Glass slide bracket and glass slide processing device

Abstract

The utility model discloses a glass slide bracket and a glass slide processing device, and belongs to biomedical equipment. The glass slide bracket and the glass slide processing device can be applied to immunohistochemical staining analysis. The glass slide bracket comprises a bearing main body, the bearing main body is provided with a slide containing groove, the slide containing groove is used for containing a glass slide, and the groove side wall of the slide containing groove is obliquely arranged outwards from bottom to top, namely is obliquely arranged inwards from top to bottom, so that the edge of the top surface of the glass slide can keep a certain distance away from the groove side wall on the inner side of a frame; therefore, the probability that the liquid on the glass slide contacts the inner wall of the bracket frame is reduced, and the liquid on the surface of the glass slide is not easy to overflow from the glass slide. According to the glass slide processing device, the opening is formed in the bottom plate of the glass slide bracket, after the glass slide bracket is placed in the processing module, the fixing base can support the glass slide bracket, the supporting base can jack up the glass slide, liquid can be discharged out of the bracket through the opening of the bottom plate of the bracket, the liquid in the bracket is convenient to discharge, and the detection efficiency can be improved.

Description

Technical Field

[0001] The utility model relates to the technical field of biomedical equipment, in particular to a slide holder and a slide processing device. Background Art

[0002] In the detection and experiments in the biomedical field, glass slides are often needed to carry tissues and samples. Considering that the position of the glass slide sometimes needs to be moved during the detection or experiment, if the glass slide is directly grabbed and moved by hand or with a robotic arm, the tissue and sample on the glass slide may be contaminated. In the related art, the glass slide is placed on a glass slide holder, and the glass slide can be moved by moving the glass slide holder.

[0003] However, in many detection or experimental steps, reagents need to be added to the slide, such as in multiple steps of the immunohistochemical staining process. Researchers have found that in some cases, after adding reagents to the slide, the liquid easily overflows and contacts the slide holder, causing the holder to be contaminated or interfering with the experimental structure. Utility Model Content

[0004] One purpose of an embodiment of the utility model is to provide a glass slide holder, which reduces the probability of liquid on the glass slide overflowing and contacting the glass slide holder.

[0005] One purpose of an embodiment of the utility model is to provide a slide processing device, which facilitates subsequent processing operations on the slide when a slide holder is placed in a processing module.

[0006] In order to achieve the above purpose, the utility model adopts the following technical solutions:

[0007] A slide holder comprises a supporting body;

[0008] The supporting body comprises a bottom plate and a frame, wherein the bottom plate is used to support the glass slide, and the frame surrounds the outer periphery of the bottom plate;

[0009] A film receiving groove is defined between the bottom plate and the frame; the inner surface of the frame is a groove side wall of the film receiving groove, the edge of the groove side wall facing away from the bottom plate is a first side edge, the edge of the groove side wall close to the bottom plate is a second side edge, and the groove side wall extends inward from the first side edge to the second side edge.

[0010] Optionally, the frame includes four frame parts, and adjacent frame parts are connected to each other; a avoidance groove is provided between adjacent frame parts, the avoidance groove is located on the inner side of the frame, and the avoidance groove is connected to the sheet receiving groove;

[0011] The inner side of each frame portion has the groove side wall, and the intersection of the extension lines of the second side edges of the adjacent groove side walls is located in the avoidance groove.

[0012] Optionally, the bottom plate is provided with an opening, and the opening passes through the bottom plate.

[0013] Optionally, the slide holder further comprises an operating panel, and the operating panel is connected to the supporting body;

[0014] The operation panel is provided with a grabbing and positioning structure, and the grabbing and positioning structure is used for positioning and cooperating with the manipulator;

[0015] And / or, the operation panel is provided with a placement and positioning structure, and the placement and positioning structure is used for positioning and cooperating with the fixing seat when the slide holder is placed on the processing module fixing seat.

[0016] A slide processing device, comprising:

[0017] The slide holder as described in the above scheme, wherein the bottom plate is provided with an opening;

[0018] A processing module, comprising a fixed seat and a supporting seat connected to each other;

[0019] Wherein, the slide holder has a placement state; when the slide holder is in the placement state, the slide holder is placed on the processing module, the fixed seat supports the slide holder, and the support seat passes through the opening of the bottom plate to be inserted into the wafer receiving slot; the support seat and the edge of the opening are gap-matched to form a first channel, and the first channel is connected to the wafer receiving slot.

[0020] Optionally, the fixing seat comprises a seat side plate, the seat side plate surrounds the outer side of the supporting seat, and the supporting seat is connected to the seat side plate;

[0021] The support seat and the seat side plate are clearance-matched to form a second channel, and the sheet receiving groove, the first channel, and the second channel are connected.

[0022] Optionally, the fixing seat further comprises a seat bottom plate connected to the seat side plate, a mounting groove is defined between the seat side plate and the seat bottom plate, and the support seat is arranged in the mounting groove;

[0023] The seat bottom plate is located below the support seat, the support seat is spaced apart from the seat bottom plate, a drainage surface is formed on a side of the seat bottom plate close to the support seat, and the drainage surface is inclined from its first end to its second end in a direction away from the support seat; a drainage hole is provided on the seat side plate, and the drainage hole is provided close to the second end of the drainage surface.

[0024] Optionally, the top surface of the support seat is a support surface, and the support surface is used to support the slide;

[0025] The processing module further includes a heating component, and the heating component is disposed inside the support seat, or the heating component is disposed on the bottom side of the support seat.

[0026] Optionally, the fixing seat is provided with a mounting groove, and the supporting seat is arranged in the mounting groove;

[0027] The fixing seat is provided with an air outlet, and the air outlet is located below the supporting seat, and the mounting groove is connected with the outside of the fixing seat through the air outlet; the slide processing device also includes a fan installed on the fixing seat, and the fan is installed on the fixing seat, and the fan is configured to at least be able to pump the gas in the mounting groove to the outside of the fixing seat.

[0028] Optionally, it further comprises a liquid guide plate, the liquid guide plate is arranged below the support seat, the liquid guide plate is mounted on the fixing seat; the liquid guide plate comprises a liquid guide surface, the first end to the second end of the liquid guide surface are inclined in a direction away from the support seat, and the liquid guide surface is located below the second channel;

[0029] The fixed seat is provided with a seat positioning structure, the bracket includes an operating plate connected to the supporting body, and a placement positioning structure is provided at the bottom of the operating plate; when the bracket is in the placement state, the placement positioning structure and the seat positioning structure are limitedly matched to limit the movement of the bracket.

[0030] The beneficial effects of the utility model are as follows: the slide holder has a slide groove, the slide groove is used to accommodate the slide, the bottom plate of the holder cooperates with the frame, and can stably carry the slide. The slide has a certain thickness, and the inner wall of the frame of the slide holder is tilted outward from bottom to top, that is, the groove side wall of the slide groove is tilted outward from bottom to top, so that the edge of the top surface of the slide can maintain a certain distance from the inner groove side wall of the frame, thereby reducing the probability of liquid on the slide contacting the inner wall of the frame of the holder, and further reducing the probability of liquid on the slide overflowing and contacting the slide holder.

[0031] In the glass slide processing device, when the glass slide holder is supported by the glass slide and the holder is placed on the processing module, the support seat of the processing module can lift the glass slide so that the glass slide is away from the bottom plate of the holder by a certain distance. In this way, when cleaning the glass slide, the inclined groove side wall on the inner side of the frame can guide the cleaning liquid to the first channel, which is beneficial to the discharge of the cleaning liquid and makes cleaning more convenient. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] The utility model is further described in detail below based on the drawings and embodiments.

[0033] Figure 1This is a three-dimensional structural diagram of the slide holder according to an embodiment of the utility model;

[0034] Figure 2 A top view of the slide holder according to an embodiment of the utility model;

[0035] Figure 3 for Figure 2 A magnified view of part A;

[0036] Figure 4 A cross-sectional view of one position of the glass slide holder according to an embodiment of the utility model;

[0037] Figure 5 It is a cross-sectional view of another position of the slide holder according to the embodiment of the utility model;

[0038] Figure 6 for Figure 5 Enlarged view of middle part B;

[0039] Figure 7 , Figure 8 It is a schematic diagram of a glass slide mounted in a glass slide holder according to an embodiment of the utility model;

[0040] Fig. 9 This is a schematic diagram of a glass slide holder with a glass slide placed in a processing module according to an embodiment of the utility model (the processing module in the figure only shows the support seat);

[0041] Fig.10 for Fig. 9 The enlarged view of the C part in FIG.

[0042] Fig.11 This is one of the schematic diagrams of the slide processing device according to the embodiment of the utility model;

[0043] Fig.12 This is a structural exploded view of the slide processing device according to an embodiment of the utility model;

[0044] Fig.13 This is a schematic structural diagram of a fixing base of a slide processing device according to an embodiment of the utility model;

[0045] Fig.14 This is a schematic diagram of the back structure of the glass slide holder according to the embodiment of the utility model;

[0046] Fig.15 This is one of the internal structure schematic diagrams of the slide processing device according to the embodiment of the utility model;

[0047] Fig.16 This is the second schematic diagram of the internal structure of the slide processing device according to the embodiment of the utility model;

[0048] Fig.17 for Fig.16 Enlarged view of part D in .

[0049] In the figure: 10, slide holder; 101, slide slot; 102, avoidance slot; 11, bottom plate; 111, opening; 12, frame; 1201, frame; 121, slot side wall; 1211, first side edge; 1212, second side edge; 13, operation panel; 131, grabbing and positioning structure; 132, placing and positioning structure; 20, fixing seat; 201, mounting slot; 21, seat side plate; 211, drainage hole; 212, air outlet; 22, seat bottom plate; 221, drainage surface; 23, seat positioning structure; 30, supporting seat; 31, supporting surface; 40, heating assembly; 50, fan; 60, liquid guide plate; 61, liquid guide surface; 80, slide; 911, first channel; 92, second channel; 93, first fitting gap; 94, second fitting gap. DETAILED DESCRIPTION

[0050] In order to make the technical problems solved by the utility model, the technical solutions adopted and the technical effects achieved clearer, the technical solutions of the embodiments of the utility model will be further described in detail below in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the utility model.

[0051] In the description of the present invention, unless otherwise clearly specified and limited, the terms "connected" and "fixed" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0052] In the present utility model, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may include that the first and second features are in direct contact, or may include that the first and second features are not in direct contact but are in contact through another feature between them. Moreover, a first feature being "above", "above" and "above" a second feature includes that the first feature is directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. A first feature being "below", "below" and "below" a second feature includes that the first feature is directly below and obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature.

[0053] In biological and medical field tests or experiments, slides are often used and reagents need to be added to the slides. For example, in the immunohistochemical staining operation steps, baking, dewaxing, hydration, enzyme blocking, antigen repair, primary and secondary antibody incubation, color development, counterstaining, dehydration, transparency, sealing and other steps are required. In some steps, the slide needs to be immersed in reagents or reagents need to be added to the surface of the slide.

[0054] In the related art, if the slide is placed directly on the operating table during the test or experiment, it is inconvenient to move the slide. If the slide is placed on a slide holder, after adding reagents to the slide, the holder may destroy the surface tension of the liquid on the surface of the slide. If there is a large amount of reagent on the surface of the slide, or if the slide holder is moved with large movements and shakes, the reagent on the surface of the slide may contact the surface of the holder, causing adverse effects.

[0055] When the reagents overflow and contact the bracket, the following situations may occur: First, if the overflowed reagents react with other substances on the bracket, new compounds or interferences may be produced. These substances may further contaminate the samples on the slides, thereby interfering with the accuracy and reliability of the experimental results; second, the volume of the reagents acting on the slide samples changes, affecting the experimental structure; third, the bracket may be contaminated, which may lead to cross-contamination of subsequent experiments, because the bracket may continue to be used to support other slides, thereby transferring contaminants to other samples.

[0056] Based on this, refer to Figures 1 to 17 The present application provides a glass slide holder 10, which is provided with a slide groove 101 to stably support the glass slide 80; and the groove side wall 121 of the glass slide groove 101 is inclined, so that after the glass slide 80 is placed in the glass slide groove 101, there is a certain distance between the side edge of the upper surface of the glass slide 80 and the groove side wall 121, and the liquid on the glass slide 80 is not easy to contact the groove side wall 121, thereby avoiding the destruction of the surface tension of the liquid on the upper surface of the glass slide 80, and the liquid on the glass slide 80 is not easy to overflow.

[0057] The present application also provides a slide processing device, which places the slide holder 10 carrying the slide 80 behind the processing module, so as to facilitate the subsequent processing of the slide 80 and achieve good processing effect. For example, when the slide 80 is cleaned, the cleaning effect is good.

[0058] Among them, the bottom plate 11 of the slide holder 10 is provided with an opening 111. When the slide holder 10 is placed on the processing module, the fixed seat 20 supports the slide holder 10, and then the support seat 30 passes through the opening 111 of the bottom plate 11 of the holder to lift the slide 80, so that the slide 80 leaves the bottom plate 11 of the holder. In this way, when cleaning the slide 80, the inclined groove side wall 121 of the holder guides the liquid to the opening 111 of the bottom plate 11, and the liquid is discharged from the slide groove 101 from the opening 111 of the bottom plate 11, and the cleaning effect is good.

[0059] Please continue to refer to the following Figures 1 to 17 , the structure of the slide holder 10 is described. For the convenience of description, the slide holder 10 is referred to as a holder below.

[0060] Figures 1 to 4 The structure of the bracket is shown in the figure. The bracket includes a supporting body. The supporting body is provided with a bottom plate 11 and a frame 12. The bottom plate 11 is used to support the glass slide 80. The frame 12 surrounds the outer periphery of the bottom plate 11. A film receiving groove 101 is defined between the bottom plate 11 and the frame 12. The film receiving groove 101 refers to a groove for receiving the glass slide 80. The bottom plate 11 of the bracket can support the glass slide 80 from bottom to top. The frame 12 of the bracket limits the glass slide 80 within a certain range to prevent the glass slide 80 from moving too much on the bracket. The glass slide bracket 10 stably supports the glass slide 80.

[0061] like Figures 5 to 8 As shown, when the glass slide 80 is placed in the slide receiving groove 101, the bottom plate 11 supports the lower surface of the glass slide 80, and the frame 12 surrounds the glass slide 80. Due to the presence of the frame 12, even if there is an accidental shake during the movement of the slide holder 10, the glass slide 80 is not easy to fall out of the holder, thereby preventing the glass slide 80 from falling and being damaged.

[0062] Among them, refer to Figure 1 , Figure 4 , Figure 6 The inner surface of the frame 12 is the slot side wall 121 of the film receiving slot 101. The frame 12 has a certain height. The side of the slot side wall 121 away from the bottom plate 11 is the first side 1211, and the side of the slot side wall 121 close to the bottom plate 11 and connected to the bottom plate 11 is the second side 1212. That is, the first side 1211 and the second side 1212 are the upper side and the lower side of the inner surface of the frame 12 respectively. Figure 4 The groove side wall 121 extends inward from the first side edge 1211 to the second side edge 1212 , and the inner side is the side close to the vertical center axis of the bottom plate 11 .

[0063] Reference Figure 5 , Figure 6When the glass slide 80 is placed into the slide holding tank 101, the bottom plate 11 supports the bottom surface of the glass slide 80, and the top surface of the glass slide 80 is used to carry the tissue sample. When reagents need to be added, the reagents are added to the top surface of the glass slide 80. Since the glass slide 80 has a certain thickness and the side wall 121 of the tank is inclined, continue to refer to Figure 6 The edge of the top surface of the slide glass 80 is spaced apart from the groove side wall 121 to form a liquid-proof distance d1 therebetween.

[0064] In this way, even if the top surface of the glass slide 80 is filled with liquid, the groove side wall 121 is still a certain distance away from the liquid surface, and is not easy to contact the liquid on the glass slide 80, thus avoiding the groove side wall 121 contacting the liquid surface and destroying the surface tension of the liquid, thereby avoiding the liquid overflowing from the contact point.

[0065] In addition, when the tray is moved with liquid on the surface of the glass slide 80, even if the tray is slightly shaken, due to the existence of the liquid-proof distance d1, the liquid is not easy to contact the tray groove side wall 121. The glass slide tray 10 is more suitable for automated detection and experimental processes. When the tray is loaded with a glass slide 80 and there is a reagent on the surface of the glass slide 80, the tray can also be transported by a robot.

[0066] Please continue to refer to Figures 1 to 3 , Figure 7 , Figure 8 The frame 12 includes four frame parts 1201, and two adjacent frame parts 1201 are connected to form a frame 12 connected end to end. In addition, end grooves are set at both ends of the inner side of each frame part 1201, and the frame grooves between adjacent frame parts 1201 are connected to form a avoidance groove 102, and the avoidance groove 102 is connected to the sheet receiving groove 101. Figure 2 As shown, four avoidance grooves 102 are provided inside the frame 12, and the four avoidance grooves 102 are respectively located at four inner corners. The positions of the four avoidance grooves 102 correspond to the positions of the four corners of the glass slide 80, and the liquid on the surface of the glass slide 80 near the four corners of the glass slide 80 is less likely to contact the groove side wall 121 inside the frame 12. For the rectangular glass slide 80, the avoidance grooves 102 extending outwardly at the four corners of the bracket make it more difficult for the bracket at the corner position to contact the liquid on the surface of the glass slide 80, and the liquid overflow prevention effect is good.

[0067] Optionally, refer to Figure 2 Each frame portion 1201 has a groove side wall 121 on its inner side. Figure 3 The extension lines of the second side edges 1212 of the groove side walls 121 of the adjacent frame parts 1201 are L, and the intersection of the extension lines of the adjacent second side edges 1212 is located in the avoidance groove 102. Figure 7 , Figure 8As shown, in some cases, when the size of the slide glass 80 is large, the four corners of the slide glass 80 can be respectively inserted into the four avoidance grooves 102, and the edge of the bottom surface of the slide glass 80 and the edge of the top surface of the slide glass 80 are spaced from the groove side wall 121 of the frame 12, and as shown in FIG. Figure 8 As shown, based on the design of the avoidance groove 102 , the corner of the glass slide 80 can also maintain a distance from the inner side of the frame 12 , thereby achieving a good effect of preventing the liquid on the glass slide 80 from contacting the frame 12 .

[0068] In other embodiments, the avoidance groove 102 may not be provided.

[0069] Please refer to Figure 1 , Figure 4 In one embodiment, the bottom plate 11 of the bracket is provided with an opening 111, and the opening 111 passes through the bottom plate 11, and the position of the bottom plate 11 where the opening 111 is not provided can support the slide glass 80. The opening 111 can achieve certain functions, and the opening 111 will be described in more detail in the subsequent description of the slide glass processing device.

[0070] Optionally, the bottom plate 11 is provided with an opening 111 , and the opening 111 is located in the middle of the bottom plate 11 , so that a solid structure can be maintained around the bottom plate 11 to support the bottom surface of the slide glass 80 around.

[0071] In other embodiments, the bottom plate 11 may also be provided with a plurality of openings 111 at intervals.

[0072] Reference Figure 1 , Figure 2 , Fig.14 In one embodiment, the bracket further includes an operation panel 13, which is connected to the supporting body. The operation panel 13 is used to cooperate with the external structure of the bracket to facilitate the external structure to operate the bracket. Optionally, the bracket as a whole is approximately rectangular, the bracket frame 12 has two short sides and two long sides, and the operation panel 13 is connected to one of the short sides of the frame 12.

[0073] In one embodiment, the operating panel 13 is provided with a gripping positioning structure 131, and the gripping positioning structure 131 is used to cooperate with the positioning of the manipulator. Optionally, the gripping positioning structure 131 is provided on the left and right sides of the operating panel 13, and the gripping positioning structure 131 is two concave positioning slots. When the manipulator or the mechanical arm grabs the bracket, the positioning protrusions of the manipulator are respectively stuck in the positioning slots on both sides, and the manipulator clamps again to ensure stable clamping and avoid the bracket from slipping when the manipulator grabs. In this embodiment, the bracket operating panel 13 is provided with a gripping positioning structure 131, which is convenient for the manipulator to quickly and accurately identify the grabbing position, and to avoid slipping during the grabbing process, and to ensure stable clamping of the bracket. In this way, when the manipulator clamps the bracket to move the bracket to move the slide 80 between different positions, even if the slide 80 is loaded with liquid, the bracket can move more stably, and the liquid is not easy to overflow or contact the bracket.

[0074] In other embodiments, the grabbing and positioning mechanism may also be disposed on the top surface or the bottom surface of the operating panel 13 , and the grabbing and positioning structure 131 may also be a clamping block.

[0075] In one embodiment, referring to Fig.14 , Fig.12 , Fig.15 The operation panel 13 is provided with a placement and positioning structure 132, and the placement and positioning structure 132 is used to cooperate with the operating table, the fixing seat 20 and other structures used to support the bracket. The placement and positioning structure 132 can be a card block or a card slot.

[0076] Please continue to refer to the following Figures 1 to 17 , the structure of the slide processing device is described in detail. For the convenience of description, the slide processing device is referred to as a processing device below.

[0077] The processing device comprises a slide holder 10 of any of the above embodiments and a processing module. The bottom plate 11 of the holder is provided with an opening 111. The processing module comprises a fixed seat 20 and a supporting seat 30 connected thereto. The holder has a placement state.

[0078] Reference Fig.11 , Figures 15 to 17 When the bracket is in the placement state, the bracket is placed on the processing module, the fixing seat 20 supports the slide bracket 10, and the support seat 30 passes through the opening 111 of the bottom plate 11 to be inserted into the wafer receiving groove 101. The support seat 30 is used to lift the slide 80 originally located on the bottom plate 11 of the bracket, so that there is a certain distance between the bottom surface of the slide 80 and the bottom plate 11. In addition, when the bracket is in the placement state, the support seat 30 and the edge of the opening 111 of the bottom plate 11 are gap-matched to form a first channel 911 between the support seat 30 and the opening 111 of the bottom plate 11, and the first channel 911 is connected to the wafer receiving groove 101.

[0079] In the case where the glass slide 80 is installed in the bracket, after the bracket is moved and placed in the processing module, it is suitable to at least clean the glass slide 80 and the bracket. Exemplarily, after the bracket is moved and placed in the processing module, the glass slide 80 is supported by the support seat 30, and the glass slide 80 leaves the bracket bottom plate 11, so that the side surface of the glass slide 80 and the bottom surface of the glass slide 80 do not contact the bracket, and a first matching gap 93 is formed between the side surface of the glass slide 80 and the bracket frame 12, and a second matching gap 94 is formed between the bottom surface of the glass slide 80 and the bracket bottom plate 11. At this time, a cleaning liquid is added to the glass slide 80 or the bracket, and the cleaning liquid can flow out of the bracket along the first matching gap 93, the second matching gap 94, and the first channel 911, so that the cleaning liquid is discharged smoothly.

[0080] Furthermore, the groove side wall 121 on the inner side of the bracket frame 12 is inclined, and the inclined groove side wall 121 allows the liquid to automatically flow to the opening 111 of the bottom plate 11, providing a diversion function for the discharge of the cleaning liquid. Therefore, the setting of the inclined groove side wall 121 not only reduces the probability of the liquid on the glass slide 80 contacting the bracket when the bracket bottom plate 11 normally supports the glass slide 80, but also allows the cleaning liquid to be discharged more quickly and smoothly during the cleaning stage, thereby reducing the residual cleaning liquid and improving the cleaning effect. The bracket of this embodiment cooperates well with the processing module.

[0081] It should be noted that the bottom plate 11 of the bracket is provided with an opening 111. In addition to allowing liquid to be discharged from the bracket when the bracket is in a placed state, in some embodiments, when the bracket is in a placed state, the opening 111 of the bottom plate 11 can also serve the function of facilitating hot air heating of the glass slide 80: hot air is blown from the bottom of the support seat 30, and the hot air is blown into the slide slot 101 through the opening 111 of the bottom plate 11 (the first channel 911 between the support seat 30 and the edge of the opening 111), and the hot air contacts the bottom of the glass slide 80, thereby heating the glass slide 80, thereby meeting the need for sample heating during some detection or experiments.

[0082] In one embodiment, please continue to refer to Figures 11 to 17 The fixed seat 20 includes a seat side plate 21 and a seat bottom plate 22. The seat side plate 21 surrounds the outer periphery of the seat bottom plate 22 to form a mounting groove 201 with an upper opening 111 between the seat side plate 21 and the seat bottom plate 22. The support seat 30 is disposed in the mounting groove 201. The seat side plate 21 surrounds the outer side of the support seat 30. The support seat 30 is connected to the seat side plate 21.

[0083] At least a portion of the support seat 30 and the seat side plate 21 is gap-matched to form a second channel 92 between the support seat 30 and the seat side plate 21. Exemplarily, the support seat 30 is a rectangular structure, the front and rear ends of the support seat 30 are against the seat side plate 21, and the left and right ends of the support seat 30 are gap-matched with the seat side plate 21.

[0084] It can be understood that the formation of the second channel 92 connects the wafer groove 101, the first channel 911, and the second channel 92. In this way, when cleaning the slide 80 or the bracket, the liquid in the wafer groove 101 can be discharged to the space below the support seat 30 through the first channel 911 and the second channel 92, which facilitates the discharge of the cleaning liquid and ensures that there is no liquid residue at the support seat 30.

[0085] In other embodiments, the fixing seat 20 may also only include the seat side plates 21 without including the seat bottom plate 22 .

[0086] In one embodiment, a first mounting boss is provided on the inner side of the seat side plate 21, the bottom of the support seat 30 is placed on the first mounting boss, and then the support seat 30 is locked on the first mounting boss by a fastener to achieve the connection between the support seat 30 and the seat side plate 21. In other embodiments, a socket may be provided on the seat side plate 21, and both ends of the support seat 30 may be inserted into the seat side plate 21.

[0087] In one embodiment, please continue to refer to Figures 11 to 17 , the seat bottom plate 22 is located below the support seat 30, the support seat 30 is spaced apart from the seat bottom plate 22, and a drainage surface 221 is formed on the side of the seat bottom plate 22 close to the support seat 30, and the drainage surface 221 is inclined from its first end to its second end in a direction away from the support seat 30; the seat side plate 21 is provided with a drainage hole 211, and the drainage hole 211 is arranged close to the second end of the drainage surface 221. In this way, the liquid can be discharged from the film holding groove 101 through the first channel 911 and the second channel 92 to the inclined drainage surface 221, and then discharged from the fixed seat 20 through the drainage hole 211, thereby discharging the processing module, and the liquid is discharged smoothly. When the bracket is placed on the processing module, the cleaning efficiency and cleaning effect can be improved, and the detection efficiency can be improved. In addition, in this embodiment, by setting the support seat 30 and the fixed seat 20 side plate 21 part of the area at a distance, the liquid above the support seat 30 can be discharged to the bottom of the support seat 30, without opening a hole in the support seat 30, and the processing technology is simple.

[0088] In other embodiments, a hole may be directly opened in the support seat 30 so that the liquid discharged from the opening 111 of the bracket bottom plate 11 can be discharged to the bottom of the support seat 30 through the hole of the support seat 30 .

[0089] Optionally, the drainage hole 211 may also be provided with a plug or a drainage pipe, a valve, etc.

[0090] In one embodiment, referring to Fig.12 , Fig.15The processing module is also provided with a heating component 40, which is used to heat the support seat 30 to meet the need to heat the tissue sample of the slide 80 in some detection and experimental scenarios. After the slide holder 10 sends the slide 80 to the processing module, a variety of operations can be performed, and the adaptability is more extensive.

[0091] Optionally, the top surface of the support seat 30 is a support surface 31, and the support surface 31 is used to support the slide 80; the processing module further includes a heating component 40, and the heating component 40 is arranged inside the support seat 30, or the heating component 40 is arranged on the bottom side of the support seat 30. The heating component 40 can be an electric heating structure such as a heating wire.

[0092] In one embodiment, referring to Fig.12 , Fig.15 The processing module further includes a fan 50, which can be used for exhausting air or supplying air, and the fan 50 can be used at least in the cleaning stage. Specifically, the fixed seat 20 is provided with a mounting groove 201, and the support seat 30 is arranged in the mounting groove 201. The fixed seat 20 is provided with an air port 212, and the air port 212 is located below the support seat 30. The mounting groove 201 is connected to the outside of the fixed seat 20 through the air port 212; the fan 50 is installed on the fixed seat 20, and the fan 50 is configured to at least be able to pump the gas in the mounting groove 201 to the outside of the fixed seat 20.

[0093] For example, after a glass slide 80 is loaded in a bracket and the bracket is placed in a processing module, the glass slide 80 is lifted up by the support seat 30. When cleaning the glass slide 80 or the bracket, the fan 50 installed on the fixed seat 20 is used to draw air, so that a negative pressure is generated in the space below the support seat 30, and a suction force is applied to the liquid in the plate receiving slot 101 of the bracket. The negative pressure provides power to allow the liquid to pass through the first channel 911 and the second channel 92 from the inside of the bracket to be discharged onto the seat bottom plate 22 more quickly and smoothly. In this way, the cleaning liquid can be discharged from the bracket more thoroughly and quickly, which not only ensures the cleaning effect, but also avoids the cleaning liquid from remaining in the glass slide 80 or the inside of the bracket. The provision of the fan 50 also improves the cleaning efficiency, which is conducive to improving the overall detection efficiency.

[0094] In one embodiment, referring to Fig.12 , Fig.15 , Fig.16As shown, the processing module also includes a liquid guide plate 60, which is disposed below the support seat 30, and the liquid guide plate 60 is mounted on the fixing seat 20 by screw locking, snap fastening, etc. The liquid guide plate 60 includes a liquid guide surface 61, and the first end to the second end of the liquid guide surface 61 is inclined in a direction away from the support seat 30, and the liquid guide surface 61 is located directly below the second channel 92, that is, the downward projection area of ​​the second channel 92 can fall on the liquid guide surface 61, so that when cleaning the slide 80 or the bracket, the liquid is discharged from the first channel 911 and the second channel 92 and falls on the inclined liquid guide surface 61, and then the liquid is guided to the seat bottom plate 22 through the liquid guide plate 60, and the setting of the liquid guide plate 60 allows the liquid to flow more smoothly.

[0095] It can be understood that, based on the provision of the liquid guide plate 60, the interval between the support seat 30 and the seat bottom plate 22 can be retained larger to accommodate more liquid when the drainage hole 211 is closed, and the provision of the liquid guide plate 60 also prevents the liquid from falling vertically after flowing out of the second channel 92, causing liquid splashing, and also prevents the splashed liquid from splashing back to the support seat 30, thereby preventing the splashed liquid from contaminating the support seat 30 or wetting the heating component 40 under the support seat 30.

[0096] In one embodiment, the fixed seat 20 is provided with a seat positioning structure 23, the bracket includes an operation panel 13 connected to the supporting body, and a placement positioning structure 132 is provided at the bottom of the operation panel 13; when the bracket is in the placement state, the placement positioning structure 132 and the seat positioning structure 23 are limitedly matched to limit the movement of the bracket. Optionally, the seat positioning structure 23 is a convex part, and the placement positioning is a convex hole, and the convex part is inserted into the convex hole to realize the placement positioning of the bracket, prevent the bracket from moving, and thus prevent the slide 80 from moving, so as to facilitate the automatic liquid adding head or other equipment to accurately operate the slide 80.

[0097] The following is a specific example of the application of the slide processing device of the present application in the dewaxing step in the immunohistochemical staining process: the slide 80 is placed on the bracket, the bracket is placed on the processing module, the support seat 30 lifts the slide 80 to make the slide 80 leave the bracket bottom plate 11, the support seat 30 is heated by the heating component 40, and the slide 80 is heated by the support seat 30 to facilitate the subsequent separation from the paraffin, and then the dewaxing liquid is added to the slide 80, and the dewaxing liquid is soaked in the tissue section. After dewaxing, alcohol needs to be added for dehydration to remove the residual dewaxing liquid in the tissue, and at the same time, the water gradually enters the tissue cells, and then distilled water or purified water is added for cleaning, so as to perform subsequent antigen repair. It can be seen that in the dewaxing process, multiple liquids need to be added. In this embodiment, the arrangement of the groove side wall 121 inclined on the inner side of the bracket frame 12, the first channel 911, the second channel 92, the liquid guide plate 60, the fan 50, etc. can improve the cleanliness and efficiency of liquid discharge in each step and ensure the efficiency of the entire process.

[0098] In the description of this article, it should be understood that the terms "upper", "lower", "left", "right" and other directions or positional relationships are based on the directions or positional relationships shown in the drawings, and are only for the convenience of description and simplified operation, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as a limitation of the present invention. In addition, the terms "first" and "second" are only used to distinguish in the description and have no special meaning.

[0099] In the description of this specification, the description with reference to the terms "an embodiment", "example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the utility model. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example.

[0100] In addition, it should be understood that although this specification is described according to implementation methods, not every implementation method contains only one independent technical solution. This narrative method of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation methods that can be understood by those skilled in the art.

[0101] The technical principle of the present invention is described above in combination with specific embodiments. These descriptions are only for explaining the principle of the present invention and cannot be interpreted as limiting the protection scope of the present invention in any way. Based on the explanations here, technicians in this field can think of other specific implementation methods of the present invention without creative work, and these methods will fall within the protection scope of the present invention.

Claims

1. A slide holder, characterized in that: Including supporting body; The supporting body comprises a bottom plate (11) and a frame (12), wherein the bottom plate (11) is used to support the glass slide (80), and the frame (12) surrounds the outer periphery of the bottom plate (11); A film receiving groove (101) is defined between the bottom plate (11) and the frame (12); the inner surface of the frame (12) is a groove side wall (121) of the film receiving groove (101); the edge of the groove side wall (121) facing away from the bottom plate (11) is a first side edge (1211); the edge of the groove side wall (121) close to the bottom plate (11) is a second side edge (1212); and the groove side wall (121) extends inwardly from the first side edge (1211) to the second side edge (1212).

2. The slide holder according to claim 1, characterized in that: The frame (12) comprises four frame parts (1201), and adjacent frame parts (1201) are connected to each other; a avoidance groove (102) is arranged between adjacent frame parts (1201), and the avoidance groove (102) is located on the inner side of the frame (12), and the avoidance groove (102) is connected to the sheet receiving groove (101); The inner side of each frame portion (1201) has the groove side wall (121), and the intersection of the extension lines of the second side edges (1212) adjacent to the groove side wall (121) is located in the avoidance groove (102).

3. The slide holder according to claim 1, characterized in that: The bottom plate (11) is provided with an opening (111), and the opening (111) passes through the bottom plate (11).

4. The slide holder according to claim 1, characterized in that: The slide holder (10) further comprises an operating panel (13), wherein the operating panel (13) is connected to the supporting body; The operating panel (13) is provided with a gripping and positioning structure (131), and the gripping and positioning structure (131) is used for positioning and cooperating with the robot; And / or, the operating panel (13) is provided with a placement positioning structure (132), and the placement positioning structure (132) is used to position and cooperate with the fixing seat (20) when the slide holder (10) is placed on the processing module fixing seat (20).

5. A slide processing device, characterized in that: include: The slide holder (10) according to any one of claims 1 to 4, wherein the bottom plate (11) is provided with an opening (111); A processing module, comprising a fixed seat (20) and a supporting seat (30) connected to each other; The slide holder (10) has a placement state; when the slide holder (10) is in the placement state, the slide holder (10) is placed on the processing module, the fixing seat (20) supports the slide holder (10), and the support seat (30) passes through the opening (111) of the bottom plate (11) to be inserted into the wafer receiving slot (101); the support seat (30) and the edge of the opening (111) are clearance-matched to form a first channel (911), and the first channel (911) is connected to the wafer receiving slot (101).

6. The slide processing device according to claim 5, characterized in that: The fixing seat (20) comprises a seat side plate (21), the seat side plate (21) surrounds the outer side of the supporting seat (30), and the supporting seat (30) is connected to the seat side plate (21); The support seat (30) and the seat side plate (21) are clearance-matched to form a second channel (92); the sheet receiving groove (101), the first channel (911), and the second channel (92) are in communication.

7. The slide processing device according to claim 6, characterized in that: The fixing seat (20) further comprises a seat bottom plate (22) connected to the seat side plate (21), a mounting groove (201) is defined between the seat side plate (21) and the seat bottom plate (22), and the supporting seat (30) is arranged in the mounting groove (201); The seat bottom plate (22) is located below the support seat (30), the support seat (30) is spaced apart from the seat bottom plate (22), a liquid discharge surface (221) is formed on a side of the seat bottom plate (22) close to the support seat (30), and the liquid discharge surface (221) is inclined in a direction away from the support seat (30) from its first end to its second end; the seat side plate (21) is provided with a liquid discharge hole (211), and the liquid discharge hole (211) is provided close to the second end of the liquid discharge surface (221).

8. The slide processing device according to claim 5, characterized in that: The top surface of the support seat (30) is a support surface (31), and the support surface (31) is used to support the slide glass (80); The processing module further comprises a heating component (40), wherein the heating component (40) is arranged inside the support base (30), or the heating component (40) is arranged on the bottom side of the support base (30).

9. The slide processing device according to claim 5, characterized in that: The fixing seat (20) is provided with a mounting groove (201), and the supporting seat (30) is arranged in the mounting groove (201); The fixing seat (20) is provided with an air outlet (212), the air outlet (212) is located below the supporting seat (30), and the mounting groove (201) is connected to the outside of the fixing seat (20) through the air outlet (212); the slide processing device also includes a fan (50) installed on the fixing seat (20), the fan (50) is installed on the fixing seat (20), and the fan (50) is configured to at least be able to pump the gas in the mounting groove (201) to the outside of the fixing seat (20).

10. The slide processing device according to claim 6, characterized in that: The liquid guide plate (60) is also included, the liquid guide plate (60) is arranged below the support seat (30), and the liquid guide plate (60) is installed on the fixing seat (20); the liquid guide plate (60) includes a liquid guide surface (61), and the first end to the second end of the liquid guide surface (61) are inclined in a direction away from the support seat (30), and the liquid guide surface (61) is located below the second channel (92); The fixed seat (20) is provided with a seat positioning structure (23), the bracket comprises an operating panel (13) connected to the supporting body, and a placement positioning structure (132) is provided at the bottom of the operating panel (13); when the bracket is in the placement state, the placement positioning structure (132) is limitedly matched with the seat positioning structure (23) to limit the movement of the bracket.

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