialysate in the second liquid storage space can achieve bilateral dialysis. At the same time, the design of introducing buffer solution on both sides can increase the dialysis area and improve the dialysis speed. Combined with the flow rate control of the first inlet pipeline and the first outlet pipeline, the dialysis effect of the second dialysis membrane layer inside the dialysis bag can be improved.

[0035] (2) The concentric arrangement of the first dialysis membrane layer and the second dialysis membrane layer can increase the contact area between the dialysate and the buffer solution, maintain a high concentration difference between the internal dialysis solution and the buffer solution, and improve the dialysis efficiency; it can also make the dialysate in the second liquid storage space evenly permeate toward the side close to the first dialysis membrane layer and the side close to the second dialysis membrane layer, further improving the dialysis efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] Figure 1 It is a schematic structural diagram of a continuous dialysis device according to an embodiment of the utility model;

[0037] Figure 2 It is a schematic structural diagram of a dialysis bag according to an embodiment of the utility model.

[0038] The reference numerals in the figures are:

[0039] 10. Dialysis bag; 101. First dialysis membrane layer; 102. Second dialysis membrane layer; 103. Connector; 104. First liquid storage space; 105. Second liquid storage space; 106. Third liquid storage space; 20. Dialysis barrel; 30. Liquid storage barrel; 40. First liquid inlet pipeline; 50. Second liquid inlet pipeline; 60. First liquid outlet pipeline; 70. Second liquid outlet pipeline; 80. First pump; 90. Second pump; 100. Flow meter. DETAILED DESCRIPTION

[0040] The utility model is described in detail below in conjunction with the accompanying drawings.

[0041] like Figure 1 and Figure 2 As shown, the present application provides a continuous dialysis device, including a dialysis bag 10, a dialysis bucket 20, a liquid storage bucket 30, a first liquid inlet pipeline 40, a second liquid inlet pipeline 50, a first liquid outlet pipeline 60 and a second liquid outlet pipeline 70;

[0042] The dialysis bag 10 includes a first dialysis membrane layer 101 and a second dialysis membrane layer 102 coated on the outside of the first dialysis membrane layer 101. The first dialysis membrane layer 101 forms a first liquid storage space 104 inwardly, and a second liquid storage space 105 is formed between the first dialysis membrane layer 101 and the second dialysis membrane layer 102. The second liquid storage space 105 is used to store dialysate.

[0043] The liquid storage barrel 30 is used to store buffer solution;

[0044] The dialysis bag 10 is accommodated in the dialysis bucket 20, and a third liquid storage space 106 is formed between the second dialysis membrane layer 102 and the dialysis bucket 20;

[0045] One end of the first liquid inlet pipeline 40 is located in the liquid storage barrel 30, and the other end is connected to the first liquid storage space 104 of the dialysis bag 10;

[0046] One end of the first liquid outlet pipeline 60 is connected to the first liquid storage space 104 of the dialysis bag 10, and the other end is located outside the dialysis barrel 20;

[0047] One end of the second liquid inlet pipeline 50 is located in the liquid storage barrel 30, and the other end is connected to the third liquid storage space 106;

[0048] One end of the second liquid outlet pipeline 70 is located in the liquid storage barrel 30 , and the other end is located outside the dialysis barrel 20 .

[0049] The continuous dialysis device provided in the present application delivers buffer solution through the inlet and outlet pipelines during the dialysis process, without the need for manual intermittent water change, thereby avoiding dialysis contamination caused by manual contact. By setting the dialysis bag 10 to a structure in which the inner and outer layers of the dialysis membrane are concentric, and separately passing buffer solution into the first liquid storage space 104 formed by the first dialysis membrane layer 101 and the third liquid storage space 106 formed between the second dialysis membrane layer 102 and the dialysis bucket 20, the dialysate in the second liquid storage space 105 can be made to perform bilateral dialysis, and at the same time, the design of passing buffer solution into the two sides can increase the dialysis area and improve the dialysis speed. By controlling the flow rate of the first inlet pipeline 40 and the first outlet pipeline 60, the dialysis effect of the second dialysis membrane layer 102 inside the dialysis bag 10 can be improved.

[0050] In actual use, by increasing the liquid flow rate in the first liquid storage space 104, a dialysis rate similar to that of the outer side with a large surface area can be achieved by realizing a larger interface concentration difference and a larger permeability under a smaller surface area on the inner side, thereby realizing real-time multi-directional diffusion of the dialysate salt component and improving the dialysis rate.

[0051] In this embodiment, the continuous dialysis device also includes a first pump 80 and a second pump 90, which are respectively arranged on the first liquid inlet pipeline 40 and the second liquid inlet pipeline 50, and the first pump 80 and the second pump 90 are used to pump liquid into the first liquid storage space 104 and the third liquid storage space 106 respectively.

[0052] The flow dialysis of the buffer solution is achieved by pumping the buffer solution. This dialysis method keeps the concentration difference on both sides of the dialysis membrane at a high value at all times, which can increase the dialysis speed.

[0053] In this embodiment, the first pump 80 and the second pump 90 are both submersible water pumps. The first pump 80 and the second pump 90 are both disposed inside the liquid storage barrel 30 and are connected to the ends of the first liquid inlet pipeline 40 and the second liquid inlet pipeline 50 respectively.

[0054] Compared with ordinary water pumps, submersible water pumps have lower power, higher efficiency and more stable operation.

[0055] In this embodiment, the continuous dialysis device further includes a flow meter 100, and the flow meter 100 includes at least two flow meters 100, and the two flow meters 100 are respectively arranged on the first liquid inlet pipeline 40 and the second liquid inlet pipeline 50;

[0056] The flow meter 100 is used to cooperate with the first pump 80 or the second pump 90 to achieve the purpose of detecting and controlling the flow rate of the liquid or the amount of liquid inflow.

[0057] During the dialysis process, it is only necessary to use the flow meter 100 to adjust the flow rates of the inlet and outlet pipes to achieve continuous dialysis, and the overall operation is simple and convenient.

[0058] In this embodiment, the flow meter 100 is disposed on the first liquid inlet pipeline 40 and the second liquid inlet pipeline 50 between the outside of the dialysis bucket 20 and the outside of the liquid storage bucket 30 .

[0059] In this embodiment, flow meters 100 are also respectively disposed on the first liquid outlet pipe 60 and the second liquid outlet pipe 70 outside the dialysis bucket 20 .

[0060] In this embodiment, an inlet and an outlet respectively connected to the first liquid storage space 104 are formed on the second dialysis membrane layer 102 of the dialysis bag 10. The inlet and the outlet are respectively penetrated on the second liquid storage space 105, so that the first liquid storage space 104 is connected to the outside.

[0061] In this embodiment, the continuous dialysis device also includes a connector 103 having a through hole. The connector 103 is arranged on the dialysis bag 10, and the through hole is arranged corresponding to the inlet or outlet. The first liquid inlet pipeline 40 and the first liquid outlet pipeline 60 are respectively arranged on the through hole and are connected to the first liquid storage space 104 through the connector 103.

[0062] In this embodiment, the connector 103 is bonded to the dialysis bag 10 .

[0063] In this embodiment, the first dialysis membrane layer 101 and the second dialysis membrane layer 102 are concentrically disposed.

[0064] In the present application, the concentric arrangement refers to the concentric arrangement of the second liquid storage space 105 and the first liquid storage space 104, that is, the distance from the first dialysis membrane layer 101 to the second dialysis membrane layer 102 is uniform. Such an arrangement can also increase the contact area between the dialysate and the buffer solution, maintain a high concentration difference between the internal dialysis solution and the buffer solution, and improve the dialysis efficiency; it can also make the dialysate in the second liquid storage space 105 evenly permeate toward the side close to the first dialysis membrane layer 101 and the side close to the second dialysis membrane layer 102, further improving the dialysis efficiency.

[0065] In this embodiment, a buffer recovery bucket is further included, and one end of the first liquid outlet pipeline 60 and the second liquid outlet pipeline 70 located outside the dialysis bucket 20 is respectively connected to the buffer recovery bucket;

[0066] The buffer recovery bucket is used to receive the dialyzed buffer discharged from the first liquid storage space 104 and the third liquid storage space 106. The above description is only a preferred embodiment of the utility model, and does not limit the patent protection scope of the utility model. Any equivalent structural transformation made by using the contents of the utility model specification and drawings, directly or indirectly used in other related technical fields, is also included in the protection scope of the utility model.

Claims

1. A continuous dialysis device, characterized in that: It includes a dialysis bag, a dialysis barrel, a liquid storage barrel, a first liquid inlet pipeline, a second liquid inlet pipeline, a first liquid outlet pipeline and a second liquid outlet pipeline; The dialysis bag comprises a first dialysis membrane layer and a second dialysis membrane layer coated on the outside of the first dialysis membrane layer, wherein the first dialysis membrane layer forms a first liquid storage space inwardly, and a second liquid storage space is formed between the first dialysis membrane layer and the second dialysis membrane layer, and the second liquid storage space is used to store dialysis fluid; The liquid storage barrel is used for storing buffer solution; The dialysis bag is accommodated in the dialysis bucket, and a third liquid storage space is formed between the second dialysis membrane layer and the dialysis bucket; One end of the first liquid inlet pipeline is located in the liquid storage barrel, and the other end is connected to the first liquid storage space of the dialysis bag; One end of the first liquid outlet pipeline is connected to the first liquid storage space of the dialysis bag, and the other end is located outside the dialysis bucket; One end of the second liquid inlet pipeline is located in the liquid storage barrel, and the other end is connected to the third liquid storage space; One end of the second liquid outlet pipeline is located in the liquid storage barrel, and the other end is located outside the dialysis barrel.

2. A continuous dialysis device as claimed in claim 1, characterized in that: The continuous dialysis device further comprises a first pump and a second pump, wherein the first pump and the second pump are respectively arranged on the first liquid inlet pipeline and the second liquid inlet pipeline, and the first pump and the second pump are used to pump liquid into the first liquid storage space and the third liquid storage space respectively.

3. A continuous dialysis device as claimed in claim 2, characterized in that: The first pump and the second pump are both submersible water pumps. The first pump and the second pump are both arranged inside the liquid storage barrel and are connected to the ends of the first liquid inlet pipeline and the second liquid inlet pipeline respectively.

4. A continuous dialysis device as claimed in claim 2, characterized in that: The continuous dialysis device further comprises a flow meter, wherein the flow meter comprises at least two flow meters, and the two flow meters are respectively arranged on the first liquid inlet pipeline and the second liquid inlet pipeline; The flow meter is used to cooperate with the first pump or the second pump to achieve the purpose of detecting and controlling the liquid flow rate or the liquid intake amount.

5. A continuous dialysis device as claimed in claim 4, characterized in that: The flow meter is arranged on the first liquid inlet pipeline and the second liquid inlet pipeline between the outside of the dialysis bucket and the outside of the liquid storage bucket.

6. A continuous dialysis device as claimed in claim 4, characterized in that: The flow meter is also respectively provided on the first liquid outlet pipeline and the second liquid outlet pipeline outside the dialysis bucket.

7. A continuous dialysis device as claimed in claim 1, characterized in that: An inlet and an outlet respectively connected to the first liquid storage space are formed on the second dialysis membrane layer of the dialysis bag. The inlet and the outlet are respectively penetrated on the second liquid storage space, so that the first liquid storage space is connected to the outside.

8. A continuous dialysis device as claimed in claim 7, characterized in that: The continuous dialysis device also includes a connector having a through hole. The connector is arranged on the dialysis bag, and the through hole is arranged corresponding to the inlet or outlet. The first liquid inlet pipeline and the first liquid outlet pipeline are respectively arranged on the through hole and are connected to the first liquid storage space through the connector.

9. A continuous dialysis device as claimed in claim 1, characterized in that: The first dialysis membrane layer and the second dialysis membrane layer are concentrically arranged.

10. A continuous dialysis device according to claim 1, characterized in that: It also includes a buffer recovery barrel, and one end of the first liquid outlet pipeline and the second liquid outlet pipeline located outside the dialysis barrel are respectively connected to the buffer recovery barrel; The buffer recovery bucket is used to receive the dialyzed buffer discharged from the first liquid storage space and the third liquid storage space.

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