Injection device, split charging device and split charging instrument

Abstract

The utility model belongs to the technical field of medical instruments, and particularly relates to an injection device, a split charging device and a split charging instrument. The injection device comprises an injector, an air filter and a flexible pipe with an internal space; the injector comprises a push rod and an injection tube provided with an inner hole, and a piston inserted into the inner hole is arranged on the push rod; the flexible tube is mounted on the injection tube, and one end, far away from the piston, of the push rod extends into the internal space and is connected with the flexible tube; and the air filter is communicated with the internal space. According to the injection device, the flexible pipe can play a role in protecting the push rod, the accident that an injector and liquid are polluted when a hand is in contact with the push rod is avoided, and the safety of the injection device is guaranteed; the air filter can balance the air pressure in the internal space, the resistance borne by the push rod in the moving process is reduced, the push rod is conveniently pushed, and the moving precision of the push rod is guaranteed.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical equipment, and particularly relates to an injection device, a packaging device and a packaging instrument. Background Art

[0002] Cell therapy technology refers to the transplantation or injection of normal or bioengineered human cells into the patient's body. The newly injected cells can replace or repair damaged cells, or stimulate and regulate the immune system, and have stronger immune killing functions, thereby achieving the purpose of treating the disease.

[0003] Cell fluid is usually stored in a packaging bag. When performing cell therapy, the cell fluid in a large packaging bag needs to be divided into small packaging bags. In the prior art, workers usually use syringes to divide cell fluid into packaging bags. However, the syringe and cell fluid are easily contaminated during the manual pushing of the syringe. In addition, manual division is inaccurate and easily affected by vision and the outside world, and the accuracy and precision are not high. Utility Model Content

[0004] The utility model aims to solve the technical problem that the syringe and the cell fluid are easily contaminated during the process of manually pushing the syringe, and provides an injection device, a filling device and a filling instrument.

[0005] In order to solve the above technical problems, the first embodiment of the utility model provides an injection device, including a syringe, an air filter and a flexible tube with an internal space; the syringe includes a push rod and an injection tube with an inner hole, and the push rod is provided with a piston inserted in the inner hole;

[0006] The flexible tube is installed on the injection tube, and one end of the push rod away from the piston extends into the internal space and is connected to the flexible tube; the air filter is connected to the internal space.

[0007] Optionally, the injection device further comprises a sleeve, wherein the sleeve is sleeved on the injection tube, and the flexible tube is sleeved on the sleeve.

[0008] Optionally, the injection tube is further provided with a flange, the flange is provided with a first mounting hole, the sleeve is provided with a second mounting hole, and the sleeve is sleeved on the injection tube via a fastener inserted into the first mounting hole and the second mounting hole.

[0009] Optionally, the flexible tube is further provided with a plug-in groove communicating with the internal space, and an inserting portion is provided at one end of the push rod away from the piston, and the inserting portion is inserted into the plug-in groove.

[0010] The second embodiment of the utility model provides a sub-packaging device, comprising an injection three-way valve, a plurality of sub-packaging three-way valves, a plurality of sub-packaging catheters and the above-mentioned injection device;

[0011] The first interface of the injection three-way valve is connected to the inner hole, the second interface of the injection three-way valve is connected to the first interface of the sub-packaging three-way valve, and the third interface of the sub-packaging three-way valve is connected to the sub-packaging conduit in a one-to-one correspondence; between two adjacent sub-packaging three-way valves, the second interface of one sub-packaging three-way valve is connected to the third interface of the other sub-packaging three-way valve; the third interface of the injection three-way valve is used to connect to an external bag to be sub-packaged.

[0012] Optionally, the packaging device further comprises a first filter and a mixing three-way valve;

[0013] The second interface of the injection three-way valve is connected to the first interface of the mixing three-way valve, the second interface of the mixing three-way valve is connected to the first filter, and the third interface of the mixing three-way valve is used to connect to an external bag to be packaged.

[0014] Optionally, the packaging device further comprises a second filter, and a pressure sensor detachably connected to the second filter;

[0015] One end of the second filter is connected to the dispensing conduit, and the other end is connected to the pressure sensor;

[0016] The pressure sensor is used to detect the air pressure in the dispensing conduit.

[0017] Optionally, the packaging device further comprises a support plate, on which a plurality of buckles are arranged, and the packaging tubes are plugged into the buckles in a one-to-one correspondence.

[0018] Optionally, the injection and dispensing device further comprises a support plate, and both the injection three-way valve and the dispensing three-way valve can be detachably mounted on the support plate.

[0019] The third embodiment of the present invention provides a packaging instrument, including the above-mentioned packaging device.

[0020] Utility Model In the utility model, the flexible tube is installed on the injection tube, the end of the push rod away from the piston extends into the internal space and connects to the flexible tube, and the air filter is connected to the internal space. The flexible tube is pressed, and the flexible tube can drive the push rod to move, and the push rod drives the piston thereon to move in the inner hole of the injection tube, so that the syringe can absorb or push liquid or gas; the flexible tube can protect the push rod, and avoid the accident of contaminating the syringe and liquid caused by hand contact with the push rod, thereby ensuring the safety of the injection device, and ensuring a sterile environment. The push rod is precisely controlled to dispense liquid with high precision, thereby improving the dispensing precision and accuracy.

[0021] In addition, during the process of compressing the flexible tube, external gas can enter the internal space through the air filter. The air filter can ensure that the gas entering the internal space is sterile gas and will not contaminate the liquid or gas in the inner hole, thereby ensuring that the pipeline is in a sterile environment. Moreover, when the push rod drives the piston to push toward the injection port, the air filter can balance the air pressure in the internal space, reduce the resistance encountered by the push rod during the movement, facilitate the pushing of the push rod, and ensure the accuracy of the movement of the push rod. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] The utility model is further described below in conjunction with the accompanying drawings and embodiments.

[0023] Figure 1 This is a front view of an injection device provided by an embodiment of the utility model;

[0024] Figure 2 is a cross-sectional view of an injection device provided by an embodiment of the utility model;

[0025] Figure 3 The utility model is a front view of a packaging device provided by one embodiment of the utility model.

[0026] The reference numerals in the specification are as follows:

[0027] 1. injection device; 11. syringe; 111. push rod; 1111. piston; 1112. plug-in portion; 112. injection tube; 1121. inner hole; 1122. flange; 12. air filter; 13. flexible tube; 131. inner space; 132. plug-in slot; 14. sleeve.

[0028] 2. Injection three-way valve; 3. Mixing three-way valve; 4. First filter; 5. Second filter; 6. Packaging three-way valve; 7. Packaging catheter; 8. Support plate; 81. Buckle. DETAILED DESCRIPTION

[0029] In order to make the technical problems, technical solutions and beneficial effects solved by the utility model more clear, the utility model is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the utility model and are not used to limit the utility model.

[0030] It should be understood that the directions or positional relationships indicated by terms such as "upper", "lower", "left", "right", "front", "back", and "middle" are based on the directions or positional relationships shown in the accompanying drawings and are only for the convenience of describing the present invention and simplifying the description. They do not indicate or imply that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore should not be understood as a limitation of the present invention.

[0031] like Figure 1 and Figure 2 As shown, the first embodiment of the utility model provides an injection device 1, comprising a syringe 11, an air filter 12 and a flexible tube 13 provided with an internal space 131; the syringe 11 comprises a push rod 111 and an injection tube 112 provided with an inner hole 1121, and the push rod 111 is provided with a piston 1111 inserted in the inner hole 1121; it can be understood that the flexible tube 13 includes but is not limited to a bellows, etc., and the injection tube 112 is provided with an injection port connected to the inner hole 1121 at one end away from the flexible tube 13.

[0032] The flexible tube 13 is installed on the injection tube 112, and one end of the push rod 111 away from the piston 1111 extends into the internal space 131 and connects to the flexible tube 13; the air filter 12 is connected to the internal space 131. It can be understood that the air filter 12 can be connected to the internal space 131 through a conduit.

[0033] In the present invention, the flexible tube 13 is installed on the injection tube 112, and one end of the push rod 111 away from the piston 1111 extends into the internal space 131 and is connected to the flexible tube 13, and the air filter 12 is connected to the internal space 131. Pressing the flexible tube 13 can drive the push rod 111 to move, and the push rod 111 drives the piston 1111 thereon to move in the inner hole 1121 of the injection tube 112, so that the syringe 11 can absorb or push liquid or gas; the flexible tube 13 can protect the push rod 111, avoiding accidents of contaminating the syringe 11 and liquid caused by hand contact with the push rod 111, ensuring the safety of the injection device 1, and ensuring a sterile environment by accurately controlling the push rod 111 to dispense liquid with high precision, thereby improving the dispensing precision and accuracy.

[0034] In addition, during the compression of the flexible tube 13, external gas can enter the internal space 131 through the air filter 12. The air filter 12 can ensure that the gas entering the internal space 131 is sterile gas and will not contaminate the liquid or gas in the inner hole 1121, thereby ensuring that the pipeline is in a sterile environment. Moreover, when the push rod 111 drives the piston 1111 to push toward the injection port, the air filter 12 can balance the air pressure in the internal space 131, reducing the resistance encountered by the push rod 111 during the movement, making it easier to push the push rod 111 and ensuring the accuracy of the movement of the push rod 111.

[0035] In one embodiment, if Figure 1 and Figure 2 As shown, the injection device 1 further includes a sleeve 14, the sleeve 14 is sleeved on the injection tube 112, and the flexible tube 13 is sleeved on the sleeve 14. It can be understood that the flexible tube 13 is installed on the injection tube 112 through the sleeve 14, the sleeve 14 and the injection tube 112 can be connected by fasteners such as bolts and screws, and the flexible tube 13 and the sleeve 14 can be connected by bonding or other methods. In this embodiment, the sleeve 14 can play the role of connecting the flexible tube 13 and the injection tube 112, thereby improving the convenience of assembling the injection device 1.

[0036] In one embodiment, if Figure 2 As shown, the injection tube 112 is further provided with a flange 1122, the flange 1122 is provided with a first mounting hole, the sleeve 14 is provided with a second mounting hole, and the sleeve 14 is sleeved on the injection tube 112 by fasteners (screws, bolts, etc.) inserted in the first mounting hole and the second mounting hole. It can be understood that the flange 1122 is bent toward the outside of the injection tube 112, the sleeve 14 is sleeved on the injection tube 112 and abuts against the flange 1122, and the fastening connection between the flange 1122 and the sleeve 14 improves the stability of the sleeve 14 sleeved on the injection tube 112.

[0037] In one embodiment, the injection tube may be provided with a first mounting hole and may be manufactured in one piece, and the first mounting hole may be connected to an air filter, thereby reducing the number of installation steps.

[0038] In one embodiment, if Figure 1 and Figure 2As shown, the flexible tube 13 is further provided with a plug-in slot 132 communicating with the internal space 131, and the end of the push rod 111 away from the piston 1111 is provided with a plug-in portion 1112, and the plug-in portion 1112 is plugged into the plug-in slot 132. It can be understood that during the process of pressing the flexible tube 13, the flexible tube 13 drives the push rod 111 to move through the plug-in portion 1112 plugged into the plug-in slot 132, thereby ensuring the smoothness of the push rod 111 driven by the flexible tube 13.

[0039] like Figure 3 As shown, the second embodiment of the utility model provides a filling device, including an injection three-way valve 2, a plurality of filling three-way valves 6, a plurality of filling tubes 7 and the above-mentioned injection device 1; it can be understood that the number of the filling three-way valves 6 and the filling tubes 7 is equal, and the number of the filling three-way valves 6 and the filling tubes 7 can be set according to actual needs.

[0040] The first interface of the injection three-way valve 2 is connected to the inner hole 1121, the second interface of the injection three-way valve 2 is connected to the first interface of the sub-packaging three-way valve 6, and the third interface of the sub-packaging three-way valve 6 is connected to the sub-packaging conduit 7 in a one-to-one correspondence; between two adjacent sub-packaging three-way valves 6, the second interface of one sub-packaging three-way valve 6 is connected to the first interface of the other sub-packaging three-way valve 6; the third interface of the injection three-way valve 2 is used to connect to an external bag to be sub-packed. It can be understood that the injection three-way valve 2 can control the on-off between its first interface, the second interface and the third interface, and the sub-packaging three-way valve 6 can control the on-off between its first interface, the second interface and the third interface; the external bag to be sub-packed can store cell fluid and the like.

[0041] Specifically, the injection three-way valve 2 controls the first interface and the third interface to be in a connected state, and the first interface and the second interface to be in a closed state, and the push rod 111 is pulled by the flexible tube 13, and the push rod 111 drives the piston 1111 to move and extracts the liquid in the external bag to be dispensed into the inner hole 1121; the injection three-way valve 2 controls the first interface and the second interface to be in a connected state, and the first interface and the third interface to be in a closed state, the first interface, the second interface and the third interface of the dispensing three-way valve 6 are all in a connected state, and the dispensing three-way valve 6 can be connected to the dispensing catheter 7 through the second interface of the injection three-way valve 2, and the push rod 111 is pushed by the flexible tube 13, and the push rod 111 drives the piston 1111 to move and pushes the sample liquid in the inner hole 1121 to the storage bag connected to the dispensing catheter 7. In the utility model, the packaging device can complete the packaging of the sample liquid in the external bag to be packaged into each storage bag, and the sample liquid is always in a closed pipeline, and the accident of contaminating the sample liquid will not occur. In addition, a sterile environment can be ensured by accurately controlling the push rod 111 to package the liquid with high precision, thereby improving the packaging precision and accuracy.

[0042] In one embodiment, if Figure 3 As shown, the packaging device further includes a first filter 4 and a mixing three-way valve 3; the third interface of the injection three-way valve 2 is connected to the first interface of the mixing three-way valve 3, the second interface of the mixing three-way valve 3 is connected to the first filter 4, and the third interface of the mixing three-way valve 3 is used to connect to an external bag to be packaged. It can be understood that the mixing three-way valve 3 can control the on-off between the first interface, the second interface and the third interface.

[0043] Specifically, the injection three-way valve 2, the filling three-way valve 6 and the mixing three-way valve 3 are used to control the pipeline between the inner hole 1121 and the filling conduit 7 to be in a conducting state, and after the pipeline between the inner hole 1121 and the mixing three-way valve 3 is in a closed state, the push rod 111 is pulled by the flexible tube 13, and the syringe 11 can draw all the storage bags into a vacuum state; after all the storage bags are drawn into a vacuum state, the injection three-way valve 2, the filling three-way valve 6 and the mixing three-way valve 3 are used to control the inner hole 1121 and all the filling conduits 7 to be in a closed state, and the pipeline between the inner hole 1121 and the first filter 4 is controlled to be in a conducting state, and then the push rod 111 is pushed by the flexible tube 13, and the push rod 111 can discharge the gas in the inner hole 1121 into the external environment through the first filter 4.

[0044] Through the injection three-way valve 2, the filling three-way valve 6 and the mixing three-way valve 3, the pipeline between the mixing three-way valve 3 and the first filter 4 is controlled to be in a closed state, the pipeline between the inner hole 1121 and the external bag to be filled is controlled to be in a conducting state, and the pipeline between the inner hole 1121 and all the filling conduits 7 is controlled to be in a closed state, and then the push rod 111 is pulled through the flexible tube 13, and the syringe 11 can extract the sample liquid in the external bag to be filled into the inner hole 1121; then the pipeline between the injection three-way valve 2 and the mixing three-way valve 3 is controlled to be in a closed state, and the pipeline between the inner hole 1121 and the filling conduit 7 is controlled to be in a conducting state, and then the push rod 111 is pushed through the flexible tube 13, and the push rod 111 pushes the sample liquid in the inner hole 1121 into the storage bag. After enough sample liquid is stored in the storage bag, the third interfaces of all the three-way valves 6 are controlled to be in a closed state, and then the inlet of the storage bag is sealed by heat sealing or other techniques, thereby completing the function of packaging the sample liquid in the external bag to be packaged into each storage bag.

[0045] In one embodiment, if Figure 3 As shown, the packaging device further includes a second filter 5, and a pressure sensor (not shown in the figure) detachably connected to the second filter 5; one end of the second filter 5 is connected to the packaging conduit, and the other end is connected to the pressure sensor; the pressure sensor is used to detect the air pressure in the packaging conduit 7. It can be understood that the pressure sensor can detect the pressure of each storage bag or the air pressure of the entire packaging conduit in real time to check the air tightness of the packaging conduit and whether it is in a negative pressure state or a quasi-vacuum state, so as to ensure that the syringe 11 can completely extract the gas in the storage bag, reduce the impact of the introduction of excess bubbles in the subsequent packaging, and avoid accidents of contaminating the sample liquid caused by the gas remaining in the storage bag.

[0046] In addition, the pressure sensor can detect the pressure of each storage bag or the air pressure of the entire filling catheter in real time to check the airtightness of the filling catheter and whether it is in a negative pressure state or a quasi-vacuum state, thereby ensuring that the syringe 11 can extract the gas in the storage bag cleanly, reduce the impact of excess bubbles introduced into subsequent filling, and avoid accidents of contaminating the sample liquid caused by the gas remaining in the storage bag.

[0047] In one embodiment, if Figure 3As shown, the dispensing device further includes a second filter 5, and a pressure sensor (not shown in the figure) detachably connected to the second filter 5; the third interface of the last dispensing three-way valve 6 far from one end of the injection three-way valve 2 is connected to the second filter 5; the pressure sensor is used to detect the air pressure in the dispensing conduit 7. It can be understood that the pressure sensor is connected to the second filter 5; after the first interface, the second interface and the third interface of the dispensing three-way valve 6 are connected, the pressure sensor can detect the pressure of each storage bag in real time, and the third interface of the last dispensing three-way valve 6 far from one end of the injection three-way valve 2 is connected to the second filter 5, so as to more accurately determine the air pressure of the dispensing conduit, because the arrangement at the farthest end can better ensure the correctness and accuracy of the pressure detection of all storage bags, thereby ensuring that the injector 11 can extract the gas in the storage bag cleanly, to reduce the influence of the introduction of excess bubbles in the subsequent dispensing, and to avoid the accident of contaminating the sample liquid caused by the gas remaining in the storage bag.

[0048] In one embodiment, if Figure 3 As shown, the subpackaging device further comprises a support plate 8, on which a plurality of buckles 81 are arranged, and the subpackaging conduits 7 are plugged into the buckles 81 one by one. It can be understood that the subpackaging conduits 7 are plugged into the buckles 81 so that the subpackaging conduits 7 and the storage bag are not on the support plate 8.

[0049] In one embodiment, if Figure 3 As shown, the injection and dispensing device further comprises a support plate 8, and the injection three-way valve 2 and the dispensing three-way valve 6 can be detachably mounted on the support plate 8. It can be understood that the injection three-way valve 2 and the dispensing three-way valve 6 can be detachably mounted on the support plate 8 by means of a snap-fit ​​structure or the like.

[0050] The third embodiment of the present invention provides a packaging instrument, including the above-mentioned packaging device.

[0051] The fourth embodiment of the present invention provides a packaging method applied to the above-mentioned packaging device, which is characterized by comprising:

[0052] S100, control the flow direction of the injection three-way valve 2 and the push rod 111 of the injection device 1, so that the sample liquid in the external bag to be dispensed flows into the injection tube 112, and control the push rod 111 to stop when the preset capacity is reached; it can be understood that the preset capacity can be determined according to actual needs.

[0053] Specifically, through the injection three-way valve 2, the pipeline between the inner hole 1121 and the filling tube 7 is controlled to be in a closed state, and the pipeline between the inner hole 1121 and the external bag to be filled is controlled to be in a conducting state, and then the push rod 111 is pulled by the flexible tube 13, and the push rod 111 drives the piston 1111 to move and draw the sample liquid in the external bag to be filled into the inner hole 1121.

[0054] S200 , switching the flow direction of the injection three-way valve 2 and the flow direction of each dispensing three-way valve 6 , and pushing the push rod 111 of the injection device 1 to dispense the sample liquid in the injection device 1 into the storage bags corresponding to each dispensing conduit 7 .

[0055] Specifically, after the pipeline between the inner hole 1121 and the dispensing conduit 7 is controlled to be in a conducting state through the injection three-way valve 2, and the pipeline between the inner hole 1121 and the external bag to be dispensed is controlled to be in a closed state, the push rod 111 is pushed through the flexible tube 13, and the push rod 111 drives the piston 1111 to move and push the sample liquid in the inner hole 1121 to the storage bag connected to the dispensing conduit 7. In the utility model, the dispensing method can complete the dispensing of the sample liquid in the external bag to be dispensed into each storage bag, and the sample liquid is always in a closed pipeline, and there will be no accident of contaminating the sample liquid, and a sterile environment can be ensured by accurately controlling the push rod 111 to dispense the liquid with high precision, thereby improving the dispensing precision and accuracy.

[0056] In one embodiment, if Figure 1 As shown, before controlling the flow direction of the injection three-way valve 2 and the push rod 111 of the injection device 1 to allow the sample liquid in the external bag to be dispensed to flow into the injection tube 112 (that is, step S100), it also includes:

[0057] S110, controlling the flow directions of the injection three-way valve 2 and the filling three-way valve 6, and controlling the push rod 111 of the injection device 1, so that the syringe 11 extracts the gas in each storage bag and discharges it.

[0058] Specifically, the injection three-way valve 2 and the sub-packaging three-way valve 6 are used to control the pipeline between the inner hole 1121 and the sub-packaging conduit 7 to be in a conducting state, and the pipeline between the inner hole 1121 and the mixing three-way valve 3 is in a closed state. Then, the push rod 111 is pulled by the flexible tube 13, and the syringe 11 can extract all storage bags into a quasi-vacuum state; after all storage bags are extracted into a quasi-vacuum state, the injection three-way valve 2 and the sub-packaging three-way valve 6 are used to control the inner hole 1121 and all the sub-packaging conduits 7 to be in a closed state, and the pipeline between the inner hole 1121 and the third interface of the sub-packaging three-way valve 6 is controlled to be in a conducting state, and then the push rod 111 is pushed by the flexible tube 13, and the push rod 111 can discharge the gas in the inner hole 1121 to the external environment through the third interface of the injection three-way valve 2. Afterwards, the syringe 11 will dispense the sample liquid in the external bag to be dispensed into each storage bag. In this embodiment, before storing the sample liquid in the storage bag, the gas therein needs to be discharged through the injection device 1 to ensure the cleanliness of the storage bag.

[0059] In one embodiment, controlling the flow direction of the injection three-way valve 2 and the dispensing three-way valve 6, and controlling the push rod 111 of the injection device 1, so that the syringe 11 extracts and discharges the gas in each storage bag (that is, step S110), includes:

[0060] Control the third interface of the injection three-way valve 2 to be connected to the first interface of the mixing three-way valve 3, the second interface of the mixing three-way valve 3 to be connected to the first filter 4, and the third interface of the mixing three-way valve 3 to be connected to the external bag to be packaged;

[0061] S111, through the injection three-way valve 2, the filling three-way valve 6 and the mixing three-way valve 3, control the pipeline between the first filter 4 and the inner hole 1121 to be in a closed state, and control the pipeline between the inner hole 1121 and all the filling tubes 7 to be in a conducting state, and then control the push rod 111 to put each storage bag in a quasi-vacuum state; it can be understood that the first interface and the third interface of the injection three-way valve 2 are in a closed state, and the first interface and the second interface of the injection three-way valve 2 are in a conducting state, and the first interface, the second interface and the third interface of the filling three-way valve 6 are all in a conducting state. At this time, the pipeline between the first filter 4 and the inner hole 1121 is in a closed state, and the pipeline between the inner hole 1121 and all the filling tubes 7 are in a conducting state. The quasi-vacuum state refers to a spatial state in which the gas pressure is lower than one atmosphere.

[0062] S112, after controlling the pipeline between the inner hole 1121 and all the sub-packaging conduits 7 to be in a closed state and the pipeline between the first filter 4 and the inner hole 1121 to be in a conducting state through the injection three-way valve 2, the sub-packaging three-way valve 6 and the mixing three-way valve 3, control the injector 11 to discharge the gas in the inner hole 1121 through the first filter 4. It can be understood that the first interface and the second interface of the injection three-way valve 2 are in a closed state, and the first interface and the third interface of the injection three-way valve 2 are in a conducting state, and the first interface, the second interface and the third interface of the mixing three-way valve 3 are all in a conducting state. At this time, the pipeline between the first filter 4 and the inner hole 1121 is in a conducting state, and the pipeline between the inner hole 1121 and all the sub-packaging conduits 7 is in a closed state.

[0063] Specifically, the injection three-way valve 2, the filling three-way valve 6 and the mixing three-way valve 3 are used to control the pipeline between the inner hole 1121 and the filling conduit 7 to be in a conducting state, and after the pipeline between the inner hole 1121 and the mixing three-way valve 3 is in a closed state, the push rod 111 is pulled by the flexible tube 13, and the syringe 11 can draw all storage bags into a quasi-vacuum state; after all storage bags are drawn into a quasi-vacuum state, the injection three-way valve 2, the filling three-way valve 6 and the mixing three-way valve 3 are used to control the inner hole 1121 and all the filling conduits 7 to be in a closed state, and the pipeline between the inner hole 1121 and the first filter 4 is controlled to be in a conducting state, and then the push rod 111 is pushed by the flexible tube 13, and the push rod 111 can discharge the gas in the inner hole 1121 into the external environment through the first filter 4, wherein the quasi-vacuum state can also refer to a spatial state in which the gas pressure is lower than a preset air pressure value (less than atmospheric pressure).

[0064] Through the injection three-way valve 2, the filling three-way valve 6 and the mixing three-way valve 3, the pipeline between the mixing three-way valve 3 and the first filter 4 is controlled to be in a closed state, the pipeline between the inner hole 1121 and the external bag to be filled is controlled to be in a conducting state, and the pipeline between the inner hole 1121 and all the filling tubes 7 is controlled to be in a closed state, and then the push rod 111 is pulled through the flexible tube 13, and the syringe 11 can extract the sample liquid in the external bag to be filled into the inner hole 1121; then the pipeline between the injection three-way valve 2 and the mixing three-way valve 3 is controlled to be in a conducting state, and the pipeline between the inner hole 1121 and the filling tube 7 is controlled to be in a conducting state, and then the push rod 111 is pushed through the flexible tube 13, and the push rod 111 pushes the sample liquid in the inner hole 1121 into the storage bag. After enough sample liquid is stored in the storage bag, the third interfaces of all the three-way valves 6 are controlled to be in a closed state, and then the inlet of the storage bag is sealed by heat sealing or other techniques, thereby completing the function of packaging the sample liquid in the external bag to be packaged into each storage bag.

[0065] In one embodiment, after controlling the pipeline between the second filter 5 and the inner hole 1121 to be in a closed state, and controlling the pipelines between the inner hole 1121 and all the dispensing conduits 7 to be in a conducting state, controlling the syringe 11 to put each storage bag in a quasi-vacuum state (i.e., step S111), comprises:

[0066] Control the third interface of the filling three-way valve 6 away from one end of the injection three-way valve 2 to connect to the pressure sensor; control the pressure sensor to connect to all the filling ducts 7 and the inner hole 1121 through the injection three-way valve 2, the filling three-way valve 6 and the mixing three-way valve 3, and control the pipeline between the pressure sensor and the inner hole 1121 to be in a closed state; it can be understood that the end cover of the second filter 5 is opened, and the pressure sensor is connected to the second filter 5; open the first interface, the second interface and the third interface of all the filling three-way valves 6, so that the pressure sensor is connected to all the filling ducts 7 and the inner hole 1121.

[0067] The push rod 111 is controlled to extract the gas in each external bag to be packed, and the pressure sensor is controlled to detect the pressure values ​​of all the packing bags in real time; it can be understood that when the first interface, the second interface and the third interface of all the packing three-way valves 6 are in the on state, all storage bags can share one pressure sensor, that is, one pressure sensor can detect the vacuum degree of all storage bags at the same time.

[0068] When the pressure value detected by the pressure sensor reaches the preset pressure value, it indicates that the syringe 11 has put each storage bag into a quasi-vacuum state. It can be understood that the preset pressure value can be set according to actual needs. When the pressure in the storage bag reaches the preset pressure, it indicates that the gas in the storage bag has been completely extracted. In this embodiment, the design of the pressure sensor ensures the cleanliness of the gas extracted from each storage bag by the syringe 11.

[0069] In one embodiment, after the sample liquid in the injection device 1 is dispensed into the storage bags corresponding to the dispensing tubes 7 (that is, after step S200), the method further includes:

[0070] After controlling the pipeline between the first filter 4 and the inner hole 1121 to be in a conducting state, the syringe 11 is controlled to draw external gas into the inner hole 1121 through the first filter 4; it can be understood that the second interface of the injection three-way valve 2 is in a closed state, the first interface and the third interface of the injection three-way valve 2 are in a conducting state, the first interface and the second interface of the mixing three-way valve 3 are in a conducting state, and the third interface of the mixing three-way valve 3 is in a closed state, and the syringe 11 can absorb external gas through the first filter 4.

[0071] After controlling the pipeline between the first filter 4 and the injection three-way valve 2 to be in a closed state, and controlling the pipelines between all the sub-packaging conduits 7 and the inner hole 1121 to be in a conducting state, the injector 11 is controlled to push the air in the inner hole 1121 to each of the sub-packaging conduits 7, and the sensor is controlled to detect in real time whether there is sample liquid in the sub-packaging conduits 7; it can be understood that after closing the third interface of the injection three-way valve 2, connecting the first interface and the second interface of the injection three-way valve 2, and connecting the first interface, the second interface and the third interface of the sub-packaging three-way valve 6, the injector 11 gradually injects the gas in the inner hole 1121 into each storage bag, and the sensor can detect in real time whether there is sample liquid in the corresponding sub-packaging conduit 7. Further explanation, since the refractive index of the sample liquid and the gas in the sub-packaging conduit 7 to light is different, the sensor can detect in real time whether there is sample liquid in the sub-packaging conduit 7.

[0072] When the sensor detects that there is no sample liquid in the subpackaging conduit 7, all pipelines between the subpackaging three-way valve 6 and the subpackaging conduit 7 are closed. It can be understood that when the sensor detects that there is no sample liquid in the subpackaging conduit 7, it indicates that the syringe 11 has pushed all the sample liquid in the subpackaging conduit 7 into the storage bag. At this time, the syringe 11 stops injecting gas into the subpackaging conduit 7 and closes the third interface of the subpackaging three-way valve 6, so that each of the subpackaging conduits 7 is an independent individual, so that the inlet of the storage bag can be closed by heat sealing and other processes, and finally the storage bag can be removed from the subpackaging conduit 7. In this embodiment, the subpackaging method can push all the sample liquid in the subpackaging conduit 7 into the storage bag, avoiding the problems of liquid waste and liquid contamination of the sample liquid remaining in the pipeline, ensuring accurate subpackaging, avoiding the influence of bubbles on the liquid in the storage bag, and ensuring the effectiveness, accuracy and high precision of subpackaging.

[0073] The above are merely embodiments of the injection device, packaging device, packaging instrument and packaging method of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention shall be included in the protection scope of the present invention.

Claims

1. An injection device, characterized in that: It comprises a syringe, an air filter and a flexible tube with an internal space; the syringe comprises a push rod and an injection tube with an inner hole, and the push rod is provided with a piston inserted in the inner hole; The flexible tube is installed on the injection tube, and one end of the push rod away from the piston extends into the internal space and is connected to the flexible tube; the air filter is connected to the internal space.

2. The injection device according to claim 1, characterized in that The injection device further comprises a sleeve, wherein the sleeve is sleeved on the injection tube, and the flexible tube is sleeved on the sleeve.

3. The injection device according to claim 2, characterized in that The injection tube is also provided with a flange, the flange is provided with a first mounting hole, the sleeve is provided with a second mounting hole, and the sleeve is sleeved on the injection tube through a fastener inserted into the first mounting hole and the second mounting hole.

4. The injection device according to claim 1, characterized in that The flexible tube is also provided with an inserting groove communicating with the internal space, and an inserting portion is provided at one end of the push rod away from the piston, and the inserting portion is inserted into the inserting groove.

5. A packaging device, characterized in that: It comprises an injection three-way valve, a plurality of sub-packaging three-way valves, a plurality of sub-packaging catheters and an injection device as claimed in any one of claims 1 to 4; The first interface of the injection three-way valve is connected to the inner hole, the second interface of the injection three-way valve is connected to the first interface of the sub-packaging three-way valve, and the third interface of the sub-packaging three-way valve is connected to the sub-packaging conduit in a one-to-one correspondence; between two adjacent sub-packaging three-way valves, the second interface of one sub-packaging three-way valve is connected to the first interface of the other sub-packaging three-way valve; the third interface of the injection three-way valve is used to connect to an external bag to be sub-packaged.

6. The packaging device according to claim 5, characterized in that: The packaging device also includes a first filter and a mixing three-way valve; The third interface of the injection three-way valve is connected to the first interface of the mixing three-way valve, the second interface of the mixing three-way valve is connected to the first filter, and the third interface of the mixing three-way valve is used to connect to an external bag to be packaged.

7. The packaging device according to claim 6, characterized in that: The packaging device further comprises a second filter, and a pressure sensor detachably connected to the second filter; One end of the second filter is connected to the dispensing conduit, and the other end is connected to the pressure sensor; The pressure sensor is used to detect the air pressure in the dispensing conduit.

8. The packaging device according to claim 7, characterized in that: The subpackaging device further comprises a support plate, on which a plurality of buckles are arranged, and the subpackaging conduits are plugged into the buckles in a one-to-one correspondence.

9. The packaging device according to claim 7, characterized in that: The sub-packaging device further comprises a support plate, and the injection three-way valve and the sub-packaging three-way valve can be detachably mounted on the support plate.

10. A packaging instrument, characterized in that: Comprising a packaging device as described in any one of claims 5 to 8.

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