Chromatographic column system

Abstract

The utility model discloses a chromatographic column system which comprises a chromatographic column and a stand for connecting the chromatographic column, the chromatographic column comprises a column barrel, an upper end piece and a lower end piece, the upper end piece and the lower end piece are respectively arranged on the upper side and the lower side of the column barrel, the upper end piece is connected with the top of the column barrel through a locking device, and a detachable joint piece II is arranged at the top of the upper end piece. The lower end piece is connected with the bottom of the column barrel through a detachable fastener I; the stand comprises a lifting mechanism for lifting the upper end piece, the lifting mechanism comprises a pair of telescopic vertical rods and a pair of lifting rods, and the bottom ends of the two lifting rods are connected with a lifting surface; and a positioning device is arranged between the chromatographic column and the stand. The chromatographic column system adopts a split design form of the chromatographic column and the stand, the positioning device is arranged between the chromatographic column and the stand capable of being connected with the chromatographic column, the positioning device can position the chromatographic columns with different specifications at proper positions on the stand capable of being connected with the chromatographic column, and the lifting and descending of upper end pieces of the chromatographic columns with different specifications can be realized.

Description

Technical Field

[0001] The utility model relates to a chromatographic column system and belongs to the technical field of column chromatography. Background Art

[0002] In the chromatography process of biopharmaceutical separation and purification, different target products have different production processes, and different column packing bed inner diameters and heights are used, such as diameters of 50mm to 2000mm, heights of 10mm to 90mm, etc. Different chromatographic column fillers are used, such as affinity fillers, anion fillers, cationic fillers, and molecular sieve fillers. In general, the filling of empty chromatographic columns and equipment maintenance are directly performed in the workshop where the equipment is located. At present, there is a demand for the same workshop to be used to produce different products in pharmaceutical production. For example, in the production line under the CDMO model, there is a demand for using different packing bed inner diameters and heights and different chromatographic column fillers in the same workshop.

[0003] The chromatographic columns currently on the market include column tubes, upper end pieces, lower end pieces, drive parts, compression parts and support frames, etc. These parts are directly integrated on the chromatographic column to form an integrated structure chromatographic column. The drive part, compression part and support frame of the integrated structure chromatographic column are generally made of metal materials, which are generally only used during packing filling and equipment maintenance, increasing the total weight and manufacturing cost of the integrated structure chromatographic column, and placing high load-bearing requirements on the production workshop. The integrated structure chromatographic column realizes packing filling and equipment maintenance by controlling the up and down movement of the upper port piston. When the compression part, such as the screw, moves upward to the highest point, the equipment maintenance height reaches the highest point, increasing the total height of the integrated structure chromatographic column, and placing high height requirements on the production workshop. Due to the high total weight and total height of the integrated structure chromatographic column, large-scale integrated structure chromatographic columns are not easy to move. The packing filling and equipment maintenance are directly operated in the production workshop where the equipment is located, and the production workshop needs to reserve sufficient installation and maintenance area. During the equipment maintenance period, the integrated structure chromatographic column cannot be used for a long time, and the downtime is too long, which reduces the operating efficiency of the production workshop.

[0004] Therefore, a separate column packing room can be set up to pack empty chromatographic columns and perform equipment maintenance, which can reduce the load-bearing, height, and area requirements of the production workshop and improve the operational efficiency of the production workshop. Therefore, a chromatographic column system is needed to meet the maintenance of chromatographic columns with different inner diameters and heights of the packed beds, and to meet the requirements of moving chromatographic columns to the production workshop for separation and purification after packing and equipment maintenance in the column packing maintenance workshop.

[0005] Equipment maintenance of empty chromatographic columns refers to the regular cleaning and replacement of chromatographic column parts, including the sieve plates, distribution plates, valves, sealing rings, etc. of the upper and lower end parts of the chromatographic column. Chromatographic columns are also called chromatography columns.

[0006] Patent CN102946959A introduces a chromatography column system and a chromatography column maintenance method, which facilitates maintenance by increasing the space from the bottom plate to the floor. When the column barrel and the bottom plate are directly lifted for maintenance, the operator works under heavy objects, which poses a safety risk. When the chromatography column barrel is first rotated sideways and then the bottom plate is lifted for maintenance through an adapter, the side rotation of the column barrel increases the floor space occupied during chromatography column maintenance. The column barrel is generally made of heavier materials such as stainless steel, glass or acrylic. If the weight of the column barrel is too large, there may be a risk of deformation of the side-rotating connector, which may cause the equipment to tip over or be damaged in severe cases.

[0007] Patent CN103505909A introduces a chromatographic column frame and a method for maintaining and filling a chromatographic column. The chromatographic column frame realizes the separation of the first end unit or the second end unit of the chromatographic column by controlling the vertical movement of the adapter rod of the chromatographic column. Among them, the chromatographic column includes an adapter rod connected to the adapter assembly, the adapter rod is arranged to extend through the opening in the first end element, and the retainer structure is arranged to releasably retain the adapter rod of the chromatographic column. When the chromatographic column is heavy and the adapter rod is a threaded structure, if the adapter rod is disassembled on the retainer structure, it is easy to cause the adapter rod and the retainer structure to be misaligned or the thread is damaged. When the chromatographic column is of large diameter and the adapter is used to act directly on the upper end piece, the force area of ​​the chromatographic column during axial compression is small, and the filler reaches the same compression force, and its annular cross-sectional area is small, and the deformation effect is large. When the force spreads from the middle to the periphery, the column diameter is large, and the filler distributed on the column edge may not be squeezed too much, which may cause uneven distribution.

[0008] Therefore, a column system is needed that avoids the risk of operators working under heavy objects, deformation of the barrel side-swing connection, easy damage between the adapter rod and the holder structure, and uneven pressure distribution of the packing during axial compression. Utility Model Content

[0009] The technical problem to be solved by the utility model is to provide a chromatographic column system with a stable structure.

[0010] In order to solve the above problems, the utility model provides a chromatographic column system, which includes a chromatographic column and a stand for connecting the chromatographic column, the chromatographic column includes a column barrel and an upper end piece and a lower end piece respectively arranged on the upper and lower sides of the column barrel, the upper end piece is connected to the top of the column barrel through a locking device, the top of the upper end piece is provided with a detachable joint piece 2, and the lower end piece is connected to the bottom of the column barrel through a detachable joint piece 1; the stand includes a lifting mechanism for lifting the upper end piece, the lifting mechanism includes a pair of telescopic vertical rods and a pair of lifting rods, and the bottom ends of the two lifting rods are connected to the lifting surface.

[0011] Preferably, the locking device includes a locking rod fixed to the top surface of the upper end piece, a first thread is provided on the outside of the locking rod, the locking rod is passed through the connecting flange and is limited by a nut, and a second thread for connecting the column barrel is also provided on the connecting flange.

[0012] Preferably, the detachable joint is a bolt and a nut.

[0013] Preferably, the second detachable joint comprises screw holes provided at corresponding positions of the upper end piece and the column barrel, and the two screw holes are connected and fixed by bolts.

[0014] Preferably, a positioning device is provided between the chromatographic column and the stand, which can position chromatographic columns of different specifications at appropriate positions on the stand to which the chromatographic columns can be connected, so that the lifting mechanism can accurately position the upper end pieces of chromatographic columns of different diameters at appropriate positions.

[0015] More preferably, the positioning device is provided with positioning holes suitable for chromatography columns of different diameters.

[0016] Furthermore, a plurality of positioning pin holes are provided on the lower end piece of the chromatography column of the same diameter specification.

[0017] Furthermore, three positioning pin holes are provided on the lower end piece of the chromatography column of the same diameter specification, and the lower end piece is ensured to be concentric with the frame of the chromatography column according to the principle of determining a circle by three points.

[0018] The installation and maintenance of chromatographic columns are safer, with lower total weight, lower total height, lower manufacturing cost, easier movement, and smaller installation and maintenance area. The stand can be compatible with the maintenance of chromatographic columns of various specifications with different inner diameters and heights of packed beds, and can be moved to the production workshop for separation and purification after packing and equipment maintenance in the column maintenance workshop, avoiding the risk of operators working under heavy objects, deformation of the side-swivel connector of the column barrel, easy damage between the adapter rod and the retainer structure, and uneven pressure distribution of the packing during axial compression.

[0019] The chromatographic column system adopts a split design of a chromatographic column and a stand. A positioning device is provided between the chromatographic column and the stand to which the chromatographic column can be connected. The positioning device can position chromatographic columns of different specifications at suitable positions on the stand to which the chromatographic column can be connected, and can realize the lifting and lowering of the upper end parts of chromatographic columns of different specifications, so that the weight and height of the driving part, compression part and support frame that were originally equipped separately for multiple one-piece structural chromatographic columns are reduced to the configuration of multiple one-piece structural chromatographic columns, so that the total weight of the chromatographic column is lower, the total height is lower, the manufacturing cost is lower, and the movement is more convenient, which meets the needs of moving the chromatographic column to the production workshop for separation and purification after filling the filler and maintaining the equipment in the column maintenance workshop. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1-3 It is a schematic diagram of the structure of the chromatographic column system provided by the utility model at different angles;

[0021] Figure 4 A side view of the chromatographic column system provided by the utility model;

[0022] Figure 5 A front view of the chromatographic column system provided by the utility model;

[0023] Figure 6 is a schematic diagram of a locking device;

[0024] Figure 7 is a schematic diagram of a detachable joint member 1;

[0025] Figure 8 A schematic diagram of the connection between the second detachable joint member and the upper end member;

[0026] Fig. 9 It is a front view of the connection between the detachable joint part 2 and the upper end part;

[0027] Fig.10 The schematic diagram of the structure of the platform is shown in FIG.

[0028] Fig.11 is a structural schematic diagram of a positioning device;

[0029] Fig.12 is a schematic diagram of a positioning hole on a positioning device;

[0030] Fig.13 is a schematic structural diagram of a detachable combination part 2;

[0031] Figure 14-22 Schematic diagram of the status of the column system at different steps in the maintenance method. DETAILED DESCRIPTION

[0032] In order to make the present invention more obvious and easy to understand, preferred embodiments are described in detail as follows in conjunction with the accompanying drawings.

[0033] Example

[0034] like Figure 1As shown, a chromatographic column system provided by the utility model comprises a chromatographic column 1 and a stand 2 for connecting the chromatographic column 1, the chromatographic column 1 comprises a column barrel 1-4 and an upper end piece 1-3 and a lower end piece 1-6 respectively arranged on the upper and lower sides of the column barrel 1-4, the upper end piece 1-3 is connected to the top of the column barrel 1-4 through a locking device 1-1 (to achieve the fixation of the upper end piece at different heights), and the lower end piece 1-6 is connected to the bottom of the column barrel 1-4 through a detachable joint piece 1-5; the stand 2 comprises a lifting mechanism 2-1 for lifting the upper end piece 1-3, the lifting mechanism 2-1 comprises a pair of telescopic vertical rods 2-4 and a pair of lifting rods 2-2, and the bottom ends of the two lifting rods 2-2 are connected to the lifting surface 2-3; a positioning device is provided between the chromatographic column 1 and the stand 2.

[0035] The locking device 1-1 includes a locking rod 1-1-1 fixed to the top surface of the upper end member 1-3, the locking rod 1-1-1 is provided with a thread 1-1-2 on the outside, the locking rod 1-1-1 is passed through a connecting flange 1-1-4 and is limited by a nut, and the connecting flange 1-1-4 is also provided with a thread 1-1-3 for connecting the column barrel 1-4.

[0036] The detachable joint 1-5 is made of bolts and nuts.

[0037] The detachable joint part 2 1-2 is arranged on the chromatographic column stand ( Fig.13 ), the outer circle of which can be positioned with the groove provided in the upper end piece, and is provided with bolt holes to be connected and fixed with the upper end piece.

[0038] The positioning device is as Fig.11 The positioning device is provided with positioning holes for different specifications of chromatography columns (such as Fig.12 ), correspondingly, three positioning pin holes are also provided on the lower end piece of each chromatography column with different diameter specifications, and the lower end piece is ensured to be concentric with the frame of the chromatography column according to the principle of determining a circle with three points.

[0039] The above-mentioned chromatographic column system, including the chromatographic column and the stand, adopts a split design. Therefore, the chromatographic column can be transported by a transport trolley (a transport trolley platform 1-7 is installed at the bottom of the chromatographic column 1, such as Figure 3 Optional transfer vehicles include air cushion vehicles or electric tanks.

[0040] The maintenance method of the above chromatographic column system is as follows:

[0041] 1. The specific steps for the transfer of the chromatographic column are as follows:

[0042] Step 1: Move the transfer cart under the chromatography column.

[0043] Step 2: Use a transfer cart to support the column.

[0044] Here, you can choose to lower the support feet of the chromatographic column to lower the chromatographic column to the support surface of the transfer cart, or you can choose to use a transfer cart that can be raised and lowered to raise the support surface of the transfer cart to the chromatographic column.

[0045] Step 3: Move the chromatographic column to the designated position using the transfer cart.

[0046] Step 4: Separate the column from the transfer cart.

[0047] Here, you can choose to raise the support feet of the chromatographic column to raise the chromatographic column away from the support surface of the transfer cart, or you can choose to use a transfer cart that can be raised and lowered to lower the support surface of the transfer cart away from the chromatographic column.

[0048] Step 5: Move the transfer cart away from under the column.

[0049] The chromatographic column includes an upper end piece, a column barrel and a lower end piece. The upper end piece of the chromatographic column and the lower end piece of the chromatographic column include a sieve plate, a distribution plate, a valve, a sealing ring, etc. The column barrel of the chromatographic column can be annular or square. Not all the parts of the chromatographic column are mentioned here, but these parts are the common parts of the chromatographic column.

[0050] The column barrel of the chromatographic column is detachably connected to the lower end member of the chromatographic column via a detachable joint piece 1. The detachable joint piece 1 can be a set of threaded structures symmetrically or asymmetrically installed along the column barrel. Figure 7 An example of a detachable joint 1 is shown. The detachable joint 1 may also be designed in other styles.

[0051] The chromatographic column is provided with a locking device, which can lock the upper end piece of the chromatographic column at any part of the chromatographic column, and when the lower end piece of the chromatographic column is separated from the chromatographic column, the chromatographic column barrel and the upper end piece can be lifted. The locking device can be a set of threaded structures symmetrically or asymmetrically installed along the barrel. Figure 6 An example of a locking device is shown. The locking device can also be designed in other styles. The locking device is detachable. The column barrel is connected to the locking plate by a thread, the locking plate is connected to the locking rod by a thread, and the locking rod is connected to the upper end piece of the chromatographic column by a thread. By adjusting the length of the locking rod extending into the column barrel, the position of the upper end piece relative to the lower end piece of the chromatographic column is adjusted. Therefore, the locking device can lock the upper end piece of the chromatographic column at any part of the chromatographic column.

[0052] There is no connection between the lower end piece of the chromatography column and the stand to which the chromatography column can be attached.

[0053] A positioning device is provided between the chromatographic column and a stand to which the chromatographic column can be connected. The positioning device can position chromatographic columns of different specifications at appropriate positions on the stand to which the chromatographic column can be connected. Fig.11 , 12An example of a positioning device is shown. The positioning device can also be designed in other styles. The positioning device includes a positioning platform, a positioning hole and a positioning pin. The positioning platform is provided with positioning holes for three specifications of chromatographic columns, so that the stand that can be connected to the chromatographic column can be used for three specifications of chromatographic columns. The positioning platform has three positioning holes for chromatographic columns of different diameters, of which two are round holes and one is a waist hole, which is convenient for the installation of the positioning pin. The positioning device uses a three-point method to determine the center of a circle to achieve concentric positioning of the stand and the chromatographic column, so that the lifting mechanism can accurately locate the appropriate position of the upper end piece of the chromatographic column of different diameters.

[0054] 2. Compatibility of chromatographic columns with different diameters. The specific implementation steps are as follows:

[0055] Step 1: Fix the positioning device to the appropriate position.

[0056] Here, the positioning platform can be fixed to the stand to which the chromatographic column can be connected by welding or bolting.

[0057] Step 2: Move the column under a rack where it can be attached.

[0058] (Steps 1 and 2 can be adjusted arbitrarily)

[0059] Step 3: Align the positioning device between the column and the stand to which the column can be attached.

[0060] Here, the positioning holes between the chromatography column and the stand to which the chromatography column can be connected are aligned.

[0061] Step 4: Perform positioning of the column and a stand to which the column can be attached.

[0062] Here, the positioning pins are inserted into the positioning holes.

[0063] A lifting mechanism is provided on the stand to which the chromatographic column can be connected. The lifting surface of the lifting mechanism and the upper end surface of the chromatographic column are designed to be concentric. The length of the lifting rod of the lifting mechanism that can be extended into the column barrel and the telescopic distance of the telescopic vertical rod of the lifting mechanism are greater than or equal to the maximum difference between the barrel height and the packing bed height required to be compatible with chromatographic columns of different diameters. It is recommended that the connection portion between the lifting surface of the lifting mechanism and the upper end surface of the chromatographic column adopts a symmetrical design, preferably a ring-shaped design. It is recommended that the radius of the lifting surface of the lifting mechanism is 1 / 3 to 2 / 3 of the radius of the upper end surface of the chromatographic column. Fig.14An example of a lifting mechanism to a stand to which the chromatographic column can be connected is shown. The lifting mechanism can also be designed in other styles. The lifting mechanism is provided with a driving motor and two retractable uprights, each of which is provided with an upper screw and a lower screw, the upper screw and the lower screw are threadedly connected, and the upper screw is fixed to the lifting mechanism by bolting or the like, so that the lifting mechanism can be lifted up and lowered by driving the lower screw to rotate by the driving motor. The figure shows an example of the connection style of the lifting surface of the lifting mechanism and the upper end surface of the chromatographic column, and the connection of the lifting surface of the lifting mechanism and the upper end surface of the chromatographic column can also be designed in other styles. Concentric symmetry and a larger contact surface are conducive to avoiding the risk of uneven pressure distribution of the packing during axial compression.

[0064] The lifting mechanism of the stand connectable to the chromatographic column is detachably connected to the upper end piece of the chromatographic column via a detachable joint piece 2. Fig. 9 An example of a detachable joint member 2 is shown. The detachable joint member 2 can also be designed in other styles. After the detachable joint member 2 is connected, the upper end member of the chromatographic column can be moved to different heights by lifting or lowering the lifting mechanism of the stand to which the chromatographic column can be connected.

[0065] 3. Compatibility of chromatographic columns of different heights. The specific implementation steps are as follows:

[0066] Step 1: Move the lifting surface of the lifting mechanism of the stand to which the chromatography column can be attached to above the chromatography column.

[0067] Step 2: Position the chromatography column and the stand to which the chromatography column can be attached.

[0068] Step 3: Keep the upper end piece of the chromatographic column connected to the locking device, and then align the upper end piece with the lifting surface of the lifting mechanism ( Fig.19 ) connection; Figure 8 He Ru Fig. 9 , the upper end assembly and the lifting surface of the lifting mechanism ( Fig.19 ) is connected by threading (or snap-on connection). Operation method: drive the chromatographic column stand motor to lower the lifting surface of the lifting mechanism into the positioning groove of the upper end piece (the upper end piece is provided with a positioning groove corresponding to the lifting surface to ensure concentricity), and then fix the two together by threading, and then remove the locking device of the chromatographic column so that only one of the upper end piece and the lifting surface is fixed, and then drive the chromatographic column stand motor to drive the lifting surface up and down to meet the different column loading height requirements of customers. When the defined height is reached, connect the upper end piece and the locking device to lock it so that the upper end piece is fixed to the column barrel, and then remove the bolts of the lifting surface and the upper end piece so that only one of the upper end piece and the column barrel is fixed. Then drive the motor to separate the lifting surface from the column barrel.

[0069] Step 4: Raise or lower the lifting mechanism of the stand to which the chromatography column can be connected, thereby moving the upper end piece of the chromatography column to different heights.

[0070] When the barrel height and packing bed height required to be compatible with chromatographic columns of different diameters are shown in Table 1, the length of the lifting rod of the lifting mechanism that can be extended into the column barrel is greater than or equal to 880 mm, and the telescopic distance of the telescopic vertical rod of the lifting mechanism is greater than or equal to 880 mm.

[0071] Table 1

[0072] Chromatographic columns 1 2 3 4 5 6 Barrel height (mm) 600 600 750 750 900 900 Packing bed height (mm) 20 550 20 700 20 850 Difference(mm) 580 50 730 50 880 50

[0073] Therefore, when the locking device locks the upper end piece of the chromatographic column at any part of the chromatographic column, when the lower end piece of the chromatographic column is separated from the chromatographic column, the chromatographic column barrel and the upper end piece can be lifted to perform maintenance on the lower end piece of the chromatographic column. When the upper end piece of the chromatographic column and the chromatographic column are unlocked, the upper end piece of the chromatographic column can be lifted to perform maintenance on the upper end piece of the chromatographic column.

[0074] 4. Maintenance of the lower end of the chromatographic column, the specific implementation steps are:

[0075] Step 1: Disassemble a detachable joint between a column barrel of the chromatographic column and a lower end piece of the chromatographic column;

[0076] Step 2: Connect the detachable joint between the upper end piece of the chromatographic column and the lifting mechanism of the stand to which the chromatographic column can be connected.

[0077] Step 3: Lock the upper end piece of the column onto any part of the column.

[0078] (Steps 1, 2, and 3 can be adjusted arbitrarily)

[0079] Fig.15 The status of the column after steps 1, 2, and 3 is shown.

[0080] Step 4: Lift the lifting mechanism of the stand to which the chromatographic column can be connected, thereby lifting the column barrel and the upper end piece of the chromatographic column, and separating the lower end piece of the chromatographic column and the chromatographic column.

[0081] Fig.16 The status of the column after step 4 is shown. At this point, the lower end piece of the column is removed along the route of the column, and there is enough space for maintenance of the lower end piece. This prevents the operator from working under heavy objects including the column barrel, and avoids the risk of the column barrel rotating sideways. If maintenance is required on the parts under the lower end piece, the lower end piece of the column can be lifted with a device such as a crane or jack to raise more space for maintenance.

[0082] Step 5: Perform column lower endpiece maintenance ( Fig. 20 ).

[0083] 5. Maintenance of the upper end of the chromatographic column, the specific implementation steps are:

[0084] Step 1: Connect the detachable joint between the upper end of the chromatographic column and the lifting mechanism of the stand to which the chromatographic column can be connected.

[0085] Step 2: Unlock the upper end piece and column.

[0086] (Steps 1 and 2 can be adjusted arbitrarily)

[0087] Fig.17 The status of the column after steps 1 and 2 is shown.

[0088] Step 3: Lift the lifting mechanism of the stand to which the chromatographic column can be connected, thereby lifting the upper end piece of the chromatographic column and separating the upper end piece of the chromatographic column and the chromatographic column.

[0089] Fig.18 shows the status of the column after step 3. At this point, the column barrel and lower end piece ( Fig. 22 As shown), there is enough space for maintenance of the upper end parts.

[0090] Step 5: Perform column endpiece maintenance.

Claims

1. A chromatographic column system, comprising a chromatographic column (1) and a stand (2) for connecting the chromatographic column (1), characterized in that: The chromatographic column (1) comprises a column barrel (1-4) and an upper end piece (1-3) and a lower end piece (1-6) respectively arranged on the upper and lower sides of the column barrel (1-4); the upper end piece (1-3) is connected to the top of the column barrel (1-4) through a locking device (1-1); a detachable joint piece 2 (1-2) is arranged on the top of the upper end piece (1-3); and the lower end piece (1-6) is connected to the bottom of the column barrel (1-4) through a detachable joint piece 1 (1-5); the stand (2) comprises a lifting mechanism (2-1) for lifting the upper end piece (1-3); the lifting mechanism (2-1) comprises a pair of telescopic vertical rods (2-4) and a pair of lifting rods (2-2); the bottom ends of the two lifting rods (2-2) are connected to the lifting surface (2-3).

2. The chromatographic column system according to claim 1, characterized in that The locking device (1-1) comprises a locking rod (1-1-1) fixed to the top surface of the upper end member (1-3); the locking rod (1-1-1) is provided with a first thread (1-1-2) on the outside; the locking rod (1-1-1) is inserted into a connecting flange (1-1-4) and is limited by a nut; the connecting flange (1-1-4) is also provided with a second thread (1-1-3) for connecting to a column barrel (1-4).

3. The chromatographic column system according to claim 1, characterized in that The detachable joint part 1 (1-5) adopts bolts and nuts.

4. The chromatographic column system according to claim 1, characterized in that The second detachable joint member (1-2) comprises screw holes arranged at corresponding positions of the upper end member (1-3) and the column barrel (1-4), and the two screw holes are connected and fixed by bolts.

5. The chromatographic column system according to claim 1, characterized in that A positioning device is provided between the chromatographic column (1) and the stand (2).

6. The chromatographic column system according to claim 5, characterized in that The positioning device is provided with positioning holes suitable for chromatography columns of different diameters.

7. The chromatographic column system according to claim 6, characterized in that The lower end piece of the chromatography column with the same diameter specification is provided with a plurality of positioning pin holes.

8. The chromatographic column system according to claim 7, characterized in that The lower end piece of the chromatography column of the same diameter specification is provided with three positioning pin holes, and the lower end piece is ensured to be concentric with the frame of the chromatography column according to the principle of determining a circle by three points.

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