MRNA preparation lotion bottle

Abstract

The utility model discloses an mRNA (messenger Ribonucleic Acid) preparation lotion bottle. The washing liquid bottle is composed of a bottle body and a bottle cap, the bottle body is used for containing mRNA preparation washing liquid, the material of the bottle body has controllable squeezing performance, a bottle opening of the bottle body is connected with the bottle cap through threads, and the bottle cap comprises a threaded connector, a liquid outlet sleeve, a screw cap, a control ring, a face cap and a face cap cover. A filter membrane, a filter membrane frame, a liquid dispersing disc, an impeller, a liquid jetting disc, a liquid distributing disc and a nozzle are arranged in the liquid outlet sleeve. The utility model not only fills up the blank of mRNA preparation lotion bottles which can be directly used for cleaning tumor operation wounds or in-vivo operation areas at home and abroad, but also provides a medical instrument which can easily control the spraying or flowing-out speed, density and angle of mRNA preparation lotion only through extrusion and avoid excessive use of the mRNA preparation lotion for medical personnel. In addition, the utility model also meets the personalized customization requirements of patients needing to clean tumor operation wounds or in-vivo operation areas.

Description

Technical Field

[0001] The utility model relates to the field of biomedical medical devices, in particular to an mRNA preparation washing liquid bottle and a use method thereof. Background Art

[0002] With the rapid development of mRNA science and technology, in vitro synthesized mRNA preparation wash solutions have begun to be used or gradually used in tumor surgical wounds or in vivo surgical area cleaning to assist in improving the control effect of postoperative cancer recurrence and metastasis, so as to minimize the risk of postoperative cancer recurrence and metastasis (1. Chinese invention patent, application number: 2023111836270, an mRNA preparation wash solution for tumor surgical wounds or in vivo surgical area cleaning; 2. Chinese invention patent, application number: 2023112807294, a new wash solution for tumor surgical wounds or in vivo surgical area cleaning).

[0003] The mRNA preparation lotion packaging bottle is a container for containing the mRNA preparation lotion. The existing mRNA preparation lotion packaging bottle is composed of a bottle body for containing the mRNA preparation lotion and a cap for sealing it. The mRNA preparation lotion cleaning is widely used in tumor surgery in various hospitals as one of the main ways to assist in reducing the risk of postoperative cancer recurrence and metastasis. In order to facilitate the transportation of mRNA preparation lotion, packaging bottles are generally used to store mRNA preparation lotion.

[0004] The utility model applicant discovered in daily work practice that the mRNA preparation lotion in the mRNA preparation lotion bottle often needs to be transferred before it can be used after surgery. During the transfer process, the mRNA preparation lotion is likely to stick to the hands of medical operators, resulting in waste of mRNA preparation lotion and other personnel accidentally touching the residual lotion, which may cause unnecessary adverse reactions or allergic reactions, affecting medical and health standards and the cleanliness of environments such as operating rooms.

[0005] In view of this, the purpose of the utility model is to provide an mRNA preparation wash bottle, which integrates the bottle body squeezing and bottle cap liquid discharge processes to meet the needs of medical staff to accurately and safely use the mRNA preparation wash directly after the operation without transfer. Utility Model Content

[0006] The technical problem to be solved by the utility model is to overcome the deficiencies in the existing operating technology of mRNA preparation washing solution, and to provide an mRNA preparation washing solution bottle that can overcome the above problems or partially solve the above problems, thereby providing a strong guarantee for the accurate and safe use of mRNA preparation washing solution by medical staff after the completion of tumor surgery.

[0007] In order to achieve the above object, the technical solution of the utility model is:

[0008] An mRNA preparation washing liquid bottle, the mRNA preparation washing liquid bottle is composed of a bottle body and a bottle cap, the bottle body is used to hold the mRNA preparation washing liquid, the bottle mouth of the bottle body is connected to the bottle cap by a thread, the bottle cap includes a threaded joint, a liquid outlet sleeve, a screw cover, a control ring, a face cover, and a face cover cover, and the liquid outlet sleeve is provided with a filter membrane, a filter membrane holder, a bulk liquid dish, an impeller, a liquid injection dish, a liquid separation plate, and a nozzle. Compared with the current mRNA preparation washing liquid use and operation technical scheme, the mRNA preparation washing liquid bottle provided by the utility model can not only avoid the cumbersome steps that need to be transferred during the operation of the mRNA preparation washing liquid, but also provide medical staff with a medical device that can easily control the speed, density, and angle of the mRNA preparation washing liquid spray or outflow only by squeezing, and avoid its excessive use, thereby ensuring the accuracy and safety of the mRNA preparation washing liquid use operation. In addition, the utility model also meets the personalized customization needs of patients who need to clean the tumor surgical wound or the surgical area in the body.

[0009] According to the embodiments of the present invention, the present invention can be further optimized. The following is the technical solution formed after optimization:

[0010] In one preferred embodiment, an mRNA preparation lotion bottle has a controllable extrudability. The controllable extrudability means that the material of the bottle can be flexibly squeezed, but has a certain elasticity, so that medical staff can more easily control the flow rate when squeezing to avoid excessive liquid outflow.

[0011] In one preferred embodiment, the bottle body of the mRNA preparation lotion bottle with controllable extrudability is made of low-density polyethylene.

[0012] In one preferred embodiment, the bottle body of the mRNA preparation lotion bottle with controllable extrudability is made of thermoplastic rubber.

[0013] In one preferred embodiment, the bottle body of the mRNA preparation lotion bottle with controllable extrudability is made of silicone.

[0014] In one preferred embodiment, the bottle body of the mRNA preparation washing liquid bottle with controllable extrudability is made of polyvinyl chloride.

[0015] In one preferred embodiment, an mRNA preparation lotion bottle is provided, wherein the bottle body of the mRNA preparation lotion bottle has not only controllable extrudability but also transparency. The controllable extrudability and transparency mean that the material of the bottle has good flexibility and extrudability, and high transparency, so that medical staff can more easily control the flow rate when squeezing, and can clearly observe the liquid in the bottle.

[0016] In one of the preferred embodiments, the bottle body of the mRNA preparation lotion bottle with controllable extrudability and transparency is made of low-density polyethylene.

[0017] In one of the preferred embodiments, the bottle body of the mRNA preparation lotion bottle with controllable extrudability and transparency is made of polyethylene terephthalate.

[0018] In one of the preferred embodiments, the bottle body of the mRNA preparation lotion bottle with controllable extrudability and transparency is made of polypropylene.

[0019] In one of the preferred embodiments, the bottle body of the mRNA preparation lotion bottle with controllable extrudability and transparency is made of styrene acrylonitrile.

[0020] In one preferred embodiment, an mRNA preparation lotion bottle, the bottle body of the mRNA preparation lotion bottle is marked with a volume scale. The volume scale meets the requirements of medical devices. The mRNA preparation lotion bottle marked with a volume scale can help medical staff accurately take the right amount of liquid to avoid waste or shortage.

[0021] In one preferred embodiment, the volume scale of the mRNA preparation lotion bottle is marked using a durable printing method, and the volume scale is directly printed or marked on the surface of the mRNA preparation lotion bottle.

[0022] In one preferred embodiment, the volume scale of the mRNA preparation washing liquid bottle is designed with scale lines to indicate the amount of liquid of different volumes, which can be milliliters (mL) or other units.

[0023] In one preferred embodiment, the capacity scale of the mRNA preparation lotion bottle uses a transparent mark to make the scale line clearly visible, so that medical staff can accurately read the capacity of the liquid to avoid errors.

[0024] In one preferred embodiment, an mRNA preparation washing liquid bottle is provided, wherein the bottle cap and the bottle mouth of the mRNA preparation washing liquid bottle are designed to be leak-proof to ensure that the bottle cap and the bottle mouth are well sealed to avoid leakage when not in use, thereby keeping the mRNA preparation washing liquid clean and safe.

[0025] In one preferred embodiment, the leak-proof design of the mRNA preparation lotion bottle adopts a double sealing structure. The double sealing structure means that the bottle cap and the bottle mouth have an inner and outer double-layer seal in the closed state. The internal seal is responsible for directly sealing the liquid, and the external seal serves as a second line of protection. Furthermore, the internal seal is located inside the bottle cap or bottle mouth, directly in contact with the liquid, responsible for the main sealing function, and ensuring that the liquid does not leak. The external seal is located outside the bottle cap or bottle mouth, tightly combined with the bottle mouth or bottle body, forming a second sealing barrier in the closed state, improving the sealing performance, and effectively preventing leakage.

[0026] In one preferred embodiment, the leak-proof design of the mRNA preparation washing liquid bottle adopts a silicone sealing ring. The silicone sealing ring leak-proof design refers to setting a silicone sealing ring at the bottle cap or bottle mouth to prevent liquid leakage and keep the washing liquid clean and safe.

[0027] In one preferred embodiment, the leak-proof design of the mRNA preparation washing liquid bottle adopts a rotary seal design. The rotary seal design means that the bottle cap or bottle mouth can form a tight seal after being tightened to prevent liquid leakage and ensure that the washing liquid remains clean and safe for a long time.

[0028] In one preferred embodiment, the leak-proof design of the mRNA preparation washing liquid bottle adopts a pressure balance hole. The rotary seal design means that the bottle cap or bottle mouth can form a tight seal after being tightened to prevent liquid leakage and ensure that the washing liquid remains clean and safe for a long time.

[0029] In one of the preferred embodiments, an mRNA preparation washing liquid bottle, the threaded joint provided on the outside of the bottle cap is the connecting part between the bottle cap and the bottle body, and the design of the threaded joint can ensure that the bottle cap is firmly connected to the bottle body to prevent leakage or loosening.

[0030] In one preferred embodiment, an mRNA preparation lotion bottle, wherein the bottle cap is made of a durable material.

[0031] In a preferred embodiment, an mRNA preparation washing liquid bottle, the bottle cap is made of polypropylene.

[0032] In a preferred embodiment, an mRNA preparation lotion bottle, the bottle cap is made of polycarbonate.

[0033] In a preferred embodiment, an mRNA preparation lotion bottle, the bottle cap is made of ABS plastic.

[0034] In a preferred embodiment, an mRNA preparation washing liquid bottle, the bottle cap is made of stainless steel.

[0035] In one preferred embodiment, an mRNA preparation lotion bottle, the liquid outlet sleeve provided on the bottle cap is the liquid outlet portion of the bottle cap, and the mRNA preparation lotion is sprayed or flows out through the liquid outlet sleeve. The design of the liquid outlet sleeve can regulate the shape, density and injection or outflow angle of the mRNA preparation lotion droplets, thereby regulating the comfort and effect of the use of the mRNA preparation lotion.

[0036] In one preferred embodiment, the liquid outlet sleeve provided on the bottle cap is a hollow cylinder or cone. The liquid outlet sleeve is provided with a filter membrane, a dispersion dish, an impeller, a liquid ejection dish, a liquid separation dish, and a nozzle in sequence from the liquid inlet at the bottom to the liquid outlet at the top.

[0037] In one of the preferred embodiments, the filter membrane provided on the liquid outlet sleeve is not only used to filter out impurities and particulate matter that may exist in the mRNA preparation washing solution, ensuring that the sprayed mRNA preparation washing solution is clean and pure, but also can buffer the instantaneous spraying of the mRNA preparation washing solution when the bottle body is squeezed, adjust and balance the flow rate of the mRNA preparation washing solution, avoid the instantaneous flow rate during spraying being too fast or too slow, ensure uniform and stable spraying or outflow effect, and ensure the effective use and application effect of the mRNA preparation washing solution.

[0038] In one of the preferred embodiments, the average pore size of the filter membrane is 0.001μm-50μm. In one of the preferred embodiments, the average pore size of the filter membrane is 0.002μm-0.01μm. In one of the preferred embodiments, the average pore size of the filter membrane is 0.011μm-0.02μm. In one of the preferred embodiments, the average pore size of the filter membrane is 0.021μm-0.03μm. In one of the preferred embodiments, the average pore size of the filter membrane is 0.031μm-0.04μm. In one of the preferred embodiments, the average pore size of the filter membrane is 0.041μm-0.05μm. In one of the preferred embodiments, the average pore size of the filter membrane is 0.051μm-0.07μm. In one of the preferred embodiments, the average pore size of the filter membrane is 0.071μm-0.1μm. In one of the preferred embodiments, the average pore size of the filter membrane is 0.11μm-0.2μm. In one of the preferred embodiments, the average pore size of the filter membrane is 0.21μm-0.3μm. In one of the preferred embodiments, the average pore size of the filter membrane is 0.31μm-0.5μm. In one of the preferred embodiments, the average pore size of the filter membrane is 0.51μm-0.7μm. In one of the preferred embodiments, the average pore size of the filter membrane is 0.71μm-0.9μm. In one of the preferred embodiments, the average pore size of the filter membrane is 0.91μm-1μm. In one of the preferred embodiments, the average pore size of the filter membrane is 1.1μm-2μm. In one of the preferred embodiments, the average pore size of the filter membrane is 2.1μm-5μm. In one of the preferred embodiments, the average pore size of the filter membrane is 5.1μm-10μm. In one of the preferred embodiments, the average pore size of the filter membrane is 10.1μm-20μm. In one of the preferred embodiments, the average pore size of the filter membrane is 20.1μm-30μm. In one preferred embodiment, the average pore size of the filter membrane is 30.1 μm-40 μm. In one preferred embodiment, the average pore size of the filter membrane is 40.1 μm-49.9 μm.

[0039] In one of the preferred embodiments, the material of the filter membrane is polytetrafluoroethylene. In one of the preferred embodiments, the material of the filter membrane is polyvinylidene fluoride. In one of the preferred embodiments, the material of the filter membrane is boron nitride. In one of the preferred embodiments, the material of the filter membrane is graphene.

[0040] In one of the preferred embodiments, a filter membrane holder is provided inside the liquid outlet sleeve for supporting and fixing the filter membrane to ensure that the filter membrane is in the correct position to prevent displacement or clogging. In one of the preferred embodiments, the filter membrane holder is a grid-like structure. In one of the preferred embodiments, the filter membrane holder is a frame-type structure.

[0041] In one preferred embodiment, the liquid outlet sleeve is provided with a dispersion dish to evenly disperse the mRNA preparation washing liquid out of the filter membrane of the liquid outlet sleeve to prevent the mRNA preparation washing liquid fluid from being too concentrated or uneven, and ensure that the mRNA preparation washing liquid fluid is evenly distributed during use. In one preferred embodiment, the dispersion dish has a disc-shaped or disc-like structure.

[0042] In one of the preferred embodiments, the material of the diffuser is polypropylene. In one of the preferred embodiments, the material of the diffuser is polycarbonate. In one of the preferred embodiments, the material of the diffuser is nylon. In one of the preferred embodiments, the material of the diffuser is stainless steel. In one of the preferred embodiments, the material of the diffuser is aluminum alloy. In one of the preferred embodiments, the material of the diffuser is boron nitride. In one of the preferred embodiments, the material of the diffuser is graphene. In one of the preferred embodiments, the material of the diffuser is zirconium boride.

[0043] In one preferred embodiment, the surface of the liquid dispersion dish is provided with a convex structure or corrugations, which are used to diffuse the mRNA preparation washing fluid, making the mRNA preparation washing fluid softer and more uniform.

[0044] In one preferred embodiment, the surface of the liquid dispersion dish is provided with a designed shunt groove or annular channel, which can allow the mRNA preparation washing fluid to be shunted and evenly dispersed when passing through the filter membrane, thereby increasing the diffusion effect of the mRNA preparation washing fluid.

[0045] In one of the preferred embodiments, a plurality of small holes are arranged on the surface of the dispersion dish, and the mRNA preparation washing fluid will be evenly dispersed into each small hole when passing through, thereby achieving diffusion and uniform spraying of the mRNA preparation washing fluid.

[0046] In one preferred embodiment, the surface of the liquid dispersion dish is provided with holes of different sizes, so that the mRNA preparation washing solution can be sprayed or flowed out with different fluid intensities and angles.

[0047] In one of the preferred embodiments, the surface of the liquid dispersion dish is provided with a streamlined structure for guiding the mRNA preparation washing liquid fluid, so that the mRNA preparation washing liquid fluid can pass through more smoothly, reduce resistance, and improve the stability and comfort of the mRNA preparation washing liquid fluid.

[0048] In one of the preferred embodiments, the impeller disposed inside the liquid outlet sleeve rotates under the impetus of the mRNA preparation washing fluid discharged from the liquid separation sleeve, so that the diffusion and injection of the mRNA preparation washing fluid are more uniform, and is used to control the strength and direction of the mRNA preparation washing fluid when the bottle is squeezed.

[0049] In one preferred embodiment, the impeller is wheel-shaped or blade-shaped, and when rotating, it pushes the mRNA preparation washing liquid, so that the mRNA preparation washing liquid fluid presents a higher flow rate and pressure. In one preferred embodiment, the blade is an arc blade. In one preferred embodiment, the blade is a fan-shaped blade. In one preferred embodiment, the blade is a spiral blade. In one preferred embodiment, the blade is a wave blade. In one preferred embodiment, the blade is a fan blade.

[0050] In one preferred embodiment, the number of blades is 1-6. In one preferred embodiment, the number of blades is 2. In one preferred embodiment, the number of blades is 3. In one preferred embodiment, the number of blades is 4. In one preferred embodiment, the number of blades is 5. The appropriate number of blades helps to increase the driving force of the impeller.

[0051] In one of the preferred embodiments, the angle of the blade is between 20 and 45 degrees. In one of the preferred embodiments, the angle of the blade is 25 degrees. In one of the preferred embodiments, the angle of the blade is 30 degrees. In one of the preferred embodiments, the angle of the blade is 35 degrees. In one of the preferred embodiments, the angle of the blade is 40 degrees. Suitable angles can effectively guide the mRNA preparation washing fluid to produce rotational motion, increasing the speed and intensity of the mRNA preparation washing fluid.

[0052] In one of the preferred embodiments, the material of the impeller is stainless steel. In one of the preferred embodiments, the material of the impeller is polyamide. In one of the preferred embodiments, the material of the impeller is polymethyl methacrylate. In one of the preferred embodiments, the material of the impeller is aluminum alloy. In one of the preferred embodiments, the material of the impeller is ceramic. In one of the preferred embodiments, the material of the impeller is carbon fiber composite material. In one of the preferred embodiments, the material of the impeller is boron nitride. In one of the preferred embodiments, the material of the impeller is zirconium boride. In one of the preferred embodiments, the material of the impeller is graphene.

[0053] In one preferred embodiment, the liquid separation sleeve is provided with an injection disc for controlling the injection or outflow mode and angle of the mRNA preparation washing fluid passing through the impeller, so that the mRNA preparation washing fluid can be uniformly injected or flowed out when the bottle is squeezed.

[0054] In one preferred embodiment, the liquid injection dish is in the shape of a disk or a disk-like shape, and is provided with a plurality of small holes, through which the mRNA preparation washing liquid is sprayed or flows.

[0055] In one of the preferred embodiments, the average pore size of the small holes of the ejection dish is 1.0 mm to 2.0 mm.

[0056] In one preferred embodiment, the small holes of the liquid ejection dish are arranged in a ring or cross arrangement.

[0057] In one of the preferred embodiments, the material of the liquid ejection dish has the characteristics of wear resistance and corrosion resistance, ensuring long service life and stability. In one of the preferred embodiments, the material of the liquid ejection dish is stainless steel. In one of the preferred embodiments, the material of the liquid ejection dish is polypropylene. In one of the preferred embodiments, the material of the liquid ejection dish is polycarbonate. In one of the preferred embodiments, the material of the liquid ejection dish is aluminum alloy. In one of the preferred embodiments, the material of the liquid ejection dish is ceramic. In one of the preferred embodiments, the material of the liquid ejection dish is carbon fiber composite material. In one of the preferred embodiments, the material of the liquid ejection dish is boron nitride. In one of the preferred embodiments, the material of the liquid ejection dish is zirconium boride. In one of the preferred embodiments, the material of the liquid ejection dish is graphene. In one of the preferred embodiments, the material of the liquid ejection dish is ceramic. In one of the preferred embodiments, the material of the liquid ejection dish is wear-resistant plastic alloy.

[0058] In one preferred embodiment, the liquid separation plate provided on the liquid separation sleeve is used to distribute the mRNA preparation washing liquid passing through the liquid injection disc to the nozzle provided on the liquid separation sleeve, and is used to control the distribution and injection or outflow effect of the mRNA preparation washing liquid fluid when the bottle body is squeezed. The liquid separation plate is disc-shaped. A plurality of liquid outlet holes are provided on the liquid separation plate, and the mRNA preparation washing liquid fluid is distributed to the nozzle through the liquid outlet holes.

[0059] In one preferred embodiment, the average pore size of the outlet holes provided on the liquid separation plate is 0.5 mm to 1.5 mm, so as to achieve a more fine and uniform mRNA preparation washing liquid fluid distribution effect.

[0060] In one of the preferred embodiments, the small holes of the separatory plate are arranged in an annular layout, a central layout, a symmetrical layout, and a diversified layout that combines the characteristics of annular, central, and symmetrical layouts. The annular layout is to arrange the small holes around the periphery of the separatory plate along a circular or elliptical outline to achieve uniform dispersion of the fluid. The central layout is to set one or more small holes in the center of the separatory plate to achieve central concentrated injection of the fluid, provide a local strong impact effect, and is suitable for surgical occasions that require strong cleaning. The symmetrical layout is to evenly distribute the small holes on the entire surface of the separatory plate, maintaining left-right symmetry or equal spacing to achieve uniform distribution and stable injection or outflow of the fluid. The diversified layout can achieve a variety of fluid distribution and injection or outflow effects.

[0061] In one of the preferred embodiments, the material of the liquid separation plate is made of wear-resistant and corrosion-resistant plastic or metal material to ensure that it will not be damaged during long-term use and maintain stable working performance. In one of the preferred embodiments, the material of the liquid separation plate is stainless steel. In one of the preferred embodiments, the material of the liquid separation plate is polypropylene. In one of the preferred embodiments, the material of the liquid separation plate is polycarbonate. In one of the preferred embodiments, the material of the liquid separation plate is aluminum alloy. In one of the preferred embodiments, the material of the liquid separation plate is nylon. In one of the preferred embodiments, the material of the liquid separation plate is carbon fiber composite material. In one of the preferred embodiments, the material of the liquid separation plate is boron nitride. In one of the preferred embodiments, the material of the liquid separation plate is zirconium boride. In one of the preferred embodiments, the material of the liquid separation plate is graphene.

[0062] In one preferred embodiment, the shape of the nozzle is circular, square or rectangular. The circular nozzle produces a uniform mRNA preparation washing fluid, the square nozzle produces a needle-like mRNA preparation washing fluid, and the rectangular nozzle produces a wide range of mRNA preparation washing fluid.

[0063] In one of the preferred embodiments, the nozzle is made of a wear-resistant and corrosion-resistant plastic or metal material to ensure that it is not damaged during long-term use and maintain stable working performance. In one of the preferred embodiments, the nozzle is made of stainless steel. In one of the preferred embodiments, the nozzle is made of polypropylene. In one of the preferred embodiments, the nozzle is made of polycarbonate. In one of the preferred embodiments, the nozzle is made of aluminum alloy. In one of the preferred embodiments, the nozzle is made of nylon. In one of the preferred embodiments, the nozzle is made of carbon fiber composite material. In one of the preferred embodiments, the nozzle is made of boron nitride. In one of the preferred embodiments, the nozzle is made of zirconium boride. In one of the preferred embodiments, the nozzle is made of graphene.

[0064] Further, the average diameter of the nozzle orifice is 0.5 mm to 5.0 mm. In one preferred embodiment, the average diameter of the nozzle orifice is 0.6 mm. In one preferred embodiment, the average diameter of the nozzle orifice is 0.7 mm. In one preferred embodiment, the average diameter of the nozzle orifice is 0.8 mm. In one preferred embodiment, the average diameter of the nozzle orifice is 0.9 mm. In one preferred embodiment, the average diameter of the nozzle orifice is 1 mm. In one preferred embodiment, the average diameter of the nozzle orifice is 2 mm. In one preferred embodiment, the average diameter of the nozzle orifice is 3 mm. In one preferred embodiment, the average diameter of the nozzle orifice is 4 mm. The nozzle with a small average diameter of the nozzle orifice produces fine mRNA preparation wash droplets, and the mRNA preparation wash fluid flows out slowly, which is suitable for surgical occasions of smearing. The nozzle with a large average diameter of the nozzle orifice produces large mRNA preparation wash droplets, and the mRNA preparation wash fluid flows out in large amounts, which is suitable for surgical occasions that require strong flushing for cleaning.

[0065] In one preferred embodiment, the nozzle orifice has a circular, square, rectangular, prismatic, leaf or flower shape, or a combination of two or more of these shapes. The square orifice produces concentrated mRNA preparation lotion droplets, while the circular orifice produces more uniform mRNA preparation lotion droplets.

[0066] In one preferred embodiment, the nozzle holes are arranged densely or spaced apart. The densely arranged nozzle holes produce dense mRNA preparation washing liquid droplets, while the spaced-apart nozzle holes produce dispersed mRNA preparation washing liquid droplets.

[0067] In one of the preferred embodiments, the control ring provided on the bottle cap is a component of the bottle cap for controlling the mRNA preparation washing fluid, and is used to further regulate the strength, injection or outflow mode of the mRNA preparation washing fluid by rotation or adjustment. In one of the preferred embodiments, the appearance design of the control ring is a circular ring design. In one of the preferred embodiments, the appearance design of the control ring is a knob-like design. The control ring changes the opening and closing degree of the nozzle orifice by rotation or movement to adjust the strength, shape and injection direction of the water flow.

[0068] In one of the preferred embodiments, the control ring is made of wear-resistant and corrosion-resistant plastic or metal material to ensure that it is not damaged during long-term use and maintain stable working performance. In one of the preferred embodiments, the control ring is made of stainless steel. In one of the preferred embodiments, the control ring is made of polypropylene. In one of the preferred embodiments, the control ring is made of polycarbonate. In one of the preferred embodiments, the control ring is made of aluminum alloy.

[0069] In one preferred embodiment, the control ring is provided with a rotation mechanism, and the medical staff can rotate the control ring manually.

[0070] In one preferred embodiment, the adjustment of the control ring includes different adjustment gears or angles.

[0071] In one of the preferred embodiments, the control ring is marked with corresponding gears or functions on the ring body so that medical personnel can clearly understand and select appropriate adjustment options.

[0072] In one of the preferred embodiments, the bottle cap is provided with a face cover for protecting the internal structure of the bottle cap and affecting the injection or outflow effect of the mRNA preparation washing solution. Further, in one of the preferred embodiments, the face cover is provided with a small hole. The aperture range of the small hole is 0.5 mm to 4.0 mm. In one of the preferred embodiments, the diameter of the small hole is 0.6 mm. In one of the preferred embodiments, the diameter of the small hole is 0.7 mm. In one of the preferred embodiments, the diameter of the small hole is 0.8 mm. In one of the preferred embodiments, the diameter of the small hole is 0.9 mm. In one of the preferred embodiments, the diameter of the small hole is 1 mm. In one of the preferred embodiments, the diameter of the small hole is 2 mm. In one of the preferred embodiments, the diameter of the small hole is 3 mm. The small holes with small pore sizes produce fine and concentrated mRNA preparation washing fluid, and the mRNA preparation washing fluid has a higher density, which is suitable for surgical occasions requiring local flushing; the small holes with large pore sizes produce a larger range of mRNA preparation washing fluid, with a larger injection angle, and the mRNA preparation washing fluid has a lower density, which is suitable for surgical occasions requiring large-area flushing for cleaning.

[0073] In one of the preferred embodiments, the material of the cover is made of wear-resistant and corrosion-resistant plastic or metal material to ensure that it is not damaged during long-term use and maintain stable working performance. In one of the preferred embodiments, the material of the cover is stainless steel. In one of the preferred embodiments, the material of the cover is polypropylene. In one of the preferred embodiments, the material of the cover is polycarbonate. In one of the preferred embodiments, the material of the cover is aluminum alloy.

[0074] In one preferred embodiment, the small holes provided on the cover are multi-porous or fan-shaped holes, providing a gentle and uniform water flow of the mRNA preparation washing fluid.

[0075] In one preferred embodiment, the small holes provided on the cover are concentratedly arranged or high-pressure designed holes, providing an mRNA preparation washing fluid with strong local penetration.

[0076] In one of the preferred embodiments, the small hole provided on the face cover is designed with a fixed angle. The fixed angle is 1 degree to 90 degrees. In one of the preferred embodiments, the fixed angle size of the small hole is 2 degrees. In one of the preferred embodiments, the fixed angle size of the small hole is 3 degrees. In one of the preferred embodiments, the fixed angle size of the small hole is 4 degrees. In one of the preferred embodiments, the fixed angle size of the small hole is 5 degrees. In one of the preferred embodiments, the fixed angle size of the small hole is 6-10 degrees. In one of the preferred embodiments, the fixed angle size of the small hole is 11-20 degrees. In one of the preferred embodiments, the fixed angle size of the small hole is 21-30 degrees. In one of the preferred embodiments, the fixed angle size of the small hole is 31-45 degrees. In one of the preferred embodiments, the fixed angle size of the small hole is 46-60 degrees. In one of the preferred embodiments, the fixed angle size of the small hole is 61-75 degrees. In one of the preferred embodiments, the fixed angle size of the small hole is 76-89 degrees. The fixed angle design is used to limit the spray angle of the mRNA preparation washing fluid, and is used in surgical scenarios with fixed cleaning ranges or specific cleaning requirements.

[0077] In one preferred embodiment, the small hole provided on the cover is designed with an adjustable angle. The adjustable angle hole design allows medical staff to adjust the injection angle of the mRNA preparation washing fluid according to needs, which is used in surgical occasions with complex cleaning requirements.

[0078] In one of the preferred embodiments, the bottle cap is provided with a surface cover for protecting the interior of the bottle cap from dust accumulation.

[0079] In one of the preferred embodiments, the face cover is made of a water-resistant, corrosion-resistant, easy-to-clean, and antibacterial material. In one of the preferred embodiments, the material is polypropylene. In one of the preferred embodiments, the material is polycarbonate. In one of the preferred embodiments, the material is stainless steel. In one of the preferred embodiments, the material is polymethyl acrylate.

[0080] In one of the preferred embodiments, the fixing method of the face cover cover and the face cover is a threaded tightening method. In one of the preferred embodiments, the fixing method of the face cover cover and the face cover is a snap-on method. In one of the preferred embodiments, the fixing method of the face cover cover and the face cover is a magnetic attraction method.

[0081] In one of the preferred embodiments, the screw cap provided on the outside of the bottle cap is used to fix and connect the various components of the bottle cap to ensure the stability and integrity of the structure of the bottle cap. In one of the preferred embodiments, the screw cap is used to fix the threaded joint and the water outlet sleeve, the water outlet sleeve and the control ring, and the control ring and the face cover of the bottle cap. In one of the preferred embodiments, the threaded joint and the water outlet sleeve, the water outlet sleeve and the control ring, and the control ring and the face cover are fixedly connected with a gasket or a washer for sealing.

[0082] In one of the preferred embodiments, the top of the screw cover is a hexagonal head or a cross head, which is used to rotate the screw cover to fix or loosen the connecting piece.

[0083] In one of the preferred embodiments, the screw cap is made of a water-resistant, corrosion-resistant, easy-to-clean, and antibacterial material. In one of the preferred embodiments, the material is polypropylene. In one of the preferred embodiments, the material is polycarbonate. In one of the preferred embodiments, the material is stainless steel. In one of the preferred embodiments, the material is polymethyl acrylate.

[0084] In one of the preferred embodiments, the side of the screw cover has a threaded design that matches the threaded hole, and the connection or fixing effect is achieved by rotating the screw cover.

[0085] In one preferred embodiment, the screw cover is cylindrical or conical, and is responsible for transmitting the rotational force to fix the screw cover in the threaded hole.

[0086] In one of the preferred embodiments, the bottom of the screw cover is a sharp tip, which is convenient for inserting into the threaded hole and ensures that the screw cover can accurately fix the connecting piece.

[0087] In one preferred embodiment, an mRNA preparation lotion bottle, the bottle cap is an integrated design and does not contain a screw cap.

[0088] In one preferred embodiment, an mRNA preparation washing liquid bottle, the fixed connection between the threaded joint of the bottle cap and the water outlet sleeve, the water outlet sleeve and the control ring, and the control ring and the surface cover is a threaded tightening design, and does not contain a screw cover.

[0089] In one preferred embodiment, an mRNA preparation washing liquid bottle, the bottle cap is of modular design, and the fixed connection between the threaded joint and the water outlet sleeve, the water outlet sleeve and the control ring, and the control ring and the surface cover are respectively a combination of threaded tightening and screw cap.

[0090] A method for preparing an mRNA preparation washing liquid bottle comprises the following steps:

[0091] The first step is to develop a mold design plan based on the shape, size and structural requirements of the mRNA preparation lotion bottle, including mold structure, size, material and other parameters; the second step is to make mold drawings: according to the design plan, make detailed drawings of the lotion bottle mold, including the size, shape and structure of each component of the mold; the third step is to mill the steel mold on a CNC milling machine according to the mold drawing, and process each component of the mold into the shape required by the design. At the same time, turn the components that require precise size to ensure the accuracy and quality of the mold. For parts that require precision, use electric spark machining; the fourth step is to assemble the processed mold components, including the upper mold, The lower mold, core block, cooling system, etc., ensure the integrity and normal operation of the mold; the fifth step is to debug and test the mold, verify whether the various functions and performances of the mold meet the design requirements, and adjust the mold parameters to achieve the best production effect; the sixth step is to select the required plastic material and cast it in the mold to form an mRNA preparation lotion bottle. The various structural features are obtained by directly casting the structure on the mold, and a small batch of trial mold production is carried out to verify the production efficiency and product quality of the mold, and the mold is further adjusted and optimized; the seventh step is to conduct formal production after the trial mold is verified to be correct. The optimized lotion bottle mold can produce a large number of mRNA preparation lotion bottle products. In addition, you can first select a whole piece of material, and then use the engraving machine CNC one-piece molding to process the structural features of the mRNA preparation lotion bottle described above.

[0092] A method for using an mRNA preparation washing liquid bottle comprises the following steps:

[0093] Step 1: Open the mask cover and squeeze the mRNA preparation lotion bottle; Step 2: The mRNA preparation lotion is quickly sprayed through the filter membrane of the liquid outlet sleeve into the dispersion dish, and the dispersion dish evenly disperses and guides the mRNA preparation lotion fluid to gradually soften the fluid; Step 3: When the mRNA preparation lotion fluid flowing through the dispersion dish passes through the impeller, the rotation of the impeller will cause the mRNA preparation lotion fluid to produce a rotating and dynamic effect, which is convenient for cleaning tumor surgical wounds or surgical areas in the body, massaging the skin, promoting blood circulation and soothing The effect on the skin; Step 4: The injection disc adjusts the direction and intensity of the injection or outflow of the mRNA preparation lotion fluid with rotation and dynamic effects flowing through the impeller; Step 5: The separation disc diverts the mRNA preparation lotion fluid flowing through the injection disc to different nozzles on the nozzle; Step 6, by rotating the control ring or adjusting the flow and pressure of the mRNA preparation lotion fluid, the mRNA preparation lotion fluid flowing through the nozzle is sprayed or outflowed through the holes of the face cover, providing a variety of mRNA preparation lotion injection or outflow effect options.

[0094] Compared with the prior art, the beneficial effects of the utility model are:

[0095] (1) It fills the gap in mRNA preparation wash bottles that can be directly used for cleaning tumor surgical wounds or in vivo surgical areas at home and abroad;

[0096] (2) Provide medical staff with a way to use the mRNA preparation lotion bottle by squeezing, but easily control the speed, density, and angle of the mRNA preparation lotion spray or outflow, and avoid excessive use of the lotion;

[0097] (3) An mRNA preparation wash bottle with customized mRNA preparation wash spray or outflow effect is provided for patients who need tumor surgical wound or body surgical area cleaning. BRIEF DESCRIPTION OF THE DRAWINGS

[0098] Figure 1 This is a front view of the mRNA preparation washing liquid bottle of Example 1.

[0099] Figure 2 4 is a cross-sectional view of the cap of the mRNA preparation washing liquid bottle of Example 1.

[0100] Figure 3 Schematic diagram of the structure of the liquid dispersion dish of Example 1.

[0101] Figure 4 This is a schematic diagram of the impeller structure of Example 1.

[0102] Figure 5 This is a schematic diagram of the structure of the liquid ejection dish of Example 1.

[0103] Figure 6 This is a schematic diagram of the water distribution plate structure of Example 1. DETAILED DESCRIPTION

[0104] The utility model will be described in detail below with reference to the accompanying drawings and in combination with the embodiments. It should be noted that, in the absence of conflict, the embodiments of the utility model and the features in the embodiments can be combined with each other. For the convenience of description, if the words "upper", "lower", "left" and "right" appear in the following text, it only means that they are consistent with the upper, lower, left and right directions of the accompanying drawings themselves, and do not limit the structure. The embodiments of the utility model are only for explaining the utility model, not for limiting the utility model, and the embodiments of the utility model are not limited to the embodiments given in the specification. The specific experimental conditions or operating conditions not indicated in the embodiments are made under conventional conditions, or made under the conditions recommended by the material supplier. In addition, it should be understood that one or more method steps mentioned in the utility model do not exclude that there may be other method steps before and after the combination steps or other method steps may be inserted between these explicitly mentioned steps, unless otherwise specified; it should also be understood that the combined connection relationship mentioned in the utility model does not exclude that there may be other connections before and after the combination or other connections may be inserted between these two explicitly mentioned connections, unless otherwise specified. Furthermore, unless otherwise specified, the numbering of each method step is only a convenient tool for identifying each method step, and is not intended to limit the order of arrangement of each method step or to limit the scope of the utility model. The change or adjustment of the relative relationship, without substantial change in the technical content, should also be regarded as the scope of the utility model. In the following examples, the reagents, materials and instruments used can be commercially available unless otherwise specified.

[0105] The bottle body 1, bottle cap 2, threaded joint 3, first screw cover 4, liquid outlet sleeve 5, filter membrane 6, filter membrane frame 7, dispersed liquid dish 8, impeller 9, injection dish 10, liquid separation plate 11, nozzle 12, second screw cover 13, control ring 14, third screw cover 15, surface cover 16, surface cover cover 17, first gasket 18, second gasket 19, third gasket 20 and other components of the utility model are all universal standard parts or components known to those skilled in the art, and their structures and principles can be known to those skilled in the art through technical manuals or through conventional experimental methods.

[0106] Example 1

[0107] An mRNA preparation washing liquid bottle, as attached Figure 1 and attached Figure 2 As shown, it is mainly composed of a bottle body 1 and a bottle cap 2, wherein the bottle cap 2 is provided with a threaded joint 3, a first screw cap 4, a liquid outlet sleeve 5, a filter membrane 6, a filter membrane frame 7, a dispersed liquid dish 8, an impeller 9, a liquid ejection dish 10, a liquid separation dish 11, a nozzle 12, a second screw cap 13, a control ring 14, a third screw cap 15, a surface cover 16, a surface cover cover 17, a first gasket 18, a second gasket 19, and a third gasket 20;

[0108] In Example 1, the bottle body 1 is made of low-density polyethylene;

[0109] In Example 1, the bottle mouth 21 of the bottle body 1 is provided with a thread 22 matching the threaded connector 3, and the surface of the bottle body 1 is provided with a scale 23;

[0110] In Example 1, the average pore size of the filter membrane 6 is 0.005 μm; the material of the filter membrane 6 is boron nitrogen; the filter membrane frame 7 is a frame structure;

[0111] In Example 1, the material of the liquid dispersion dish 8 is boron nitride; the surface of the liquid dispersion dish 8 is provided with corrugations;

[0112] In Example 1, the material of the impeller 9 is boron nitride; the blades of the impeller 9 are arc-shaped blades, the number of blades is 2, and the angle of the blades is 30 degrees;

[0113] In Example 1, the material of the liquid ejection dish 10 is boron nitride, and the average aperture of the small holes of the liquid ejection dish 10 is 1.0 mm;

[0114] In Example 1, the material of the liquid separation plate 11 is boron nitride, and the average aperture of the small holes of the liquid separation plate 11 is 0.5 mm;

[0115] In Example 1, the material of the nozzle 12 is boron nitride, the nozzle holes of the nozzle 12 are circular, the nozzle holes are arranged at intervals, and the average diameter of the nozzle holes is 0.5 mm;

[0116] In Example 1, the gears marked on the control circle 14 are VL, L, M, H, and VH. Among them, VL represents extremely low speed, extremely low density, and extremely large angle cleaning, L represents low speed, low density, and large angle cleaning, M represents conventional cleaning, H represents high speed, high density, and small angle cleaning, and VH represents extremely high speed, extremely high density, and extremely small angle cleaning;

[0117] In Example 1, the diameter of the small holes of the cover 16 is 0.5 mm, the small holes are arranged in a concentrated manner, and the angle can be adjusted;

[0118] In Example 1, the control ring 14, the face cover 16 and the face cover cover 17 are made of polypropylene, and the fixing method with the face cover 16 is threaded tightening;

[0119] In Example 1, the first screw cover 4, the second screw cover 13, and the third screw cover 15 are all made of polypropylene, and the screw covers are all cylindrical, with a cross head on the top and a threaded design on the side.

[0120] A method for preparing an mRNA preparation washing liquid bottle comprises the following steps:

[0121] The first step is to use AutoCAD software to draw the designed mRNA preparation washing liquid bottle and its various components, and make a steel mold; the second step is to cast on the mold, and after the mold is reversed, the bottle body 1, the bottle cap 2, the threaded joint 3, the first screw cover 4, the liquid outlet sleeve 5, the filter membrane 6, the filter membrane rack 7, the dispersed liquid dish 8, the impeller 9, the injection dish 10, the liquid separation plate 11, the nozzle 12, the second screw cover 13, the control circle 14, the third screw cover 15, and the surface cover 16 are functionalized; the third step is to assemble the functionalized bottle body 1 and the bottle cap 2, and equip the surface cover 17 to make the mRNA preparation washing liquid bottle.

[0122] A method for using an mRNA preparation washing liquid bottle comprises the following steps:

[0123] Step 1: Open the mask cover 17 and squeeze the mRNA preparation washing liquid bottle 1; Step 2: The mRNA preparation washing liquid is quickly sprayed through the filter membrane 6 provided on the liquid outlet sleeve 5 and flows into the scattered liquid dish 8, and the scattered liquid dish 8 evenly disperses and guides the mRNA preparation washing liquid fluid, so that the fluid flow rate gradually slows down; Step 3: When the mRNA preparation washing liquid fluid flowing through the scattered liquid dish 8 passes through the impeller 9, the impeller 9 is driven to rotate, so that the mRNA preparation washing liquid fluid produces a rotating and dynamic effect, which is convenient for cleaning the tumor surgical wound or the surgical area in the body, and plays a role in massaging the skin, promoting blood circulation and soothing The effect on the skin; Step 4: The injection disc 10 adjusts the direction and intensity of the injection or outflow of the mRNA preparation washing fluid with rotation and dynamic effects flowing through the impeller 9; Step 5: The separation disc 11 diverts the mRNA preparation washing fluid flowing out of the injection disc 10 to different nozzles on the nozzle 12; Step 6, by rotating the control circle 14 or adjusting the flow rate of the mRNA preparation washing fluid as needed, the mRNA preparation washing fluid distributed by the separation disc 11 is sprayed or flowed out through the holes of the cover 16, providing a variety of mRNA preparation washing liquid injection or outflow effect options.

[0124] Example 2

[0125] The effect of the mRNA preparation washing liquid bottle in Example 1 of the present invention on the injection or outflow of the mRNA preparation washing liquid is evaluated according to the following process: First, take a bottle of fully packaged mRNA preparation washing liquid, carefully pour the mRNA preparation washing liquid therein into the mRNA preparation washing liquid bottle in Example 1 of the present invention, and cover the bottle cap: Secondly, the mRNA preparation washing liquid bottle in Example 1 of the present invention filled with mRNA preparation washing liquid is tested for the extrusion injection or outflow effect of the mRNA preparation washing liquid according to Table 1-5 below, and the results are shown in Table 1-5. Each control circle is adjusted and measured in parallel 3 times. As shown in the results of Table 1-5, the coefficient of variation of the injection or outflow effect measurement results is less than 15%, which meets the repeatability requirements and intermediate precision requirements of the injection or outflow effect measurement. Among them, the control circle shift positions are represented by VL, L, M, H, and VH respectively, VL represents extremely low speed, extremely low density, and extremely large angle cleaning, L represents low speed, low density, and large angle cleaning, M represents conventional cleaning, H represents high speed, high density, and small angle cleaning, and VH represents extremely high speed, extremely high density, and extremely small angle cleaning. The units of the jet or outflow speed, density, and angle in Table 1-5 are milliliters per second, holes per square centimeter, and degrees respectively;

[0126] .

[0127] Example 3

[0128] The average values ​​and coefficients of variation of three parallel test results of the mRNA preparation lotion bottle composed of three different specifications of components produced according to the mRNA preparation lotion bottle preparation method in Example 1 of the utility model for the determination of the injection or outflow effect of the mRNA preparation lotion were summarized, and the results are shown in Tables 6-10. As shown in the results of Tables 6-10, the coefficients of variation of the injection or outflow effect determination results are all less than 15%, which meets the repeatability requirements and intermediate precision requirements of the injection or outflow effect determination. This illustrates the reliability of the mRNA preparation lotion bottle preparation method in Example 1 of the utility model. In addition, the mRNA preparation lotion bottle product produced according to the mRNA preparation lotion bottle preparation method in Example 1 of the utility model can meet the requirements of a larger range of speed, density, and angle of the mRNA preparation lotion injection or outflow. In other words, the mRNA preparation lotion bottle of the utility model can be produced and sold according to the speed, density, and angle of the mRNA preparation lotion injection or outflow as specifications and models to meet the personalized customization needs of different patients for tumor surgical wounds or internal surgical area cleaning, and realize the precise and safe operation and use of the mRNA preparation lotion;

[0129] in:

[0130] The specifications of the product 1 are as follows: the bottle body 1 is made of low-density polyethylene; the bottle body 1 and the bottle cap 2 are designed to be a rotary seal; the scale 19 is a capacity scale, and the maximum capacity scale is 120 ml; the average pore size of the filter membrane 6 is 0.005 μm; the material of the filter membrane 6 is boron nitrogen; the filter membrane frame 7 is a frame structure; the material of the bulk liquid disc 8 is boron nitride; the surface of the bulk liquid disc 8 is provided with corrugations; the material of the impeller 9 is boron nitride; the blades of the impeller 9 are arc-shaped blades, and the number of blades is The amount is 2 pieces, and the angle of the blade is 30 degrees; the material of the injection disc 10 is boron nitride, and the average aperture of the small holes of the injection disc 10 is 1.0 mm; the material of the liquid separation disc 11 is boron nitride, and the average aperture of the small holes of the liquid separation disc 11 is 0.5 mm; the material of the nozzle 12 is boron nitride, and the nozzle 12 has a circular spray hole, and the spray holes are arranged at intervals, and the average diameter of the spray holes is 0.5 mm; the gears marked on the control circle 14 are VL, L, M, H, and VH. Among them, VL represents extremely low speed, extremely low density, and extremely large angle cleaning, L represents low speed, low density, and large angle cleaning, M represents conventional cleaning, H represents high speed, high density, and small angle cleaning, and VH represents extremely high speed, extremely high density, and extremely small angle cleaning; the diameter of the small holes of the face cover 16 is 0.5 mm, and the small holes are arranged in a concentrated manner, and the angle design can be adjusted; the control circle 14, the face cover 16, and the face cover cover 17 are made of polypropylene;

[0131] The specifications of product 2 are as follows: the bottle body 1 is made of polyethylene terephthalate; the bottle body 1 and the bottle cap 2 are designed to be a rotary seal; the scale 19 is a capacity scale, and the maximum capacity scale is 120 ml; the average pore size of the filter membrane 6 is 0.001 μm; the material of the filter membrane 6 is graphene; the filter membrane frame 7 is a grid structure; the material of the bulk liquid dish 8 is polypropylene; the surface of the bulk liquid dish 8 is provided with a drainage groove; the material of the impeller 9 is polyamide; the blades of the impeller 9 are fan-shaped blades, the number of blades is 3, and the angle of the blades is 45 degree; the material of the injection dish 10 is polypropylene, and the average pore size of the small holes of the injection dish 10 is 0.5 mm; the material of the liquid separation dish 11 is polypropylene, and the average pore size of the small holes of the liquid separation dish 11 is 0.5 mm; the material of the nozzle 12 is boron nitride, and the nozzle 12 has a square spray hole, and the spray holes are arranged at intervals, and the average diameter of the spray holes is 0.5 mm; the gears marked on the control circle 14 are VL, L, M, H, and VH. Among them, VL represents extremely low speed, extremely low density, and extremely large angle cleaning, L represents low speed, low density, and large angle cleaning, M represents conventional cleaning, H represents high speed, high density, and small angle cleaning, and VH represents extremely high speed, extremely high density, and extremely small angle cleaning; the diameter of the small holes of the face cover 16 is 0.5 mm, and the small holes are arranged in a concentrated manner, and the angle design can be adjusted; the control circle 14, the face cover 16, and the face cover 17 are made of polypropylene;

[0132] The specifications of the product 3 are as follows: the bottle body 1 is made of polypropylene; the bottle body 1 and the bottle cap 2 are designed to be a rotary seal; the scale 19 is a capacity scale, and the maximum capacity scale is 120 ml; the average pore size of the filter membrane 6 is 0.01 μm; the material of the filter membrane 6 is boron nitrogen; the filter membrane frame 7 is a grid structure; the material of the bulk liquid disc 8 is polycarbonate; the surface of the bulk liquid disc 8 is provided with a plurality of small holes; the material of the impeller 9 is polymethyl methacrylate; the blades of the impeller 9 are spiral blades, the number of blades is 4, and the angle of the blades is 40 degree; the material of the injection dish 10 is polypropylene, and the average pore size of the small holes of the injection dish 10 is 1.0 mm; the material of the liquid separation dish 11 is polypropylene, and the average pore size of the small holes of the liquid separation dish 11 is 1.5 mm; the material of the nozzle 12 is boron nitride, and the nozzle hole of the nozzle 12 is a leaf, and the nozzle holes are densely arranged, and the average diameter of the nozzle holes is 0.5 mm; the gears marked on the control circle 14 are VL, L, M, H, and VH. Among them, VL represents extremely low speed, extremely low density, and extremely large angle cleaning, L represents low speed, low density, and large angle cleaning, M represents conventional cleaning, H represents high speed, high density, and small angle cleaning, and VH represents extremely high speed, extremely high density, and extremely small angle cleaning; the diameter of the small holes of the face cover 16 is 0.5 mm, and the small holes are concentratedly arranged, and the angle design can be adjusted; the control circle 14, the face cover 16, and the face cover cover 17 are made of polypropylene;

[0133] .

[0134] Example 4

[0135] The results of mRNA preparation washing liquid were compared by using the mRNA preparation washing liquid bottle in Example 1 of the present invention and directly using a handheld washing liquid sprayer (Braun, Germany), a pressure sprayer (Hudson, USA), and an electric sprayer (Victory Innovations, USA). The results showed that the spraying or outflowing effects of the four were consistent. However, compared with directly using a handheld washing liquid sprayer (Braun, Germany), a pressure sprayer (Hudson, USA), and an electric sprayer (Victory Innovations, USA), the present invention shortened the operation time required for cleaning a tumor surgical wound or a surgical area in the body by 40 minutes, 35 minutes, and 25 minutes, respectively, and shortened the total operation time required for a tumor surgical wound or a surgical area in the body that required three cleanings by 2 hours, 1 hour and 45 minutes, and 1 hour and 15 minutes, greatly improving the cleaning efficiency of the tumor surgical wound or the surgical area in the body.

[0136] The contents explained in the above embodiments should be understood as these embodiments are only used to more clearly illustrate the present invention, and are not used to limit the scope of the present invention. After reading the present invention, various equivalent forms of modifications to the embodiments by those skilled in the art fall within the scope defined by the claims attached to the present invention.

Claims

1. An mRNA preparation lotion bottle, characterized in that: The washing liquid bottle is composed of a bottle body and a bottle cap, the bottle body is used to contain the mRNA preparation washing liquid, the material of the bottle body has controllable extrudability, the bottle mouth of the bottle body is connected to the bottle cap by a thread, the bottle cap includes a threaded joint, a liquid outlet sleeve, a screw cover, a control ring, a face cover, and a face cover cover, the threaded joint arranged on the outside of the bottle cap is the connecting part of the bottle cap and the bottle body, the liquid outlet sleeve is the liquid outlet part of the bottle cap, the screw cover is used to fix the threaded joint and the liquid outlet sleeve of the bottle cap, the liquid outlet sleeve and the control ring, the control ring and the face cover, the face cover cover and the face cover are fixed in a threaded tightening manner, and the inside of the liquid outlet sleeve is sequentially arranged with a filter membrane, a filter membrane frame, a dispersed liquid dish, an impeller, an injection dish, a liquid separator, etc. from the liquid inlet at the bottom to the liquid outlet at the top. The filter membrane is made of polytetrafluoroethylene, the filter membrane frame is a grid structure, the filter membrane frame is used to support and fix the filter membrane, the dispersion dish is used to evenly disperse the mRNA preparation washing liquid coming out of the filter membrane, the dispersion dish is made of polypropylene, and the surface of the dispersion dish is provided with a convex structure. The impeller rotates under the impelling force of the mRNA preparation washing liquid fluid coming out of the dispersion dish, the impeller is made of boron nitride, the ejection dish is used to control the injection or outflow mode and angle of the mRNA preparation washing liquid fluid passing through the impeller, the ejection dish is made of boron nitride, the liquid separation dish is used to distribute the mRNA preparation washing liquid passing through the ejection dish to the nozzle, the liquid separation dish is made of boron nitride, and the nozzle is made of boron nitride.

2. An mRNA preparation washing liquid bottle according to claim 1, characterized in that, The liquid outlet sleeve is a hollow cylinder or cone.

3. An mRNA preparation washing liquid bottle according to claim 1, characterized in that, The average pore size of the filter membrane is 0.001 μm-50 μm.

4. The mRNA preparation washing liquid bottle according to claim 1, characterized in that: The dispersion dish has a disc-shaped structure.

5. The mRNA preparation washing liquid bottle according to claim 1, characterized in that: The liquid ejection dish is in the shape of a disk, the average aperture of the small holes of the liquid ejection dish is 0.5 mm to 2.0 mm, and the small holes of the liquid ejection dish are arranged in a ring or cross arrangement.

6. The mRNA preparation washing liquid bottle according to claim 1, characterized in that: The liquid separation plate is in the shape of a disc, the average aperture of the liquid outlet holes arranged on the liquid separation plate is 0.5 mm to 1.5 mm, and the small holes of the liquid separation plate are arranged in a ring shape.

7. The mRNA preparation washing liquid bottle according to claim 1, characterized in that: The shape of the nozzle is circular, the average diameter of the nozzle holes is 0.5 mm to 5.0 mm, the nozzle holes are circular, and the nozzle holes are densely arranged or spaced.

8. The mRNA preparation washing liquid bottle according to claim 1, characterized in that: The control ring is in the shape of a ring, and gear positions or functions are marked on the ring.

9. The mRNA preparation washing liquid bottle according to claim 1, characterized in that: The surface cover is provided with small holes with an aperture range of 0.5 mm to 4.0 mm. The small holes are concentratedly arranged holes. The small holes are designed with a fixed angle or an adjustable angle. The fixed angle is 1 degree to 90 degrees.

Images