Rodent catheter type uterus operation auxiliary device
By designing a catheter-type long-scissor uterine surgery auxiliary device suitable for rodents, the problem of bilateral simultaneous administration and damage in the prior art is solved, and efficient and safe uterine surgery operation under no open conditions is achieved, which significantly improves the success rate and efficiency of animal model construction.
Patent Information
- Application Number
- CN202421611198.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-07-09
- Publication Date
- 2025-05-13
- Estimated Expiration
- 2034-07-09
AI Technical Summary
The existing rodent uterine surgical devices cannot be administered bilaterally and damaged in the absence of open abdominal conditions, and cannot be applied to the 'Y'-shaped bicornered uterus of rodents, with low operation efficiency and high failure rate.
A catheter-type long scissor-shaped uterine surgical assistance device is designed, using a combination of catheter-type scissors and spiral cell brushes, which can be administered and damaged on both sides without opening the abdomen. It is suitable for the 'Y'-shaped bicornered uterus of rodents.
The device can significantly reduce operational difficulty and infection risk, improve the efficiency and success rate of animal model construction, reduce failure rate, simplify operation process, and reduce modeling costs.
Smart Images

Figure CN222854021U_ABST
Abstract
Description
Technical field:
[0001] The utility model belongs to the field of animal medical experiments and relates to a rodent catheter-type uterine surgery auxiliary device, which is used for conveniently administering medication and damaging the animal uterus on both sides simultaneously without opening the abdomen when performing surgical operations for constructing uterine-related animal models on rodents, thereby facilitating the construction of animal models. Background technology:
[0002] The development of human diseases is very complex. Using humans as experimental subjects to deeply explore the mechanism of disease occurrence and promote the development of medicine is slow. The accumulated clinical experience is not only limited in time and space, but many experiments are also limited in morality and methods. With the help of indirect research on animal models, factors that are impossible or difficult to eliminate under natural conditions can be consciously changed, so as to more accurately observe the experimental results of the model and conduct comparative studies with human diseases, which will help to more conveniently and effectively understand the occurrence and development of human diseases, study prevention and treatment measures, and provide support and guarantee for the prevention and treatment of human-related diseases.
[0003] With the development of modern medicine, people's attention and research on gynecological diseases have gradually increased. Among them, uterine diseases, as a common type of gynecological diseases, have received widespread attention. For the study of uterine diseases, it is often necessary to use methods such as building animal models; rodents, as commonly used economical model animals, have a clear genetic background, are close to human pathogenesis, are inexpensive, and are convenient for experimental operation. They are ideal animal models for studying physiological and pathological damage and repair of the endometrium. However, the uterus of adult rodents is a "Y"-shaped bicornuate uterus that penetrates deep into the abdominal cavity. In the process of building animal models for diseases such as endometrial adhesions, endometriosis, and endometritis, abdominal surgery must be performed before alcohol can be infused through the intra-abdominal opening of the uterus at both ends to damage its endometrium, or the uterus needs to be cut open for related injury operations. Both of the above methods will cause a whole-abdominal inflammatory response, and the efficiency, success rate, and accuracy are relatively low. Not only does it waste a large number of experimental animals, but it also causes differences in experimental results, which greatly affects disease research and clinical transformation, and greatly reduces the reliability of preclinical animal model construction.
[0004] In the prior art, Chinese patent CN111839798A discloses a method for constructing a mouse endometrial injury model and the constructed model, comprising the following steps: inducing respiratory anesthesia in mice, injecting phloroglucinol intramuscularly after successful anesthesia induction, entering the mouse vagina with a mouse gavage needle, entering the uterine horn after probing for cervical relaxation, injecting 95% ethanol and staying for a specific time, and then removing the residual ethanol. The method for constructing a mouse endometrial injury model will not cause damage to the local myometrium of the mouse uterus by laparotomy, and the modeling effect is stable and the success rate is high. However, the angle of the mouse gavage needle used in this method is not adjustable, and the fixed curvature of its front end is difficult to operate for the "Y"-shaped bicornuate uterus, and the drug administration operation can only be performed on one side, and it is impossible to cause damage to the endothelial cell layer to the greatest extent without destroying the basal layer of the uterus. It is inconvenient to use and has low operating efficiency, which affects the overall success rate and complexity of animal model construction.
[0005] Chinese patent CN210673488U discloses a rat thin endometrial modeler, comprising: a scraper placed in the rat uterus, the outer surface of the scraper consists of a rough surface and a smooth surface arranged along the length direction of the scraper; the rough surface is evenly covered with sawtooth patterns, and the cross-sectional central angle of the rough surface is 90°-110°; the scraper is also provided with a plurality of warning rings; a handle for fixing the scraper, which comprises a first body and a second body, the first body and the second body are rotatably connected; a pointer is provided on the first body, and an angle scale is provided on the outer periphery of the second body; the scraper and the handle are threadedly connected. The shape and size of the scraper of the utility model device conform to the structural characteristics of the "Y"-shaped bicornuate uterus of rats, the structure is simple and scientific, the operation is convenient, and the perforation of the uterus can be effectively avoided, the psychological burden of the operator can be reduced, and the accuracy of the experimental results can be improved. However, the device needs to be operated laparotomy first, which is easy to increase the risk of infection, and can only be operated on one side, which is difficult to operate, inefficient, and has a very high failure rate.
[0006] Chinese patent CN208958282U discloses an endometrial scraping tool, including a scraping head, an intermediate connecting rod, and a handle. The scraping head, the intermediate connecting rod, and the handle are connected in sequence from top to bottom. The scraping head is hinged to the upper end of the intermediate connecting rod, and the handle is detachably connected to the lower end of the intermediate connecting rod. The scraping head is provided with a scraping claw body with multiple claws, and the front end of each claw of the scraping claw body is round and blunt. The utility model can achieve a suitable and effective contact area through the scraping claw body with three claws, and can avoid negative damage to the endometrium caused during the scraping procedure; and the scraping head provided in the utility model can be driven by the central rod to adjust the angle, so as to achieve a better scraping effect on the endometrium. However, the structure and shape of the utility model are only applicable to the pear-shaped uterus of humans, and cannot be applied to the "Y"-shaped uterus of rodents. It is easy to cause other injuries such as cervical rupture during operation, and the animal model construction is easy to fail, which is extremely inconvenient to use.
[0007] The rodent uterine surgery device involved in the above-mentioned prior art has the problems of being unable to perform bilateral operations simultaneously, requiring anterior laparotomy, being unable to adapt to the shape of the rodent uterus, and being unable to take into account both functions of damage and medication in a single operation. After searching and analyzing by the inventor, the prior art has not disclosed a rodent uterine surgery auxiliary device that utilizes a catheter-type long scissor-shaped design to perform medication and damage to the bicornuate uterus on both sides simultaneously without laparotomy. Therefore, the invention of a rodent catheter-type uterine surgery auxiliary device can improve the deficiencies of the prior art, simplify the process steps, reduce the difficulty of operation and the risk of infection, and improve the efficiency and success rate of animal model construction. Summary of the invention:
[0008] The purpose of the utility model is to overcome the shortcomings of the prior art. Based on the improvement of the existing rodent uterine surgical device, a rodent uterine surgical auxiliary device is designed to provide a device that utilizes a catheter-type long scissors-shaped design to simultaneously administer medication and damage the bicornuate uterus without the need for laparotomy. The utility model solves the problems of the existing operating device that it is impossible to perform bilateral operations simultaneously, that anterior laparotomy operations are required, that it is not suitable for the shape of the rodent uterus, and that a single operation cannot take into account the dual functions of damage and medication.
[0009] In order to achieve the above-mentioned purpose, the utility model provides a rodent catheter-type uterine surgery auxiliary device, which consists of a catheter scissors and a spiral cell brush. The catheter scissors are a scissor-like structure composed of two identical scissor legs hinged together. The front end of the scissor leg is an insertion piece composed of a funnel-shaped hollow introduction component and a hollow tube connected to the narrow end of the introduction component, and the rear end is a handpiece composed of a long rod-shaped connecting rod and an arc-shaped handle. The insertion piece at the front end and the handpiece at the rear end are connected by a wide connecting piece. The connecting rod is provided with a connecting rod opening on the outside away from the hinge point. The connecting rods from the connecting rod opening to the connection with the connecting piece are all hollow in design, so that the connecting rod opening can be connected to the internal cavity of the connecting rod; the spiral cell brush is a deformable slender soft-handled brush, one end of which is fixed with a pull ring, and the other end is provided with bristles. The pull ring end extends from the connecting rod opening of the scissor leg connecting rod for easy pulling. Except for the pull ring, the rest of the brush body enters the introduction component and the hollow tube along the connecting rod through the connecting piece and is placed in the hollow part of the scissor leg.
[0010] The utility model relates to a catheter shear in which the intersection of the spiral cell brushes in the connecting rods at both sides is located at a side of the hinge point of the catheter shear close to the handpiece.
[0011] The insertion piece of the utility model is shorter than the hand-held piece.
[0012] The connecting piece involved in the utility model has the same thickness as the side wall of the connecting rod and the introduction device, and the connecting piece is welded to the side wall fracture on the same side of the connecting rod and the introduction device, and can be horizontally and smoothly connected with the side wall, so that the hollow openings of the connecting rod and the introduction device can be relative and connected.
[0013] The position relationship of the two shear legs of the catheter shear involved in the utility model is that one shear leg is placed horizontally, and the other shear leg is rotated 180 degrees around the vertical center axis of the previous shear leg, and the connecting pieces of the two shear legs are connected by a connecting piece at the same vertical position.
[0014] The inserting piece involved in the utility model is a hollow structure with a continuous and smooth interior. The wide mouth and the narrow mouth of the introduction component are aligned at one point, and the wide mouth corresponding to the narrow mouth on the other side is connected to the narrow mouth to form an inwardly inclined structure. The inclined side of the introduction component is arranged on the outside of the catheter shear, and the vertical side corresponding to the wide mouth is arranged on the inside of the catheter shear, so as to introduce the spiral cell brush bent outward into the hollow tube; the end of the hollow tube connected downwardly by the narrow mouth is a soft catheter with a certain supporting force but capable of deformation.
[0015] The utility model relates to a spiral cell brush with a handle that is a hollow structure, wherein the head of one end with bristles is sealed, and the end with a pull ring is provided with a small opening from the pull ring, so that the internal hollow structure can communicate with the outside through the pull ring opening; the bristles are arranged vertically in a spiral on the side of the brush handle, and one side of the connection between the brush handle and each bristle is provided with a small hole, that is, there is only one small hole on the side of the brush handle on the same horizontal plane; when the spiral cell brush is received in a hollow tube, the bristles are constrained by the tube wall and form an angle of 45° with the brush handle, which can effectively prevent the liquid in the brush handle from flowing out.
[0016] The spiral cell brush involved in the utility model is also provided with a liquid pressure controller at the opening of the pull ring. The liquid pressure controller is composed of an injection tube, a syringe with a small hole at the front end and a piston core rod matched therewith. The piston core rod is inserted into the syringe. One end of the injection tube is connected to the small hole of the syringe, and the other end is connected to the opening of the pull ring, so as to control the liquid to enter the brush handle of the spiral cell brush.
[0017] The pull ring and the brush handle involved in the utility model form an angle of 135°-160°.
[0018] The soft catheter involved in the utility model is made of rubber material and has a length of 1-2 mm.
[0019] The outside of the connecting piece involved in the utility model is wrapped with soft material.
[0020] When the rodent catheter-type uterine surgery auxiliary device involved in the utility model is used to build an animal model of endometrial disease, since no laparotomy is required and the cervix can be protected from being torn, the risk of uterine rupture is basically eliminated, and the failure rate can be reduced by 50% or more. The average number of training cycles is less than 5 times for practical operation, which greatly reduces the difficulty and training cost of animal model construction and is conducive to research in related fields.
[0021] Compared with the prior art, the utility model has the following advantages: (1) The utility model is designed with a long scissors with a catheter at the front end, which can be applied to the "Y"-shaped bicornuate uterus of rodents and can be operated on both sides to ensure balanced force, greatly reducing the risk of cervical rupture caused by unilateral operation, reducing the difficulty of surgery and improving surgical efficiency; (2) A soft-headed catheter is designed to protect the junction of the vagina and uterus in the body, and can change the angle of the insertion piece by adjusting the handpiece without damaging the cervix so that the hollow tubes on both sides can enter the bilateral uterus of the rodent at the same time; (3) The spiral cell brush It can create the piston-type endometrial destruction required for the construction of an animal model of endometrial disease. When the spiral cell brush is extended out of the soft catheter, the bristles are at about 90 degrees to the uterine wall. On the basis of not damaging the basal layer of the uterus, the maximum damage stress can be caused to the uterine wall by pulling the pull ring of the spiral cell brush, thereby satisfying the operator's maximum endometrial damage area as much as possible. (4) When the spiral cell brush is retracted, the bristles are at 45 degrees to the brush handle, which can smoothly retract the cell brush while ensuring that the liquid in the brush handle does not flow out. The spirally arranged bristle design utilizes the siphon principle. After the bristles extend out of the soft catheter, they can be controlled by a liquid pressure controller. The outflow of liquid in the brush handle is controlled, and the drug is administered to the designated location, so that the drug can directly enter the damaged area along with the endometrial damage to construct a model of endometritis; (5) The wide connecting piece design enables the connection of the catheter scissors to be restricted by the vaginal orbicularis oculi muscle when the insert enters the animal's body, and it cannot be opened too wide or move freely. There is no need to set other limiting structures, which simplifies the overall structure and reduces costs; (6) Since there is no need for laparotomy and the cervix can be protected from being torn, the risk of uterine infection and rupture is basically eliminated, and the failure rate can be reduced by 50% or more, and the average training cycle The number of repetitions is less than 5, which makes the animal model closer to clinical manifestations. At the same time, the repeatability of model construction is almost 90%, which greatly reduces the difficulty and training cost of animal model construction. (7) It saves time for abdominal anatomy learning, antibiotic use after abdominal opening, and mouse care, simplifies the operation process, reduces the cost of modeling, and is easy to promote. Its overall design is scientific and reasonable, with a simple structure, which can be adapted to the unique uterine shape of rodents, simplifies the process steps, reduces the difficulty of operation and the risk of infection, improves the efficiency and success rate of animal model construction, reduces unnecessary costs and losses, and is economical and applicable. Description of the drawings:
[0022] Figure 1 The utility model is a schematic diagram of the structural principle of the rodent catheter-type uterine surgery auxiliary device.
[0023] Figure 2 It is a schematic diagram of the local structural principle of the connecting piece after being hinged involved in the utility model.
[0024] Figure 3 The utility model is a schematic diagram of the structural principle of the spiral cell brush bristles.
[0025] Figure 4 The utility model is a schematic diagram of the structural principle of the liquid pressure controller.
[0026] The components in the accompanying drawings are marked as follows: catheter scissors 1, spiral cell brush 2, scissor legs 3, insertion part 4, introduction part 5, hollow tube 6, handpiece 7, connecting rod 8, grip 9, connecting piece 10, connecting part 11, connecting rod opening 12, pull ring 13, bristles 14, brush handle 15, liquid pressure controller 16, injection tube 17, syringe 18, piston core rod 19. Specific implementation method:
[0027] The technical solution of the utility model is further described below in conjunction with the accompanying drawings and specific embodiments.
[0028] Embodiment 1:
[0029] The present embodiment relates to a rodent catheter-type uterine surgery auxiliary device, which is composed of a catheter scissors 1 and a spiral cell brush 2. The catheter scissors 1 is a scissor-like structure composed of two identical scissor legs 3 hinged together. The front end of the scissor legs 3 is an insertion piece 4 composed of a hollow introduction component 5 with a funnel-shaped design and a hollow tube 6 connected to the narrow end of the introduction component 5, and the rear end is a handpiece 7 composed of a long rod-shaped connecting rod 8 and an arc-shaped grip 9. The front insertion piece 4 is connected to the rear handpiece 7 by a wide connecting piece 10. The connecting rod 8 is provided with a A connecting rod opening 12, the connecting rod 8 from the connecting rod opening 12 to the connection with the connecting piece 10 is hollow, so that the connecting rod opening 12 can be connected to the internal cavity of the connecting rod 8; the spiral cell brush 2 is a deformable slender soft-handled brush, one end of which is fixed with a pull ring 13, and the other end is provided with bristles 14, and the pull ring 13 end extends from the connecting rod opening 12 of the connecting rod 8 of the scissor leg 3 for easy pulling. Except for the pull ring 13, the rest of the brush body follows the connecting rod 8 through the connecting piece 10 into the introduction component 5 and the hollow tube 6, and is placed in the hollow part of the scissor leg 3.
[0030] The intersection of the spiral cell brushes 2 in the connecting rods 8 on both sides of the catheter shears 1 in this embodiment is located on the side of the hinge point of the catheter shears 1 close to the handpiece 7.
[0031] The insertion piece 4 involved in this embodiment is shorter than the handpiece 7 .
[0032] The connecting piece 10 involved in this embodiment has the same thickness as the side walls of the connecting rod 8 and the introduction device. The connecting piece 10 is welded to the side wall fracture on the same side of the connecting rod 8 and the introduction device, and can be horizontally and smoothly connected with the side wall, so that the hollow opening of the connecting rod 8 and the introduction device can be relative and connected.
[0033] The positional relationship of the two shear legs 3 of the catheter shear 1 involved in this embodiment is that one shear leg 3 is placed horizontally, and the other shear leg 3 is rotated 180° around the vertical center axis of the previous shear leg 3, and the connecting pieces 10 of the two shear legs 3 are connected by a connecting piece 11 at the same vertical position.
[0034] The insertion part 4 involved in this embodiment is a hollow structure with a continuous and smooth interior. The wide mouth and the narrow mouth of the introduction component 5 are aligned at one point, and the corresponding wide mouth on the other side is connected to the narrow mouth to form an inwardly inclined structure. The inclined side of the introduction component 5 is arranged on the outside of the catheter shear 1, and the corresponding vertical side is arranged on the inside of the catheter shear 1, which is used to introduce the spiral cell brush 2 bent outward into the hollow tube 6; the end of the hollow tube 6 connected downward by the narrow mouth is a soft catheter with a certain supporting force but can be deformed.
[0035] The handle 15 of the spiral cell brush 2 involved in this embodiment is a hollow structure, the head of one end with bristles 14 is sealed, and the end with the pull ring 13 has a small opening from the pull ring 13, so that the internal hollow structure can communicate with the outside through the opening of the pull ring 13; the bristles 14 are arranged vertically in a spiral manner on the side of the handle 15, and one side of the connection between the handle 15 and each bristle 14 is provided with a small hole, that is, there is only one small hole on the side of the handle 15 on the same horizontal plane; when the spiral cell brush 2 is received in the hollow tube 6, the bristles 14 are constrained by the tube wall and form an angle of 45° with the handle 15, which can effectively prevent the liquid in the handle 15 from flowing out.
[0036] The spiral cell brush 2 involved in this embodiment is also provided with a liquid pressure controller 16 at the opening of the pull ring 13. The liquid pressure controller 16 is composed of an injection tube 17, a syringe 18 with a small hole at the front end and a piston core rod 19 matching it. The piston core rod 19 is inserted into the syringe 18. One end of the injection tube 17 is connected to the small hole of the syringe 18, and the other end is connected to the opening of the pull ring 13, which is used to control the liquid to enter the brush handle 15 of the spiral cell brush 2.
[0037] The pull ring 13 and the brush handle 15 involved in this embodiment form an angle of 135°-160°.
[0038] The soft catheter involved in this embodiment is made of rubber material and has a length of 1-2 mm.
[0039] The connection piece 10 involved in this embodiment is wrapped with soft material on the outside to avoid scratching tissue when the device is placed into the animal's body.
[0040] The inner diameter of the hollow tube 6 in this embodiment is 1.4 mm, and the length of the bristles 14 of the spiral cell brush 2 is 1.5 mm.
[0041] The vagina of an adult mouse is about 9-9.5 mm long, the inner diameter of the vaginal opening is about 5.5-6 mm, the cervical intersection is about 3.5 mm long, the inner diameter is about 1.5-2 mm, the bilateral uterus is about 12.5-14.5 mm long, and the inner diameter is about 1 mm; referring to the physiological structure and data of adult mice, the introduction component 5 involved in this embodiment is 7 mm long, the hollow part of the connecting rod 8 is 7 mm long, the entire handpiece 7 is 28 mm long, the spiral cell brush 2 is about 25 mm long, and the part with bristles 14 at the front end is 3-5 mm.
[0042] The rodent catheter-type uterine surgery auxiliary device involved in this embodiment is designed as a long scissor-type surgical device based on the bicornuate uterus, vaginal width and uterine separation angle of rodents. A soft-head catheter is designed for the junction of the vagina and uterus when the device enters the body. The angle of the insertion piece 4 can be changed by adjusting the handpiece 7 without damaging the cervix, so that the hollow tubes 6 on both sides can enter the bilateral uterus of the rodent at the same time, which can ensure the balance of force, greatly reduce the risk of cervical rupture caused by unilateral operation, and greatly shorten the training cost of mastering the method of building the animal model. The design of the spiral cell brush 2 refers to the piston-type endometrial destruction required for the construction of an animal model of endometrial disease. When the spiral cell brush 2 extends out of the soft catheter, the bristles 14 are about 90 degrees to the uterine wall. On the basis of not damaging the basal layer of the uterus, the maximum damage stress can be caused to the uterine wall by pulling the pull ring 13 of the spiral cell brush 2, so as to meet the operator's maximum endometrial damage area as much as possible; when retracted, the bristles 14 and the brush handle 15 are 45 degrees, so that the cell brush can be smoothly retracted while ensuring that the liquid in the brush handle 15 does not flow out; the design of the spirally arranged bristles 14 utilizes the siphon principle. After the bristles 14 extend out of the soft catheter, the outflow of the liquid in the brush handle 15 can be controlled by the liquid pressure controller 16, and the drug (such as lipopolysaccharide) can be administered to the designated location, so that the drug can directly enter the damaged area along with the endometrial damage to construct a model of endometritis. The wide connecting piece 10 is designed so that when the insert 4 enters the animal body, the connection of the catheter scissors 1 is limited by the vaginal orbicularis oculi muscle and cannot be opened too much or move freely. There is no need to set other limiting structures, which simplifies the overall structure and reduces costs.
[0043] When the rodent catheter-type uterine surgery assisting device involved in this embodiment is used to construct an animal model of endometrial disease, since no laparotomy is required and the cervix can be protected from being torn, the risk of uterine rupture is basically eliminated, and the failure rate can be reduced by 50% or more. The average number of training cycles is less than 5 times for practical operation, which greatly reduces the difficulty and training cost of animal model construction and is conducive to research in related fields.
[0044] This embodiment relates to a method for using a rodent catheter-type uterine surgery auxiliary device, and the specific steps are as follows:
[0045] 1. Inhale the required drugs into the liquid pressure controller 16, and connect the liquid pressure controller 16 to the opening of the pull ring 13 of the spiral cell brush 2 through the injection tube 17; lay the anesthetized rodent flat on a flat surface with its abdomen facing upward and fix it;
[0046] 2. Pull the pull ring 13 outward until the bristles 14 of the spiral cell brush 2 are all retracted into the hollow tube 6, and bring the catheter shears 1 together until the insertion pieces 4 of the two shear legs 3 are parallel;
[0047] 3. Hold the handpiece 7 of the catheter scissors 1 and slowly insert the insertion piece 4 into the vagina of the animal. When you feel a slight resistance from the front end, slowly separate the handpiece 7. When the angle is appropriate, slowly continue to insert the insertion piece 4 until the connecting piece 11 is stuck and the insertion piece 4 cannot be further inserted;
[0048] 4. Push the pull rings 13 of the left and right spiral cytology brushes 2 forward respectively, so that the entire spiral cytology brush 2 is driven forward, and the bristles 14 extend out of the hollow tube 6 to contact the uterine wall. After pushing the pull ring 13 to the bottom, pull out the pull rings 13 on the left and right sides again, so that the bristles 14 are retracted into the hollow tube 6;
[0049] 5. Repeat step 4 30 times;
[0050] 6. Push the pull rings 13 of the left and right spiral cytology brushes 2 forward again, so that the pull rings 13 drive the entire spiral cytology brush 2 forward, and the bristles 14 extend out of the hollow tube 6 to contact the uterine wall, pushing the piston core rod 19 of the liquid pressure controller 16, so that the internal medicine passes through the small holes below the bristles 14 and enters the wound on the inner wall of the uterus along the bristles 14;
[0051] 7. Pull out the pull ring 13 again to retract the bristles 14 into the hollow tube 6, hold the handpiece 7 and slowly withdraw the implant 4 from the animal's uterus until the front end of the implant 4 is stuck, slowly close the opening angle of the handpiece 7 and slowly withdraw the implant 4 at the same time, until the entire device is completely out of the animal's body.
Claims
1. A rodent catheter-type uterine surgery auxiliary device, characterized in that: The utility model is composed of a catheter scissors and a spiral cell brush. The catheter scissors are a scissor-like structure formed by hinged two identical scissor legs. The front end of the scissor legs is an insertion piece composed of a funnel-shaped hollow introduction component and a hollow tube connected to the narrow end of the introduction component, and the rear end is a handpiece composed of a long rod-shaped connecting rod and a grip. The length of the insertion piece is less than the length of the handpiece. The insertion piece at the front end is connected to the handpiece at the rear end by a wide connecting piece. The connecting rod is provided with a connecting rod opening on the outside away from the hinge point. The connecting rod from the connecting rod opening to the connection with the connecting piece is hollow in design, so that the connecting rod opening can be connected with the internal cavity of the connecting rod; the spiral cell brush is a deformable slender soft-handled brush, one end of which is fixed with a pull ring, and the other end is provided with bristles, the pull ring end of which extends out from the connecting rod opening of the scissor leg connecting rod for easy pulling. Except for the pull ring, the rest of the brush body enters the introduction component and the hollow tube along the connecting rod through the connecting piece and is placed in the hollow part of the scissor legs. The intersection of the spiral cell brushes in the connecting rods on both sides of the catheter scissors is located on the side of the hinge point of the catheter scissors close to the handpiece.
2. The rodent catheter-type uterine surgery auxiliary device according to claim 1, characterized in that: The handle is in an arc shape.
3. The rodent catheter-type uterine surgery auxiliary device according to claim 1, characterized in that: The connecting piece is consistent in thickness with the side walls of the connecting rod and the introduction device. The connecting piece is welded to the side wall fracture on the same side of the connecting rod and the introduction device, and can be horizontally and smoothly connected with the side wall, so that the hollow openings of the connecting rod and the introduction device can be opposite and connected.
4. The rodent catheter-type uterine surgery auxiliary device according to claim 1, characterized in that: The position relationship of the two shear legs of the catheter shear is that one shear leg is placed horizontally, and the other shear leg is rotated 180 degrees around the vertical center axis of the previous shear leg, and the connecting pieces of the two shear legs are connected by a connecting piece at the same vertical position.
5. The rodent catheter-type uterine surgery auxiliary device according to claim 1, characterized in that: The insert is a hollow structure with a continuous and smooth interior. The wide opening and the narrow opening of the introduction component are aligned at one point, and the corresponding wide opening on the other side is connected to the narrow opening to form an inwardly inclined structure. The inclined side of the introduction component is arranged on the outside of the catheter cutter, and the corresponding vertical side is arranged on the inside of the catheter cutter; the end of the hollow tube connected downwardly by the narrow opening is a soft catheter with a certain supporting force but capable of deformation.
6. The rodent catheter-type uterine surgery auxiliary device according to claim 1, characterized in that: The handle of the spiral cell brush is a hollow structure, the head of one end with bristles is sealed, and the end with a pull ring has a small opening from the pull ring, so that the internal hollow structure can communicate with the outside through the pull ring opening; the bristles are arranged vertically in a spiral on the side of the brush handle, and one side of the connection between the brush handle and each bristle is provided with a small hole, that is, there is only one small hole on the side of the brush handle on the same horizontal plane; when the spiral cell brush is received in the hollow tube, the bristles are constrained by the tube wall and form a 45° angle with the brush handle.
7. The rodent catheter-type uterine surgery auxiliary device according to claim 6, characterized in that: The pull ring and the brush handle form an angle of 135°-160°.
8. The rodent catheter-type uterine surgery auxiliary device according to claim 7, characterized in that: The spiral cell brush is also provided with a liquid pressure controller at the opening of the pull ring. The liquid pressure controller is composed of an injection tube, a syringe with a small hole at the front end and a piston core rod matching it. The piston core rod is inserted into the syringe. One end of the injection tube is connected to the small hole of the syringe, and the other end is connected to the opening of the pull ring, which is used to control the liquid to enter the brush handle of the spiral cell brush.
9. The rodent catheter-type uterine surgery auxiliary device according to claim 5, characterized in that: The soft catheter is made of rubber and has a length of 1-2 mm.
10. The rodent catheter-type uterine surgery auxiliary device according to claim 1, characterized in that: The outside of the connecting piece is wrapped with soft material.
Citation Information
Patent Citations
Construction method of mouse endometrial injury model and constructed model
CN111839798A
Endometrium scratching tool
CN208958282U
Thin endometrium molding device for rat
CN210673488U