Multifunctional pipetting and uniform mixing workstation

Abstract

The utility model relates to the technical field of medical equipment, and discloses a multifunctional pipetting and mixing workstation which comprises a shell, an outer door is arranged at the front end of the shell, a fixed frame is fixedly connected to the inner wall of the shell, a bearing assembly is arranged at the bottom of the inner wall of the fixed frame, and a driving top frame is fixedly connected to the top end of the fixed frame. A magnetic mixing table is arranged at the opposite end of the driving top frame, a supporting plate is fixedly connected to the bottom end of the magnetic mixing table, a first motor driver is fixedly connected to the top end of the supporting plate, a first supporting frame is fixedly connected to the driving end of the first motor driver, and a bearing table is fixedly connected to the bottom end of the first supporting frame; a second driving motor is fixedly connected to one side of the top end of the bearing table. According to the utility model, the functions of rotary uniform mixing and up-down uniform mixing can be realized, meanwhile, batch uniform mixing can be carried out by virtue of a multi-channel uniform mixing structure, and the bar sleeve can be automatically demagnetized after uniform mixing is finished, so that biological cross contamination is avoided.

Description

Technical Field

[0001] The utility model relates to the technical field of medical equipment, in particular to a multifunctional liquid transfer and mixing workstation. Background Art

[0002] Liquid transfer often occurs in biomedical and chemical experiments. In order to facilitate high-throughput transfer of biological and chemical reagents, automatic liquid transfer workstations are usually used to replace manual pipettes and use a large number of high-quality pipette tips to achieve the purpose of automatic transfer of biological and chemical reagents.

[0003] At present, most of the pipetting workstations and mixing equipment in the biological and medical industry markets are single-function devices with little flexibility. When pipetting, the same liquid is usually aspirated, and two separate liquids cannot be completed independently. The pipetting module generally has capacity limitations and cannot achieve large capacity. The liquid aspiration function, liquid discharge function, and flushing function of the pipetting module cannot be realized in the same pipeline, and it is impossible to collect large volumes of liquid into a storage device; functions such as magnetic bead rotation and up and down mixing are all on a single machine. Utility Model Content

[0004] The purpose of the utility model is to solve the shortcomings of the prior art and to propose a multifunctional liquid transfer mixing workstation, which can realize the functions of rotation mixing and up and down mixing, and has a multi-channel mixing structure that can perform batch mixing. At the end of mixing, the magnet rod cover can be automatically demagnetized to avoid biological cross contamination.

[0005] In order to achieve the above purpose, the utility model provides the following technical solutions:

[0006] A multifunctional pipetting and mixing workstation comprises a shell, the front end of the shell is provided with an outer door, the inner wall of the shell is fixedly connected to a fixed frame, the bottom of the inner wall of the fixed frame is provided with a bearing assembly, the top of the fixed frame is fixedly connected to a driving top frame, the opposite end of the driving top frame is provided with a magnetic mixing platform, the bottom end of the magnetic mixing platform is fixedly connected to a support plate, the top of the support plate is fixedly connected to a motor driver 1, the driving end of the motor driver 1 is fixedly connected to a support frame 1, the bottom end of the support frame 1 is fixedly connected to a bearing platform, a top side of the bearing platform is fixedly connected to a driving motor 2, the driving end of the driving motor 2 is fixedly connected to a driving roller, a plurality of magnetic rollers are rotatably connected to the inner wall of the bearing platform, the outer walls of the magnetic rollers are all fixedly connected to pulleys, an XY moving part is provided at the opposite end of the driving top frame, and a pipetting assembly is provided at the top of the XY moving part.

[0007] Furthermore, the upper side of the outer wall of the support frame is slidably connected to the inner wall of the magnetic mixing platform, and the middle part of the outer wall of the support frame is slidably connected to the inner wall of the support plate.

[0008] Furthermore, the outer wall of the driving roller is connected to the pulley through S-shaped winding of the belt.

[0009] Furthermore, the supporting assembly includes a fixing frame 1, a test tube rack and a fixing frame 2 which are arranged at the top of the tray, a plurality of PCR tubes are arranged on the inner wall of the fixing frame 1, two waste boxes are arranged in the middle of the top of the fixing frame 1, a plurality of magnetic rod sleeves are arranged on the rear side of the top of the fixing frame 1, a plurality of through holes are opened on the top of the test tube rack, and a plurality of tips are arranged on the top of the fixing frame 2.

[0010] Furthermore, the pipetting assembly includes a pipetting platform arranged at the top of the XY moving part, the left and right sides of the top of the pipetting platform are fixedly connected to motor drive frames three, the driving ends of the motor drive frames three are fixedly connected to support frames two, the adjacent sides of the bottom end of the support frame two are fixedly connected to pipettes, and the outer walls of the support frame two are provided with pipette withdrawal assemblies.

[0011] Furthermore, the two outer walls of the support frame are both slidably connected to the inner wall of the pipetting platform, and the outer walls of the pipette are both slidably connected to the inner wall of the pipetting platform.

[0012] Furthermore, the pipe withdrawal assembly includes a fixed block slidably connected to the outer wall of the second support frame, the bottom end of the fixed block is fixedly connected to the second motor drive frame, and the outer side of the bottom end of the fixed block is fixedly connected to a pipe withdrawal piece.

[0013] Furthermore, the two driving ends of the motor drive frame are slidably connected to the two outer walls of the support frame, and the inner wall of the pipe withdrawing member is slidably connected to the outer wall of the pipette.

[0014] Furthermore, the XY moving part adopts a parallel motor solution, and its torque and speed are the sum of the two motors.

[0015] The utility model has the following beneficial effects:

[0016] 1. In the utility model, the magnetic roller cooperates with the magnetic mixing table, the motor driver 1, the support frame 1, the drive motor 2, the drive roller, the pulley and the bearing table to realize the functions of rotation mixing and up and down mixing. At the same time, it has a multi-channel mixing structure that can perform batch mixing. At the end of mixing, the magnet rod cover can be automatically demagnetized to avoid biological cross contamination.

[0017] 2. In the utility model, the pipette station cooperates with the motor drive frame 2, the support frame 2, the motor drive frame 3, the pipette, the fixing block and the pipe withdrawing member, so that the device can automatically replace the tips of the pipette head, and adopts a peristaltic pump as the suction and discharge driving mechanism, which can not limit the suction and discharge capacity of the liquid. At the same time, when two pipettes are used, one is used for suction and the other can be cleaned without interfering with each other, thereby minimizing biological contamination. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 A three-dimensional diagram of a multifunctional liquid transfer and mixing workstation proposed by the utility model;

[0019] Figure 2 The utility model proposes a structure of a fixed frame in a multifunctional liquid transfer and mixing workstation Figure 1 ;

[0020] Figure 3 The utility model proposes a structure of a fixed frame in a multifunctional liquid transfer and mixing workstation Figure 2 ;

[0021] Figure 4 This is a structural diagram of a tray in a multifunctional liquid transfer and mixing workstation proposed by the utility model;

[0022] Figure 5 This is a structural diagram of a magnetic mixing table in a multifunctional liquid transfer and mixing workstation proposed by the utility model;

[0023] Figure 6 The utility model provides a structural diagram of a pipetting platform in a multifunctional pipetting and mixing workstation.

[0024] Legend:

[0025] 1. Shell; 2. Outer door; 3. Fixed frame; 4. Driving top frame; 5. Magnetic mixing table; 6. Tray; 7. XY moving parts; 8. Pipetting station; 9. Support plate; 10. Fixed frame one; 11. Test tube rack; 12. Fixed frame two; 13. Tips; 14. Through hole; 15. Magnetic rod sleeve; 16. Waste box; 17. PCR tube; 18. Motor driver one; 19. Support frame one; 20. Drive motor two; 21. Drive roller; 22. Pulley; 23. Magnetic roller; 24. Carrying platform; 25. Motor drive frame two; 26. Support frame two; 27. Motor drive frame three; 28. Pipette; 29. ​​Fixed block; 30. Tube withdrawal piece. DETAILED DESCRIPTION

[0026] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0027] Reference Figure 1 , Figure 2 and Figure 4The utility model provides an embodiment: a multifunctional liquid transfer and mixing workstation, comprising a shell 1, an outer door 2 is arranged at the front end of the shell 1, a fixed frame 3 is fixedly connected to the inner wall of the shell 1, a tray 6 is arranged at the bottom of the inner wall of the fixed frame 3, a fixed frame 10, a test tube rack 11 and a fixed frame 2 12 are arranged at the top of the tray 6, a plurality of PCR tubes 17 are arranged on the inner wall of the fixed frame 10, two waste boxes 16 are arranged in the middle of the top of the fixed frame 10, a plurality of magnetic rod sleeves 15 are arranged on the rear side of the top of the fixed frame 10, a plurality of through holes 14 are opened at the top of the test tube rack 11, and a plurality of tips 13 are arranged at the top of the fixed frame 2 12;

[0028] Specifically, the outer door 2 is opened by manually pressing the operation panel on the surface of the shell 1, and the tray 6 is moved out from the inside of the shell 1. Then, the test tubes containing different reagents are placed in the through holes 14 on the test tube rack 11, and the magnetic rod sleeve 15, PCR tube 17 and tips 13 are placed in the corresponding fixing frame 10 and tips 13 respectively. The control panel is operated again to retract the tray 6 and close the outer door 2.

[0029] Reference Figure 3 , Figure 4 and Figure 6 , the top of the fixed frame 3 is fixedly connected to a driving top frame 4, and an XY moving part 7 is arranged at the opposite end of the driving top frame 4. A pipetting platform 8 is arranged at the top of the XY moving part 7. The left and right sides of the top of the pipetting platform 8 are fixedly connected to motor driving frames 3 27, and the driving ends of the motor driving frames 3 27 are fixedly connected to the supporting frames 2 26, and the adjacent sides of the bottom ends of the supporting frames 26 are fixedly connected to the pipettes 28. The outer walls of the supporting frames 26 are slidably connected to the inner walls of the pipetting platform 8, and the outer walls of the pipettes 28 are slidably connected to the inner walls of the pipetting platform 8. Fixed blocks 29 are arranged on the outer walls of the supporting frames 26, and the bottom ends of the fixed blocks 29 are fixedly connected to the motor driving frames 25. The bottom ends of the fixed blocks 29 are fixedly connected to the outer side of the fixed blocks 29. The pipette withdrawal parts 30 are fixedly connected, and the driving ends of the motor driving frames 25 are slidably connected to the outer walls of the supporting frames 26, and the inner walls of the pipette withdrawal parts 30 are slidably connected to the outer walls of the pipettes 28. The XY moving part 7 adopts a parallel motor solution, and its torque and speed are the sum of the two motors.

[0030] Specifically, the control panel controls the driving frame 4 to drive the XY moving part 7 to move on the driving frame 4. The driving frame 4 adopts a COREXY structural design, which gives full play to the advantages of parallel motors. The speed and torque are the superposition and the torque of the two motors. Therefore, under the same power condition, only a motor with half the torque needs to be selected to reduce production costs and improve the overall cost performance. In addition, a synchronous belt method is adopted to reduce noise. When the driving frame 4 moves the pipetting table 8 to the top of the fixed frame 2 12, the motor driving frame 3 27 drives the support frame 2 26 to move downward so that the pipette 28 is equipped with the tips 13. Then the driving frame 4 drives the XY moving part 7 to drive the pipette 28 to the top of the test tube rack 11, and the driving frame 4 controls the pipetting table 8 Move horizontally to the mouth of the test tube to absorb liquid. After the washing is completed, the liquid is sent to the inside of the PCR tube 17, and then the pipetting platform 8 is moved to the top of the waste box 16. The motor driving frame 25 drives the fixed block 29 to slide on the support frame 26, so that the pipette withdrawal piece 30 moves on the pipette 28 to withdraw the used tips 13 from the pipette 28 and drop it into the waste box 16 for recovery. Then repeat the above process multiple times until the pipetting is completed. During the pipetting process, the pipette 28 uses a peristaltic pump as the suction and discharge driving mechanism, which does not limit the liquid suction and discharge capacity. At the same time, the two pipettes 28 can work independently without affecting each other. Since they share a main body component, the motion mechanism is reduced, the motion efficiency is improved, and the production cost is reduced.

[0031] Reference Figure 3 and Figure 5 , a magnetic mixing platform 5 is provided at the opposite end of the driving top frame 4, the bottom end of the magnetic mixing platform 5 is fixedly connected to a support plate 9, the top of the support plate 9 is fixedly connected to a motor driver 18, the driving end of the motor driver 18 is fixedly connected to a support frame 19, the upper side of the outer wall of the support frame 19 is slidably connected to the inner wall of the magnetic mixing platform 5, the middle part of the outer wall of the support frame 19 is slidably connected to the inner wall of the support plate 9, the bottom end of the support frame 19 is fixedly connected to a bearing platform 24, a driving motor 20 is fixedly connected to one side of the top of the bearing platform 24, a driving motor 20 is fixedly connected to a driving roller 21 at the driving end of the driving motor 20, a plurality of magnetic rollers 23 are rotatably connected to the inner wall of the bearing platform 24, the outer walls of the magnetic rollers 23 are fixedly connected to pulleys 22, and the outer wall of the driving roller 21 is connected to the pulley 22 by S-shaped winding of the belt;

[0032] Specifically, after the transfer is completed, the magnetic mixing table 5 is driven by the top frame 4 to move to the rear side of the top of the fixed frame 10, and then the motor driver 18 drives the support frame 19 to move the carrier 24 to descend and insert the magnetic roller 23 into the magnetic rod sleeve 15 for assembly, and then the carrier 24 is reset to move the magnetic roller 23 equipped with the magnetic rod sleeve 15 to the top of the PCR tube 17, and the motor driver 18 drives the magnetic roller 23 to descend and insert it into the PCR tube 17 again, and then the driving motor 20 drives the magnetic roller 23 to rotate in cooperation with the belt and the pulley 22 to mix the reagents inside the PCR tube 17, which can realize the functions of rotation mixing and up and down mixing, and at the same time has a multi-channel mixing structure to perform batch mixing. After mixing, the magnetic roller 23 is moved to the top of the waste box 16 to retract the magnetic rod sleeve 15, and then the outer door 2 is controlled to open and the tray 6 is extended to take the mixed reagents.

[0033] Working principle: The outer door 2 is opened by manually pressing the operation panel on the surface of the shell 1, and the tray 6 is moved out from the inside of the shell 1. Then, the test tubes containing different reagents are placed in the through holes 14 on the test tube rack 11, and the magnetic rod sleeve 15, PCR tube 17 and tips 13 are placed in the corresponding fixed frame 10 and tips 13 respectively. The control panel is operated again to retract the tray 6 and close the outer door 2. The control panel controls the driving top frame 4 to drive the XY moving part 7 to move on the driving top frame 4. The driving top frame 4 adopts the COREXY structure design, which gives full play to the advantages of the parallel motor; the speed and torque are the superposition and of the two motors, so under the same power condition Under the present invention, only a motor with half the torque needs to be selected, which can reduce production costs and improve comprehensive cost performance. In addition, a synchronous belt method is adopted to reduce noise. When the driving top frame 4 moves the liquid transfer platform 8 to the top of the fixed frame 12, the motor driving frame 3 27 drives the support frame 2 26 to move downward so that the pipette 28 is equipped with the tips 13. Then, the driving top frame 4 drives the XY moving part 7 to drive the pipette 28 to the top of the test tube rack 11. The driving top frame 4 controls the liquid transfer platform 8 to move horizontally to the test tube mouth for liquid aspiration. After the washing is completed, the liquid is sent to the inside of the PCR tube 17. Then, the liquid transfer platform 8 is moved to the top of the waste box 16, and the motor driving frame 25 drives the fixed block 29 to slide on the support frame 26. The pipette 28 is moved to make the withdrawing member 30 move on the pipette 28 to withdraw the used tips 13 from the pipette 28 and drop them into the waste box 16 for recovery. Then the above process is repeated several times until the transfer is completed. During the transfer, the pipette 28 uses a peristaltic pump as a suction and discharge driving mechanism, which can not limit the capacity of liquid suction and discharge. At the same time, the two pipettes 28 can work independently without affecting each other. Since they share a main body component, the movement mechanism is reduced, the movement efficiency is improved, and the production cost is reduced. After the transfer is completed, the magnetic mixing table 5 is driven by the driving top frame 4 to move to the rear side of the top of the fixed frame 10, and then the motor driver 18 drives the support frame 19 to move so that the carrier 2 4 is lowered to insert the magnetic roller 23 into the magnetic rod sleeve 15 for assembly, and then the carrier 24 is reset to move the magnetic roller 23 equipped with the magnetic rod sleeve 15 to the top of the PCR tube 17, and the motor driver 1 18 drives the magnetic roller 23 to descend and insert it into the PCR tube 17 again, and then the driving motor 20 drives the magnetic roller 23 to rotate under the cooperation of the belt and the pulley 22 to mix the reagents inside the PCR tube 17, which can realize the functions of rotation mixing and up and down mixing, and has a multi-channel mixing structure to perform batch mixing. After the mixing is completed, the magnetic roller 23 is moved to the top of the waste box 16 to withdraw the magnetic rod sleeve 15, and then the outer door 2 is controlled to open and the tray 6 is extended to take the mixed reagents.

[0034] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A multifunctional liquid transfer and mixing workstation, comprising a housing (1), characterized in that: The front end of the shell (1) is provided with an outer door (2); the inner wall of the shell (1) is fixedly connected to a fixed frame (3); the bottom of the inner wall of the fixed frame (3) is provided with a bearing assembly; the top of the fixed frame (3) is fixedly connected to a driving top frame (4); the opposite end of the driving top frame (4) is provided with a magnetic mixing platform (5); the bottom end of the magnetic mixing platform (5) is fixedly connected to a support plate (9); the top of the support plate (9) is fixedly connected to a motor driver (18); the driving end of the motor driver (18) is fixedly connected to the support frame One (19), the bottom end of the support frame one (19) is fixedly connected to a bearing platform (24), the top side of the bearing platform (24) is fixedly connected to a driving motor two (20), the driving end of the driving motor two (20) is fixedly connected to a driving roller (21), the inner wall of the bearing platform (24) is rotatably connected to a plurality of magnetic rollers (23), the outer walls of the magnetic rollers (23) are fixedly connected to pulleys (22), the opposite end of the driving top frame (4) is provided with an XY moving part (7), and the top of the XY moving part (7) is provided with a pipetting assembly.

2. A multifunctional liquid transfer and mixing workstation according to claim 1, characterized in that: The upper side of the outer wall of the support frame (19) is slidably connected to the inner wall of the magnetic mixing platform (5), and the middle part of the outer wall of the support frame (19) is slidably connected to the inner wall of the support plate (9).

3. A multifunctional liquid transfer and mixing workstation according to claim 1, characterized in that: The outer wall of the driving roller (21) is connected to the pulley (22) through an S-shaped belt winding.

4. A multifunctional liquid transfer and mixing workstation according to claim 1, characterized in that: The bearing assembly comprises a tray (6) arranged at the bottom of the inner wall of the fixed frame (3); a fixed frame 1 (10), a test tube rack (11) and a fixed frame 2 (12) are arranged at the top of the tray (6); a plurality of PCR tubes (17) are arranged on the inner wall of the fixed frame 1 (10); two waste boxes (16) are arranged in the middle of the top of the fixed frame 1 (10); a plurality of magnetic rod sleeves (15) are arranged at the rear side of the top of the fixed frame 1 (10); a plurality of through holes (14) are opened at the top of the test tube rack (11); a plurality of tips (13) are arranged at the top of the fixed frame 2 (12).

5. A multifunctional liquid transfer and mixing workstation according to claim 1, characterized in that: The pipetting assembly comprises a pipetting platform (8) arranged at the top of the XY moving part (7), the left and right sides of the top of the pipetting platform (8) are fixedly connected to the motor drive frame three (27), the driving end of the motor drive frame three (27) is fixedly connected to the support frame two (26), the adjacent side of the bottom end of the support frame two (26) is fixedly connected to the pipette (28), and the outer wall of the support frame two (26) is provided with a pipette withdrawal assembly.

6. A multifunctional liquid transfer and mixing workstation according to claim 5, characterized in that: The outer walls of the second support frame (26) are slidably connected to the inner wall of the transfer platform (8), and the outer walls of the pipette (28) are slidably connected to the inner wall of the transfer platform (8).

7. A multifunctional liquid transfer and mixing workstation according to claim 5, characterized in that: The pipe withdrawal assembly comprises a fixed block (29) disposed on the outer wall of the second support frame (26), the bottom end of the fixed block (29) is fixedly connected to the second motor drive frame (25), and the outer side of the bottom end of the fixed block (29) is fixedly connected to a pipe withdrawal piece (30).

8. A multifunctional liquid transfer and mixing workstation according to claim 7, characterized in that: The driving ends of the second motor drive frame (25) are slidably connected to the outer wall of the second support frame (26), and the inner wall of the pipe withdrawing member (30) is slidably connected to the outer wall of the pipette (28).

9. A multifunctional liquid transfer and mixing workstation according to claim 1, characterized in that: The XY moving part (7) adopts a parallel motor solution, and its torque and speed are the sum of the two motors.

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