Portable fluorescence detection device

Abstract

According to the portable fluorescence detection device provided by the utility model, the flip cover and the pull rod which are arranged on the side of the shell, the pull rod transition through hole formed in the gland and the sliding chute are matched, the flip cover is turned over, the sliding chute and a reagent card slot formed in the sliding chute are pulled out through the pull rod connected with the flip cover, and a test paper card can be put into the test paper card slot; the turning cover is closed, and the sliding groove, the reagent card groove formed in the sliding groove and the test paper card placed in the reagent card groove are pushed into the fluorescence detection device through the pull rod connected with the turning cover; after fluorescence detection is completed, the flip cover is turned over, the sliding groove, the reagent card groove formed in the sliding groove and the test paper card placed in the reagent card groove are pulled out of the fluorescence detection device in a linkage mode, contact between a test paper card user and the test paper card is reduced in the whole process, and through cooperation of the flip cover, the pull rod, the sliding groove and the reagent card groove, the test paper card can be conveniently taken out. The test paper card can be efficiently and accurately conveyed to the initial position of fluorescence detection, and the operation is efficient and convenient.

Description

Technical Field

[0001] The utility model belongs to the technical field of fluorescence detection, in particular to a portable fluorescence detection device. Background Art

[0002] Fluorescence detection of test strips is a method of detecting target analytes using specific chemical substances, and quantitatively or qualitatively analyzing the target substances through changes in fluorescence signals. This technology has been widely used in medical diagnosis, environmental monitoring, food safety and other fields due to its simplicity, rapidity and high sensitivity.

[0003] Fluorescent test strips usually contain a fluorescent marker, which can be a fluorescent dye or a fluorescently labeled antibody. When the target molecules in the sample to be tested bind to these markers, it will cause a change in the fluorescent signal. The fluorescent signal in the fluorescent test strip can be quantified by a special reading device, or semi-quantitatively judged by directly observing the color change with the naked eye. Some advanced equipment can also convert the fluorescent signal into a digital signal, and achieve fast and accurate detection through computer image processing.

[0004] At present, most fluorescence detection devices still require hand contact with the test strip to push the test strip from the test strip insertion port into the fluorescence detection device, for example: a portable scanning electronic detector disclosed in Chinese patent CN 116047049 A and an optical path module for a dry fluorescent immunoassay disclosed in Chinese patent CN 208313795 U. Utility Model Content

[0005] The purpose of the utility model is to provide a portable fluorescence detection device, so as to facilitate pushing a test strip into the fluorescence detection device or conveniently pushing the test strip out of the fluorescence detection device.

[0006] To this end, the above-mentioned purpose of the utility model is achieved through the following technical solutions:

[0007] A portable fluorescence detection device comprises a shell, a pressure cover is provided on the top of the shell, an optical path box is provided on the bottom plate of the shell, a reagent card slot is provided in the cavity between the pressure cover and the shell, the reagent card slot is arranged in a slide groove, the reagent card slot is used to accommodate a reagent card, the optical path box and the reagent card slot are also provided with a driving mechanism, the driving mechanism is used to drive the optical path box and / or the reagent card slot to move relative to each other, and is characterized in that: a flap is provided on the side of the shell, a pull rod is provided on the side of the flap facing the reagent card inlet of the shell, a pull rod transfer through hole is provided on the pressure cover, the pull rod is inserted into the pull rod transfer through hole and the two ends are respectively hinged to the flap and the slide groove.

[0008] While adopting the above technical solutions, the present invention can also adopt or combine the following technical solutions:

[0009] As a preferred technical solution of the utility model: an optical path box slide rail is provided on the bottom plate of the housing, and the optical path box is arranged on the optical path box slide rail via an optical path box slide table;

[0010] The optical path box comprises an upper cover and a lower cover of the optical path box, a fluorescent sensor circuit board and a light source circuit board are arranged on the peripheral side of the optical path box, and a first convex lens, a dichroic mirror, a first filter, a second convex lens, a reflector, a second filter, a collimating lens, a fluorescent sensor and a lamp bead are arranged in the optical path box;

[0011] The optical path box is arranged on the side of the reagent card slot and arranged side by side, and the reflector is arranged above the reagent card slot and is arranged in the direction of the dichroic mirror and the fluorescence sensor.

[0012] In this way, by setting a reflector to reflect the light path, the light path box can be arranged as a whole on the side of the reagent card slot instead of on the top (for example: a portable scanning electronic detector disclosed in Chinese patent CN 116047049 A will inevitably occupy a large amount of upper space, which will cause the overall thickness of the detection device), which can greatly reduce the overall thickness or volume of the portable fluorescence detection device.

[0013] As an optimal technical solution of the utility model: the driving mechanism includes a stepper motor, a motor seat, an optical path box rack, and a gear; the stepper motor is arranged on the motor seat, and the power output end of the stepper motor is fixed with a gear; the upper part of the gear is meshed with the optical path box rack, and the lower part of the gear is meshed with the teeth on the side wall of the reagent card slot, so as to enable relative movement between the optical path box and the reagent card slot; one end of the optical path box rack is fixed to the optical path box.

[0014] In this way, the optical path box rack and the optical path box are driven by the upper gear on the stepper motor, and the reagent card slot and the reagent card are driven by the lower gear on the stepper motor, so that the optical path box and the reagent card can move relative to each other synchronously, thereby shortening the detection time by half.

[0015] As a preferred technical solution of the utility model: the driving mechanism further comprises a cover plate, and the cover plate is used to at least accommodate the moving section of the rack of the optical path box.

[0016] As a preferred technical solution of the utility model: a side wall of the slide is provided with a slide side wall groove, the opening of the slide side wall groove is arranged upward, and a space for the spring and the limit pin to move up and down is formed in the slide side wall groove; the upper end of the limit pin has a wedge-shaped surface, and the wedge-shaped surface of the limit pin faces the reagent card entrance direction of the shell; the bottom of the spring is against the slide side wall groove, and the limit pin extends at least part of the wedge-shaped surface upward from the limit hole of the pressure cover under the elastic force of the spring; a downward convex block is provided on the rack of the optical path box; in the initial state, the convex block extrude at least part of the wedge-shaped surface of the limit pin downward from the limit hole of the pressure cover;

[0017] In this way, the slide slot is locked on the pressure cover by the upward movement of the limit pin, so as to prevent the slide slot, the test paper card slot, and most importantly, the test paper card from being pulled out of the fluorescence detection device by flipping the cover during the fluorescence detection process. The limit pin can move upward by driving the light path box rack to drive the light path box to move toward the reagent card entrance through the rotation of the gear, thereby moving the downward protrusion of the light path box rack away. Under the elastic force of the spring, at least part of the wedge-shaped surface of the limit pin extends upward from the limit hole of the pressure cover to lock the slide slot on the pressure cover.

[0018] After the fluorescence detection is completed, the gear rotates to drive the optical path box rack to return the optical path box to the initial state position, then the downward protrusion of the optical path box rack will push at least part of the wedge-shaped surface of the limit pin downward from the limit hole of the pressure cover, so that the locking relationship between the slide groove and the pressure cover is unlocked;

[0019] A reagent card slot side wall groove is provided on the side wall of the reagent card slot, and the opening of the reagent card slot side wall groove is arranged downward, and a space for the spring and the linkage pin to move up and down is formed in the reagent card slot side wall groove; the lower end of the linkage pin has a wedge-shaped surface, and the wedge-shaped surface of the linkage pin faces away from the reagent card inlet direction of the shell; the top of the spring is against the reagent card slot side wall groove, and the linkage pin extends at least part of the wedge-shaped surface downward from the bottom surface of the slide groove groove of the slide groove and extends into the groove in the shell under the elastic force of the spring; the top of the side wall of the slide groove groove is provided with an inclined surface on the side of the wedge-shaped surface facing the linkage pin.

[0020] In this way, the working state and non-working state of the fluorescence detection are converted by the linkage pin, which is roughly the switching between the unlocked state and the locked state. These two states are realized by opening or closing the flip cover to drive the reagent card slot to move. Specifically, in the non-working state, the linkage pin extends at least part of the wedge surface downward from the bottom surface of the slide groove of the slide groove and extends into the groove in the shell under the elastic force of the spring, thereby locking the reagent card slot and the slide groove, so that the slide groove, the reagent card slot, and the reagent card can be pulled out of the fluorescence detection device by opening the flip cover, or the slide groove, the reagent card slot, and the reagent card can be sent into the fluorescence detection device by closing the flip cover; in the working state, first, it is necessary to close the flip cover to slide The slot, reagent card slot, and reagent card are transported to the initial position of the working state. During the process, the wedge-shaped surface of the linkage pin is lifted upward under the extrusion of the shell (for example, a groove in the shell with an inclined surface is set so that the linkage pin slides out of the groove in the shell) until at least part of the wedge-shaped surface is higher than the surface of the slide slot (facilitating the wedge-shaped surface of the linkage pin to slide out of the slide slot through the inclined surface at the top of the side wall of the slide slot groove). At this time, the initial position of the working state is reached, and then, the reagent card slot is driven to move away from the reagent card entrance through the rotation of the gear. Gradually, the wedge-shaped surface of the linkage pin slides out of the slide slot through the inclined surface at the top of the side wall of the slide slot groove, and the locking relationship between the reagent card slot and the slide slot is unlocked.

[0021] As a preferred technical solution of the utility model: a reagent card slot slide rail is arranged in the slide slot, and the reagent card slot slide rail cooperates with the bottom of the reagent card slot to slide the reagent card slot.

[0022] The utility model provides a portable fluorescence detection device. Through the cooperation of a flip cover, a pull rod, a pull rod transfer through hole provided on a pressure cover and a slide groove on the side of a shell body: the flip cover is opened, and the slide groove and a reagent card slot arranged in the slide groove are pulled out through the pull rod connected with the flip cover, so that a test paper card can be put into the test paper card slot; the flip cover is closed, and the slide groove, the reagent card slot arranged in the slide groove, and the test paper card placed in the reagent card slot are pushed into the fluorescence detection device through the pull rod connected with the flip cover; after the fluorescence detection is completed, the flip cover is opened, and the slide groove, the reagent card slot arranged in the slide groove, and the test paper card placed in the reagent card slot are pulled out of the fluorescence detection device in a linked manner, so that the contact between the test paper card user and the test paper card is reduced in the whole process, and through the cooperation among the flip cover, the pull rod, the slide groove and the reagent card slot, the test paper card can be efficiently and accurately sent to the starting position of the fluorescence detection, which is efficient and convenient. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 This is an overall structural diagram of the portable fluorescence detection device provided by the utility model.

[0024] Figure 2 This is a disassembly diagram of the portable fluorescence detection device provided by the utility model.

[0025] Figure 3 Schematic diagram of the position of the light path box and reagent card.

[0026] Figure 4 This is a cross-sectional view of the portable fluorescence detection device provided by the utility model.

[0027] Figure 5 The diagram shows the unlocking and locking relationship of the linkage pin.

[0028] Figure 6 This is a cross-sectional view of the portable fluorescence detection device provided by the utility model at the start and end states of operation.

[0029] Figure 7 This is a cross-sectional view of the portable fluorescence detection device provided by the utility model during the working process.

[0030] Figure 8 This is a cross-sectional view of the portable fluorescence detection device provided by the utility model when the reagent card is being filled or taken out.

[0031] In the figure: 100-housing; 101-groove in the housing; 110-reagent card; 120-limiting pin; 200-pressing cover; 201-pull rod transfer hole; 202-limiting hole; 300-pull rod; 400-flip cover; 500-light path box; 501-light path box slide rail; 502-light path box upper cover; 503-fluorescence sensor circuit board; 504-light source circuit board; 505-light path box slide; 506-light path box lower cover; 507-first convex lens; 508-dichroic mirror; 509-first filter; 510-first Two convex lenses; 511-reflector; 512-second filter; 513-collimating lens; 514-fluorescence sensor; 515-lamp bead; 600-driving mechanism; 601-stepping motor; 602-motor seat; 603-cover plate; 604-optical path box rack; 604a-bump; 605-gear; 700-slide; 701-slide side wall groove; 702-slide groove; 702a-inclined surface; 800-linkage pin; 900-reagent card slot; 901-reagent card slot side wall groove; 902-reagent card slot slide rail. DETAILED DESCRIPTION

[0032] The present invention will be further described in detail with reference to the accompanying drawings and specific embodiments.

[0033] A portable fluorescence detection device includes a shell 100, a pressure cover 200 is provided above the shell 100, an optical path box 500 is provided on the bottom plate of the shell 100, a reagent card slot 900 is provided in a cavity between the pressure cover 200 and the shell 100, the reagent card slot 900 is arranged in a slide groove 700, and the reagent card slot 900 is used to accommodate a reagent card 110. The optical path box 500 and the reagent card slot 900 are also provided with a driving mechanism 600, and the driving mechanism 600 is used to drive the optical path box 500 and / or the reagent card slot 900 to move relative to each other. A flip cover 400 is provided on the side of the shell 100, and a pull rod 300 is provided on the side of the flip cover 400 facing the reagent card entrance of the shell 100, and a pull rod transfer through hole 201 is provided on the pressure cover 200, and the pull rod 300 penetrates into the pull rod transfer through hole 201 and the two ends are respectively hinged to the flip cover 400 and the slide groove 700.

[0034] An optical path box slide rail 501 is provided on the bottom plate of the housing 100, and the optical path box 500 is arranged on the optical path box slide rail 501 via an optical path box slide platform 505;

[0035] The optical path box 500 includes an optical path box upper cover 502 and an optical path box lower cover 506. A fluorescence sensor circuit board 503 and a light source circuit board 504 are arranged on the peripheral side of the optical path box 500. A first convex lens 507, a dichroic mirror 508 (for example, transmitting light of 680 nm and reflecting light of 635 nm), a first filter 509 (for example, a 680 nm narrow-band filter), a second convex lens 510, a reflector 511, a second filter 512 (for example, a 635 nm narrow-band filter), a collimating lens 513, a fluorescence sensor 514 and a lamp bead 515 are arranged in the optical path box 500.

[0036] The optical path box 500 is disposed on the side of the reagent card slot 900 and arranged side by side, and the reflector 511 is disposed above the reagent card slot 900 and is disposed in the direction of the dichroic mirror 508 and the fluorescent sensor 514 .

[0037] The driving mechanism 600 includes a stepper motor 601, a motor seat 602, an optical path box rack 604, and a gear 605; the stepper motor 601 is arranged on the motor seat 602, and the power output end of the stepper motor 601 is fixed to the gear 605; the upper part of the gear 605 is meshed with the optical path box rack 604, and the lower part of the gear 605 is meshed with the teeth on the side wall of the reagent card slot 900, so that the optical path box 500 and the reagent card slot 900 can move relative to each other; one end of the optical path box rack 604 is fixed to the optical path box 500.

[0038] The driving mechanism 600 further includes a cover plate 603 , which is used to accommodate at least a moving section of the optical path box rack 604 .

[0039] A slide groove side wall groove 701 is provided on the side wall of the slide groove 700, and the opening of the slide groove side wall groove 701 is set upward, and a space for the spring and the limit pin 120 to move up and down is formed in the slide groove side wall groove 701; the upper end of the limit pin 120 has a wedge-shaped surface, and the wedge-shaped surface of the limit pin 120 faces the reagent card entrance direction of the housing 100; the bottom of the spring is against the slide groove side wall groove 701, and the limit pin 120 extends at least part of the wedge-shaped surface upward from the limit hole 202 of the pressure cover 200 under the elastic force of the spring; a downward protrusion 604a is provided on the optical path box rack 604; in the initial state, the protrusion 604a squeezes at least part of the wedge-shaped surface of the limit pin 120 downward from the limit hole 202 of the pressure cover 200;

[0040] A reagent card slot side wall groove 901 is provided on the side wall of the reagent card slot 900, and the opening of the reagent card slot side wall groove 901 is set downward, and a space for the up and down movement of the spring and the linkage pin 800 is formed in the reagent card slot side wall groove 901; the lower end of the linkage pin 800 has a wedge-shaped surface, and the wedge-shaped surface of the linkage pin 800 faces away from the reagent card entrance direction of the shell 100; the top of the spring is against the reagent card slot side wall groove 901, and the linkage pin 800 extends at least part of the wedge-shaped surface from the bottom surface of the slide groove 702 of the slide groove 700 downward and extends into the groove 101 in the shell under the elastic force of the spring; the top of the side wall of the slide groove 702 is provided with an inclined surface 702a on the side facing the wedge-shaped surface of the linkage pin 800.

[0041] A reagent card slot slide rail 902 is disposed in the slide slot 700 , and the reagent card slot slide rail 902 cooperates with the bottom of the reagent card slot 900 to slide the reagent card slot 900 .

[0042] The above-mentioned specific implementation methods are used to explain the present invention and are only preferred embodiments of the present invention, rather than limiting the present invention. Any modifications, equivalent substitutions, improvements, etc. made to the present invention within the spirit of the present invention and the protection scope of the claims shall fall within the protection scope of the present invention.

Claims

1. A portable fluorescence detection device, comprising a housing (100), a pressure cover (200) is provided above the housing (100), an optical path box (500) is provided on the bottom plate of the housing (100), a reagent card slot (900) is provided in a cavity between the pressure cover (200) and the housing (100), the reagent card slot (900) is arranged in a slide groove (700), the reagent card slot (900) is used to accommodate a reagent card (110), the optical path box (500) and the reagent card slot (900) are further provided with a driving mechanism (600), the driving mechanism (600) is used to drive the optical path box (500) and / or the reagent card slot (900) to move relative to each other, characterized in that: A flip cover (400) is provided on the side of the shell (100), a pull rod (300) is provided on the side of the flip cover (400) facing the reagent card entrance of the shell (100), a pull rod transfer hole (201) is provided on the pressure cover (200), the pull rod (300) is inserted into the pull rod transfer hole (201) and the two ends are respectively hinged to the flip cover (400) and the slide groove (700).

2. The portable fluorescence detection device according to claim 1, characterized in that: An optical path box slide rail (501) is provided on the bottom plate of the housing (100), and the optical path box (500) is arranged on the optical path box slide rail (501) via an optical path box slide platform (505); The optical path box (500) comprises an optical path box upper cover (502) and an optical path box lower cover (506); a fluorescence sensor circuit board (503) and a light source circuit board (504) are arranged on the peripheral side of the optical path box (500); and a first convex lens (507), a dichroic mirror (508), a first filter (509), a second convex lens (510), a reflector (511), a second filter (512), a collimating lens (513), a fluorescence sensor (514), and a lamp bead (515) are arranged inside the optical path box (500); The optical path box (500) is disposed on the side of the reagent card slot (900) and arranged side by side, and the reflector (511) is disposed above the reagent card slot (900) and in the direction of the dichroic mirror (508) and the fluorescence sensor (514).

3. The portable fluorescence detection device according to claim 1, characterized in that: The driving mechanism (600) comprises a stepper motor (601), a motor seat (602), an optical path box rack (604), and a gear (605); the stepper motor (601) is arranged on the motor seat (602), and the gear (605) is fixed to the power output end of the stepper motor (601); the upper part of the gear (605) is meshed with the optical path box rack (604), and the lower part of the gear (605) is meshed with the teeth on the side wall of the reagent card slot (900), so that the optical path box (500) and the reagent card slot (900) can move relative to each other; one end of the optical path box rack (604) is fixed to the optical path box (500).

4. The portable fluorescence detection device according to claim 3, characterized in that: The driving mechanism (600) further comprises a cover plate (603), wherein the cover plate (603) is used to at least accommodate a moving section of the optical path box rack (604).

5. The portable fluorescence detection device according to claim 3, characterized in that: The side wall of the slide groove (700) is provided with a slide groove side wall groove (701), the opening of the slide groove side wall groove (701) is arranged upward, and the slide groove side wall groove (701) forms a space for the spring and the limit pin (120) to move up and down; the upper end of the limit pin (120) has a wedge-shaped surface, and the wedge-shaped surface of the limit pin (120) faces the reagent card entrance direction of the shell (100); the bottom of the spring is against the slide groove side wall groove (701), and the limit pin (120) extends at least part of the wedge-shaped surface upward from the limit hole (202) of the pressure cover (200) under the elastic force of the spring; the optical path box rack (604) is provided with a downward projection (604a); in the initial state, the projection (604a) extrude at least part of the wedge-shaped surface of the limit pin (120) downward from the limit hole (202) of the pressure cover (200); The side wall of the reagent card slot (900) is provided with a reagent card slot side wall groove (901), the opening of the reagent card slot side wall groove (901) is arranged downward, and the reagent card slot side wall groove (901) forms a space for the spring and the linkage pin (800) to move up and down; the lower end of the linkage pin (800) has a wedge-shaped surface, and the wedge-shaped surface of the linkage pin (800) faces away from the reagent card entrance direction of the shell (100); the top of the spring is against the reagent card slot side wall groove (901), and the linkage pin (800) extends at least part of the wedge-shaped surface downward from the bottom surface of the slide groove (702) of the slide groove (700) and extends into the groove (101) in the shell under the elastic force of the spring; the top of the side wall of the slide groove (702) is provided with an inclined surface (702a) on the side facing the wedge-shaped surface of the linkage pin (800).

6. The portable fluorescence detection device according to claim 1, characterized in that: A reagent card slot slide rail (902) is arranged in the slide groove (700), and the reagent card slot slide rail (902) cooperates with the bottom of the reagent card slot (900) to slide the reagent card slot (900).

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