Polypeptide synthesis equipment

Abstract

The utility model provides polypeptide synthesis equipment which comprises a cabinet, the cabinet is internally provided with a mixing container, the mixing container is provided with a horizontally arranged tubular main body part, the top side of one end of the main body part is provided with a feed port, and the bottom side of the other end of the main body part is provided with a discharge port; the uniform shaking mechanism is used for driving the mixing container to swing, so that the liquid in the main body part surges between the two ends in a reciprocating manner; the heating mechanism is used for heating the mixing container. According to the polypeptide synthesis equipment provided by the utility model, the mixing container adopts a horizontally arranged tubular structure and is driven to swing back and forth through the shaking mechanism, so that liquid in the mixing container surges back and forth between the two ends, and the mixing efficiency is improved; compared with a traditional stirring and mixing structure, the structure can avoid the problem of poor mixing effect caused by layering of different solutions, and is simple in structure and suitable for popularization and application.

Description

Technical Field

[0001] The utility model relates to the technical field of polypeptide synthesis, in particular to a polypeptide synthesis device. Background Art

[0002] Peptide is a biologically active substance related to various cell functions in the body. Its molecular structure is between amino acids and proteins. It is a compound composed of multiple amino acids connected by peptide bonds in a certain order. Peptide is a general term for biologically active substances related to various cell functions in the body. It is often used in functional analysis, antibody research, and especially in drug development. Compared with liquid phase synthesis method, solid phase synthesis method has become the preferred method for peptide synthesis because of its convenience and rapidity.

[0003] A stirring rod is usually provided in a peptide synthesizer to stir the reaction raw materials, but the stirring rod cannot directly contact the filter plate of the reaction tank. The reaction raw materials at the bottom layer will stick to the filter plate due to their own viscous nature. The stirring rod needs to be continuously stirred to allow the reaction raw materials at the bottom layer to react fully. The stirring time required is long, resulting in a low reaction rate.

[0004] Therefore, in view of the shortcomings of the prior art, it is necessary to design a polypeptide synthesis device to solve the above problems. Utility Model Content

[0005] In order to overcome the above-mentioned deficiencies in the prior art, the utility model aims to provide a polypeptide synthesis device.

[0006] In order to achieve the above-mentioned purpose and other related purposes, the technical solution provided by the utility model is: a polypeptide synthesis device, including a cabinet, wherein the cabinet is provided with:

[0007] The mixing container has a horizontally arranged tubular main body, a top side of one end of the main body is provided with a feed inlet, and a bottom side of the other end of the main body is provided with a discharge port;

[0008] A shaking mechanism, the shaking mechanism is used to drive the mixing container to swing so that the liquid in the main body surges back and forth between the two ends;

[0009] A heating mechanism is used to heat the mixing container.

[0010] The preferred technical solution is that the feed port extends upward to form a feed pipe with an open opening.

[0011] The preferred technical solution is: the discharge port extends downward to form a discharge pipe with a closed end, and a discharge valve is provided on the discharge pipe.

[0012] The preferred technical solution is: the shaking mechanism is composed of a motor, a rotating shaft and a jig plate, the motor is used to drive the rotating shaft to rotate forward or reverse, the jig plate is fixed on the rotating shaft and arranged parallel to the rotating shaft; the jig plate is used to fix the mixing container.

[0013] The preferred technical solution is: a fixing rod is also provided on the top side of the main body, a flange structure is formed at the top end of the fixing rod, a through hole is provided on the jig plate for accommodating the fixing rod, and a groove structure corresponding to the flange structure is formed at the edge of the through hole; a notch connected to the through hole is provided on one side of the jig plate.

[0014] The preferred technical solution is: the heating mechanism is composed of a heating plate and a hot water circulation system, the heating plate is connected to the bottom side of the fixture plate through a bracket, a heating curved surface is formed on the heating plate and is arranged in contact with the main body, a circulating water circuit is provided in the heating plate, and the circulating water circuit is connected to the hot water circulation system.

[0015] The preferred technical solution is: the cabinet is also provided with a liquid adding head, a raw material barrel and a raw material pump, the liquid adding head and the feeding end of the feeding pipe are arranged correspondingly, and the liquid adding head, the raw material pump and the raw material barrel are connected in sequence through pipelines.

[0016] The preferred technical solution is: a liquid collecting barrel is further provided in the cabinet, and the liquid collecting barrel is connected to the discharge end of the discharge pipe.

[0017] Due to the application of the above technical solution, the utility model has the following beneficial effects:

[0018] The utility model provides a polypeptide synthesis device, wherein the mixing container adopts a horizontally arranged tubular structure, which is driven to swing back and forth by a shaking mechanism so that the liquid in the mixing container surges back and forth between the two ends, thereby improving the mixing efficiency; compared with the traditional stirring and mixing structure, the structure can avoid the problem of poor mixing effect caused by stratification of different solutions, and the structure is simple and suitable for popularization and use. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 The utility model is a schematic diagram of the overall structure of the polypeptide synthesis equipment involved.

[0020] Figure 2 The utility model is a schematic diagram of the structure of the shaking mechanism.

[0021] Figure 3 This is a schematic diagram of the structure of the mixing container involved in the utility model. DETAILED DESCRIPTION

[0022] The following is a description of the implementation of the present invention by means of specific embodiments. People familiar with the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification.

[0023] See also Figure 1-Figure 3 . It should be noted that in the description of the present utility model, it should be noted that the terms "center", "up", "down", "left", "right", "vertical", "horizontal", "inside", "outside" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, or the positions or positional relationships in which the utility model product is usually placed when in use. They are only for the convenience of describing the present utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present utility model. In addition, the terms "first", "second", "third" and the like are only used to distinguish the description, and cannot be understood as indicating or implying relative importance. Terms such as "horizontal", "vertical", and "overhanging" do not mean that the components are required to be absolutely horizontal or overhanging, but can be slightly tilted. For example, "horizontal" only means that its direction is more horizontal than "vertical", and does not mean that the structure must be completely horizontal, but can be slightly tilted.

[0024] In the description of the present invention, it is also necessary to explain that, unless otherwise clearly specified and limited, the terms "set", "install", "connect", and "connect" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection, it can be a mechanical connection, it can be an electrical connection, it can be a direct connection, it can be indirectly connected through an intermediate medium, and it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0025] Example:

[0026] like Figure 1 As shown, according to an overall technical concept of the utility model, a polypeptide synthesis device is provided, including a cabinet 1, in which is provided: a mixing container 2, having a horizontally arranged tubular main body 21, a top side of one end of the main body 21 is provided with a feed inlet, and a bottom side of the other end of the main body is provided with a discharge port; a shaking mechanism 3, the shaking mechanism 3 is used to drive the mixing container 2 to swing so that the liquid in the main body 21 reciprocates between the two ends; a heating mechanism 4, the heating mechanism 4 is used to heat the mixing container 2.

[0027] like Figures 1 to 3 As shown, in an exemplary embodiment of the present invention, the feed port extends upward to form a feed pipe 22 with an open opening.

[0028] like Figures 1 to 3As shown, in an exemplary embodiment of the present utility model, the discharge port extends downward to form a discharge pipe 23 with a closed end, and a discharge valve (not shown) is provided on the discharge pipe 23.

[0029] like Figures 1 to 3 As shown, in an exemplary embodiment of the utility model, the shaking mechanism 3 is composed of a motor (not shown), a rotating shaft 31 and a fixture plate 32, the motor is used to drive the rotating shaft 31 to rotate forward or reverse, the fixture plate 32 is fixed on the rotating shaft 31 and arranged parallel to the rotating shaft 31; the fixture plate 32 is used to fix the mixing container 2.

[0030] like Figures 1 to 3 As shown, in an exemplary embodiment of the utility model, a fixing rod 24 is further provided on the top side of the main body 21, and a circle of flange structure 241 is formed at the top end of the fixing rod 24, and a through hole 321 for accommodating the fixing rod 24 is provided on the jig plate 32, and a groove structure 322 corresponding to the flange structure 221 is formed at the edge of the through hole 321; a notch 323 connected to the through hole 321 is provided on one side of the jig plate 32.

[0031] like Figures 1 to 3 As shown, in an exemplary embodiment of the utility model, the heating mechanism 4 is composed of a heating plate 41 and a hot water circulation system 42. The heating plate 41 is connected to the bottom side of the fixture plate 32 through a bracket. A heating curved surface is formed on the heating plate 41 and is fitted with the main body 21. A circulating water circuit is provided in the heating plate 41, and the circulating water circuit is connected to the hot water circulation system 42.

[0032] like Figures 1 to 3 As shown, in an exemplary embodiment of the present invention, a liquid adding head 5, a raw material barrel 6 and a raw material pump 7 are also provided in the cabinet 1. The liquid adding head 5 and the feeding end of the feeding pipe 22 are correspondingly arranged, and the liquid adding head 5, the raw material pump 7 and the raw material barrel 6 are connected in sequence through pipelines.

[0033] like Figures 1 to 3 As shown, in an exemplary embodiment of the present utility model, a liquid collecting barrel 8 is further provided in the cabinet 1 , and the liquid collecting barrel 8 is communicated with the discharge end of the discharge pipe 23 .

[0034] Therefore, the utility model has the following advantages:

[0035] The utility model provides a polypeptide synthesis device, wherein the mixing container adopts a horizontally arranged tubular structure, which is driven to swing back and forth by a shaking mechanism so that the liquid in the mixing container surges back and forth between the two ends, thereby improving the mixing efficiency; compared with the traditional stirring and mixing structure, the structure can avoid the problem of poor mixing effect caused by stratification of different solutions, and the structure is simple and suitable for popularization and use.

[0036] The above embodiments are merely illustrative of the principles and effects of the present invention, and are not intended to limit the present invention. Anyone familiar with the technology may modify or alter the above embodiments without violating the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by a person of ordinary skill in the art without departing from the spirit and technical concept disclosed by the present invention shall still be covered by the claims of the present invention.

Claims

1. A polypeptide synthesis device, comprising a cabinet, characterized in that: The cabinet is provided with: The mixing container has a horizontally arranged tubular main body, a top side of one end of the main body is provided with a feed inlet, and a bottom side of the other end of the main body is provided with a discharge port; A shaking mechanism, the shaking mechanism is used to drive the mixing container to swing so that the liquid in the main body surges back and forth between the two ends; A heating mechanism is used to heat the mixing container.

2. A polypeptide synthesis device according to claim 1, characterized in that: The feed port extends upward to form a feed pipe with an open opening.

3. A polypeptide synthesis device according to claim 1, characterized in that: The discharge port extends downward to form a discharge pipe with a closed end, and a discharge valve is arranged on the discharge pipe.

4. A polypeptide synthesis device according to claim 2, characterized in that: The shaking mechanism is composed of a motor, a rotating shaft and a jig plate, wherein the motor is used to drive the rotating shaft to rotate forward or reversely, and the jig plate is fixed on the rotating shaft and arranged parallel to the rotating shaft; the jig plate is used to fix the mixing container.

5. A polypeptide synthesis device according to claim 4, characterized in that: A fixing rod is also provided on the top side of the main body, a flange structure is formed at the top end of the fixing rod, a through hole is provided on the jig plate for accommodating the fixing rod, and a groove structure corresponding to the flange structure is formed at the edge of the through hole; a notch connected to the through hole is provided on one side of the jig plate.

6. A polypeptide synthesis device according to claim 4, characterized in that: The heating mechanism is composed of a heating plate and a hot water circulation system. The heating plate is connected to the bottom side of the fixture plate through a bracket. A heating curved surface is formed on the heating plate and is arranged in contact with the main body. A circulating water path is provided in the heating plate, and the circulating water path is connected to the hot water circulation system.

7. A polypeptide synthesis device according to claim 2, characterized in that: The cabinet is also provided with a liquid adding head, a raw material barrel and a raw material pump. The liquid adding head and the feeding end of the feeding pipe are arranged correspondingly, and the liquid adding head, the raw material pump and the raw material barrel are connected in sequence through pipelines.

8. A polypeptide synthesis device according to claim 3, characterized in that: The cabinet is also provided with a liquid collecting barrel, and the liquid collecting barrel is communicated with the discharge end of the discharge pipe.

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