Mouse liver perfusion temperature and speed control device

Abstract

The utility model relates to the field of perfusion devices, and discloses a mouse liver perfusion temperature and speed control device which comprises a perfusion table, a temperature control mechanism and a speed control mechanism. The temperature control mechanism comprises a thermostatic bath formed in the top of the filling table, a heating assembly fixedly installed on the surface of the inner side wall of the thermostatic bath, a temperature sensor fixedly installed on the surface of the inner bottom wall of the thermostatic bath and a liquid storage assembly movably placed in the thermostatic bath. The speed control mechanism comprises a base and a speed control assembly arranged on the base, one end of a liquid guide pipe is connected with the liquid storage assembly, and the other end of the liquid guide pipe is wound around the speed control assembly and then connected with an infusion needle. According to the mouse liver perfusion temperature and speed control device, the independent temperature control mechanism and speed control mechanism are designed, and the accuracy and flexibility of experimental operation are effectively enhanced through the design characteristics.

Description

Technical Field

[0001] The utility model relates to the field of perfusion devices, in particular to a mouse liver perfusion temperature and speed control device. Background Art

[0002] In the current experimental environment, mouse liver perfusion is the primary and key step in isolating liver cells, which directly affects the quality and efficiency of separation. However, there are some problems in the existing technology:

[0003] First, it is difficult for traditional perfusion devices to effectively control the liquid temperature, which can easily cause instability in experimental results.

[0004] In addition, it is difficult to maintain a stable flow rate with a manually operated syringe. Due to different operating habits of each person, the perfusion process lacks precision and the perfusion effect varies from person to person.

[0005] Secondly, it is inconvenient to change the liquid when operating alone, which may affect the continuity and efficiency of the experiment.

[0006] Therefore, there is an urgent need to design a mouse liver perfusion temperature and speed control device that can solve the above technical problems. Utility Model Content

[0007] In view of the problems mentioned in the background technology, the purpose of the utility model is to provide a mouse liver perfusion temperature and speed control device to solve the problems mentioned in the background technology.

[0008] In order to achieve the above purpose, the utility model mainly provides the following technical solutions:

[0009] A mouse liver perfusion temperature and speed control device comprises a perfusion platform and also comprises:

[0010] Temperature control mechanism and speed control mechanism; wherein:

[0011] The temperature control mechanism includes a thermostatic tank opened on the top of the perfusion table, a heating component fixedly installed on the inner wall surface of the thermostatic tank, a temperature sensor fixedly installed on the inner bottom wall surface of the thermostatic tank, and a liquid storage component movably placed in the thermostatic tank;

[0012] The speed control mechanism comprises a base and a speed control component arranged thereon, one end of the liquid guide tube is connected to the liquid storage component, and the other end is wound around the speed control component and then connected to the infusion needle.

[0013] Furthermore, the speed control assembly includes a motor fixedly mounted on the back side of the base, the rotating shaft of the motor passes through the center of the base and is connected to the rotor, a slot is provided on the outer periphery of the rotor, and the liquid guide tube is wound between the slot and the rotor.

[0014] Furthermore, the liquid storage assembly includes a liquid storage cylinder and a sealing cover arranged at the top opening of the liquid storage cylinder, the sealing cover is connected to the opening through threads, and ventilation holes are provided on the sealing cover and the opening.

[0015] Furthermore, the slot is C-shaped and the edge of its outer wall is provided with a protruding structure.

[0016] Furthermore, a main switch, a flow increase button and a flow decrease button are fixedly installed on the right side of the front of the filling station from top to bottom.

[0017] Furthermore, there are three constant temperature baths, which are respectively arranged on the top of the pouring table from left to right, and there are three speed control mechanisms and three sub-switches, which respectively correspond to the positions of the constant temperature baths.

[0018] Furthermore, the heating component is an electric heating coil fixedly installed on the inner wall of the thermostatic bath.

[0019] Furthermore, the catheter is made of rubber or silicone.

[0020] Compared with the prior art, the beneficial effects of the utility model are mainly reflected in:

[0021] First, compared with traditional perfusion devices, it is difficult to effectively control the temperature of the liquid, which easily leads to instability of the experimental results. To solve this problem, the temperature and speed control device for mouse liver perfusion in the utility model adopts a temperature control mechanism including a heating component and a temperature sensor. This design effectively controls the temperature of the heating component and combines the temperature sensor to monitor the temperature of the liquid in real time, thereby achieving precise control of the liquid temperature, thereby improving the stability and repeatability of the experiment.

[0022] In addition, compared with traditional perfusion devices, manually operated syringes are difficult to maintain a stable flow rate. Due to different operating habits of each person, the perfusion process lacks precision and the perfusion effect varies from person to person. To solve this problem, the temperature and speed control device for mouse liver perfusion in the utility model is provided with a speed control structure, which controls the increase or decrease of the flow rate of the liquid medicine based on the speed of the rotor. The experimenter can ensure the stability of the flow rate during the perfusion process without manual adjustment, so that the operation differences between different experimenters no longer affect the perfusion effect, further improving the credibility and scientific value of the experiment.

[0023] Secondly, compared with the traditional perfusion device, it is inconvenient to replace the liquid when operated by one person, which may affect the continuity and efficiency of the experiment. To solve this problem, the temperature and speed control device for mouse liver perfusion in the utility model adopts three sets of temperature control mechanisms and speed control mechanisms, and each sub-switch controls the start and stop of the corresponding temperature and speed control mechanism. This design effectively improves the continuity and efficiency of the experiment, allowing the experimenter to easily replace the liquid medicine under single-person operation without affecting the smooth progress of the experimental process.

[0024] The above description is only an overview of the technical solution of the utility model. In order to clearly understand the technical means of the utility model and implement it according to the contents of the specification, the following preferred embodiments of the utility model are described in detail with reference to the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0026] Figure 1 This is a schematic structural diagram of a mouse liver perfusion temperature and speed control device of the utility model;

[0027] Figure 2 It is a top view of a mouse liver perfusion temperature and speed control device of the utility model;

[0028] Figure 3 It is a partial structural schematic diagram of the liquid storage component of the utility model;

[0029] Figure 4 It is a partial structural schematic diagram of the speed control component of the utility model;

[0030] Description of reference numerals:

[0031] 1. Filling table; 11. Power cord;

[0032] 2. Temperature control mechanism; 21. Constant temperature bath; 22. Heating assembly; 23. Temperature sensor; 24. Liquid storage assembly;

[0033] 241, liquid storage cylinder; 242, sealing cover; 243, vent hole; 244, liquid inlet hole;

[0034] 3. Speed ​​control mechanism; 31. Base; 32. Speed ​​control assembly;

[0035] 311, fixed column;

[0036] 321, motor; 322, rotating shaft; 323, rotor; 324, slot;

[0037] 4. Catheter; 5. Needle handle; 6. Infusion needle; 7. Sub-switch; 8. Main switch; 9. Flow increase button; 10. Flow decrease button; DETAILED DESCRIPTION

[0038] The present application is further described in detail below in conjunction with the accompanying drawings and embodiments. It is to be understood that the specific embodiments described herein are only used to explain the relevant utility model, rather than to limit the utility model. It is also necessary to explain that, for ease of description, only the parts related to the utility model are shown in the accompanying drawings.

[0039] like Figure 1-4 As shown, a mouse liver perfusion temperature and speed control device of the utility model comprises a perfusion platform 1, and also comprises:

[0040] Temperature control mechanism 2 and speed control mechanism 3; wherein:

[0041] The temperature control mechanism 2 includes a thermostatic tank 21 opened on the top of the filling table 1, which is used to provide a space for the container containing the liquid medicine, a heating component 22 fixedly installed on the inner wall surface of the thermostatic tank 21, which is used to realize the heating function inside the thermostatic tank 21, a temperature sensor 23 fixedly installed on the inner bottom wall surface of the thermostatic tank 21 to monitor the temperature change of the liquid in real time, so as to adjust the working state of the heating component 22 in time to keep the constant temperature of the liquid at 37°C, and a liquid storage component 24 movably placed in the thermostatic tank 21, which stores the liquid to be filled and needs to ensure that the liquid is not contaminated by the outside;

[0042] The speed control mechanism 3 includes a base 31 and a speed control component 32 arranged thereon. The base 31 is fixedly installed on the perfusion table 1 through four fixing columns 311, providing a stable support for the entire speed control system. The speed control component 32 drives the rotor 323 through the motor 321 to control the flow rate of the perfusion liquid to ensure the stability and consistency of the flow rate during the perfusion process. One end of the liquid guide tube 4 is connected to the liquid storage component 24 and extends into the bottom end of the liquid storage component 24 through the liquid inlet hole 244. The other end is wound around the speed control component 32 and connected to the infusion needle 6 to ensure that the liquid can flow smoothly from the liquid storage component 24 to the mouse liver to complete the perfusion experiment process.

[0043] like Figure 4 As shown, in this embodiment, the speed control component 32 includes a motor 321 fixedly installed on the back side of the base 31. The motor 321 is installed on the back side of the base 31, which can ensure the stability and safety of the motor 321. The rotating shaft 322 of the motor 321 passes through the center of the base 31 and is connected to the rotor 323. The outer periphery of the rotor 323 is provided with a slot 324, and the slot 324 is fixedly installed on the surface of the base 31 for fixing the catheter 4. The catheter 4 is wound between the slot 324 and the rotor 323. This design enables the motor 321 to drive the flow of liquid in the catheter 4 through the rotation of the rotor 323.

[0044] In this embodiment, the liquid storage component 24 includes a liquid storage cylinder 241 and a sealing cover 242 provided at the top opening thereof. The liquid to be infused is poured into the liquid storage cylinder 241 from the opening. The sealing cover 242 is connected to the opening through a threaded connection, thereby ensuring that the liquid is not easily leaked and foreign matter is not easily entered into the liquid storage cylinder 241. The sealing cover 242 and the opening are provided with air vents 243. The air vents 243 are designed to balance the pressure on the inside and outside of the liquid storage cylinder 241. When the liquid is sucked out, the air vents 243 allow air to enter the liquid storage cylinder 241 to avoid vacuum formed when the liquid is sucked out, thereby preventing the liquid flow from being obstructed. At the same time, the air vents 243 can also make the liquid infusion process smoother and more continuous.

[0045] In this embodiment, the slot 324 is C-shaped and the edge of its outer wall is set as a protruding structure with an open mouth for the catheter 4 to extend into. At the same time, a protruding structure is designed at the outer edge of the slot 324 to prevent the catheter 4 from slipping out of the slot 324, thereby firmly fixing the catheter 4.

[0046] In this embodiment, a main switch 8, a flow increase button 9 and a flow decrease button 10 are fixedly installed on the right side of the front of the perfusion table 1 from top to bottom. The main switch 8 is used to start and stop the temperature control mechanism 2 and the speed control mechanism 3. By controlling the state of the main switch 8, the operating state of the entire device can be controlled at the same time, and the flow increase button 9 and the flow decrease button 10 are used to adjust the speed of the motor 321, thereby controlling the flow rate of the liquid to be perfused. This design allows the experimenter to easily adjust the flow rate of the liquid according to the experimental requirements, thereby achieving precise control of the experimental process.

[0047] In this embodiment, there are three thermostatic baths 21, which are respectively arranged on the top of the perfusion table 1 from left to right. There are three speed control mechanisms 3 and sub-switches 7, which correspond to the positions of the thermostatic baths 21. Each sub-switch 7 is independently used to start and stop the corresponding temperature control mechanism 2 and speed control mechanism 3. The purpose of this design is to cope with the situation that multiple liquid medicines may need to be used at the same time during the experiment. Each thermostatic bath 21 can control the temperature of the liquid medicine at the same time, so as to ensure that each liquid medicine can reach a suitable temperature state. This setting enables the experimenter to easily switch back and forth between different liquid medicines during the experiment without stopping the experiment or waiting for the temperature to be adjusted. At the same time, since each thermostatic bath 21 can work alone, the experiment can be completed by a single person without the need for collaboration of multiple people, which improves the efficiency and convenience of the experiment.

[0048] In this embodiment, the heating component 22 is an electric heating coil fixedly mounted on the inner wall of the thermostatic bath 21. Such a design enables the electric heating coil to fit closely to the inner surface of the thermostatic bath 21 and be evenly distributed. When the heating component 22 is powered on, the heat generated by the electric heating coil is transferred to the interior of the thermostatic bath 21, thereby increasing the temperature of the liquid medicine and achieving constant temperature control of the liquid medicine.

[0049] In this embodiment, the catheter 4 is made of flexible materials such as rubber or silicone. The catheter 4 is made of rubber or silicone mainly because these materials have corrosion resistance and can withstand the chemical environment of different drug solutions that may appear in the experiment and maintain their stability. Secondly, when the rotor 323 rotates, the catheter 4 will be squeezed and pushed due to the fixation of the slot 324, and the catheter 4 made of soft material can ensure the smooth progress of the experiment, and has stronger durability and is not easily damaged.

[0050] The present invention is further described above in conjunction with the embodiments, but the present invention is not limited to the above embodiments, and various changes can be made within the knowledge scope of ordinary technicians in this field without departing from the purpose of the present invention.

Claims

1. A temperature and speed control device for mouse liver perfusion, comprising a perfusion platform (1), characterized in that: Also includes: A temperature control mechanism (2) and a speed control mechanism (3); wherein: The temperature control mechanism (2) comprises a thermostatic bath (21) disposed on the top of the pouring table (1), a heating component (22) fixedly mounted on the inner wall surface of the thermostatic bath (21), a temperature sensor (23) fixedly mounted on the inner bottom wall surface of the thermostatic bath (21), and a liquid storage component (24) movably placed in the thermostatic bath (21); The speed control mechanism (3) comprises a base (31) and a speed control assembly (32) arranged thereon; one end of the liquid guide tube (4) is connected to the liquid storage assembly (24), and the other end is wound around the speed control assembly (32) and then connected to the infusion needle (6).

2. A mouse liver perfusion temperature and speed control device according to claim 1, characterized in that: The speed control assembly (32) comprises a motor (321) fixedly mounted on the back side of the base (31); a rotating shaft (322) of the motor (321) passes through the center of the base (31) and is connected to a rotor (323); a slot (324) is provided on the outer periphery of the rotor (323); and a liquid guide tube (4) is wound between the slot (324) and the rotor (323).

3. A mouse liver perfusion temperature and speed control device according to claim 1, characterized in that: The liquid storage assembly (24) comprises a liquid storage cylinder (241) and a sealing cover (242) arranged at the top opening of the liquid storage cylinder. The sealing cover (242) is connected to the opening via threads, and ventilation holes (243) are provided between the sealing cover (242) and the opening.

4. A mouse liver perfusion temperature and speed control device according to claim 2, characterized in that: The slot (324) is C-shaped and the edge of its outer wall is configured as a protruding structure.

5. The device for controlling temperature and speed of mouse liver perfusion according to claim 1, characterized in that: A main switch (8), a flow rate increase button (9) and a flow rate decrease button (10) are fixedly installed on the right side of the front of the filling station (1) from top to bottom.

6. A mouse liver perfusion temperature and speed control device according to claim 1, characterized in that: The number of the thermostatic baths (21) is three, which are respectively arranged on the top of the pouring table (1) from left to right. The number of the speed control mechanisms (3) and the number of the sub-switches (7) are both three, which respectively correspond to the positions of the thermostatic baths (21).

7. A mouse liver perfusion temperature and speed control device according to claim 1, characterized in that: The heating component (22) is an electric heating coil fixedly mounted on the inner wall of the thermostatic bath (21).

8. A mouse liver perfusion temperature and speed control device according to claim 1, characterized in that: The liquid guiding tube (4) is made of rubber or silicone.

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