Rapid tissue dyeing machine

Abstract

The utility model discloses a rapid tissue dyeing machine, which relates to a biological tissue dyeing machine with a microwave function, is used for improving the dyeing efficiency and quality of human body or animal tissues, and comprises a transfer manipulator, an outer groove box, an inner groove box for placing materials, a heating device and a microwave generator, wherein the inner groove box can be placed in the outer groove box, and the inner groove box, including the whole process from feeding to discharging, of the tissue dyeing procedure can be placed in the outer groove box; a groove beam is arranged on the outer groove box, an inner groove hook is arranged on the inner groove box, and the inner groove box is hung on the groove beam and / or the outer groove box through the inner groove hook; the transfer manipulator is arranged above the outer tank; the microwave generator comprises a magnetron and a microwave conduit, the magnetron is arranged at the bottom of the outer tank, the microwave conduit is arranged on the side wall of the outer tank, and the microwave conduit penetrates through the side wall of the outer tank and extends into the outer tank. Compared with the prior art, the technology can obviously improve the efficiency and the dyeing quality.

Description

Technical Field

[0001] The utility model relates to a biological tissue dyeing machine for human body, animal body and the like, in particular to a tissue dyeing machine with a rapid detection function of microwaves. Background Art

[0002] The existing human tissue staining machine includes an external tank and a plurality of internal tank structures placed in the external tank. A human tissue wax sheet is placed in the internal tank, and the human tissue wax sheet is dewaxed and dyed according to the dyeing process, and then the human tissue is pathologically confirmed according to the dyeing situation. The existing tissue staining machine uses a patch to heat the water in the external tank, and then conducts heat to the human tissue in the internal tank through the water for a series of treatments. The quality of this method is unstable and the entire operation process is long. At present, there are also related technologies using manipulators, but the quality of steps such as dewaxing, washing, dyeing, and dehydration is also unstable, and the time consumed is long. The film production time is generally more than 1-2 hours, and if the film production time is short, the quality is worse, which is easy to cause the viewer to misjudge and cause adverse consequences. In the disclosed technology, a Chinese patent number CN2018218470202, named "A fully automatic ultrasonic biological tissue staining machine", discloses a staining machine, which includes a staining tank connected to a liquid storage tank, and the staining tank is installed in a processing tank. The technical solution also installs an ultrasonic vibrator (see the attached figure of the patent specification) and a manipulator under almost every staining tank. The technology claims to improve the dyeing effect and quality, but it does not show that the device can be used for other steps such as dewaxing, washing, and dehydration. The device is only used for the dyeing step and improving the dyeing quality. Therefore, the device is not complete for human tissue dyeing, and cannot efficiently process and produce human tissue wax slices in one go. Utility Model Content

[0003] The utility model provides a rapid tissue dyeing machine, which is used for improving the efficiency and quality of human tissue dyeing.

[0004] In order to achieve the above technical purpose, the utility model proposes a rapid tissue staining machine, which is characterized by comprising: a manipulator, an outer tank box, an inner tank box for placing materials, a heating device and a microwave generator; wherein,

[0005] The inner tank box can be placed in the outer tank box, and the inner tank box for the whole process of tissue staining including loading and unloading can be placed in the outer tank box; a tank beam is provided on the outer tank box, and an inner tank hook is provided on the inner tank box, and the inner tank box is hung on the tank beam and / or the outer tank box through the inner tank hook;

[0006] The manipulator is provided above the outer tank box, and the manipulator is a transfer manipulator, which can grab the inner tank box placed inside the outer tank box; the outer tank box is equipped with an inlet and outlet pipe, and the inlet and outlet pipe is controlled by a solenoid valve; the heating device includes a heating plate, which is arranged on the wall of the outer tank box and can heat the liquid in the outer tank box;

[0007] The microwave generator comprises a magnetron and a microwave guide tube connected to the magnetron, wherein the magnetron is arranged at the bottom of the outer tank box, the microwave guide tube is arranged on the side wall of the outer tank box, and the microwave guide tube passes through the side wall of the outer tank box and extends into the outer tank box.

[0008] Preferably: the microwave generator is a pair, and the magnetrons of the two microwave generators are arranged at the bottom of the outer tank box, close to the two sides, and they are arranged oppositely; an inlet and outlet pipe is provided between the two microwave generators. The microwave generator itself acts on the liquid in the inner tank box and the biological tissue of the human body, but it is arranged between the inlet and outlet pipes, so it can act on the water in the outer tank box to promote the heat exchange and diffusion of the water. Due to the relatively symmetrical arrangement of the microwave generators, the water in the outer tank box and the inner tank box can be more evenly affected by the microwave. And due to the principle of wave interference, the two microwave generators will form a virtual vibration source in the middle of them, so that there can be 3 obvious wave sources acting in the outer tank box, so that the ultrasonic wave is more evenly distributed, which is conducive to the change of the substance in the inner tank box.

[0009] Preferably, the heating sheet is connected to a heat conducting sheet, and the heat conducting sheet is arranged on the bottom of the outer tank box. The heating sheet is installed on the outer wall or inner wall of the outer tank box, which will produce local overheating. In order to reduce this effect, the use of the heat conducting sheet can make the water in the outer tank box more evenly heated, which is conducive to the change of the material in the inner tank box.

[0010] Preferably, an inlet and outlet pipe is provided on the outer tank near the heating plate. Providing an inlet and outlet pipe near the heating plate is conducive to the flow of water in the outer tank, and the water in the tank can be more evenly distributed in the tank.

[0011] Preferably: a groove is provided on the front wall of the outer tank box, the two microwave magnetrons are connected to two microwave guide tubes, the two microwave guide tubes are respectively arranged on both sides of the groove, extend into the groove wall, and are arranged in opposite directions. A baffle is arranged above the groove. This groove structure can realize a pair of microwave guide tubes extending into the outer tank box through the two groove side walls, so that the microwaves entering the outer tank box have a larger energy space, the energy propagation range is wider, and the energy difference in various places in the outer tank box is smaller.

[0012] Preferably: the trough beam is located in the middle of the outer trough box, and one row of inner trough boxes can be hung on both sides of the trough beam. The structure of the trough beam enables the device to handle the dyeing work completely at one time, from loading, dewaxing, washing, cytoplasm staining, re-washing, anti-blueing, re-washing, nucleus staining, washing, drying and other processes, and directly unloading. The structure of the two rows of inner trough boxes is compact, and the trough beam plays a key supporting role.

[0013] Preferably, the front and rear ends of the outer tank box are both provided with inlet and outlet pipes, and a middle inlet and outlet pipe is also provided at the bottom of the outer tank box between the front inlet and outlet pipe and the rear inlet and outlet pipe. The inlet and outlet pipes at the front and rear ends are conducive to the flow of water in the outer tank box, making the water temperature inside more uniform. The inlet and outlet pipe is provided in the middle position of the outer tank box. When the water temperature in the outer tank box changes and becomes uneven, the middle inlet and outlet pipe can promote the active flow of water in the box, thereby regulating the water temperature.

[0014] Preferably, an activated carbon filter is installed downstream of the exhaust port of the dyeing machine.

[0015] Preferably: a liquid level gauge is installed in the outer tank box, the liquid level gauge is located near the microwave conduit, and the installation height of the liquid level gauge is not lower than the microwave conduit. Microwaves are effective in water but not in air, so it is necessary to ensure that the microwave conduit works in water. In a structure with two microwave conduits, liquid level gauges need to be installed near both microwave conduits, so that the released microwave energy will act evenly on each inner tank box to avoid affecting the overall effect.

[0016] The beneficial effects of the utility model are as follows: compared with the prior art, in order to improve efficiency and quality, the utility model adopts a more reasonable structure of an outer tank box and an inner tank box, and configures a manipulator, a heating plate, a microwave generator and an inlet and outlet pipe device according to the spatial characteristics of the structure. Such a structure can achieve the dyeing effect of human biological tissue wax slices to the greatest extent possible while saving costs, and the efficiency is better than that of the prior art. All work such as dewaxing, washing, dyeing and drying can be completed at one time. After experimental testing, the filming time of the wax slice can be controlled within 45-60 minutes, and the color depth of the film is consistent. The filming quality of the prior art is poor, the color is uneven, and professional doctors need to judge, which is easy to misjudge. The utility model does not need it, and the requirements for professionals are not high, and it does not require high experience, which is not easy to cause misjudgment. Compared with the prior art, which requires more than 2 hours of filming time, the utility model greatly improves efficiency and quality, does not require other equipment to cooperate, and can be completed at one time from dewaxing to transparent drying of the wax slice, and the efficiency is greatly improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a three-dimensional exploded schematic diagram of the first viewing angle of the top view of the utility model;

[0018] Figure 2 for Figure 1 A schematic diagram of the bottom structure of an embodiment;

[0019] Figure 3 for Figure 1 A schematic diagram of a three-dimensional structure decomposition of the embodiment from a second viewing angle.

[0020] Figure 4 It is a schematic diagram of the three-dimensional structure of the outer tank box from an upward perspective.

[0021] Figure 5 It is a schematic diagram of the three-dimensional structure of the outer tank box from a top view angle.

[0022] Explanation of the symbols in the figure: 1. Manipulator; 2. Outer tank box; 3. Inner tank box; 4. Tank beam; 5. Bottom plate; 6. Electric box; 7. Activated carbon filter; 8. Platform plate; 12. First water inlet and outlet pipe; 120. First solenoid valve; 301. Inner tank hook; 302. Unloading inner tank box; 303. Loading inner tank box;

[0023] 10. Magnetron; 11. Heating plate; 13. Second water inlet and outlet pipe; 14. Third water inlet and outlet pipe; 110. Fan; 201. Outer wall of the bottom of the outer tank box;

[0024] 100. Robot support;

[0025] 15. Microwave duct; 16. Groove; 17. Liquid level indicator. DETAILED DESCRIPTION

[0026] In order to make the purpose, technical solution and advantages of the utility model more clear, the utility model is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the utility model and are not used to limit the utility model.

[0027] In the description of the present invention, it should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention. In addition, in the description of the present invention, "multiple" means two or more, unless otherwise clearly and specifically defined.

[0028] See also Figures 1 to 3. The rapid tissue staining machine proposed in the utility model includes a manipulator 1, an outer tank box 2, a plurality of inner tank boxes 3, an electric box 6, a bottom plate 5, a heating device, a microwave generator and other devices. The inner tank box 3 can be placed in the outer tank box 2, and the inner tank box of the tissue staining process including the whole process from loading to unloading can be placed in the outer tank box. A tank beam 4 is provided on the outer tank box, and an inner tank hook 301 is provided on the inner tank box. The inner tank box is hung on the tank beam and / or the outer tank box through the inner tank hook. A manipulator 1 is provided above the outer tank box 2. The manipulator 1 is a three-axis transfer manipulator. The manipulator can grab the staining rack in the inner tank box above the outer tank box, and the staining rack is provided with glass slides. An inlet and outlet pipe is installed on the outer tank box, and its switch is controlled by an electromagnetic valve. Figure 1 It is shown that a first water inlet and outlet pipe 12 and a first solenoid valve 120 for controlling the first water inlet and outlet pipe 12 are provided at the front end of the outer tank box.

[0029] Combination Figure 2 The heating device includes a heating plate 11, which is arranged on the wall of the outer tank box and located on the outer side wall of the rear part of the outer tank box, and can heat the liquid in the outer tank box. A fan 110 is installed on the heating plate. In a preferred embodiment, the heating plate can be connected to a heat conductive plate, which is arranged on the bottom of the outer tank box. The heating plate is installed on the outer wall or inner wall of the outer tank box, which will cause local overheating. In order to weaken this effect, the use of a heat conductive plate can make the water in the outer tank box more evenly heated, which is conducive to the change of the material in the inner tank box.

[0030] A second inlet and outlet pipe 13 is provided on the outer tank box near the heating plate 11. The inlet and outlet pipes provided near the heating plate are conducive to the flow of water in the outer tank box, and the water in the box can be more evenly distributed in the box. Inlet and outlet pipes are provided at the front and rear ends of the outer tank box, and an intermediate inlet and outlet pipe, i.e., a third inlet and outlet pipe 14, is also provided at the bottom of the outer tank box between the front inlet and outlet pipe and the rear inlet and outlet pipe. The inlet and outlet pipes provided at the front and rear ends are conducive to the flow of water in the outer tank box, making the water temperature therein more uniform. The inlet and outlet pipes are provided in the middle position of the outer tank box. When the water temperature in the outer tank box changes and becomes uneven, the intermediate inlet and outlet pipe can promote the active flow of water in the box, which plays a role in regulating the water temperature. The inlet and outlet pipes are connected to a water tank or a water source.

[0031] In a preferred embodiment, the inner tank box is made of plastic.

[0032] See also Figure 3 and Figure 4The microwave generator includes a magnetron 10 and a microwave guide tube 15 connected to the magnetron, wherein the magnetron 10 is arranged at the bottom of the outer tank box, the microwave guide tube 15 is arranged on the side wall of the outer tank box, and the microwave guide tube 15 passes through the side wall of the outer tank box and extends into the outer tank box. In one embodiment, the microwave generator includes a pair of magnetrons and microwave guide tubes arranged oppositely, and the two magnetrons 10 are respectively arranged at the bottom of the groove of two opposite walls of the outer tank box; a first water inlet and outlet pipe 12 is arranged between the two magnetrons. A groove 16 is arranged on the front wall of the outer tank box, and the two microwave magnetrons are connected to the two microwave guide tubes 15. The two microwave guide tubes are respectively arranged on both sides of the groove, extending into the groove wall, and arranged in opposite directions.

[0033] A liquid level gauge 17 is installed in the outer tank box. The liquid level gauge is located near the microwave guide tube, and the installation height of the liquid level gauge is not lower than the microwave guide tube.

[0034] The microwave conduit itself acts on the liquid in the inner tank box and the human biological tissue, but it is set between the inlet and outlet pipes, so it can act on the water in the outer tank box to promote the heat exchange and diffusion of the water. Due to the relatively symmetrical setting of the microwave conduit, the water in the outer tank box and the inner tank box can be more evenly affected by the energy of the microwave. And due to the interference principle of waves, the two relative microwave sources will form multiple virtual wave sources in the middle of them, so that there can be multiple obvious wave sources acting in the outer tank box, making the ultrasonic waves more evenly distributed, which is conducive to the change of the substances in the inner tank box. Such microwave treatment has better effect, higher quality and higher efficiency.

[0035] The trough beam 4 is located in the middle of the outer trough box, and a row of inner trough boxes can be hung on both sides of the trough beam. Figure 1 There are 2 rows of inner tank boxes shown in the figure. The structure of the tank beam allows the device to handle the staining work completely at one time, from loading, dewaxing, washing, hematoxylin cytoplasm staining, differentiation, anti-blueing, re-washing, nucleus staining, dehydration, transparency, drying and other processes, and directly unloading. The structure of the two rows of inner tank boxes is compact, and the tank beam plays a key supporting role. The surface of the outer tank box 2 includes a platform plate 8, which can be used as an operating table. The outer tank box, electrical box, etc. are all installed on the bottom plate 5, and the manipulator 1 is fixed to the outer tank box through the manipulator bracket 100.

[0036] An activated carbon filter 7 is installed downstream of the exhaust port of the dyeing machine.

[0037] The utility model can complete the dyeing work of human tissue wax slices at one time. In one embodiment, the glass slide with wax slices is operated, and the operation is briefly described as follows: Figure 1, start loading the glass slides from the loading inner tank box 303, then perform two xylene dewaxing steps in sequence, then wash the xylene with anhydrous ethanol twice, then wash with 85% ethanol solution and 95% ethanol solution, then wash with water, and then stain with hematoxylin twice; then wash with water, differentiate, wash with water again, reverse blue, wash with water, stain with eosin, wash with 85% ethanol solution and 95% ethanol solution, then dehydrate with anhydrous ethanol, then use xylene to make it transparent, finally dry the slides, and then move them into the unloading inner tank box 302; in this way, a complete staining process is completed.

[0038] The utility model has been tested and both the film output quality and the film output efficiency are significantly improved. After experimental testing, the film output time of the wax film can be controlled within 30-60 minutes, and the color depth consistency of the film output is very obvious. Generally, non-professionals can also observe and judge, and professional doctors no longer need to judge based on experience.

[0039] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A rapid tissue staining machine, characterized in that include: A manipulator, an outer tank box, an inner tank box for placing materials, a heating device and a microwave generator; wherein, The inner tank box can be placed in the outer tank box, and the inner tank box for the whole process of tissue staining including loading and unloading can be placed in the outer tank box; a tank beam is provided on the outer tank box, and an inner tank hook is provided on the inner tank box, and the inner tank box is hung on the tank beam and / or the outer tank box through the inner tank hook; The manipulator is provided above the outer tank box, and the manipulator is a transfer manipulator, which can grab the inner tank box placed inside the outer tank box; the outer tank box is equipped with an inlet and outlet pipe, and the inlet and outlet pipe is controlled by a solenoid valve; the heating device includes a heating plate, which is arranged on the wall of the outer tank box and can heat the liquid in the outer tank box; The microwave generator comprises a magnetron and a microwave guide tube connected to the magnetron, wherein the magnetron is arranged at the bottom of the outer tank box, the microwave guide tube is arranged on the side wall of the outer tank box, and the microwave guide tube passes through the side wall of the outer tank box and extends into the outer tank box.

2. The rapid tissue staining machine according to claim 1, characterized in that: The microwave generator is a pair, and the magnetrons of the two microwave generators are arranged at the bottom of the outer tank box and close to the two sides, and they are arranged opposite to each other.

3. The rapid tissue staining machine according to claim 1, characterized in that: The heating plate is connected to a heat conducting plate, and the heat conducting plate is arranged on the bottom of the outer tank box.

4. The rapid tissue staining machine according to claim 1, characterized in that: In the vicinity of the heating plate, an inlet and outlet pipe is provided on the outer tank box.

5. The rapid tissue staining machine according to claim 2, characterized in that: A groove is arranged on the front wall of the outer tank box. The magnetrons of the two microwave generators are respectively connected to two microwave guide tubes. The two microwave guide tubes are respectively arranged on both sides of the groove, extending into the tank wall and arranged in opposite directions.

6. The rapid tissue staining machine according to claim 1, characterized in that: The trough beam is located in the middle of the outer trough box, and one row of inner trough boxes can be hung on both sides of the trough beam.

7. The rapid tissue staining machine according to claim 1, characterized in that; Inlet and outlet pipes are provided at the front and rear ends of the outer tank box, and a middle inlet and outlet pipe is also provided at the bottom of the outer tank box between the front inlet and outlet pipe and the rear inlet and outlet pipe.

8. The rapid tissue staining machine according to claim 1, characterized in that: An activated carbon filter is installed downstream of the exhaust port of the dyeing machine.

9. The rapid tissue staining machine according to claim 1, characterized in that: A liquid level gauge is installed in the outer tank box. The liquid level gauge is located near the microwave guide tube, and the installation height of the liquid level gauge is not lower than that of the microwave guide tube.

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