Particle analyzer

Abstract

The particle analyzer comprises a sample loading module, an optical module, a liquid path module and an electric appliance module, the sample loading module comprises a sample loading assembly and a fixing frame, the optical module comprises an optical detection device and a detection chamber, the liquid path module comprises a negative pressure source and a pipeline, the pipeline is communicated with the sample loading assembly and the detection chamber, the negative pressure source is arranged on the pipeline, and the electric appliance module is arranged on the pipeline. The electric appliance module comprises a shell, a power supply device and a circuit board, the power supply device and the circuit board are installed in the shell, and the circuit board is electrically connected with the power supply device, the sample loading assembly, the negative pressure source and the optical detection device. The sample loading module, the optical module, the liquid path module and the electric appliance module are independently arranged, so that the structure of the particle analyzer can be refined, the internal layout of the particle analyzer is simplified, and debugging and mounting are facilitated. The sample loading module, the optical module and the liquid path module carry out sample transmission through the pipeline, and the electric appliance module is independently arranged outside the pipeline, so that power supply and sample transmission are isolated from each other, the electric appliance module is prevented from being damaged by sample leakage, and the safety is improved.

Description

Technical Field

[0001] The present application relates to the technical field of biological equipment, and in particular to a particle analyzer. Background Art

[0002] A particle analyzer is a device that automatically analyzes and sorts cells. It plays an important role in clinical tests such as hematology and tumor diagnosis, immune function, and reticulocyte count. Particle analyzers have multiple different workflows, such as sampling, liquid transmission, optical detection, and electrical control. The existing particle analyzers have complex internal module layouts and disordered electrical transmission systems, which may increase the size of the particle analyzer, increase the difficulty of operation, and reduce the stability of use. Utility Model Content

[0003] The embodiment of the present application provides a particle analyzer to at least partially improve the above technical problems.

[0004] An embodiment of the present application provides a particle analyzer, including a sample loading module, an optical module, a liquid circuit module and an electrical module. The sample loading module is used to collect samples in a sample tube. The optical module includes an optical detection device and a detection chamber. The optical detection device is used to obtain information about the sample in the detection chamber. The liquid circuit module includes a negative pressure source and a pipeline. The pipeline connects the sample loading module, the detection chamber and the negative pressure source. The negative pressure source provides power for the sample to flow. The electrical module includes a housing, a power supply device and a circuit board. The power supply device and the circuit board are installed in the housing. The circuit board is electrically connected to the power supply device, the sample loading module, the negative pressure source and the optical detection device.

[0005] In one embodiment, the shell includes a top surface, a bottom surface, and a first side surface, a second side surface, a third side surface, and a fourth side surface arranged between the top surface and the bottom surface, the first side surface and the third side surface are arranged opposite to each other, the second side surface and the fourth side surface are arranged opposite to each other, the optical module is installed on the outside of the top surface, the liquid path module is installed on the outside of the first side surface, and the loading module is installed on the outside of the second side surface.

[0006] In one embodiment, the first side surface is located directly opposite to an operating station of the particle analyzer, and the second side surface is located on the right side of the operating station.

[0007] In one embodiment, the first side surface is located on the right side of an operating station of the particle analyzer, and the second side surface is located directly opposite to the operating station.

[0008] In one embodiment, the shell also includes a second connecting plate, which is connected to the top surface, and the second connecting plate is located between the liquid circuit module and the optical module. The second connecting plate is provided with a second connecting hole. The liquid circuit module includes a flow meter, which is passed through the second connecting hole, and one end of the flow meter is connected to the detection chamber, and the other end is connected to the sample loading module.

[0009] In one embodiment, the circuit board includes a first circuit board and a second circuit board. The first circuit board is fixed to the first side and corresponds to the negative pressure source. The first circuit board is electrically connected to the sample loading module, the negative pressure source and the power supply device. The second circuit board is fixed to the fourth side and is electrically connected to the optical detection device and the power supply device.

[0010] In one embodiment, a through slot is formed on the top surface, and at least a portion of the second circuit board passes through the through slot and is electrically connected to the optical detection device.

[0011] In one embodiment, the optical detection device also includes a third circuit board, the third circuit board is installed on the top surface, the optical detection device is electrically connected to the third circuit board, the second circuit board is provided with a first connector, the third circuit board is provided with a second connector, and the first connector is plugged into the second connector.

[0012] In one embodiment, the shell further includes a first connecting plate, the first connecting plate is connected to the second side, the first connecting plate is located between the liquid path module and the sample loading module, the first connecting plate is provided with a first connecting hole, and the pipeline is passed through the first connecting hole.

[0013] In one embodiment, the liquid circuit module is further provided with a liquid inlet and a liquid outlet, and a pipeline connects the liquid inlet and the liquid outlet.

[0014] The particle analyzer provided by the embodiment of the present application is powered by the negative pressure source of the liquid circuit module, the sample loading module can collect samples from the sample tube, the samples are transmitted to the optical module along the pipeline, and then the sample detection is performed by the optical detection device of the optical module, the power supply device of the electrical module supplies power to the negative pressure source, the sample loading component and the optical detection device, and the circuit board can control the operation of the negative pressure source, the sample loading component and the optical detection device. The sample loading module, the optical module, the liquid circuit module and the electrical module are independently arranged, which can refine the structure of the particle analyzer, simplify its internal layout, and facilitate the debugging and installation of the particle analyzer. In addition, the sample loading module, the optical module, and the liquid circuit module transmit samples through the pipeline, and the electrical module is independently arranged outside the pipeline to achieve isolation between power supply and sample transmission, avoid sample leakage and damage to the electrical module, and improve the safety of the particle analyzer. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] In order to more clearly illustrate the technical solutions in the implementation modes of the present application, the drawings required for use in the description of the implementation modes will be briefly introduced below. Obviously, the drawings described below are only some implementation modes of the present application. For those skilled in the art, other drawings can be obtained based on these drawings without creative work.

[0016] Figure 1 A schematic diagram of the structure of a particle analyzer proposed in an embodiment of the present application;

[0017] Figure 2 A schematic diagram of the structure of another particle analyzer proposed in an embodiment of the present application;

[0018] Figure 3 A schematic diagram of the structure of another particle analyzer proposed in an embodiment of the present application;

[0019] Figure 4 A schematic diagram of the structure of a liquid path module of another particle analyzer proposed in an embodiment of the present application;

[0020] Figure 5 A schematic diagram of the structure of yet another particle analyzer proposed in an embodiment of the present application;

[0021] Figure 6 A schematic diagram of a liquid path structure of a particle analyzer proposed in an embodiment of the present application;

[0022] Figure 7 A schematic diagram of the electrical structure of a particle analyzer proposed in an embodiment of the present application.

[0023] Figure numerals: particle analyzer 100, sample loading module 10, sample loading component 11, fixing frame 12, optical module 20, optical detection device 21, front optical path system 211, rear optical path system 212, third circuit board 213, detection chamber 22, liquid path module 30, negative pressure source 31, pipeline 32, liquid inlet 33, liquid outlet 34, sheath liquid bottle 35, sheath liquid pump 36, cleaning liquid bottle 37, waste liquid bottle 38, flow meter 39, electrical module 40, shell 41, top surface 411, through groove 4111, bottom surface 412, first side surface 413, mounting hole 4131, second side surface 414, third side surface 415, fourth side surface 416, accommodating cavity 417, first connecting plate 418, second connecting plate 419, power supply device 42, circuit board 43, first circuit board 431, second circuit board 432, first connecting hole 441, second connecting hole 442, sample tube 51. DETAILED DESCRIPTION

[0024] In order to enable those skilled in the art to better understand the solution of the present application, the technical solution in the implementation mode of the present application will be clearly and completely described below in conjunction with the drawings in the implementation mode of the present application. Obviously, the described implementation mode is only a part of the implementation mode of the present application, not all the implementation modes. Based on the implementation mode in the present application, all other implementation modes obtained by those skilled in the art without making creative work are within the scope of protection of the present application.

[0025] In this application, unless otherwise clearly specified or limited, the terms "installation", "connection", "fixation" and the like should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or an indirect connection through an intermediate medium, or it can be internal communication between two elements, or it can be only surface contact, or surface contact connection through an intermediate medium. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0026] In addition, the terms "first", "second", etc. are only used to distinguish descriptions and cannot be understood as specific or special structures. The descriptions of the terms "some embodiments", "other embodiments", etc. mean that the specific features, structures, materials or characteristics described in conjunction with the embodiments or examples are included in at least one embodiment or example of the present application. In the present application, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art can combine and combine the different embodiments or examples described in the present application and the features of the different embodiments or examples without contradiction.

[0027] Example

[0028] This embodiment provides a particle analyzer 100, see Figure 1 as well as Figure 2 The particle analyzer 100 includes a sample loading module 10, an optical module 20, a liquid circuit module 30 and an electrical module 40, the electrical module 40 is connected to the liquid circuit module 30, the optical module 20 is connected to the liquid circuit module 30 and the electrical module 40, and the sample loading module 10 is connected to the liquid circuit module 30 and the electrical module 40.

[0029] Please also see Figure 2 as well as Figure 3 The electrical module 40 may include a shell 41, a power supply device 42 and a circuit board 43. The power supply device 42 and the circuit board 43 are installed in the shell 41. The circuit board 43 is electrically connected to the sample loading module 10, the optical module 20, the liquid circuit module 30 and the electrical module 40.

[0030] In this embodiment, please refer to Figure 1 , Figure 2 as well as Figure 3The housing 41 may be a metal housing, such as stainless steel, aluminum alloy, etc. The metal housing has sufficient structural strength to protect the internal components. The housing 41 includes a top surface 411, a bottom surface 412, and a first side surface 413, a second side surface 414, a third side surface 415, and a fourth side surface 416 disposed between the top surface 411 and the bottom surface 412. The first side surface 413 and the third side surface 415 are disposed oppositely, and the second side surface 414 and the fourth side surface 416 are disposed oppositely. The sizes and shapes of the first side surface 413, the second side surface 414, the third side surface 415, and the fourth side surface 416 may be the same or different. For example, the first side surface 413, the second side surface 414, the third side surface 415, and the fourth side surface 416 may all be rectangular plates. Exemplarily, the top surface 411, the bottom surface 412, the first side surface 413, the second side surface 414, the third side surface 415, and the fourth side surface 416 enclose a receiving cavity 417, and the receiving cavity 417 may be used to receive the power supply device 42 and the circuit board 43. The housing 41 has a protective effect. During operation, the sample or sheath fluid flowing in the detection chamber 22, the liquid path module 30 and the sample loading assembly 11 may leak due to other reasons, and the protective design of the housing 41 can effectively prevent this from happening. Once leaking, the housing 41 can prevent the sample or sheath fluid from directly contacting the power supply device 42 and the circuit board 43, thereby reducing the risk of damage to the particle analyzer 100.

[0031] In one embodiment, please refer to Figure 1 as well as Figure 2 The first side surface 413 is located directly opposite to the operating station of the particle analyzer 100, and the second side surface 414 is located on the right side of the operating station. The operating station is the station where the operator operates the particle analyzer 100, and the first side surface 413 faces the operating station. Figure 1 L1 in the figure is the field of vision of the operator sitting at the operating station. The first side surface 413 and the liquid circuit module 30 arranged on the first side surface 413 are located directly opposite the operating station of the particle analyzer 100. The operator at the operating station can directly observe or touch the liquid circuit module 30. In addition, the second side surface 414 and the sample loading module 10 arranged on the second side surface 414 are located on the right side of the operating station. The position of the sample loading module 10 is in line with the right-hand operation habits of most people. The operator can directly reach into the sample loading module 10 to operate, and this setting is more ergonomic. The sample loading module 10 and the liquid circuit module 30 are often required for debugging or cleaning of the particle analyzer 100. The position setting of the operating station and the first side surface 413 and the second side surface 414 can shorten the distance between the operator and the sample loading module 10 and the liquid circuit module 30, which is more convenient for the operator to operate.

[0032] In another embodiment, see Figure 4 , Figure 4L2 in the figure is the field of vision of the operator sitting at the operating station. The first side 413 is located on the right side of the operating station of the particle analyzer 100, and the second side 414 is located directly opposite the operating station. The first side 413 and the liquid circuit module 30 arranged on the first side 413 are located on the right side of the operating station, and the second side 414 and the sample loading module 10 arranged on the second side 414 are located directly opposite the operating station of the particle analyzer 100. The position setting of the operating station and the first side 413 and the second side 414 can shorten the distance between the operator and the sample loading module 10 and the liquid circuit module 30, which is more convenient for the operator to operate.

[0033] In this example, see Figure 1 The top surface 411, the bottom surface 412, the first side surface 413 and the fourth side surface 416 form an inspection port, and the inspection port is connected to the accommodating cavity 417. The third side surface 415 is detachably connected to the top surface 411, the bottom surface 412, the first side surface 413 and the fourth side surface 416. The third side surface 415 can close or open the inspection port. The installer can enter the shell 41 through the inspection port to install and debug the circuit system of the particle analyzer 100, which is convenient for preliminary installation and subsequent maintenance.

[0034] In one embodiment, please refer to Figure 1 The housing 41 may further include a first connecting plate 418 and a second connecting plate 419, wherein the first connecting plate 418 is connected to the second side 414, and the first connecting plate 418 may improve the structural performance of the second side 414. The first connecting plate 418 is located between the liquid circuit module 30 and the sample loading module 10, and the first connecting plate 418 may ensure the independence of the liquid circuit module 30 and the sample loading module 10, and avoid one of them being affected by the other, thereby improving the safety of use. The first connecting plate 418 is provided with a first connecting hole 441, and the pipeline 32 is arranged in the first connecting hole 441. The pipeline 32 may connect the negative pressure source 31 of the liquid circuit module 30 and the detection chamber 22, and the first connecting hole 441 ensures that the pipeline 32 can be smoothly connected. In addition, the adjacent arrangement of the liquid circuit module 30 and the sample loading module 10 may shorten the length of the pipeline 32, and is conducive to the layout of the pipeline 32, further reducing the cost.

[0035] The second connecting plate 419 is connected to the top surface 411, and the second connecting plate 419 can improve the structural performance of the top surface 411. The second connecting plate 419 is located between the liquid circuit module 30 and the optical module 20. The second connecting plate 419 can ensure the independence of the liquid circuit module 30 and the optical module 20, avoid one of them being affected by the other, and improve the safety of use. The second connecting plate 419 is provided with a second connecting hole 442, and the liquid circuit module 30 may include a flow meter 39, the flow meter 39 is penetrated in the second connecting hole 442, and one end of the flow meter 39 is connected to the detection chamber 22, and the other end is connected to the sample loading module 10. The flow meter 39 can detect the flow value and other parameters of the sample flowing into the detection chamber 22 for subsequent calculation. The second connecting hole 442 can fix the flow meter 39 to prevent the flow meter 39 from falling off. The flow meter 39 of the liquid circuit module 30 connects the liquid circuit module 30 and the optical module 20 to complete the monitoring of the sample flow and ensure the liquid circuit connection between the two. Furthermore, the adjacent arrangement of the liquid circuit module 30 and the optical module 20 can shorten the length of the pipeline 32 and facilitate the layout of the pipeline 32, thereby further reducing costs.

[0036] It is understandable that the first connecting plate 418 and the second side surface 414 can be configured to be integrally formed, and / or the second connecting plate 419 and the top surface 411 can be configured to be integrally formed, and this configuration can further improve the stability of the structure of the particle analyzer 100.

[0037] Please continue reading Figure 2 , the power supply device 42 is arranged on the bottom surface 412, the optical module 20 can be installed on the top surface 411 and located outside the housing 41, the sample loading module 10 is installed on the second side surface 414 and located outside the housing 41, and the liquid circuit module 30 is installed on the first side surface 413 and located outside the housing 41. The way in which the optical module, the sample loading module 10 and the liquid circuit module 30 are installed or fixed to the housing 41 can shorten the distance between the optical module, the sample loading module 10 and the liquid circuit module 30 and the power supply device 42, shorten the length of the cable, ensure the cleanliness of the power supply device 42, and reduce the loss of signal transmission, electrical transmission, etc.

[0038] In this example, see Figure 3, the power supply device 42 can supply power to the optical module 20, the sample loading module 10 and the liquid circuit module 30, and the power supply device 42 can convert AC power such as mains electricity into DC power for subsequent use. In addition, the power supply device 42 can also adjust the current parameters so that it can meet the use requirements. Specifically, the power supply device 42 may include but is not limited to a transformer, a rectifier circuit, a filter circuit, a voltage stabilizing circuit and a protection circuit, etc. The transformer can be used to convert the input AC power into a suitable voltage. The rectifier circuit can convert AC power into DC power. The filter circuit can filter out clutter and interference in the DC power to make the current more stable. The voltage stabilizing circuit can maintain the stability of the output voltage to prevent damage to the particle analyzer 100 due to voltage fluctuations. The protection circuit can automatically cut off the power supply when the voltage of the particle analyzer 100 is too high, too low or the current is too large to protect it from damage.

[0039] In one embodiment, please refer to Figure 3 The power supply device 42 can supply power to the optical module 20, the sample loading module 10, and the liquid circuit module 30 through the circuit board 43, thereby reducing the length of cables used and ensuring that the interior of the electrical module 40 is clean. In addition, the circuit board 43 can control the working states of the optical module 20, the sample loading module 10, and the liquid circuit module 30. The optical module 20 can transmit the detected fluorescence information to the circuit board 43 for subsequent calculation and analysis by the circuit board 43.

[0040] It is understandable that the power supply device 42 can also directly supply power to the optical module 20, the sample loading module 10 and the liquid circuit module 30 to avoid excessive current load on the circuit board 43, reduce the heat generated by the circuit board 43, and improve the safety of the circuit board 43.

[0041] Please continue reading Figure 1 The sample loading module 10 may include a sample loading component 11 and a fixing frame 12. The fixing frame 12 is used to carry the sample tube 51. The sample loading component 11 may be installed or disposed adjacent to the second side surface 414. This arrangement may also prevent numerous cables from interfering with the movement of the sample loading needle when the sample loading component 11 is working, and may also prevent the sample from leaking and directly contacting the cable when the sample tube 51 is placed. The fixing frame 12 may be a multi-well plate, an in-line test tube rack, a disc test tube rack, etc., and may be selected and designed according to the specific sample and the parameters of the sample tube 51. The present embodiment does not limit the structure and size of the fixing frame 12. Specifically, the fixing frame 12 may be provided with a plurality of mounting positions, and the sample tube 51 may be inserted or removed from the mounting positions to achieve the placement of the sample tube 51.

[0042] It is understandable that the sample tube 51 is provided with a sample, and the sample can be made into a single cell suspension through the specimen to be tested, and then dyed with a specific fluorescent dye and placed in the sample tube 51. Different forms or types of samples can be configured according to the specific type of the specimen to be tested, and this embodiment is not limited.

[0043] The sample loading component 11 is used to collect samples in the sample tube 51. The sample loading component 11 can absorb the sample of the sample tube 51, and the sample is used for subsequent optical module 20 to detect information. In one embodiment, the sample loading component 11 may include a sample loading needle (not shown in the figure) and a driving member (not shown in the figure), etc. The driving member can drive the sample loading needle to move around the fixed frame 12, and drive the sample loading needle to move in or out of the sample tube 51. Specifically, the driving member can drive the sample loading needle to move to a specified position, and the specified position can be a relative position of a certain installation position. And when the sample loading needle is arranged relative to the specified sample tube 51, the driving member can also drive the sample loading needle to move in a direction parallel or colinear with the axis of the sample tube 51, so that the sample loading needle is inserted or removed from the sample tube 51, and then the sample loading needle can absorb the sample in the sample tube 51.

[0044] See also Figure 2 , the optical module 20 may include an optical detection device 21 and a detection chamber 22, and the optical detection device 21 and the detection chamber 22 may be installed on the top surface 411. More specifically, the cables of the optical detection device 21 may directly pass through the top surface 411 to the inside of the power supply device 42, which can reduce the length of the exposed cables in the optical module and further improve safety. The detection chamber 22 can be connected to the sample loading module 10 through the liquid path module 30 so that the sample can flow through the detection chamber 22. The optical detection device 21 is used to obtain information about the sample in the detection chamber 22, and transmit the sample information to the electronic device through wired transmission or wireless transmission. Among them, the electronic device includes but is not limited to computers, mobile devices, display screens, etc.

[0045] Specifically, the optical detection device 21 may include a front optical path system 211 and a rear optical path system 212, etc., and the detection chamber 22 may be arranged between the front optical path system 211 and the rear optical path system 212. The front optical path system 211 may include one or more laser generators, etc., and the front optical path system 211 may control the detection light such as laser to be emitted into the detection chamber 22. Under the pressure of the gas, the sample enters the sheath liquid, and the sheath liquid may be pre-stored in the liquid path module 30 or transmitted from the outside. Among them, the sheath liquid may be a balanced electrolyte solution without a fluorescent background, and the sheath liquid includes but is not limited to sodium chloride, potassium chloride, disodium ethylenediaminetetraacetic acid and antibacterial agents. The detection chamber 22 has a nozzle. When the pressure difference between the sheath liquid pressure and the sample pressure reaches a certain level, the cells in the sample are arranged in a single row and ejected from the nozzle under the constraint of the sheath liquid, and the nozzle can form a stable liquid flow. In addition, the liquid flow passes through the detection light focusing area of ​​the detection chamber 22, and the cells stained with specific fluorescent dyes are excited by the laser to produce fluorescence of a specific wavelength. The rear optical path system 212 may include an optical collection device, and the rear optical path system 212 can collect the fluorescence information. In addition, the rear optical path system 212 also includes optical components, including but not limited to lenses, apertures, filters, etc. The fluorescence information can be adjusted by the optical components for subsequent more accurate calculation and analysis.

[0046] In one embodiment, a flow cell (not shown in the figure) is provided in the detection chamber 22, and the flow cell can enable the cell suspension to flow in the detection chamber 22 and pass through a narrow channel so that the sample cells can be arranged and flowed in a single line. Then, each sample cell can pass through the detection light beam in turn, so as to be detected and analyzed by the particle analyzer 100. The design of the flow cell can also ensure that the sample cells maintain a stable flow speed and direction during the flow process, thereby avoiding confusion or aggregation of the sample cells in the detection chamber 22, which affects the accuracy of the detection results.

[0047] In this example, see Figure 5 as well as Figure 6 The liquid circuit module 30 may include a negative pressure source 31 and a pipeline 32. The negative pressure source 31 may be installed in the second side 414. The pipeline 32 connects the sample loading component 11, the negative pressure source 31 and the detection chamber 22. The negative pressure source 31 is used to provide power for the sample to flow. The negative pressure source 31 may be a plunger pump, a pressure pump, a negative pressure tank, etc. For example, Figure 6 As shown, Figure 6A partial schematic diagram of the liquid circuit structure of the particle analyzer 100 is shown, which is a schematic diagram of the flow structure of the sample and / or sheath liquid in the particle analyzer 100. Furthermore, the liquid circuit module 30 may also include a sheath liquid bottle 35 and a sheath liquid pump 36. The sheath liquid bottle 35 may be used to store the sheath liquid, and the sheath liquid in the sheath liquid bottle 35 may also be driven into the detection chamber 22 by the sheath liquid pump 36. At the same time, driven by the driving member, the sample loading needle is inserted into the sample tube 51, the negative pressure source 31 works to generate negative pressure, the sample is sucked into the detection chamber 22 and mixed with the sheath liquid, and the sample after mixing with the sheath liquid can be provided for optical detection by the optical module 20.

[0048] In one embodiment, see Figure 5 as well as Figure 6 The liquid circuit module 30 may also include a cleaning liquid bottle 37 and a waste liquid bottle 38. The cleaning liquid bottle 37 stores cleaning liquid, and the cleaning liquid is driven to flow through the detection chamber 22 and the sample loading needle to complete the cleaning of the detection chamber 22 and the sample loading needle. Among them, the sample loading component 11 may also be configured with a swab (not shown in the figure) for cleaning the sample loading needle. The cleaning liquid is driven to flow into the swab, and the sample loading needle can be placed in the swab to complete the cleaning. At the same time, the waste liquid generated by the detection or cleaning of the particle analyzer 100 is driven to flow into the waste liquid bottle 38 to ensure the cleanliness of the particle analyzer 100.

[0049] It is understandable that the power for the flow of both the cleaning liquid and the waste liquid can be provided by the negative pressure source 31 or other separately configured pump bodies and other power sources, which can be selected and designed according to the specific implementation method, and this embodiment does not limit it.

[0050] In another embodiment, the liquid circuit module 30 may further include a liquid inlet 33 and a liquid outlet 34, and the liquid inlet 33 and the liquid outlet 34 may be disposed on a side of the negative pressure source 31 away from the sample loading assembly 11. The liquid inlet 33 and the liquid outlet 34 may be provided for fluid medium to flow into or out of the particle analyzer 100, and the fluid medium includes but is not limited to sheath fluid, waste liquid, cleaning liquid, etc., so as to improve the use efficiency of the particle analyzer 100.

[0051] In this example, see Figure 3 as well as Figure 7 , Figure 7A schematic diagram of the power structure of the particle analyzer 100 is shown, and the power structure is the transmission structure of the current and / or signal in the particle analyzer 100. The circuit board 43 may include a first circuit board 431 and a second circuit board 432, and the first circuit board 431 and the second circuit board 432 may be electrically connected to each other. The first circuit board 431 is electrically connected to the sample loading component 11, the negative pressure source 31 and the power supply device 42, the first circuit board 431 is fixed to the first side 413, and the first circuit board 431 corresponds to the negative pressure source 31. The way in which the first circuit board 431 is opposite to the negative pressure source 31 can further shorten the connection distance between the two to ensure the connection effect between the first circuit board 431 and the negative pressure source 31.

[0052] For details, please refer to Figure 2 as well as Figure 5 The first side surface 413 is provided with a mounting hole 4131. It is understandable that in order to facilitate observation of the specific structure of the mounting hole 4131, Figure 2 Only a partial schematic diagram of the liquid circuit module 30 is shown. The liquid circuit module 30 also includes a connector (not shown in the figure), which is installed in the mounting hole 4131, one end of which extends into the housing 41 and is electrically connected to the second circuit board 432, and the other end extends to the negative pressure source 31 and is electrically connected to the negative pressure source 31. The connector connects the negative pressure source 31 and the first circuit board 431, and the negative pressure source 31 can be fixed by the connector to ensure the installation effect of the negative pressure source 31, so that the connector can not only realize the electrical connection between the negative pressure source 31 and the first circuit board 431, but also fix the negative pressure source 31 and the first circuit board 431, thereby improving the structural stability.

[0053] See also Figure 1 as well as Figure 2 , the second circuit board 432 is fixed to the fourth side surface 416, and the second circuit board 432 is electrically connected to the optical detection device 21 and the power supply device 42. Because the first side surface 413 is adjacent to the bottom surface 412 and the fourth side surface 416, the first circuit board 431 is adjacent to the power supply device 42 arranged on the bottom surface 412 and the second circuit board 432 arranged on the fourth side surface 416, which facilitates the first circuit board 431 to connect the power supply device 42 and the second circuit board 432, ensures the connection effect, and improves the installation efficiency. In addition, the fourth side surface 416 is adjacent to the bottom surface 412, which facilitates the second circuit board 432 to be electrically connected to the power supply device 42 to ensure the normal power supply of the second circuit board 432. The top surface 411 is provided with a through groove 4111, Figure 2The structure of the through slot 4111 is conveniently referred to in the figure, and the fourth side 416 is not shown. It is understandable that the through slot 4111 can be a notch arranged in the top surface 411 and adjacent to the fourth side 416. The through slot 4111 can be selected and designed according to specific implementation requirements. For example, the through slot 4111 can also be adjacent to one of the second side 414, the third side 415, etc. In addition, the specific size of the through slot 4111 can be selected and designed according to the size of the second circuit board 432. The through slot 4111 can be a waist-shaped hole, a square hole, etc., which can be set according to the specific implementation scenario. At least part of the second circuit board 432 passes through the through slot 4111 and is electrically connected to the optical detection device 21. The second circuit board 432 can extend directly into the optical module, which can not only ensure the normal connection between it and the optical detection device 21, but also reduce the cable layout. Furthermore, the through slot 4111 is disposed close to the rear optical path module, which is used to collect sample information. The rear optical path module can directly transmit the sample information to the second circuit board 432, thereby reducing signal loss during transmission and ensuring the integrity of the sample information.

[0054] In one embodiment, see Figure 2 , the optical detection device 21 may also include a third circuit board 213, the third circuit board 213 is installed on the top surface 411, the optical detection device 21 is electrically connected to the third circuit board 213, and the third circuit board 213 can be used for power supply and control of the optical detection device 21. Further, the third circuit board 213 can be electrically connected to the front optical path module and the rear optical path module of the optical detection device 21, which can control the front optical path module to emit detection light, and control the rear optical path module to obtain sample information. The third circuit board 213 is adjacent to the through groove 4111 of the top surface 411, the second circuit board 432 is provided with a first plug-in connector, and the third circuit board 213 is provided with a second plug-in connector, and the first plug-in connector is plugged with the second plug-in connector. The first plug-in connector and the second plug-in connector cooperate with each other. For example, the first plug-in connector can be a socket, and the second plug-in connector can be a corresponding plug, so that the second circuit board 432 and the third circuit board 213 can be stably connected, reduce the exposure of the line, and ensure its safe use. In addition, the number of the first plug-in connector and the second plug-in connector can be one or more, which can be set according to specific connection needs.

[0055] Preferably, the second circuit board 432 can be detachably connected to the third circuit board 213 or the top surface 411, for example, the second circuit board 432 can be threadedly connected to the third circuit board 213 to ensure the installation effect of the second circuit board 432 and prevent the second circuit board 432 from detaching due to vibration or the like.

[0056] It is understandable that the optical detection device 21, the sample loading component 11 and the negative pressure source 31 need to be powered by the power supply device 42. The optical module 20, the sample loading module 10 and the liquid circuit module 30 are arranged around the power supply device 42, which can shorten the length of the cable, facilitate the internal cable layout, and improve neatness. At the same time, the negative pressure source 31 is connected to the sample loading component 11 and the detection chamber 22 through the pipeline 32. The sample loading module 10 and the optical module 20 are arranged around the liquid circuit module 30, which can shorten the length of the pipeline 32 and avoid the pipeline 32 occupying a large amount of space. This layout method is conducive to improving the integration of the particle analyzer 100, reducing costs, reducing the volume of the particle analyzer 100, and increasing its scope of application.

[0057] In the particle analyzer 100 provided in this embodiment, the negative pressure source 31 of the liquid circuit module 30 provides power, the sample loading module 10 can collect samples from the sample tube 51, the samples are transmitted to the optical module 20 along the pipeline 32, and then the samples are detected by the optical detection device 21 of the optical module 20, the power supply device 42 of the electrical module 40 supplies power to the negative pressure source 31, the sample loading component 11 and the optical detection device 21, and the circuit board 43 can control the operation of the negative pressure source 31, the sample loading component 11 and the optical detection device 21. The sample loading module 10, the optical module 20, the liquid circuit module 30 and the electrical module 40 are independently arranged, which can refine the structure of the particle analyzer 100, simplify its internal layout, and facilitate the debugging and installation of the particle analyzer 100. In addition, the sample loading module 10, the optical module 20 and the liquid path module 30 transmit samples through the pipeline 32, and the electrical module 40 is independently arranged outside the pipeline 32 to achieve isolation between power supply and sample transmission, avoid sample leakage and damage to the electrical module 40, and improve the safety of the particle analyzer 100.

[0058] The above implementation modes are only used to illustrate the technical solutions of the present application, rather than to limit them. Although the present application has been described in detail with reference to the aforementioned implementation modes, a person skilled in the art should understand that the technical solutions described in the aforementioned implementation modes can still be modified, or some of the technical features can be replaced by equivalents. These modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various implementation modes of the present application, and should all be included in the protection scope of the present application.

Claims

1. A particle analyzer, characterized in that: include: A sample loading module, the sample loading module is used to collect samples in the sample tube; An optical module, the optical module comprising an optical detection device and a detection chamber, the optical detection device being used to obtain information of a sample in the detection chamber; A liquid circuit module, the liquid circuit module comprising a negative pressure source and a pipeline, the pipeline connecting the sample loading module, the detection chamber and the negative pressure source, the negative pressure source providing power for the sample to flow; as well as An electrical module, the electrical module includes a shell, a power supply device and a circuit board, the power supply device and the circuit board are installed in the shell, and the circuit board is electrically connected to the power supply device, the sample loading module, the negative pressure source and the optical detection device.

2. The particle analyzer according to claim 1, characterized in that The shell includes a top surface, a bottom surface, and a first side surface, a second side surface, a third side surface, and a fourth side surface arranged between the top surface and the bottom surface, the first side surface and the third side surface are arranged opposite to each other, the second side surface and the fourth side surface are arranged opposite to each other, the optical module is installed on the outside of the top surface, the liquid path module is installed on the outside of the first side surface, and the sample loading module is installed on the outside of the second side surface.

3. The particle analyzer according to claim 2, characterized in that The first side surface is located directly opposite to an operating station of the particle analyzer, and the second side surface is located on the right side of the operating station.

4. The particle analyzer according to claim 2, characterized in that The first side surface is located on the right side of an operating station of the particle analyzer, and the second side surface is located directly opposite to the operating station.

5. The particle analyzer according to claim 2, characterized in that: The shell also includes a second connecting plate, which is connected to the top surface, and the second connecting plate is located between the liquid circuit module and the optical module. The second connecting plate is provided with a second connecting hole. The liquid circuit module includes a flow meter, and the flow meter is passed through the second connecting hole. One end of the flow meter is connected to the detection chamber, and the other end is connected to the sample loading module.

6. The particle analyzer according to claim 2, characterized in that: The circuit board includes a first circuit board and a second circuit board. The first circuit board is fixed to the first side and corresponds to the negative pressure source. The first circuit board is electrically connected to the sample loading module, the negative pressure source and the power supply device. The second circuit board is fixed to the fourth side and is electrically connected to the optical detection device and the power supply device.

7. The particle analyzer according to claim 6, characterized in that The top surface is provided with a through slot, and at least a portion of the second circuit board passes through the through slot and is electrically connected to the optical detection device.

8. The particle analyzer according to claim 6, characterized in that The optical detection device also includes a third circuit board, which is installed on the top surface. The optical detection device is electrically connected to the third circuit board. The second circuit board is provided with a first connector, and the third circuit board is provided with a second connector. The first connector is plugged into the second connector.

9. The particle analyzer according to claim 2, characterized in that: The shell also includes a first connecting plate, the first connecting plate is connected to the second side surface, the first connecting plate is located between the liquid path module and the sample loading module, the first connecting plate is provided with a first connecting hole, and the pipeline is passed through the first connecting hole.

10. The particle analyzer according to claim 9, characterized in that The liquid circuit module is also provided with a liquid inlet and a liquid outlet, and the pipeline is connected with the liquid inlet and the liquid outlet.

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