Compression and decompression integrated chromatographic column easy to disassemble
By designing an easily disassembled integrated chromatography column with pressure reduction, the problems of traditional chromatography columns being difficult to disassemble, the lower part of the column is easily damaged, and the pressure reduction in pressure is inconvenient, achieving more efficient experimental operation and maintenance.
Patent Information
- Application Number
- CN202421829932.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-07-31
- Publication Date
- 2025-05-06
- Estimated Expiration
- 2034-07-31
AI Technical Summary
Traditional kg-grade glass chromatography column packing is not easy to disassemble, the finer lower part of the column is easily damaged and difficult to repair, and the pressure and pressure reduction during operation are inconvenient.
An easy-to-disassemble integrated chromatography column is designed, adopting a split design, including a column, an upper cover and a fixing ring. The upper cover and the column are fixed by a fixing ring and a fixing sheet to achieve pressurization and decompression functions, and a pressure reducing head is designed at the lower part of the column.
The design of a larger opening on the upper part of the chromatography column is realized, which is convenient for packing disassembly; the finer parts of the lower part of the column are easy to replace and repair; the pressure and pressure reduction operations are more convenient, improving the efficiency and reliability of experimental operations.
Smart Images
Figure CN222829108U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of chromatography columns, in particular to an easily disassembled pressure-increasing and pressure-reducing integrated chromatography column. Background Art
[0002] Traditional kilogram-level glass chromatography columns often face the following problems: the packing is difficult to disassemble, the thinner part at the bottom of the column is easy to damage and difficult to repair, and the pressurization and decompression operations are inconvenient, etc. These problems seriously affect the effective use of chromatography columns in laboratory and industrial applications.
[0003] The upper opening of traditional chromatography columns is small, which makes it difficult to remove the packing, increasing the time and cost of maintenance and replacement of packing. The lower part of the column of traditional chromatography columns is thinner. Once damaged, the entire column usually needs to be replaced, which is costly and complicated to operate. The decompression column function of traditional chromatography columns in experimental operations is unclear or difficult to achieve, affecting the efficiency and reliability of experimental operations. Utility Model Content
[0004] In response to the above technical problems, the present application solves the problems that the traditional chromatography column packing is difficult to disassemble, the thinner part at the bottom of the column is easy to be damaged and difficult to repair, and the pressurization and decompression operations during operation are inconvenient.
[0005] In order to achieve the above-mentioned purpose, the technical solution adopted in the present application is: an easily detachable integrated pressure-induction and pressure-reduction chromatography column, comprising a column body, an upper cover and a fixing ring, wherein a plurality of fixing plates are fixedly installed on the fixing ring, the upper cover is slidably connected to the column body, and the connection between the column body and the upper cover is fixed by a plurality of fixing plates, a pressurizing tee is slidably connected to the upper cover, a pressure-reducing head is slidably connected to the column, and ground joints are arranged on the column body, the pressurizing tee and the pressure-reducing head.
[0006] Preferably, the pressurizing tee is rotatably connected to an upper valve, and the upper valve is provided with a handle and a through hole.
[0007] Preferably, a pressurizing interface is fixedly connected to the pressurizing tee.
[0008] Preferably, the pressure reducing head is rotatably connected to a lower valve, and the lower valve is provided with a handle and a through hole.
[0009] Preferably, a decompression structure is fixedly connected to the decompression head.
[0010] Preferably, two ends of the fixing plate are bent inwardly to form a trapezoidal structure.
[0011] Preferably, the fixing ring is elastic, a connecting rod is rotatably connected to the fixing ring, a threaded rod is threadedly connected to the connecting rod, a limiting shaft is threadedly connected to the threaded rod, a limiting plate is fixedly installed on the fixing ring, and an arc-shaped notch is provided on the limiting plate.
[0012] Compared with the prior art, the technical solution provided by the utility model has the following beneficial effects:
[0013] 1. Aiming at the shortcoming that the fillers of the traditional kilogram-level glass chromatography columns are difficult to disassemble, the utility model adopts a split design at the upper end of the chromatography column, which is divided into a column body and an upper cover, and is fixed by a fixing ring and a fixing sheet, so that the upper opening of the chromatography column is larger and the fillers are easy to remove.
[0014] 2. The utility model aims at the defects that the thinner part below the column of the traditional kilogram-level glass chromatography column is easy to be damaged and difficult to repair after being damaged. The utility model adopts a split design for the thinner part at the bottom of the chromatography column, so that the thinner part is easy to replace and repair after being damaged, which greatly saves the maintenance cost.
[0015] 3. Aiming at the problem that it is difficult to achieve decompression through the traditional kilogram-level glass chromatography column, the utility model designs a decompression head in the split fittings at the bottom of the chromatography column, realizing the integrated functions of pressurization and decompression, which greatly facilitates the experimental operation. BRIEF DESCRIPTION OF THE DRAWINGS
[0016] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For those skilled in the art, other drawings can be obtained based on these drawings without paying any creative labor.
[0017] Figure 1 It is a schematic diagram of the overall structure of the utility model;
[0018] Figure 2 It is an exploded view of the column of the utility model;
[0019] Figure 3 This is a schematic diagram of the structure of the pressurized tee of the utility model;
[0020] Figure 4 This is a schematic diagram of the structure of the pressure reducing head of the utility model;
[0021] Figure 5 It is a structural schematic diagram of the fixing ring of the utility model;
[0022] In the figure: 101, column; 102, upper cover; 103, pressurizing tee; 104, upper valve; 105, pressurizing interface; 106, pressure reducing head; 107, pressure reducing structure; 108, lower valve; 109, fixing ring; 110, fixing plate; 111, threaded rod; 112, limiting shaft; 113, connecting rod; 114, limiting plate. DETAILED DESCRIPTION
[0023] In order to make the purpose, technical solution and advantages of the embodiments of the present application clearer, the technical solution in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, rather than all the embodiments. The components of the embodiments of the present application described and shown in the drawings here can be arranged and designed in various different configurations.
[0024] Therefore, the following detailed description of the embodiments of the present application provided in the accompanying drawings is not intended to limit the scope of the present application for which protection is sought, but merely represents selected embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in the field without creative work are within the scope of protection of the present application.
[0025] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.
[0026] In the description of this application, it should be noted that if the terms "center", "up", "down", "left", "right", "vertical", "horizontal", "inside", "outside", etc. appear, the orientation or position relationship indicated is based on the orientation or position relationship shown in the drawings, or the orientation or position relationship in which the product of the application is usually placed when in use. It is only for the convenience of describing this application and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore cannot be understood as a limitation on this application. In addition, if the terms "first", "second", etc. appear in the description of this application, they are only used to distinguish the description and cannot be understood as indicating or implying relative importance.
[0027] In addition, if the terms "horizontal" or "vertical" appear in the description of this application, it does not mean that the components are required to be absolutely horizontal or suspended, but can be slightly tilted. For example, "horizontal" only means that its direction is more horizontal than "vertical", and does not mean that the structure must be completely horizontal, but can be slightly tilted.
[0028] In the description of this application, it should also be noted that, unless otherwise clearly specified and limited, the terms "set", "install", "connect", and "connect" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal connection of two components. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.
[0029] Embodiment 1:
[0030] like Figures 1 to 5 As shown, an easily detachable pressure-increasing and pressure-reducing integrated chromatography column comprises a column body 101, an upper cover 102 and a fixing ring 109, a plurality of fixing plates 110 are fixedly mounted on the fixing ring 109, the upper cover 102 is slidably connected to the column body 101, and the connection between the column body 101 and the upper cover 102 is fixed by the plurality of fixing plates 110, a pressurizing tee 103 is slidably connected to the upper cover 102, a pressure-reducing head 106 is slidably connected to the column body 101, and the column body 101, the pressurizing tee 103 and the pressure-reducing head 106 are all provided with ground joints.
[0031] When in use, the upper cover 102 is fixedly mounted on the column 101 through the fixing ring 109 and the fixing sheet 110, and is mounted together through the ground joint on the upper cover 102 and the pressurizing tee 103, and the ground joint improves the stability of the connection between 10 and the pressurizing tee 103 to avoid loosening and ensure the stability of subsequent pressurization. The upper cover 102 is mounted together with the ground joint on the pressure reducing head 106, and the pressure reducing head 106 and the column 101 are provided with fixing hooks, and the fixing hooks on the column 101 and the pressure reducing head 106 are connected by a rubber band, so that the pressure reducing head 106 is fixed on the column 101, and the stability of the connection between the column 101 and the pressure reducing head 106 is ensured by the ground joint and the fixing hook.
[0032] like Figure 3 As shown, the pressurizing three-way valve 103 is rotatably connected to an upper valve 104, and the upper valve 104 is provided with a handle and a through hole.
[0033] The pressurizing tee 103 is fixedly connected with a pressurizing interface 105 .
[0034] The through hole on the upper valve 104 is in the shape of a 90-degree pipe. Figure 3 In the state shown, the two openings of the through hole on the upper valve 104 are oriented at 90 degrees, which is the handle direction of the upper valve 104 and the downward direction. At this time, when pressurizing through the pressurizing interface 105, it cannot be input into the column 101 through the through hole on the upper valve 104. When the upper valve 104 is rotated 90 degrees clockwise, the opening direction of the through hole on the upper valve 104 changes to facing the pressurizing interface 105 and downward, so that at this time, high-pressure gas input through the pressurizing interface 105 can be input into the column 101 through the through hole of the upper valve 104.
[0035] like Figure 4 As shown, the pressure reducing head 106 is rotatably connected to a lower valve 108 , and the lower valve 108 is provided with a handle and a through hole.
[0036] The decompression head 106 is fixedly connected with a decompression structure 107 .
[0037] The through hole on the lower valve 108 is in the shape of a straight through pipe with an angle of 180 degrees. Figure 4 In the state shown, the angle between the two openings of the through hole on the lower valve 108 is 100 to 80 degrees, which is toward the handle of the lower valve 108 and the opposite direction of the handle of the lower valve 108. In the state shown, the upper end and the lower end of the pressure reducing head 106 are not connected, that is, the axis of the through hole of the lower valve 108 and the vertical axis of the pressure reducing head 106 are 90 degrees, so that the pressure reducing head 106 is blocked by the lower valve 108. When the lower valve 108 rotates 90 degrees, the axis of the through hole on the lower valve 108 coincides with the vertical axis of the pressure reducing head 106, and then the upper end and the lower end of the pressure reducing head 106 are connected through the through hole of the lower valve 108, so that the material can fall through the pressure reducing head 106 and the lower valve 108 for collection, and the pressure reducing structure 107 on the pressure reducing head 106 is pressurized to drive the airflow on the column 101 to flow downward, so as to prevent the material from floating in the column 101 when adding the material.
[0038] like Figure 5 As shown, both ends of the fixing plate 110 are bent inward to form a trapezoidal structure.
[0039] The fixing ring 109 is elastic, and a connecting rod 113 is rotatably connected to the fixing ring 109 . A threaded rod 111 is threadedly connected to the connecting rod 113 . A limiting shaft 112 is threadedly connected to the threaded rod 111 . A limiting plate 114 is fixedly installed on the fixing ring 109 , and an arc-shaped notch is provided on the limiting plate 114 .
[0040] like Figure 5 In the state shown, the column 101 and the upper cover 102 are fixed, and the limit shaft 112 is tightly connected with the limit plate 114 through the threaded rod 111, and the limit plate 114 is pushed close to the connecting rod 113, thereby driving the two ends of the fixing ring 109 to approach each other, and then the column 101 and the upper cover 102 are clamped and fixed through the fixing plate 110 on the fixing ring 109.
[0041] When it is necessary to disassemble the column 101 and the upper cover 102, the threaded rod 111 is manually rotated close to one end of the connecting rod 113, so that the threaded rod 111 rotates on the connecting rod 113, and the limiting shaft 112 is driven to move on the threaded rod 111 through the thread, so that the limiting shaft 112 slides on the limiting plate 114, so that the friction between the limiting shaft 112 and the limiting plate 114 is reduced and the limiting shaft 112 is away from the limiting plate 114, thereby canceling the pushing effect of the limiting shaft 112 on the limiting plate 114. As a result, the two ends of the fixing ring 109 are no longer pushed toward each other, so that the two ends of the fixing ring 109 are reset under the action of the elastic force of the fixing ring 109 itself, that is, the two ends of the fixing ring 109 are away from each other, so that the connection between the fixing sheet 110 on the fixing ring 109 and the column 101 and the upper cover 102 is no longer tight, and the effect of clamping and fixing the column 101 and the upper cover 102 is lost. Finally, the upper cover 102 is manually removed from the column 101 to achieve the separation of the column 101 and the upper cover 102.
[0042] Embodiment 2:
[0043] When in use, place absorbent cotton at the lower end of the inner cavity of the column 101, then insert the pressure reducing head 106 at the lower end of the column 101, connect the column 101 and the fixed hook of the pressure reducing head 106 through a rubber band, and then connect the collecting bottle through the ground mouth of the lower end of the pressure reducing head 106. Then turn the lower valve 108 on the pressure reducing head 106, use the pressure reducing structure 107 on the pressure reducing head 106 to evacuate, form pressure reduction on the pressure reducing head 106 and the column 101, thereby driving the airflow on the column 101 to flow downward and flow out through the pressure reducing structure 107, thereby adding silica gel powder filler through the upper end of the column 101, and using the downward airflow to drive the silica gel powder filler to fall, so as to avoid floating in the column 101. Then add the separation material solution and the elution solvent, so that the separation material is adsorbed on the silica gel powder filler, and eluted with the elution solvent, and use the principle that the adsorption and desorption speeds of different components on silica gel are different, so as to achieve the effect of separation and purification. After adding the solvent, insert the upper cover 102 into the upper end of the column 101, and fix the column 101 and the upper cover 102 with a fixing ring 109 and a fixing plate 110, then connect the pressurizing tee 103 to the upper end of the upper cover 102, and turn the upper valve 104 on the pressurizing tee 103, and pressurize through the pressurizing interface 105 on the pressurizing tee 103, so that high-pressure gas is input into the column 101 through the pressurizing interface 105, so that the column 101 is eluted, and the solution is forced to penetrate the absorbent cotton and flow downward, so that the solution passes through the pressure reducing head 106 into the collection bottle for collection, so as to obtain a pure product. After the separation is completed, the chromatography column is removed, and the waste silica gel powder in the column 101 is taken out for waste treatment.
[0044] The above description is only the preferred embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.
Claims
1. An easily disassembled pressure-increasing and pressure-reducing integrated chromatography column, comprising a column body (101), an upper cover (102) and a fixing ring (109), characterized in that: A plurality of fixing plates (110) are fixedly mounted on the fixing ring (109); the upper cover (102) is slidably connected to the column (101); the connection between the column (101) and the upper cover (102) is fixed by the plurality of fixing plates (110); a pressurizing tee (103) is slidably connected to the upper cover (102); a pressure reducing head (106) is slidably connected to the column (101); and ground edges are provided on the column (101), the pressurizing tee (103) and the pressure reducing head (106).
2. The easily detachable pressure-increasing and pressure-reducing integrated chromatography column according to claim 1, characterized in that: The pressurizing three-way valve (103) is rotatably connected to an upper valve (104), and the upper valve (104) is provided with a handle and a through hole.
3. The easily detachable pressure-increasing and pressure-reducing integrated chromatography column according to claim 1, characterized in that: The pressurizing tee (103) is fixedly connected with a pressurizing interface (105).
4. The easily detachable pressure-increasing and pressure-reducing integrated chromatography column according to claim 1, characterized in that: The pressure reducing head (106) is rotatably connected to a lower valve (108), and the lower valve (108) is provided with a handle and a through hole.
5. The easily detachable pressure-increasing and pressure-reducing integrated chromatography column according to claim 1, characterized in that: A decompression structure (107) is fixedly connected to the decompression head (106).
6. The easily detachable pressure-increasing and pressure-reducing integrated chromatography column according to claim 1, characterized in that: Both ends of the fixing plate (110) are bent inwards to form a trapezoidal structure.
7. The easily detachable pressure-increasing and pressure-reducing integrated chromatography column according to claim 1, characterized in that: The fixing ring (109) is elastic, a connecting rod (113) is rotatably connected to the fixing ring (109), a threaded rod (111) is threadedly connected to the connecting rod (113), a limiting shaft (112) is threadedly connected to the threaded rod (111), a limiting plate (114) is fixedly mounted on the fixing ring (109), and an arc-shaped notch is provided on the limiting plate (114).