Ultrafiltration membrane protein pollution detection device

Abstract

The utility model discloses an ultrafiltration membrane protein pollution detection device which comprises an upper cylinder and a lower cylinder, the open end of the upper cylinder is connected to the open end of the lower cylinder, the closed end of the upper cylinder is provided with a liquid inlet, the closed end of the lower cylinder is provided with a liquid outlet, and the liquid outlet is connected with a silicone tube and connected to the liquid inlet of the upper cylinder through the silicone tube. A peristaltic pump is installed on the silicone tube, an ultrafiltration membrane is arranged at the open end of the lower cylinder body, and a connector is arranged on the side wall of the lower cylinder body and located below the ultrafiltration membrane. According to the utility model, the peristaltic pump is used for pumping, so that a protein solution circulates among the upper cylinder body, the lower cylinder body and the silicone tube, the ultrafiltration membrane is used for circularly filtering the protein solution, the protein pollution resistance test of the ultrafiltration membrane is carried out through multiple times of dynamic filtration, the test is close to the use environment of the ultrafiltration membrane, and the pollution resistance of the ultrafiltration membrane can be judged according to the test result.

Description

Technical Field

[0001] The utility model relates to the technical field of ultrafiltration membrane detection, and more specifically to an ultrafiltration membrane protein contamination detection device. Background Art

[0002] Ultrafiltration is a pressurized membrane separation technology, that is, under a certain pressure, small molecular solutes and solvents are allowed to pass through a special membrane with a certain pore size, while large molecular solutes cannot pass through and remain on one side of the membrane, thereby partially purifying the large molecular substances. Ultrafiltration is one of the membrane separation technologies that uses pressure as a driving force, and its purpose is to separate large molecules from small molecules.

[0003] Membrane fouling is an important factor that affects the smooth progress of the ultrafiltration process. Once the membrane is fouled, it will cause the membrane's permeation flux to decrease, causing the membrane to deteriorate, resulting in a series of problems such as shortened membrane service life, increased equipment costs, and reduced product quality. Therefore, it is necessary to conduct a protein fouling resistance test on the membrane to evaluate the membrane's anti-fouling properties, so as to understand the product quality of the membrane. Utility Model Content

[0004] The purpose of the utility model is to overcome the deficiencies of the prior art and provide an ultrafiltration membrane protein contamination detection device.

[0005] In order to achieve the above purpose, the utility model adopts the following technical solutions:

[0006] An ultrafiltration membrane protein contamination detection device comprises an upper cylinder and a lower cylinder, wherein the open end of the upper cylinder is connected to the open end of the lower cylinder, the closed end of the upper cylinder is provided with a liquid inlet, the closed end of the lower cylinder is provided with a liquid outlet, the liquid outlet is connected to a silicone tube and connected to the liquid inlet of the upper cylinder through the silicone tube, a peristaltic pump is installed on the silicone tube, the open end of the lower cylinder is provided with an ultrafiltration membrane, and the side wall of the lower cylinder is provided with an interface, and the interface is located below the ultrafiltration membrane.

[0007] Furthermore, a mounting ring is provided on the inner wall of the open end of the lower cylinder, and a mounting plate for mounting an ultrafiltration membrane is mounted on the mounting ring.

[0008] Furthermore, the ultrafiltration membrane is installed on the upper surface of the mounting plate, a rubber ring is provided on the upper surface of the ultrafiltration membrane, the lower end of the rubber ring abuts the edge of the upper surface of the ultrafiltration membrane, and a retaining ring is provided on the inner wall at the opening end of the upper cylinder, the retaining ring abuts the upper end of the rubber ring.

[0009] Furthermore, a plurality of flow guide grooves are provided on the upper surface of the mounting plate, a through hole is provided on the edge of the mounting plate, and the ultrafiltration membrane abuts against the upper surface of the mounting plate and covers the flow guide grooves and the through holes.

[0010] Furthermore, a first liquid level sensor is installed on the inner wall at the closed end of the upper cylinder, and a second liquid level sensor is installed on the inner wall at the open end of the lower cylinder.

[0011] Furthermore, a funnel is installed on the inner wall at the open end of the lower cylinder, and the funnel is located below the ultrafiltration membrane. The wide end of the funnel faces the open end of the lower cylinder, and the narrow end of the funnel faces the closed end of the lower cylinder.

[0012] Furthermore, the sealing end of the lower cylinder is conical, and the liquid outlet is located at the center of the sealing end of the lower cylinder.

[0013] Furthermore, the open end of the upper cylinder is threadedly connected to the open end of the lower cylinder.

[0014] The beneficial effects of the utility model are:

[0015] 1. In the utility model, the protein solution is circulated between the upper cylinder, the lower cylinder and the silicone tube by a peristaltic pump, and the ultrafiltration membrane performs cyclic filtration on the protein solution. The protein pollution resistance test of the ultrafiltration membrane is carried out through multiple dynamic filtrations, which is close to the use environment of the ultrafiltration membrane. The anti-fouling property of the ultrafiltration membrane can be judged based on the test results.

[0016] 2. In the utility model, a first liquid level sensor is installed on the inner wall at the closed end of the upper cylinder, and the first liquid level sensor is used to monitor the liquid level change of the protein solution in the upper cylinder. When the liquid level is too high, the peristaltic pump is turned off; a second liquid level sensor is installed on the inner wall at the open end of the lower cylinder, and the second liquid level sensor is used to monitor the liquid level of the protein solution in the lower cylinder to prevent the liquid level from being sucked into the vacuum pump due to excessively high liquid level, thereby improving the reliability of detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 A schematic diagram of the structure of the ultrafiltration membrane protein contamination detection device in this embodiment;

[0018] Figure 2 A schematic cross-sectional view of the ultrafiltration membrane protein contamination detection device in this embodiment;

[0019] Figure 3 for Figure 2 Enlarged view of part A in the middle;

[0020] Figure 4 A structural schematic diagram of the upper cylinder in this embodiment;

[0021] Figure 5 A schematic diagram of the structure of the lower cylinder in this embodiment;

[0022] Figure 6 It is a structural schematic diagram of the mounting plate in this embodiment.

[0023] Figure numerals: upper cylinder 1, lower cylinder 2, liquid inlet 3, liquid outlet 4, silicone tube 5, peristaltic pump 6, ultrafiltration membrane 7, interface 8, mounting ring 9, mounting plate 10, rubber ring 11, retaining ring 12, guide groove 13, through hole 14, first liquid level sensor 15, second liquid level sensor 16, funnel 17. DETAILED DESCRIPTION

[0024] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0025] Embodiment: An ultrafiltration membrane protein contamination detection device, such as Figure 1-Figure 6 As shown, it includes an upper cylinder 1 and a lower cylinder 2, both of which are hollow cylindrical structures with one end open and the other end closed. The upper cylinder 1 and the lower cylinder 2 are coaxially arranged, and the open end of the upper cylinder 1 is connected to the open end of the lower cylinder 2. Specifically, the inner wall of the open end of the upper cylinder 1 is provided with an internal thread, and the outer wall of the open end of the lower cylinder 2 is provided with an external thread matched with the internal thread of the upper cylinder 1. The open end of the upper cylinder 1 is connected to the open end of the lower cylinder 2 through a threaded connection of the internal thread and the external thread.

[0026] like Figure 1 , Figure 2 As shown, the closed end of the upper cylinder 1 is provided with a liquid inlet 3 connected to the upper cylinder 1, the closed end of the lower cylinder 2 is provided with a liquid outlet 4 connected to the lower cylinder 2, the liquid outlet 4 is connected with a silicone tube 5, and is connected to the liquid inlet 3 of the upper cylinder 1 through the silicone tube 5, a peristaltic pump 6 is installed on the silicone tube 5, an ultrafiltration membrane 7 is provided at the open end of the lower cylinder 2, and an interface 8 is provided on the side wall of the lower cylinder 2, the interface 8 is used to connect a vacuum extraction device, such as a vacuum pump, and the interface 8 is located below the ultrafiltration membrane 7.

[0027] During use, the vacuum pump is connected to the interface 8, and after a certain amount of protein solution is injected into the lower cylinder 2, the ultrafiltration membrane 7 to be tested is installed on the open end of the lower cylinder 2, and then the upper cylinder 1 and the lower cylinder 2 are connected, and the threaded connection of the internal thread and the external thread is matched to realize the sealing connection of the upper cylinder 1 and the lower cylinder 2 to prevent leakage of the protein solution; then the vacuum pump and the peristaltic pump 6 are turned on, and the vacuum pump is used to discharge the air in the lower cylinder 2 to make the upper and lower pressure difference of the ultrafiltration membrane 7, and the peristaltic pump 6 is used to pump the protein solution, so that the protein solution circulates between the upper cylinder 1, the lower cylinder 2 and the silicone tube 5, and the ultrafiltration membrane 7 performs a circulation filtration on the protein solution. Through multiple dynamic filtrations to carry out the protein pollution resistance test of the ultrafiltration membrane 7, close to the use environment of the ultrafiltration membrane 7, the anti-fouling property of the ultrafiltration membrane 7 can be judged according to the test results.

[0028] Further, such as Figure 2 , Figure 3 and Figure 4 As shown, the inner wall of the open end of the lower cylinder 2 is provided with a mounting ring 9, and the mounting ring 9 is installed with a mounting plate 10. The mounting plate 10 is used to install the ultrafiltration membrane 7, which can support the ultrafiltration membrane 7 and prevent the ultrafiltration membrane 7 from deforming under the filtering pressure.

[0029] like Figure 2 , Figure 3 and Figure 6 As shown, the upper surface of the mounting plate 10 is provided with a plurality of guide grooves 13, and the edge of the mounting plate 10 is provided with through holes 14. When the ultrafiltration membrane 7 is mounted on the upper surface of the mounting plate 10, the ultrafiltration membrane 7 abuts against the upper surface of the mounting plate 10 and covers the guide grooves 13 and the through holes 14. When in use, the protein solution in the upper cylinder 1 is filtered by the ultrafiltration membrane 7 and flows into the guide grooves 13 of the mounting plate 10, and flows from the through holes 14 through the guide grooves 13 to the lower cylinder 2.

[0030] like Figure 2 , Figure 3 As shown, a rubber ring 11 is provided on the upper surface of the ultrafiltration membrane 7, and the lower end of the rubber ring 11 abuts against the edge of the upper surface of the ultrafiltration membrane 7. A retaining ring 12 is provided on the inner wall at the open end of the upper cylinder 1. When the upper cylinder 1 and the lower cylinder 2 are connected, the baffle abuts against the upper end of the rubber ring 11. By providing the rubber ring 11, on the one hand, when the upper cylinder 1 and the lower cylinder 2 are connected, the edge of the ultrafiltration membrane 7 can be pressed by the rubber ring 11 to prevent the edge of the ultrafiltration membrane 7 from warping under the filtration pressure. On the other hand, the sealing performance when the upper cylinder 1 and the lower cylinder 2 are connected can be further improved.

[0031] Further, such as Figure 2As shown, a first liquid level sensor 15 is installed on the inner wall at the closed end of the upper cylinder 1. The first liquid level sensor 15 is used to monitor the liquid level change of the protein solution in the upper cylinder 1. For example, when the liquid level is too high, the peristaltic pump 6 is turned off; a second liquid level sensor 16 is installed on the inner wall at the open end of the lower cylinder 2. The second liquid level sensor 16 is used to monitor the liquid level of the protein solution in the lower cylinder 2 to prevent the liquid level from being too high and being sucked into the vacuum pump.

[0032] A funnel 17 is installed on the inner wall at the open end of the lower cylinder 2, and the funnel 17 is located below the ultrafiltration membrane 7, with the wide end of the funnel 17 facing the open end of the lower cylinder 2 and the narrow end of the funnel 17 facing the closed end of the lower cylinder 2. The funnel 17 is provided to prevent the protein solution from being sucked back.

[0033] Furthermore, the closed end of the lower cylinder 2 is conical, and the liquid outlet 4 is located at the center of the closed end of the lower cylinder 2. With the above design, the closed end of the lower cylinder 2 has a certain flow guiding effect, so as to facilitate the circulation of the protein solution.

[0034] The above is only a preferred embodiment of the present invention. The protection scope of the present invention is not limited to the above embodiments. All technical solutions under the concept of the present invention belong to the protection scope of the present invention. It should be pointed out that for ordinary technicians in this technical field, some improvements and modifications without departing from the principle of the present invention should also be regarded as the protection scope of the present invention.

Claims

1. An ultrafiltration membrane protein contamination detection device, comprising an upper cylinder (1) and a lower cylinder (2), characterized in that: The open end of the upper cylinder (1) is connected to the open end of the lower cylinder (2); the closed end of the upper cylinder (1) is provided with a liquid inlet (3); the closed end of the lower cylinder (2) is provided with a liquid outlet (4); the liquid outlet (4) is connected to a silicone tube (5) and is connected to the liquid inlet (3) of the upper cylinder (1) through the silicone tube (5); a peristaltic pump (6) is installed on the silicone tube (5); the open end of the lower cylinder (2) is provided with an ultrafiltration membrane (7); the side wall of the lower cylinder (2) is provided with an interface (8); the interface (8) is located below the ultrafiltration membrane (7).

2. The ultrafiltration membrane protein contamination detection device according to claim 1, characterized in that: The inner wall of the open end of the lower cylinder (2) is provided with a mounting ring (9), and the mounting ring (9) is provided with a mounting plate (10) for mounting an ultrafiltration membrane (7).

3. The ultrafiltration membrane protein contamination detection device according to claim 2, characterized in that: The ultrafiltration membrane (7) is mounted on the upper surface of the mounting plate (10); a rubber ring (11) is provided on the upper surface of the ultrafiltration membrane (7); the lower end of the rubber ring (11) abuts against the edge of the upper surface of the ultrafiltration membrane (7); a retaining ring (12) is provided on the inner wall at the open end of the upper cylinder (1); the retaining ring (12) abuts against the upper end of the rubber ring (11).

4. The ultrafiltration membrane protein contamination detection device according to claim 2, characterized in that: The upper surface of the mounting plate (10) is provided with a plurality of flow guide grooves (13), the edge of the mounting plate (10) is provided with through holes (14), and the ultrafiltration membrane (7) abuts against the upper surface of the mounting plate (10) and covers the flow guide grooves (13) and the through holes (14).

5. The ultrafiltration membrane protein contamination detection device according to claim 1, characterized in that: A first liquid level sensor (15) is installed on the inner wall at the closed end of the upper cylinder (1), and a second liquid level sensor (16) is installed on the inner wall at the open end of the lower cylinder (2).

6. The ultrafiltration membrane protein contamination detection device according to claim 1, characterized in that: A funnel (17) is installed on the inner wall at the open end of the lower cylinder (2). The funnel (17) is located below the ultrafiltration membrane (7). The wide end of the funnel (17) faces the open end of the lower cylinder (2), and the narrow end of the funnel (17) faces the closed end of the lower cylinder (2).

7. The ultrafiltration membrane protein contamination detection device according to claim 1, characterized in that: The sealing end of the lower cylinder (2) is conical, and the liquid outlet (4) is located at the center of the sealing end of the lower cylinder (2).

8. The ultrafiltration membrane protein contamination detection device according to claim 1, characterized in that: The open end of the upper cylinder (1) is threadedly connected to the open end of the lower cylinder (2).

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