Multi-channel antibody purification and collection device

Abstract

The utility model relates to the technical field of collecting devices, and discloses a multi-channel antibody purifying and collecting device which comprises a bottom plate, a first rotating shaft is rotationally connected to the bottom plate, a handle is fixedly connected to one end of the first rotating shaft, a worm is fixedly connected to the first rotating shaft, a worm gear is connected to the worm in a meshed mode, and a plurality of second rotating shafts are fixedly connected to the worm gear. The multi-channel antibody purification and collection device comprises a base plate, a worm gear is fixedly connected to the base plate, a second rotating shaft is fixedly connected to the worm gear and rotationally connected to the base plate, a disc is fixedly connected to the second rotating shaft, a guide rail is fixedly connected to the disc, and a container groove is formed in the disc. The positions of the collection containers are sequentially adjusted by rotating the handle, efficient collection of purified antigens can be achieved, the tedious process of manually replacing the collection containers is avoided, time is saved, the working efficiency of antigen purification is improved, the device can treat the multiple collection containers at the same time, and the collection efficiency is further improved.

Description

Technical Field

[0001] The utility model relates to the technical field of collection devices, in particular to a multi-channel antibody purification and collection device. Background Art

[0002] Antibodies are proteins with protective effects produced by the body in response to antigen stimulation. They are large Y-shaped proteins secreted by plasma cells and used by the immune system to identify and neutralize foreign substances such as bacteria and viruses. They are only found in the blood and other body fluids of vertebrates and on the cell membrane surface of their B cells. As the core reagent of immunoassay, antibodies are widely used in life science research, biotechnology and medicine.

[0003] When the collection device is in use, the following defects still exist: when collecting antibodies for purification, the staff can only wait until one collection container is completed, and then take out and place the empty collection container, which wastes too much time and reduces the collection efficiency. In addition, when replacing the container, it is easy to cause the loss of antibodies, thereby generating waste. Utility Model Content

[0004] The utility model aims to solve the shortcomings in the prior art and proposes a multi-channel antibody purification and collection device.

[0005] In order to achieve the above-mentioned purpose, the utility model adopts the following technical scheme: a multi-channel antibody purification and collection device, comprising a base plate, a rotating shaft 1 is rotatably connected to the base plate, one end of the rotating shaft 1 is fixedly connected to a handle, a worm is fixedly connected to the rotating shaft 1, a worm wheel is meshingly connected to the worm, a rotating shaft 2 is fixedly connected to the worm wheel, the rotating shaft 2 is rotatably connected to the base plate, a disc is fixedly connected to the rotating shaft 2, a guide rail is fixedly connected to the disc, a container groove is provided on the disc, a spring 1 is fixedly connected inside the disc, one end of the spring 1 is fixedly connected to a slider 1, the slider 1 is slidably connected to the disc, and one end of the slider 1 is fixedly connected to a wedge block.

[0006] As a further description of the above technical solution: a sleeve is fixedly connected to the base plate, a spring 2 is fixedly connected to the sleeve, one end of the spring 2 is fixedly connected to a slide rod 1, the slide rod 1 slides in the sleeve, one end of the slide rod 1 is fixedly connected to a fixed plate 1, a fixed rod is fixedly connected to the bottom of the fixed plate 1, a wheel is rotatably connected to the fixed rod, and the wheel is fitted on the guide rail.

[0007] As a further description of the above technical solution: a fixing column is fixedly connected to the bottom plate, one end of the fixing column is fixedly connected to a fixing plate two, the fixing plate two is fixedly connected to a supporting column, a purification barrel is fixedly connected to the supporting column, the purification barrel is fixedly connected to the fixing plate two, a water pipe one is fixedly connected to the purification barrel, a sliding rod two is slidably connected to the bottom of the water pipe one, the sliding rod two is fixedly connected to the fixing plate one, one end of the sliding rod two is fixedly connected to a sliding block two, the sliding block two slides in the water pipe one, one end of the water pipe one is fixedly connected to a telescopic hose, one end of the telescopic hose is fixedly connected to water pipe two, the water pipe two is fixedly connected to the fixing plate one, and a water outlet is fixedly connected to the water pipe two.

[0008] As a further description of the above technical solution: the bottom of the base plate is fixedly connected with supporting legs, and the supporting legs are provided in four groups.

[0009] As a further description of the above technical solution: the water pipe 1 penetrates through the fixed plate 2, the sliding rod 2 penetrates through the water pipe 1, and the water pipe 2 penetrates through the fixed plate 1.

[0010] As a further description of the above technical solution: the support columns are provided in four groups, the fixed columns are provided in two groups, the slide rods are provided in two groups, the springs are provided in two groups, and the sleeves are provided in two groups.

[0011] As a further description of the above technical solution: the wedge block is arranged in the container groove, and the second spring is arranged in the sleeve.

[0012] The utility model has the following beneficial effects:

[0013] In the utility model, when using the multi-channel antibody purification and collection device, the positions of the collection containers are adjusted in sequence by turning the handle, so that efficient collection of purified antigens can be achieved, and the tedious process of manually replacing the collection containers is avoided, thereby saving time and improving the work efficiency of antigen purification. In addition, the device can process multiple collection containers at the same time, further improving the collection efficiency.

[0014] In the utility model, when the multi-channel antibody purification and collection device is used, through the action of spring one and spring two, and the sliding connection of slider two in water pipe one, the purified antibodies can be accurately controlled when the collection container is replaced, effectively preventing the waste of purified antigens. When the collection container is full, the device can automatically block the inflow of purified antigens, avoiding the spillage and waste of purified antigens when moving or replacing the collection container. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 A schematic diagram of the structure of a multi-channel antibody purification and collection device proposed in the utility model Figure 1 ;

[0016] Figure 2 A schematic diagram of the structure of a multi-channel antibody purification and collection device proposed in the utility model Figure 2 ;

[0017] Figure 3 A local explosion of a multi-channel antibody purification and collection device proposed by the utility model Figure 1 ;

[0018] Figure 4 A local explosion of a multi-channel antibody purification and collection device proposed by the utility model Figure 2 ;

[0019] Figure 5 A local explosion of a multi-channel antibody purification and collection device proposed by the utility model Figure 3 .

[0020] Legend:

[0021] 1. Bottom plate; 2. Rotation axis 1; 3. Handle; 4. Worm; 5. Worm wheel; 6. Rotation axis 2; 7. Disc; 8. Guide rail; 9. Container slot; 10. Spring 1; 11. Slider 1; 12. Wedge block; 13. Sleeve; 14. Spring 2; 15. Slider 1; 16. Fixed plate 1; 17. Fixed rod; 18. Wheel; 19. Fixed column; 20. Fixed plate 2; 21. Support column; 22. Purification barrel; 23. Water pipe 1; 24. Slider 2; 25. Slider 2; 26. Telescopic hose; 27. Water pipe 2; 28. Water outlet; 29. ​​Leg. DETAILED DESCRIPTION

[0022] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0023] Reference Figure 1-Figure 5The utility model provides an embodiment: a multi-channel antibody purification and collection device, comprising a bottom plate 1, a rotating shaft 2 is rotatably connected to the bottom plate 1, a handle 3 is fixedly connected to one end of the rotating shaft 2, a worm 4 is fixedly connected to the rotating shaft 2, a worm wheel 5 is meshingly connected to the worm 4, a rotating shaft 6 is fixedly connected to the worm wheel 5, the rotating shaft 6 is rotatably connected to the bottom plate 1, a disc 7 is fixedly connected to the rotating shaft 6, a guide rail 8 is fixedly connected to the disc 7, a container groove 9 is provided on the disc 7, and a spring 1 is fixedly connected inside the disc 7. 10, one end of the spring 10 is fixedly connected to a slider 11, the slider 11 is slidably connected to the disc 7, and one end of the slider 11 is fixedly connected to a wedge block 12. When using the multi-channel antibody purification and collection device, the position of the collection container is adjusted in sequence by rotating the handle 3, so that the purified antigen can be efficiently collected, and the tedious process of manually replacing the collection container is avoided, thereby saving time and improving the work efficiency of antigen purification. The device can process multiple collection containers at the same time, further improving the collection efficiency.

[0024] The bottom plate 1 is fixedly connected with a sleeve 13, and the sleeve 13 is fixedly connected with a spring 2 14, one end of the spring 2 14 is fixedly connected with a slide rod 15, and the slide rod 15 slides in the sleeve 13, and one end of the slide rod 15 is fixedly connected with a fixed plate 16, and the bottom of the fixed plate 16 is fixedly connected with a fixed rod 17, and the fixed rod 17 is rotatably connected with a wheel 18, and the wheel 18 fits on the guide rail 8, and the bottom plate 1 is fixedly connected with a fixed column 19, and one end of the fixed column 19 is fixedly connected with a fixed plate 20 A support column 21 is fixedly connected to the fixed plate 20, a purification barrel 22 is fixedly connected to the support column 21, the purification barrel 22 is fixedly connected to the fixed plate 20, a water pipe 23 is fixedly connected to the purification barrel 22, a slide bar 24 is slidably connected to the bottom of the water pipe 23, the slide bar 24 is fixedly connected to the fixed plate 16, one end of the slide bar 24 is fixedly connected to a slider 25, the slider 25 slides in the water pipe 23, one end of the water pipe 23 is fixedly connected to a telescopic hose 26, the telescopic hose One end of 26 is fixedly connected with water pipe 27, water pipe 27 is fixedly connected to fixed plate 16, water pipe 27 is fixedly connected with water outlet 28, the bottom of bottom plate 1 is fixedly connected with supporting leg 29, supporting leg 29 has four groups, water pipe 1 23 runs through fixed plate 20, slide bar 24 runs through water pipe 1 23, water pipe 27 runs through fixed plate 16, support column 21 has four groups, fixed column 19 has two groups, slide bar 15 has two groups, spring 2 14 has two groups, sleeve 13 has Two groups, the wedge block 12 is arranged in the container groove 9, and the spring 2 14 is arranged in the sleeve 13. When using the multi-channel antibody purification and collection device, through the action of the spring 10 and the spring 2 14, and the sliding connection of the slider 25 in the water pipe 1 23, the purified antibody can be accurately controlled when the collection container is replaced, and the waste of purified antigens is effectively prevented. When the collection container is full, the device can automatically block the inflow of purified antigens, avoiding the spillage and waste of purified antigens when moving or replacing the collection container.

[0025] Working principle: When using the multi-channel antibody purification and collection device, the staff first puts the collection containers in the container slots 9 in turn, and presses the containers to make the two groups of wedge blocks 12 in each group of container slots 9 slide inward on the disc 7 through the compression of the slider 11 against the spring 10. When the collection container is pressed to the bottom, the two groups of wedge blocks 12 are firmly fixed to the collection container through the rebound of the spring 10 against the two groups of sliders 11, which is used to prevent the collection container from tipping over or tilting when collecting the antigen purification liquid, thereby causing the liquid after antigen purification to spill and waste. Then, the required antibodies are placed in the purification barrel 22, and the purified antibodies are removed from the purification barrel 22. The purified antibodies dripping from the inner chamber flow into the telescopic hose 26 through the water pipe 1 23, and then flow into the water pipe 2 27 from the telescopic hose 26, and then flow into the two groups of water outlets 28 from the water pipe 27, and then flow into the two corresponding collection containers from the two groups of water outlets 28. When the two corresponding collection containers are full, the staff twists the handle 3, and the handle 3 drives the rotating shaft 1 2 to rotate on the bottom plate 1, and the rotating shaft 1 2 drives the worm 4 to rotate, and the worm 4 drives the worm wheel 5 to rotate, and the worm wheel 5 drives the rotating shaft 2 6 to rotate on the bottom plate 1, and the rotating shaft 2 6 drives the disc 7 to rotate, and the disc 7 drives the guide rail 8 to rotate, and when the guide rail 8 rotates, it drives the wheel 18 to rotate, and the guide rail 8 rotates. The wheel 18 drives the fixed plate 16 on the fixed rod 17 to rise through the pull of the slide bar 15 on the spring 14, so that the two groups of water outlets 28 leave the relative collection container to prevent the collection container from being blocked when moving. At the same time, the fixed plate 16 drives the slider 25 on the slide bar 24 to slide in the water pipe 1 23, thereby blocking the purified antibody from flowing into the telescopic hose 26, which is used to block the purified antibody when replacing the collection container to prevent the purified antibody from being wasted during movement, thereby increasing the cost. When the guide rail 8 rotates to a certain extent, the wheel 18 falls from the highest point at one end of the guide rail 8, and is driven by the pull of the spring 14 on the slide bar 15. The fixed plate 16 moves downward, and at the same time, the two groups of empty collecting containers correspond to the two groups of water outlets 28. The two groups of water outlets 28 are re-attached to the upper mouths of the two groups of collecting containers through the descent of the fixed plate 16. At the same time, the fixed plate 16 drives the slider 25 on the slide rod 24 to slide downward in the water pipe 1 23, so that the purified antigen continues to flow from the water pipe 1 23 into the telescopic hose 26, and then flows from the telescopic hose 26 into the water outlet 28, and then flows from the water outlet 28 into the collecting container. It is suitable for adjusting the collection of purified antigens by the collecting container in turn by twisting the handle 3, thereby increasing the efficiency of collecting purified antigens and not causing waste of purified antigens during the collection process.

[0026] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A multi-channel antibody purification and collection device, comprising a bottom plate (1), characterized in that: A rotating shaft 1 (2) is rotatably connected to the base plate (1), one end of the rotating shaft 1 (2) is fixedly connected to a handle (3), a worm (4) is fixedly connected to the rotating shaft 1 (2), a worm wheel (5) is meshingly connected to the worm (4), a rotating shaft 2 (6) is fixedly connected to the worm wheel (5), the rotating shaft 2 (6) is rotatably connected to the base plate (1), a disk (7) is fixedly connected to the rotating shaft 2 (6), a guide rail (8) is fixedly connected to the disk (7), a container groove (9) is provided on the disk (7), a spring 1 (10) is fixedly connected inside the disk (7), one end of the spring 1 (10) is fixedly connected to a slider 1 (11), the slider 1 (11) is slidably connected to the disk (7), and one end of the slider 1 (11) is fixedly connected to a wedge block (12).

2. A multi-channel antibody purification and collection device according to claim 1, characterized in that: The base plate (1) is fixedly connected to a sleeve (13), the sleeve (13) is fixedly connected to a spring (14), one end of the spring (14) is fixedly connected to a slide bar (15), the slide bar (15) slides in the sleeve (13), one end of the slide bar (15) is fixedly connected to a fixed plate (16), the bottom of the fixed plate (16) is fixedly connected to a fixed rod (17), the fixed rod (17) is rotatably connected to a wheel (18), and the wheel (18) is fitted on the guide rail (8).

3. A multi-channel antibody purification and collection device according to claim 2, characterized in that: The bottom plate (1) is fixedly connected to a fixing column (19), one end of the fixing column (19) is fixedly connected to a fixing plate (20), the fixing plate (20) is fixedly connected to a supporting column (21), the supporting column (21) is fixedly connected to a purification barrel (22), the purification barrel (22) is fixedly connected to the fixing plate (20), the purification barrel (22) is fixedly connected to a water pipe (23), the bottom of the water pipe (23) is slidably connected to a sliding rod (24), The second slide bar (24) is fixedly connected to the first fixed plate (16); one end of the second slide bar (24) is fixedly connected to the second slide block (25); the second slide block (25) slides in the first water pipe (23); one end of the first water pipe (23) is fixedly connected to the telescopic hose (26); one end of the telescopic hose (26) is fixedly connected to the second water pipe (27); the second water pipe (27) is fixedly connected to the first fixed plate (16); and the second water pipe (27) is fixedly connected to the second water pipe (27).

4. A multi-channel antibody purification and collection device according to claim 3, characterized in that: The bottom of the base plate (1) is fixedly connected with supporting legs (29), and the supporting legs (29) are provided in four groups.

5. A multi-channel antibody purification and collection device according to claim 4, characterized in that: The water pipe one (23) passes through the fixed plate two (20), the sliding rod two (24) passes through the water pipe one (23), and the water pipe two (27) passes through the fixed plate one (16).

6. A multi-channel antibody purification and collection device according to claim 5, characterized in that: The support columns (21) are provided in four groups, the fixed columns (19) are provided in two groups, the sliding rods (15) are provided in two groups, the springs (14) are provided in two groups, and the sleeves (13) are provided in two groups.

7. A multi-channel antibody purification and collection device according to claim 6, characterized in that: The wedge block (12) is arranged in the container groove (9), and the second spring (14) is arranged in the sleeve (13).

Images