Three-dimensional multi-mode accurate imaging device
By designing a three-dimensional multimodal precise imaging device integrating biooptical imaging unit and CT imaging unit, the image inaccuracy problem caused by frequent replacement of imaging equipment in the prior art is solved, and efficient and accurate multimodal image acquisition is achieved.
Patent Information
- Application Number
- CN202421755131.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Priority Date
- 2023-09-08
- Filing Date
- 2024-07-24
- Publication Date
- 2025-05-30
- Estimated Expiration
- 2034-07-24
AI Technical Summary
The prior art requires multiple replacement of imaging equipment when obtaining internal organ structures and lesion molecular information of animals. The operation is complicated, the imaging efficiency is low, the image fusion is inconvenient, and repeated replacement of the equipment will lead to inaccurate images.
A three-dimensional multimodal precision imaging device is designed, integrating biooptical imaging unit and CT imaging unit, with crossed imaging paths and equipped with lifting turntables to achieve the integration and efficient operation of biooptical imaging and CT imaging.
It achieves simple operation, high imaging efficiency and high image accuracy, avoids the problem of image inaccuracy caused by repeated replacement of imaging equipment, and improves the efficiency and accuracy of multi-modal image acquisition.
Smart Images
Figure CN222917544U_ABST
Abstract
Description
[0001] This application claims the priority of "A Three - Dimensional Multimodal Precision Imaging Device" with the application number 2023224500579 filed on September 8, 2023, and the original receiving authority is China. Technical Field
[0002] The utility model relates to the technical field of medical imaging equipment, and specifically relates to a three - dimensional multimodal precision imaging device. Background Technique
[0003] Medical image registration is to transform images collected at different times and by different medical devices into a unified spatial coordinate system, so that the image information at the same spatial position corresponds to the same anatomical structure, thereby fusing the information collected at different times and by different devices to complete monitoring of lesion changes, fusing multimodal information for auxiliary diagnosis, etc. Therefore, it has a wide range of applications in medical image processing. Typical registration applications include auxiliary diagnosis, surgical planning, surgical navigation, radiotherapy target delineation, lesion deformation monitoring, dose mapping and dose accumulation, image - guided radiotherapy, adaptive radiotherapy, etc. Multimodal image registration is a technology for registering multiple images of the same patient collected by different types of devices at different times. It is used to integrate the advantages of different types of images and provide more information for diagnosis and treatment. Therefore, it has important research significance and application value.
[0004] Compared with the multimodal image registration of multiple images collected by the same device, multimodal image registration faces more technical challenges. Due to the differences in imaging methods and principles of different modalities, there are obvious differences in the same anatomical structure in different - modality images. For example, CT images have high resolution and a large imaging range, and can provide obvious anatomical structure information, but they cannot finely distinguish different types of soft tissues, nor can they display molecular and functional imaging information. Optical imaging methods can be divided into fluorescence - based methods and bioluminescence - based methods. Optics is smaller and cheaper than MRI and PET. Three - dimensional optical imaging methods can measure fluorescence in a non - invasive, quantitative, and three - dimensional manner.
[0005] Currently, to simultaneously obtain the internal organ structure and lesion molecular information of an animal, multiple devices are needed. When changing devices, the experimental animal needs to be fixed multiple times, the operation is complex, the imaging efficiency is low, image fusion is inconvenient, and repeatedly changing the imaging device will result in inaccurate images. Therefore, it is urgently needed to be solved. Content of the Utility Model
[0006] In order to avoid and overcome the technical problems existing in the prior art, the utility model provides a three - dimensional multimodal precision imaging device, which is simple to operate and has high imaging efficiency.
[0007] To achieve the above - mentioned purpose, the utility model provides the following technical solutions:
[0008] A three-dimensional multimodal precise imaging device, comprising a base and a loading unit mounted on the base. A biological optical imaging unit and a CT imaging unit are also provided on the base. The imaging paths of the biological optical imaging unit and the CT imaging unit cross each other, and the intersection point of the imaging paths converges on the vertical center line of the loading station of the loading unit.
[0009] As a further solution of the present utility model: The CT imaging unit includes a radiation source and a flat panel detector distributed on both sides of the loading unit. The detection surface of the flat panel detector is perpendicular to the horizontal axis of the irradiation end of the radiation source, and the path where the horizontal axis is located constitutes the imaging path of the CT imaging unit.
[0010] As a further solution of the present utility model: The biological optical imaging unit includes a CCD camera, and a filter is provided at the front end of the lens of the CCD camera.
[0011] As a further solution of the present utility model: The CCD camera and the flat panel detector are arranged side by side. The biological optical imaging unit further includes a reflector, and the biological light is reflected by the reflector and then projected into the acquisition end of the CCD camera; the path of the biological light constitutes the imaging path of the biological optical imaging unit, and an intersection point is formed between a section of the optical path of the biological light before entering the reflector and the imaging path of the CT imaging unit.
[0012] As a further solution of the present utility model: The filter is provided with at least two, and at least two filters can be respectively and movably switched to the front end of the lens of the CCD camera.
[0013] As a further solution of the present utility model: The biological optical imaging unit further includes a laser, which is used to irradiate the organism on the loading unit and cause the fluorescent molecules in the organism to emit fluorescence.
[0014] As a further solution of the present utility model: A guide rail parallel to the lens acquisition path of the CCD camera is installed on the base, and the laser is slidably fitted on the guide rail.
[0015] As a further solution of the present utility model: The loading unit includes a loading table fixed on the base. A lifting turntable that can perform lifting movement and can rotate around the vertical axis is provided on the top of the loading table. The top surface of the lifting turntable constitutes the loading station, and the rotation axis of the lifting turntable coincides with the vertical center line.
[0016] As a further solution of the present utility model: A motor for driving the rotation of the lifting turntable is arranged in the loading table.
[0017] As a further solution of the present utility model: A lifter is coaxially fixed on the output shaft of the motor. The lifting turntable has a disc structure, and the lifting turntable is coaxially fixed on the telescopic end of the lifter.
[0018] Compared with the prior art, the beneficial effects of the present utility model are as follows:
[0019] 1. The bio-optical imaging unit and the CT imaging unit are integrated. After fixing the organism on the loading station, bio-optical imaging and CT imaging can be respectively performed, which is not only convenient to operate but also has a high imaging accuracy rate, solving the problem of inaccurate images caused by repeatedly replacing imaging devices or moving imaging animals.
[0020] 2. By bending the imaging path of the bio-optical imaging unit through a reflector, a juxtaposed layout is formed between the CT imaging unit and the optical imaging unit. Compared with the crossed layout structure, it occupies less space and improves the compactness of the overall layout of the device.
[0021] 3. The bio-optical imaging unit integrates bioluminescence imaging and molecular fluorescence imaging, enhancing the polymorphism of bio-optical imaging.
[0022] 4. The lifting turntable can achieve lifting movement and rotation around the vertical axis, thereby adjusting the loading height and imaging angle of the organism, so that it no longer moves after being fixed on the lifting turntable, avoiding the negative impact on imaging caused by multiple fixations, and enabling rapid multi-modal image acquisition, thus improving the efficiency and accuracy of multi-modal image acquisition. BRIEF DESCRIPTION OF THE DRAWINGS
[0023] Figure 1 It is a top view structural schematic diagram of the present utility model.
[0024] Figure 2 It is a three-dimensional structural schematic diagram of the present utility model.
[0025] In the figure: 1. Base; 2. Loading table; 3. Lifting turntable; 4. Radiation source; 5. Flat panel detector; 6. CCD camera; 7. Reflector; 8. Laser; 9. Guide rail. DETAILED DESCRIPTION OF THE EMBODIMENTS
[0026] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present utility model.
[0027] For the convenience of understanding, the specific structure and working mode of the present utility model are further described as follows in conjunction with the accompanying drawings:
[0028] The specific structure of the present utility model refers to Figure 1-2As shown in the figure, its main structure includes a load-carrying unit, a bio-optical imaging unit, and a CT imaging unit installed on the base 1. Among them, the imaging paths of the bio-optical imaging unit and the CT imaging unit cross each other, and the intersection point of the imaging paths converges on the vertical center line of the load-carrying station of the load-carrying unit, realizing non-interfering bio-optical imaging operations and CT imaging operations. This device integrates the bio-optical imaging unit and the CT imaging unit. After fixing the organism at the load-carrying station, bio-optical imaging and CT imaging can be carried out respectively, which is not only convenient to operate but also has a high imaging rate, solving the problem of inaccurate images caused by repeatedly replacing imaging equipment.
[0029] Specifically, as Figure 1 shown, the CT imaging unit includes a radiation source 4 and a flat panel detector 5 distributed on both sides of the load-carrying unit. The detection surface of the flat panel detector 5 is distributed perpendicular to the horizontal axis of the irradiation end of the radiation source 4, and the path where the horizontal axis is located constitutes the imaging path of the CT imaging unit; during use, rays are emitted by the radiation source 4, and the projection images after the radiation source 4 irradiates the organism are collected by the flat panel detector 5.
[0030] Bioluminescence imaging and molecular fluorescence imaging are two imaging methods in bioluminescence imaging.
[0031] The principle of bioluminescence imaging is that the chemical reaction inside the imaging object comes from the enzymatic reaction in the organism, which is the spontaneous fluorescence in animals. The enzyme that catalyzes such reactions is called luciferase. The common method is to construct an expression vector of the luciferase gene, transfect the target cells, and transplant them into the target organ of the receptor. When observing, an exogenous luciferin is injected, and a reaction can occur in the target cells to produce fluorescence. Then, the real-time monitoring of the expression of target cells or target molecules can be realized by using a highly sensitive in vivo bio-optical imaging system.
[0032] On the above basis, as Figure 1 shown, the bio-optical imaging unit includes a CCD camera 6, and a filter is provided at the front end of the lens of the CCD camera 6. The cooperation of the CCD camera 6 and the filter can be used to collect bioluminescence imaging.
[0033] Furthermore, as Figure 1As shown, the CCD camera 6 and the flat panel detector 5 are arranged side by side. The bio-optical imaging unit further includes a mirror 7. The bio-light is reflected by the mirror 7 and then projected onto the acquisition end of the CCD camera 6. The imaging path of the bio-optical imaging unit is formed by the passing path of the bio-light. An intersection point is formed between a section of the optical path of the bio-light before entering the mirror 7 and the imaging path of the CT imaging unit. Preferably, the acquisition path of the CCD camera 6 is parallel to the imaging path of the CT imaging unit. In the downward viewing angle, the reflecting surface of the mirror 7 is inclined at 45° with respect to the acquisition path of the CCD camera 6, so that a section of the optical path of the bio-light before entering the mirror 7 intersects perpendicularly with the imaging path of the CT imaging unit. By bending the imaging path of the bio-optical imaging unit through the mirror 7, a side-by-side layout is formed between the CT imaging unit and the optical imaging unit. Compared with the intersecting layout structure, it occupies less space and improves the compactness of the overall layout of the device.
[0034] Of course, in actual implementation, the mirror 7 may not be provided, and the acquisition path of the CCD camera 6 can be directly used as the imaging path of the bio-optical imaging unit. In addition, the intersecting arrangement between the acquisition path of the CCD camera 6 and the imaging path of the CT imaging unit is preferably perpendicular intersection, as long as the independent imaging between the CCD camera 6 and the CT imaging unit is not affected.
[0035] In addition, at least two filters are provided. The at least two filters can be respectively and actively switched to the front end of the lens of the CCD camera 6. Specifically, the filters can be installed on an electric rotating wheel, and different filters can be adjusted and replaced according to the bio-optical imaging requirements for filtering operations. Whether it is molecular fluorescence imaging or bioluminescence imaging, the bio-light can be processed by the filter or not, which is determined according to the actual acquisition needs.
[0036] To further enhance the polymorphism of the bio-optical imaging function, the acquisition of molecular fluorescence imaging can also be realized in this application. Compared with bioluminescence imaging, an additional laser 8 is required to irradiate the organism to excite the fluorescent molecules carried by the organism to emit fluorescence. In actual implementation, the bio-optical imaging unit further includes a laser 8, and the laser 8 is used to irradiate the organism on the sample stage and cause the fluorescent molecules in the organism to emit fluorescence.
[0037] In addition, as Figure 2 shown, a guide rail 9 parallel to the lens acquisition path of the CCD camera 6 is installed on the base 1, and the laser 8 is slidably fitted on the guide rail 9, which can be used to adjust the irradiation position of the laser 8 on the organism to achieve excitation in different regions.
[0038] On the above basis, as Figure 2As shown in the figure, the loading unit includes a loading platform 2 fixed on the base 1. At the top of the loading platform 2, there is a lifting turntable 3 that can move up and down and rotate around the vertical axis. The top surface of the lifting turntable 3 constitutes the loading station, and the rotation axis of the lifting turntable 3 coincides with the vertical center line. When performing bio-optical imaging and CT imaging, the organism on the loading station can be adjusted to the appropriate imaging angle and height.
[0039] Specifically, a motor for driving the rotation of the lifting turntable 3 is arranged inside the loading platform 2; a lifter is coaxially fixed on the output shaft of the motor. The lifting turntable 3 is in a disc structure, and the lifting turntable 3 is coaxially fixed on the telescopic end of the lifter, thereby realizing the lifting and rotation operations of the loading platform 2.
[0040] The working principle of a three-dimensional multimodal precise imaging device of the present utility model is as follows:
[0041] Before starting the imaging operation, the experimental animal is fixed on the lifting turntable 3, and the rotation and height of the lifting turntable 3 can be adjusted according to the imaging requirements to adjust the experimental animal to the appropriate imaging angle and imaging height.
[0042] When performing CT imaging, the lifting turntable 3 is first fixed at a certain angle, the radiation source 4 emits radiation and irradiates on the experimental animal, and the projection image of the experimental animal is obtained through the flat panel detector 5. Subsequently, the lifting turntable 3 is rotated to another angle, and the CT imaging steps are repeated until enough projection images are obtained for subsequent three-dimensional CT image reconstruction.
[0043] When performing bio-optical imaging, the base 1 is kept in a dark environment. Specifically:
[0044] When performing molecular fluorescence imaging, the laser 8 in the guide rail 9 needs to be moved to a suitable position, and the laser light source emitted by the laser 8 irradiates on the experimental animal to excite the fluorescent molecules carried by the experimental animal to generate emitted fluorescence; after the fluorescence is reflected by the reflector 7 and selectively transmitted through the filter, the light is finally collected by the CCD camera 6 with a lens, and the bio-fluorescence imaging can be completed after subsequent processing.
[0045] When performing bioluminescence imaging, compared with bio-fluorescence imaging, the step of excitation by the laser 8 is missing; the acquisition of bioluminescence light is also reflected by the reflector 7, filtered by the filter, and finally collected by the CCD camera 6 with a lens, and the bioluminescence imaging can be completed after subsequent processing.
[0046] When the device performs multimodal imaging, the experimental animal is fixed on the lifting turntable 3 and no longer moves, avoiding the negative impact on imaging caused by multiple fixations, and can quickly realize multimodal image acquisition, thereby improving the efficiency and accuracy of multimodal image acquisition.
[0047] A three-dimensional multimodal precise imaging device of the present utility model integrates a bio-optical imaging unit and a CT imaging unit through a compact structural design. Image acquisition of CT imaging and bio-optical imaging can be carried out inside the device, and the image acquisition processes do not affect each other. A single fixation of the experimental animal can complete multimodal image acquisition, improving the efficiency of multimodal image acquisition and avoiding inaccurate images caused by switching between different imaging devices for the imaging object.
[0048] It is worth mentioning that the present utility model is also equipped with a central control system. The pictures collected in various scenarios, after being processed by the software provided in the central control system, can achieve registration of different pictures and finally present a highly precise fused image. The main structural components involved in the CT imaging, bio-optical imaging, rotation or position angle of the stage 2, excitation position of the laser 8, etc. of the present utility model can be intelligently controlled by the provided software.
[0049] Certainly, for those skilled in the art, the present utility model is not limited to the details of the above-described exemplary embodiments, but also includes the same or similar structures that can be implemented in other specific forms without departing from the spirit or basic characteristics of the present utility model. Therefore, from any point of view, the embodiments should be regarded as exemplary and non-limiting. The scope of the present utility model is defined by the appended claims rather than the above description. Therefore, all changes falling within the meaning and scope of the equivalent elements of the claims are intended to be included in the present utility model. Any reference signs in the claims should not be regarded as limiting the claimed rights.
[0050] In addition, it should be understood that although this specification is described in accordance with the embodiments, not every embodiment only contains an independent technical solution. This narrative way of the specification is only for clarity. Those skilled in the art should regard the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.
[0051] The technologies, shapes, and structures not detailedly described in the present utility model are all well-known technologies.
Claims
1. A three-dimensional multimodal precision imaging device, characterized in that: The invention comprises a base (1) and a loading unit mounted on the base (1); a bio-optical imaging unit and a CT imaging unit are also arranged on the base (1); imaging paths of the bio-optical imaging unit and the CT imaging unit intersect with each other, and the intersection of the imaging paths converges on the vertical center line of the loading station of the loading unit.
2. A three-dimensional multi-modal precise imaging device according to claim 1, characterized in that: The CT imaging unit comprises a ray source (4) and a flat panel detector (5) distributed on both sides of a carrier unit; the detection plate surface of the flat panel detector (5) is perpendicular to a horizontal axis of an irradiation end of the ray source (4), and the path where the horizontal axis is located constitutes an imaging path of the CT imaging unit.
3. A three-dimensional multimodal precision imaging device according to claim 1 or 2, characterized in that: The bio-optical imaging unit comprises a CCD camera (6), and a filter is arranged at the front end of the lens of the CCD camera (6).
4. The three-dimensional multi-modal precise imaging device according to claim 3, characterized in that: The CCD camera (6) and the flat panel detector (5) are arranged side by side, and the bio-optical imaging unit further comprises a reflector (7), and the bio-light is reflected by the reflector (7) and then input into the collection end of the CCD camera (6); the passage path of the bio-light constitutes the imaging path of the bio-optical imaging unit, and the intersection is formed between a section of the optical path of the bio-light before entering the reflector (7) and the imaging path of the CT imaging unit.
5. The three-dimensional multi-modal precise imaging device according to claim 3, characterized in that: The optical filters are arranged in at least two pieces, and the at least two optical filters can be movably switched to the front end of the lens of the CCD camera (6) respectively.
6. The three-dimensional multi-modal precise imaging device according to claim 3, characterized in that: The biological optical imaging unit also includes a laser (8), which is used to irradiate the organism on the carrier unit and cause the fluorescent molecules in the organism to emit fluorescence.
7. The three-dimensional multi-modal precise imaging device according to claim 6, characterized in that: A guide rail (9) parallel to the lens collection path of the CCD camera (6) is installed on the base (1), and the laser (8) is slidably fitted on the guide rail (9).
8. A three-dimensional multi-modal precise imaging device according to claim 1 or 2, characterized in that: The loading unit comprises a loading platform (2) fixed on a base (1); a lifting turntable (3) capable of lifting and lowering motion and rotating about a vertical axis is arranged on the top of the loading platform (2); the loading station is formed by the top surface of the lifting turntable (3), and the rotation axis of the lifting turntable (3) coincides with the vertical center line.
9. The three-dimensional multi-modal precise imaging device according to claim 8, characterized in that: A motor for driving the lifting turntable (3) to rotate is arranged inside the loading platform (2).
10. The three-dimensional multi-modal precise imaging device according to claim 9, characterized in that: A lifter is coaxially fixed on the motor output shaft, the lift turntable (3) is in a disc structure, and the lift turntable (3) is coaxially fixed on the telescopic end of the lifter.