Tissue chip sampler

Abstract

The utility model relates to a tissue chip sampler which comprises a hollow cylinder and a push rod, a push head is arranged at the bottom of the push rod, a limiting ring is arranged in the hollow cylinder, a rotating shaft seat is fixedly installed on the outer wall of the hollow cylinder, a transmission handle is movably installed in the rotating shaft seat, and a handle is arranged in the transmission handle. And a rotating head assembly is fixedly mounted at the bottom of the transmission handle. The sampling device has the beneficial effects that the large-caliber sampling head, the medium-caliber sampling head and the small-caliber sampling head are connected with the transmission handle through the connecting rotating plate, when the transmission handle rotates, the connecting rotating plate rotates together, and one of the three sampling heads rotates to the lower part of the hollow cylinder and is attached to the hollow cylinder; after a sealed space is formed in the hollow cylinder, the push rod is pulled upwards, so that the paraffin tissue microarray is sucked into the hollow cylinder and stored in the limiting ring, the cylinder body or the sampling head does not need to be replaced, and the paraffin tissue microarray does not need to be cut due to the size mismatching problem.

Description

Technical Field

[0001] The utility model relates to the technical field of tissue chip sampling, in particular to a tissue chip sampler. Background Art

[0002] Tissue chip, also known as tissue microarray, is a tissue slice made by arranging dozens to thousands of small tissues neatly on a glass slide. It is another important biochip after gene chip and protein chip. It is mainly used to study the expression of the same gene or protein molecule in different cells or tissues. Tissue chip, gene chip, protein chip and cell chip together constitute biochip, which enables humans to effectively use hundreds of tissue specimens for the first time to conduct research at the three levels of genome, transcriptome and proteome.

[0003] Existing manual tissue chips are usually divided into cuttable samplers and samplers with replaceable sampling heads. If the former encounters size problems, the tissue chip needs to be re-divided before being taken out, while the latter requires repeatedly replacing the sampling head according to the specifications of the tissue chip. Both groups have obvious limitations, so a tissue chip sampler is proposed to solve the above problems. Utility Model Content

[0004] The utility model aims to provide a tissue chip sampler to solve the above problems existing in the prior art.

[0005] The technical solution of the utility model to solve the above technical problems is as follows:

[0006] A tissue chip sampler comprises a hollow tube and a push rod, wherein a push head is arranged at the bottom of the push rod, a limit ring is arranged inside the hollow tube, a rotating shaft seat is fixedly installed on the outer wall of the hollow tube, a transmission handle is movably installed inside the rotating shaft seat, a rotating head assembly is fixedly installed at the bottom of the transmission handle, and the rotating head assembly consists of a connecting rotating plate, a large-caliber sampling head, a medium-caliber sampling head and a small-caliber sampling head, the connecting rotating plate is fixedly installed at the bottom of the transmission handle, and the large-caliber sampling head, the medium-caliber sampling head and the small-caliber sampling head are all fixedly connected to the connecting rotating plate.

[0007] The beneficial effects of the utility model are as follows: a large-caliber sampling head, a medium-caliber sampling head and a small-caliber sampling head are connected to a transmission handle by connecting a rotating plate; when the transmission handle rotates, the connecting rotating plate rotates together, and one of the three sampling heads is rotated to the bottom of the hollow cylinder and fits in; after a sealed space is formed inside the hollow cylinder, the push rod is pulled upward, so that the paraffin tissue microarray is sucked into the hollow cylinder and stored in a limiting ring; the large-caliber sampling head, the medium-caliber sampling head and the small-caliber sampling head can respectively take paraffin tissue microarrays of different shapes and sizes, without having to replace the cylinder body or the sampling head, and without having to cut the paraffin tissue microarray due to size mismatch problems; the utility model has the characteristics of strong versatility, convenience and no need for replacement.

[0008] On the basis of the above technical solution, the present invention can also be improved as follows.

[0009] Furthermore, the push head is spherical in shape, and the shape of the push head is compatible with the inner diameter of the limiting ring.

[0010] Furthermore, a buffer rubber pad is arranged on the top of the hollow cylinder, and the material of the buffer rubber pad is rubber.

[0011] Furthermore, carrying platforms are provided on both sides of the outer wall of the hollow tube, and the bottom of the carrying platforms is provided with a curved surface.

[0012] Furthermore, the push rod is composed of a rubber handle, a rod body and a piston head, and the rubber handle is fixedly installed at one end of the rod body, and the piston head is arranged at the other end, and the push head is arranged at the bottom of the piston head.

[0013] Furthermore, sealing gaskets are arranged on the tops of the large-caliber sampling head, the medium-caliber sampling head and the small-caliber sampling head. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 It is a schematic diagram of the structure of the utility model;

[0015] Figure 2 It is a structural schematic diagram of the rotary head assembly of the utility model.

[0016] In the accompanying drawings, the components represented by the reference numerals are listed as follows:

[0017] 1. Hollow cylinder; 2. Push rod; 3. Push head; 4. Limiting ring; 5. Rotating shaft seat; 6. Transmission handle; 7. Rotating head assembly; 70. Connecting rotating plate; 71. Large-caliber sampling head; 72. Medium-caliber sampling head; 73. Small-caliber sampling head; 8. Buffer rubber pad; 9. Carrying support. DETAILED DESCRIPTION

[0018] The principles and features of the present invention are described below in conjunction with the accompanying drawings. The examples given are only used to explain the present invention and are not used to limit the scope of the present invention.

[0019] like Figure 1 to Figure 2 As shown, embodiment 1 of the utility model is a tissue chip sampler, comprising a hollow tube 1 and a push rod 2, a push head 3 is arranged at the bottom of the push rod 2, a limiting ring 4 is arranged inside the hollow tube 1, a rotating shaft seat 5 is fixedly installed on the outer wall of the hollow tube 1, a transmission handle 6 is movably installed inside the rotating shaft seat 5, a rotating head assembly 7 is fixedly installed at the bottom of the transmission handle 6, and the rotating head assembly 7 is composed of a connecting rotating plate 70, a large-diameter sampling head 71, a medium-diameter sampling head 72 and a small-diameter sampling head 73, the connecting rotating plate 70 is fixedly installed at the bottom of the transmission handle 6, and the large-diameter sampling head 71, the medium-diameter sampling head 72 and the small-diameter sampling head 73 are all fixedly connected to the connecting rotating plate 70.

[0020] The large-caliber sampling head 71, the medium-caliber sampling head 72 and the small-caliber sampling head 73 are connected to the transmission handle 6 by connecting the rotating plate 70. When the transmission handle 6 rotates, the connecting rotating plate 70 will rotate together, and one of the three sampling heads will rotate to the bottom of the hollow cylinder 1 and fit in. After a sealed space is formed inside the hollow cylinder 1, the push rod 2 is pulled upward to suck the paraffin tissue microarray into the hollow cylinder 1 and store it in the limiting ring 4. The large-caliber sampling head 71, the medium-caliber sampling head 72 and the small-caliber sampling head 73 can respectively take paraffin tissue microarrays of different shapes and sizes without replacing the cylinder or the sampling head, and there is no need to cut the paraffin tissue microarray due to size mismatch. It has the characteristics of strong versatility, convenience and no need for replacement.

[0021] In addition, the materials of the large-caliber sampling head 71 , the medium-caliber sampling head 72 , the small-caliber sampling head 73 and the limiting ring 4 are all visual polymers.

[0022] Embodiment 2 of the present invention is a tissue chip sampler. Based on Embodiment 1, the pusher head 3 is spherical in shape, and the shape of the pusher head 3 is adapted to the inner diameter of the limiting ring 4 .

[0023] The spherical pusher head 3 can ensure safety when in contact with the paraffin tissue microarray, and push the paraffin tissue microarray without damaging it, while the limiting ring 4 can temporarily limit the position of the paraffin tissue microarray to ensure that the paraffin tissue microarray can be accurately sucked in and pushed out.

[0024] Embodiment 3 of the present invention is a tissue chip sampler. Based on Embodiment 1 or 2, a cushioning rubber pad 8 is provided on the top of the hollow tube 1, and the material of the cushioning rubber pad 8 is rubber.

[0025] The buffer rubber pad 8 acts to reduce the wear caused by the contact between the push rod 2 and the hollow tube 2 , and also has a certain prompting effect when the push rod 2 contacts the buffer rubber pad 8 , indicating that the push head 3 has been pushed to the inside of the limit ring 4 .

[0026] Embodiment 4 of the present invention is a tissue chip sampler. Based on any one of embodiments 1 to 3, both sides of the outer wall of the hollow tube 1 are provided with carrying supports 9, and the bottom of the carrying support 9 is provided with an arc surface.

[0027] The carrying support 9 can improve the stability of holding the hollow tube 1 and facilitate stable and accurate operation of the push rod 2.

[0028] Embodiment 5 of the utility model is a tissue chip sampler. Based on any one of embodiments 1 to 4, the push rod 2 is composed of a rubber handle, a rod body and a piston head, and the rubber handle is fixedly installed on one end of the rod body, and the piston head is arranged on the other end, and the push head 3 is arranged at the bottom of the piston head.

[0029] The piston head ensures that the rod body can squeeze the space and gas during the movement inside the hollow cylinder 1, so that the paraffin tissue microarray can be sucked in or pushed out.

[0030] Embodiment 6 of the present invention is a tissue chip sampler. Based on any one of embodiments 1 to 5, sealing gaskets are arranged on the tops of the large-caliber sampling head 71, the medium-caliber sampling head 72 and the small-caliber sampling head 73.

[0031] The sealing gasket is used to increase the sealing performance of the connection between the hollow tube 1 and the large-caliber sampling head 71 , the medium-caliber sampling head 72 and the small-caliber sampling head 73 .

[0032] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A tissue chip sampler, characterized in that: The invention comprises a hollow cylinder (1) and a push rod (2), wherein a push head (3) is arranged at the bottom of the push rod (2), a limit ring (4) is arranged inside the hollow cylinder (1), a rotating shaft seat (5) is fixedly installed on the outer wall of the hollow cylinder (1), a transmission handle (6) is movably installed inside the rotating shaft seat (5), a rotating head assembly (7) is fixedly installed at the bottom of the transmission handle (6), and the rotating head assembly (7) consists of a connecting rotating plate (70), a large-caliber sampling head (71), a medium-caliber sampling head (72) and a small-caliber sampling head (73), wherein the connecting rotating plate (70) is fixedly installed at the bottom of the transmission handle (6), and the large-caliber sampling head (71), the medium-caliber sampling head (72) and the small-caliber sampling head (73) are all fixedly connected to the connecting rotating plate (70).

2. A tissue chip sampler according to claim 1, characterized in that: The pusher head (3) is spherical in shape, and the shape of the pusher head (3) is compatible with the internal diameter of the limiting ring (4).

3. A tissue chip sampler according to claim 1, characterized in that: A buffer rubber pad (8) is arranged on the top of the hollow cylinder (1), and the material of the buffer rubber pad (8) is rubber.

4. A tissue chip sampler according to claim 1, characterized in that: Both sides of the outer wall of the hollow cylinder (1) are provided with carrying and supporting platforms (9), and the bottom of the carrying and supporting platforms (9) is provided with a curved surface.

5. A tissue chip sampler according to any one of claims 1 or 2, characterized in that: The push rod (2) is composed of a rubber handle, a rod body and a piston head, wherein the rubber handle is fixedly mounted on one end of the rod body and the piston head is arranged on the other end, and the push head (3) is arranged at the bottom of the piston head.

6. A tissue chip sampler according to claim 1, characterized in that: The tops of the large-caliber sampling head (71), the medium-caliber sampling head (72) and the small-caliber sampling head (73) are all provided with sealing rubber gaskets.

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