Manual filling equipment for cryopreservation bags

By designing manual filling equipment for frozen storage bags, temperature control and filling are achieved using motors and ice drawers, the problems of temperature control and inefficiency in traditional methods are solved, and cell survival and operating efficiency are improved.

CN222833190UActive Publication Date: 2025-05-06SHENZHEN ZHONGJIA BIOMEDICAL TECH CO LTD
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Patent Information

Application Number
CN202421926619.0
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-08-09
Publication Date
2025-05-06
Estimated Expiration
2034-08-09

AI Technical Summary

Technical Problem

The traditional cell freezing bag filling method has many defects in temperature control, efficiency and cost, resulting in low cell survival rate, affected quality and performance, and high operating efficiency and cost.

Method used

A manual filling equipment for frozen bags was designed, including a sterile bag placement platform and a frozen bag placement platform. Both were equipped with drawers for ice cubes, which were driven by the motor to flip the sterile bag and mix the cell suspension, and fill it with gravity.

Benefits of technology

Effectively maintain the low temperature environment required for cell suspension, improves cell survival rate, simplifies operational processes, saves manpower, improves work efficiency, and reduces operational difficulty and error rate.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model discloses manual filling equipment for cryopreservation bags. The manual filling equipment comprises a sterile bag placing platform, a cryopreservation bag placing platform, a motor and the like. The sterile bag placing platform and the cryopreservation bag placing platform are both of hollow structures, drawers capable of placing ice blocks are arranged on the right sides and connected through a triangular support, and the motor drives the rotary disc and the connecting rod to achieve overturning and even mixing of the sterile bag placing platform. The equipment is provided with a hollow sterile bag placing platform cover, a buckle, a fence and a control panel. During operation, firstly checking, cleaning and disinfecting, adding ice cubes, fixedly placing a sterile bag and a cryopreservation bag, connecting an opening, starting a motor, uniformly mixing, filling by utilizing gravity, and finishing post-treatment. Compared with the prior art, the low-temperature environment can be maintained, the cell survival rate can be improved, operation is easy, manpower is saved, a control panel is easy to control, equipment is small, suitable for the limited environment and convenient to clean and maintain, and filling standardization can be achieved easily.
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Description

Technical Field

[0001] The utility model relates to the field of medical equipment, in particular to a manual filling device for a cryopreservation bag. Background Art

[0002] In the field of cell cryopreservation technology, high-quality and safe cell cryopreservation is a key link in many biomedical research and clinical applications. However, the traditional method of filling cell cryopreservation bags has a series of significant and urgent problems. On the one hand, precise temperature control is of great importance in the process of cell cryopreservation. Traditional manual filling equipment often cannot effectively maintain the low temperature environment required for cell suspension. At room temperature, cells are in contact with inappropriate cryopreservation fluid, which can easily cause damage to the internal structure of cells, destroy the physiological function of cells, and eventually lead to cell death. This not only reduces the survival rate of cells, but also seriously affects the quality and performance of cells in subsequent experiments and applications. From the perspective of efficiency and cost, the traditional filling method is extremely inefficient. The long operation process requires a lot of manpower investment, and due to problems such as incomplete filling and cell residue, it not only causes a waste of cell resources, but also increases the cost of experiments and production.

[0003] In general, the traditional method of filling cell cryopreservation bags has many defects in temperature control, efficiency and cost, which seriously restricts the development and application of cell cryopreservation technology. Therefore, it is urgent to develop a manual filling device that can overcome these defects, achieve precise temperature control, high efficiency and energy saving, and low cost. Utility Model Content

[0004] The utility model aims to provide a manual filling device for freezing bags, which saves manpower and improves work efficiency to solve the above-mentioned problems.

[0005] In order to achieve the above purpose, the utility model provides the following technical solutions:

[0006] A manual filling device for freezing bags, characterized in that it includes a sterile bag placing platform, a sterile bag placing platform cover is buckled on the top of the sterile bag placing platform, the bottoms of the two side surfaces of the sterile bag placing platform are rotatably connected through the top angles of the triangular brackets, the bottoms of the triangular brackets are fixedly installed on both sides of the freezing bag placing platform, a motor is fixedly installed on the right side of the upper end surface of the freezing bag placing platform through a bracket, a turntable is fixedly installed on the rotating shaft of the motor, the turntable is rotatably connected to one end of a connecting rod through an outer connecting shaft of the side wall, and the other end of the connecting rod is rotatably connected to a pin seat on one side of the bottom of the sterile bag placing platform through a pin.

[0007] The sterile bag placement platform cover is a hollow structure, and an opening is provided on the left side of the sterile bag placement platform cover for connecting the freezing bag opening using a disposable sterile connector.

[0008] Buckles are arranged at four corners of the upper end surface of the sterile bag placement platform, and the buckles are matched and connected with the openings at the four corners of the sterile bag.

[0009] The sterile bag placement platform is a hollow structure. A drawer slot is arranged on the right side of the sterile bag placement platform, and a drawer is slidably inserted therein.

[0010] The freezing bag placement platform is a hollow structure, and a drawer slot is arranged on the right side of the sterile bag placement platform, and a drawer is slidably inserted therein.

[0011] A fence is arranged on the right side of the upper end of the freezing bag placement platform, and an opening is arranged on the left side of the fence. The opening is used to connect the sterile bag opening using a disposable sterile connector.

[0012] A control panel is installed on the front side of the freezing bag placement platform, and the control panel is electrically connected to the motor.

[0013] First, conduct a comprehensive inspection of the equipment and clean and disinfect it. Next, pull out the drawers on the right side of the cryopreservation bag placement platform and the sterile bag placement platform, add pre-cooled ice cubes and push them back. Then, fix the pre-treated sterile bag on the sterile bag placement platform with the buckles at the four corners, and place the cryopreservation bag in the enclosure of the cryopreservation bag placement platform. Connect the sterile bag and cryopreservation bag openings with a disposable sterile connector through the corresponding openings of the two platforms. Turn on the power start motor on the control panel, drive the turntable and connecting rod to tilt the sterile bag placement platform up and down to mix the cell suspension, then make it horizontal, and use gravity to fill the cell suspension from the sterile bag into the cryopreservation bag. After filling, clamp the tube mouth with hemostatic forceps, remove the connector to separate the interface, take out the bag and clean the equipment.

[0014] Compared with the prior art, the beneficial effects of the utility model are:

[0015] Drawers for placing ice cubes are set up on the sterile bag placement platform and the freezing bag placement platform, which can effectively maintain the low-temperature environment required for the cell suspension, avoid damage to the cells at normal temperature, and improve the survival rate of the cells.

[0016] The equipment has a reasonable structure design and is easy to operate. It uses a motor to turn over and mix the sterile bags, and uses gravity for filling, which saves manpower and improves work efficiency. The control panel is simple and clear, easy for operators to master and control, and reduces the difficulty of operation and the error rate.

[0017] The device is small and compact, does not take up too much space, and is suitable for use in limited working environments such as clean benches. It facilitates daily cleaning and maintenance of the equipment, ensuring that the equipment is always in good working condition. The standardized structure and operating procedures help to achieve the standardization of cell cryopreservation filling and improve the repeatability and comparability of experimental results. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 This is a three-dimensional diagram of the main structure of a manual filling device for freezing bags of the utility model;

[0019] Figure 2 This is a three-dimensional diagram of the rear structure of a manual filling device for a freezing bag of the utility model;

[0020] Figure 3 This is a three-dimensional diagram of the main structure of a manual filling device for freezing bags of the utility model;

[0021] In the figure: 11, sterile bag placement platform cover; 12, sterile bag placement platform; 121, buckle; 13, triangular bracket; 14, drawer; 21, cryobag placement platform; 22, enclosure; 23, drawer; 31, motor; 32, turntable; 33, connecting rod; 34, latch seat; 4, control panel. DETAILED DESCRIPTION

[0022] The technical solutions in the embodiments of the present invention will be fully described below in conjunction with the accompanying drawings in the embodiments of the present invention.

[0023] like Figure 1-3 As shown, a manual filling device for freezing bags is characterized in that it includes a sterile bag placing platform 12, a sterile bag placing platform cover 11 is buckled on the sterile bag placing platform 12, the bottoms of the two side surfaces of the sterile bag placing platform 12 are rotatably connected through the top angles of the triangular bracket 13, the bottoms of the triangular bracket 13 are fixedly installed on both sides of the freezing bag placing platform 21, a motor 31 is fixedly installed on the right side of the upper end surface of the freezing bag placing platform 21 through a bracket, a turntable 32 is fixedly installed on the motor rotating shaft, the turntable 32 is rotatably connected to one end of a connecting rod 33 through an outer connecting shaft of the side wall, and the other end of the connecting rod 33 is rotatably connected to a pin seat 34 on one side of the bottom of the sterile bag placing platform 12 through a pin.

[0024] The sterile bag placement platform cover 11 is a hollow structure, and an opening is provided on the left side of the sterile bag placement platform cover 11 for connecting the freezing bag opening using a disposable sterile connector.

[0025] Buckles 121 are provided at four corners of the upper end surface of the sterile bag placement platform 12 , and the buckles 121 are matched and connected with the openings at the four corners of the sterile bag.

[0026] The sterile bag placement platform 12 is a hollow structure. A drawer slot is provided on the right side of the sterile bag placement platform 12, and a drawer 14 is slidably inserted therein.

[0027] The freezing bag placement platform 21 is a hollow structure. A drawer slot is provided on the right side of the sterile bag placement platform 21, and a drawer 23 is slidably inserted therein.

[0028] A fence 22 is provided on the right side of the upper end of the freezing bag placement platform 21, and an opening is provided on the left side of the fence 22. The opening is used to connect the sterile bag opening using a disposable sterile connector.

[0029] A control panel 4 is installed on the front side of the freezing bag placement platform 21 , and the control panel 4 is electrically connected to the motor 31 .

[0030] First, conduct a comprehensive inspection of the equipment and clean and disinfect it. Next, pull out the drawers on the right side of the freezing bag placement platform 21 and the sterile bag placement platform 12, add pre-cooled ice cubes and push them back. Then, fix the pre-treated sterile bag on the sterile bag placement platform 12 with the buckles 121 at the four corners, and place the freezing bag in the enclosure 22 of the freezing bag placement platform 21. Connect the sterile bag and the freezing bag openings with a disposable sterile connector through the corresponding openings of the two platforms. Turn on the power starter motor 31 on the control panel 4, drive the turntable 32 and the connecting rod 33 to tilt the sterile bag placement platform 12 up and down to mix the cell suspension, then make it horizontal, and use gravity to fill the cell suspension from the sterile bag into the freezing bag. After the filling is completed, clamp the tube mouth with hemostatic forceps, remove the connector to separate the interface, take out the bag and clean the equipment.

Claims

1. A manual filling device for cryopreservation bags, characterized in that The invention comprises a sterile bag placing platform (12), a sterile bag placing platform cover (11) is buckled on the top of the sterile bag placing platform (12), the bottom of the two side surfaces of the sterile bag placing platform (12) are respectively connected by rotational cooperation through the top angles of the triangular bracket (13), the bottom of the triangular bracket (13) is fixedly installed on both sides of the freezing bag placing platform (21), a motor (31) is fixedly installed on the right side of the upper end surface of the freezing bag placing platform (21) through a bracket, a turntable (32) is fixedly installed on the rotating shaft of the motor, the turntable (32) is rotationally connected to one end of a connecting rod (33) through an outer connecting shaft of the side wall, and the other end of the connecting rod (33) is rotationally connected to a latch seat (34) on one side of the bottom of the sterile bag placing platform (12) through a latch.

2. A manual filling device for cryopreservation bags according to claim 1, characterized in that: The sterile bag placement platform cover (11) is a hollow structure, and an opening is provided on the left side of the sterile bag placement platform cover (11) for connecting the freezing bag opening using a disposable sterile connector.

3. A manual filling device for cryopreservation bags according to claim 1, characterized in that: Buckles (121) are provided at four corners of the upper end surface of the sterile bag placement platform (12), and the buckles (121) are matched and connected with the openings at the four corners of the sterile bag.

4. The manual filling device for cryopreservation bags according to claim 1, characterized in that: The sterile bag placement platform (12) is a hollow structure, and a drawer slot is provided on the right side of the sterile bag placement platform (12), and a drawer (14) is slidably inserted therein.

5. The manual filling device for freezing bags according to claim 1, characterized in that: The freezing bag placement platform (21) is a hollow structure. A drawer slot is provided on the right side of the freezing bag placement platform (21), and a drawer (23) is slidably inserted therein.

6. The manual filling device for cryopreservation bags according to claim 1, characterized in that: A fence (22) is provided on the right side of the upper end of the freezing bag placement platform (21), and an opening is provided on the left side of the fence (22), and the opening is used to connect the sterile bag opening using a disposable sterile connector.

7. The manual filling device for cryopreservation bags according to claim 1, characterized in that: A control panel (4) is installed on the front side of the freezing bag placement platform (21), and the control panel (4) is electrically connected to the motor (31).