Novel freezing and thawing system

Abstract

The utility model discloses a novel freezing and thawing system, which comprises a freezing and thawing bag and a container body which can be combined for use, the freezing and thawing bag can be of a three-dimensional structure after liquid filling is completed, the container body comprises an upper cover and a lower cover which can be buckled with each other, and a cavity for accommodating the freezing and thawing bag can be formed after the upper cover and the lower cover are buckled with each other. An upper bottom plate and a lower bottom plate are correspondingly arranged in the middle of the upper cover and the middle of the lower cover respectively, an upper side edge and a lower side edge are arranged along the side length of the upper bottom plate and the side length of the lower bottom plate, a first dip angle is formed between the upper side edge and the upper bottom plate, and a second dip angle is formed between the lower side edge and the lower bottom plate. The freezing and thawing bag is arranged in the cavity, so that the cavity is filled with the freezing and thawing bag, and the temperature is uniformly distributed in the freezing process on the premise of ensuring the temperature transfer rate.

Description

Technical Field

[0001] The utility model belongs to the field of disposable consumables, and more specifically relates to a novel freeze-thaw system. Background Art

[0002] The market demand for freeze-thaw of monoclonal antibodies and protein stock solutions is gradually increasing. During rethawing, the drug solution will recrystallize. The slower the thawing, the more serious the recrystallization, and the protein will be further damaged. In addition, the uneven temperature distribution will also cause different concentrations of drug solution to accumulate at different locations, reducing protein activity. Therefore, the freeze-thaw bag must be able to ensure that the temperature transfer rate is as fast as possible to ensure that the temperature distribution at different locations of the protein is uniform when it is frozen.

[0003] However, currently most flexible bags are used to contain biopharmaceutical liquids. Flexible packaging bags are 2D-shaped and will form an "egg-shaped effect" after freezing, that is, the two sides are low and the middle is high, making the entire freezing process uneven. Utility Model Content

[0004] The main purpose of the utility model is to provide a novel freeze-thaw system which can prevent the "egg-shaped effect" and achieve uniform temperature distribution during the freezing process while ensuring the temperature transfer rate.

[0005] In order to achieve the above object, the technical solution of the utility model is:

[0006] A novel freeze-thaw system comprises a freeze-thaw bag and a container body which can be used in combination. The freeze-thaw bag can present a three-dimensional structure after being filled with liquid. The container body comprises an upper cover and a lower cover which can be buckled with each other. When the upper cover and the lower cover are buckled together, a chamber for accommodating the freeze-thaw bag can be formed. An upper bottom plate and a lower bottom plate are respectively provided in the middle of the upper cover and the lower cover. An upper side edge and a lower side edge are respectively provided along the side lengths of the upper bottom plate and the lower bottom plate. A first inclination angle is provided between the upper side edge and the upper bottom plate, and a second inclination angle is provided between the lower side edge and the lower bottom plate. The upper side edge and the lower side edge can be used to make the freeze-thaw bag close to the inner wall of the chamber after being filled with liquid.

[0007] In a specific embodiment of the present invention, the first inclination angle and the second inclination angle are both between 45° and 75°.

[0008] In a specific embodiment of the present invention, the size of the freeze-thaw bag is smaller than the size of the chamber.

[0009] In a specific embodiment of the present invention, the freeze-thaw bag is a flexible material component.

[0010] In a specific embodiment of the present invention, at least two buckles are respectively provided on both sides of the upper cover and the lower cover, and the upper cover and the lower cover can be connected via the buckles.

[0011] In a specific embodiment of the present invention, it further comprises a frame for fixing the upper cover and the lower cover, wherein the frame comprises an upper outer frame and a lower outer frame detachably connected to the upper outer frame.

[0012] In a specific embodiment of the present invention, the edges of the upper cover and the lower cover can be fitted together under the action of the upper outer frame and the lower outer frame.

[0013] In a specific embodiment of the present invention, after the upper cover and the lower cover are buckled together, a channel for accommodating the freeze-thaw bag pipeline can be formed in the chamber.

[0014] In a specific embodiment of the present invention, a first groove is respectively provided at a connection between the upper side and the upper base plate, and a second groove is respectively provided at a connection between the lower side and the lower base plate.

[0015] One of the above technical solutions of the utility model has at least one of the following advantages or beneficial effects:

[0016] The utility model arranges an upper bottom plate and a lower bottom plate respectively in the middle of the upper cover and the lower cover, and arranges an upper side edge and a lower side edge along the side lengths of the upper bottom plate and the lower bottom plate respectively, and further arranges a first inclination angle between the upper side edge and the upper bottom plate, and a second inclination angle between the lower side edge and the lower bottom plate. Therefore, after the freeze-thaw bag is filled with liquid, it can be tightly attached to the inner wall of the chamber, thereby ensuring that the chamber is filled with the freeze-thaw bag, and then under the premise of ensuring the temperature transfer rate, the temperature is evenly distributed during the freezing process. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The present invention will be further described below in conjunction with the accompanying drawings and embodiments;

[0018] Attached Figure 1 This is a structural diagram of a container body according to an embodiment of the utility model;

[0019] Attached Figure 2 An exploded view of an embodiment of the utility model;

[0020] Attached Figure 3 This is an overall structural diagram of an embodiment of the utility model;

[0021] Attached Figure 4 This is a front view of a container body according to an embodiment of the present utility model. DETAILED DESCRIPTION

[0022] The embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals represent the same or similar elements or elements having the same or similar functions from beginning to end. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0023] In the description of the present invention, it should be understood that descriptions involving orientation, such as up, down, front, back, left, right, etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0024] In the description of the present utility model, "several" means one or more, "more" means more than two, "greater than", "less than", "exceed" etc. are understood to exclude the number itself, and "above", "below", "within" etc. are understood to include the number itself. If there is a description of "first" or "second", it is only used for the purpose of distinguishing the technical features, and cannot be understood as indicating or implying the relative importance or implicitly indicating the number of the indicated technical features or implicitly indicating the order of the indicated technical features.

[0025] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, the features defined as "first" and "second" may explicitly or implicitly include one or more features.

[0026] In the description of the present utility model, it should be noted that, unless otherwise clearly stipulated and limited, the term "connection" should be understood in a broad sense. For example, it can be a fixed connection or a movable connection, a detachable connection or a non-detachable connection, or an integral connection; it can be a mechanical connection, an electrical connection, or mutual communication; it can be a direct connection, or an indirect connection through an intermediate medium, and it can be internal connection between two elements, indirect connection, or an interactive relationship between two elements.

[0027] The following disclosure provides many different embodiments or examples for implementing different solutions of the present invention.

[0028] Refer to the attached Figure 1 To Attachment Figure 4 As shown, a novel freeze-thaw system includes a freeze-thaw bag, a container body 1 and a frame 7 that can be used in combination, wherein the container body 1 includes an upper cover and a lower cover that can be buckled together, and the upper cover and the lower cover can form a chamber for accommodating the freeze-thaw bag when buckled together, and a channel for accommodating the freeze-thaw bag pipeline can be formed in the chamber.

[0029] In an embodiment of the utility model, two buckles 6 are respectively provided on both sides of the upper cover and the lower cover, and the upper cover and the lower cover can be connected by the buckles 6, or the upper cover and the lower cover can be assembled together by interference fit.

[0030] In one embodiment of the utility model, the freeze-thaw bag is a flexible material component, and the freeze-thaw bag can present a three-dimensional structure after being filled with liquid. The length and width of the freeze-thaw bag are determined according to the length and width of the chamber. The length and width of the freeze-thaw bag are set to be less than or equal to the internal dimensions of the chamber, and the height of the freeze-thaw bag after being filled with liquid is consistent with the height inside the chamber.

[0031] In one embodiment of the utility model, an upper bottom plate 2 and a lower bottom plate 3 are respectively provided in the middle of the upper cover and the lower cover, and an upper side edge 4 and a lower side edge 5 are respectively provided along the side lengths of the upper bottom plate 2 and the lower bottom plate 3, a first inclination angle is provided between the upper side edge 4 and the upper bottom plate 2, and a second inclination angle is provided between the lower side edge 5 and the lower bottom plate 3.

[0032] In one embodiment of the utility model, the first inclination angle and the second inclination angle are both set between 45° and 75°, so that after the freeze-thaw bag is filled with liquid, its two side parts will also present a certain inclination angle, and then the freeze-thaw bag can be tightly attached to the inner wall of the chamber through the upper side 4 and the lower side 5 after filling with liquid, ensuring that the chamber is filled with the freeze-thaw bag, and then under the premise of ensuring the temperature transfer rate, the occurrence of the "egg-shaped effect" is effectively avoided, so that the temperature is evenly distributed during the freezing process.

[0033] In one embodiment of the utility model, the frame 7 is used to fix the upper cover and the lower cover. The frame 7 includes an upper outer frame 71 and a lower outer frame 72 detachably connected to the upper outer frame 71 . The edges of the upper cover and the lower cover can be fitted together under the action of the upper outer frame 71 and the lower outer frame 72 .

[0034] In one embodiment of the utility model, a first groove is provided at the connection between the upper side 4 and the upper bottom plate 2, and a second groove 8 is provided at the connection between the lower side 5 and the lower bottom plate 3, so as to further increase the contact area with the freeze-thaw bag and ensure the temperature transfer rate.

[0035] Although the embodiments of the present invention have been shown and described, those skilled in the art will appreciate that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the claims and their equivalents.

Claims

1. A novel freeze-thaw system, characterized in that: The invention comprises a freeze-thaw bag and a container body (1) which can be used in combination. The freeze-thaw bag can present a three-dimensional structure after being filled with liquid. The container body (1) comprises an upper cover and a lower cover which can be buckled with each other. When the upper cover and the lower cover are buckled with each other, a chamber for accommodating the freeze-thaw bag can be formed. An upper bottom plate (2) and a lower bottom plate (3) are respectively provided in the middle of the upper cover and the lower cover. An upper side edge (4) and a lower side edge (5) are respectively provided along the side lengths of the upper bottom plate (2) and the lower bottom plate (3). A first inclination angle is provided between the upper side edge (4) and the upper bottom plate (2), and a second inclination angle is provided between the lower side edge (5) and the lower bottom plate (3). The upper side edge (4) and the lower side edge (5) can make the freeze-thaw bag closely attached to the inner wall of the chamber after being filled with liquid.

2. The novel freeze-thaw system according to claim 1, characterized in that: The first inclination angle and the second inclination angle are both between 45° and 75°.

3. The novel freeze-thaw system according to claim 1, characterized in that: The size of the freeze-thaw bag is smaller than the size of the chamber.

4. The novel freeze-thaw system according to claim 3, characterized in that: The freeze-thaw bag is a flexible material component.

5. The novel freeze-thaw system according to claim 1, characterized in that: At least two buckles (6) are respectively provided on both sides of the upper cover and the lower cover, and the upper cover and the lower cover can be connected via the buckles (6).

6. The novel freeze-thaw system according to claim 1, characterized in that: It also comprises a frame (7) for fixing the upper cover and the lower cover, wherein the frame (7) comprises an upper outer frame (71) and a lower outer frame (72) detachably connected to the upper outer frame (71).

7. The novel freeze-thaw system according to claim 6, characterized in that: The edges of the upper cover and the lower cover can be fitted together under the action of the upper outer frame (71) and the lower outer frame (72).

8. The novel freeze-thaw system according to claim 1, characterized in that: After the upper cover and the lower cover are buckled together, a channel for accommodating the freeze-thaw bag pipeline can be formed in the chamber.

9. The novel freeze-thaw system according to claim 1, characterized in that: A first groove is provided at the connection between the upper side edge (4) and the upper bottom plate (2), and a second groove (8) is provided at the connection between the lower side edge (5) and the lower bottom plate (3).

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