Multi-modal image guide irradiation device

Abstract

The utility model relates to the technical field of biomedical imaging and radiotherapy, in particular to a multi-mode image guide irradiation device. The biological optical imaging device comprises a base, an irradiation mechanism is mounted on the base, an object carrying unit and a detection unit which are sequentially arranged along a horizontal irradiation path coaxial with the irradiation end of the irradiation mechanism are further arranged on the base, a biological optical imaging unit is further arranged on the base, and the imaging path of the biological optical imaging unit points to the object carrying unit. The imaging path and the detection path of the detection unit intersect with each other, and the irradiation end of the irradiation mechanism is detachably provided with a collimator. According to the utility model, the position of a tumor can be accurately positioned, and the treatment effect and the treatment accuracy of irradiation are effectively improved.

Description

[0001] This application claims the priority of "A Multimodal Image-Guided Irradiation Device" with the application number 2023224500475 filed on September 8, 2023, and the original receiving agency is China. Technical Field

[0002] The utility model relates to the technical field of biomedical imaging and radiotherapy, and specifically relates to a multimodal image-guided irradiation device. Background Art

[0003] Tumor radiotherapy is a local treatment method that uses radiation to treat tumors. The radiation includes α, β, and γ rays generated by radioactive isotopes and X-rays, electron beams, proton beams, and other particle beams generated by various X-ray therapy machines or accelerators.

[0004] The role and status of radiotherapy in tumor treatment have become increasingly prominent and have become one of the main means of treating malignant tumors.

[0005] In order to study the radiation biological effects and verify the effect of radiotherapy, animal irradiation experiments need to be carried out before clinical treatment. In animal tumor irradiation experiments and cell irradiation experiments, irradiators are required. Due to the single image guidance of existing irradiator equipment, it is impossible to simultaneously obtain the internal organ structure and lesion molecular information of animals, resulting in a large uncertainty in tumor positioning, which will reduce the treatment effect and increase the damage to normal tissues. Therefore, it is urgent to solve this problem. Content of the Utility Model

[0006] In order to avoid and overcome the technical problems existing in the prior art, the utility model provides a multimodal image-guided irradiation device, which can accurately locate the tumor position and effectively improve the treatment effect and accuracy of irradiation.

[0007] To achieve the above object, the utility model provides the following technical solutions:

[0008] A multimodal image-guided irradiation device includes a base, on which an irradiation mechanism is installed. On the base, a loading unit and a detection unit are sequentially arranged along the horizontal irradiation path coaxial with the irradiation end of the irradiation mechanism. A bio-optical imaging unit is also arranged on the base. The imaging path of the bio-optical imaging unit points to the loading unit, and this imaging path intersects with the detection path of the detection unit. The irradiation end of the irradiation mechanism is detachably installed with a collimator.

[0009] As a further solution of the utility model: The irradiation mechanism includes a mounting plate fixed on the base. The mounting plate is rotationally fitted with a ray source bracket around a horizontal axis, and this horizontal axis is perpendicular to the horizontal irradiation path. A ray source is installed on the ray source bracket, and the beam outlet of the ray source constitutes the irradiation end.

[0010] As a further solution of the present utility model: the detection unit includes a flat panel detector whose detection surface is perpendicular to the horizontal irradiation path, and a detector baffle for blocking the detection surface of the flat panel detector is movably arranged between the detection surface of the flat panel detector and the loading unit.

[0011] As a further solution of the present utility model: the flat panel detector is fixed to the base through a detector fixing plate, and a lead screw slider mechanism for driving the detector baffle to reciprocate vertically is installed on the detector fixing plate.

[0012] As a further solution of the present utility model: the biological optical imaging unit includes a CCD camera, and a filter is arranged at the front end of the lens of the CCD camera.

[0013] As a further solution of the present utility model: the CCD camera and the detection unit are arranged side by side, and the biological optical imaging unit further includes a reflecting mirror. The biological light is reflected by the reflecting mirror and then enters the acquisition end of the CCD camera; the imaging path of the biological optical imaging unit is formed by the passing path of the biological light, and an intersection is formed between a section of the optical path of the biological light before entering the reflecting mirror and the detection path.

[0014] As a further solution of the present utility model: at least two filters are provided, and at least two filters can be respectively and movably switched to the front end of the lens of the CCD camera.

[0015] As a further solution of the present utility model: the biological optical imaging unit further includes an excitation light source, and the excitation light source is used to irradiate the organism on the loading unit and cause the fluorescent molecules in the organism to generate fluorescence emission.

[0016] As a further solution of the present utility model: the loading unit includes a loading platform and a four-axis module for adjusting the spatial position of the loading platform.

[0017] As a further solution of the present utility model: the four-axis module includes a Z-axis rotation assembly installed on the base, a slide table module fixing plate is fixed on the rotation power end of the Z-axis rotation assembly, a Z-axis linear slide table module is installed on the slide table module fixing plate, a Y-axis linear slide table module is installed on the sliding end of the Z-axis linear slide table module, and an X-axis linear slide table module is arranged on the sliding end of the Y-axis linear slide table module.

[0018] Compared with the prior art, the beneficial effects of the present utility model are:

[0019] 1. The integrated structure enables CT imaging and bio-optical imaging of organisms, ensuring the three-dimensional precise positioning of tumors during treatment. In addition, by using the same irradiation mechanism and installing a collimator on the irradiation mechanism, bio-irradiation operations can be carried out. Combining with the precise positioning of the tumor location above, it can accurately kill tumors while avoiding radiation damage to normal tissues, improving the treatment effect.

[0020] 2. The radiation source bracket installed with the radiation source can rotate around the horizontal axis, thereby driving the radiation source to rotate synchronously, that is, realizing the adjustment of the irradiation angle of the radiation source to perform irradiation treatment from a better angle.

[0021] 3. A detector baffle is provided. During the irradiation treatment process, the detection surface of the flat panel detector is blocked by the detector baffle to prevent the rays of the irradiation treatment from irradiating the detection surface of the flat panel detector.

[0022] 4. By bending the imaging path of the bio-optical imaging unit through a reflector, a parallel layout is formed between the detection unit for CT imaging of organisms, the irradiation mechanism, and the optical imaging unit. Compared with the crossed layout structure, it occupies less space and improves the compactness of the overall layout of the device.

[0023] 5. The bio-optical imaging unit integrates bioluminescence imaging and molecular fluorescence imaging, enhancing the polymorphism of bio-optical imaging.

[0024] 6. A four-axis module for adjusting the spatial position of the loading platform is provided. It can not only adjust the position of the organism in the three-dimensional space coordinate system according to the image acquisition and irradiation treatment requirements, but also rotate the organism around the vertical axis to achieve multi-angle image acquisition of the organism. In addition, the multi-angle rotation of the organism around the vertical axis can also be used in combination with the rotation of the radiation source driven by the radiation source bracket around the horizontal axis, enabling the radiation source to achieve multi-angle adjustment in the horizontal and vertical directions, so as to facilitate finding a better irradiation treatment angle. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 It is a schematic structural diagram of the present utility model.

[0026] Figure 2 It is a schematic top view structural diagram of the present utility model.

[0027] Figure 3 It is the first schematic structural diagram of the four-axis module in the present utility model.

[0028] Figure 4 It is the second schematic structural diagram of the four-axis module in the present utility model.

[0029] Figure 5 It is the third schematic structural diagram of the four-axis module in the present utility model.

[0030] Figure 6 This is the fourth schematic diagram of the structure of the four-axis module in the present utility model.

[0031] Figure 7 This is the first schematic diagram of the structure of the detection mechanism in the present utility model.

[0032] Figure 8 This is the second schematic diagram of the structure of the detection unit in the present utility model.

[0033] Figure 9 This is the third schematic diagram of the structure of the detection unit in the present utility model.

[0034] Figure 10 This is the fourth schematic diagram of the structure of the detection unit in the present utility model.

[0035] Figure 11 This is the schematic diagram of the embodiment of the present utility model.

[0036] In the figure: 1, base; 2, four-axis module; 3, load platform; 4, mounting plate; 5, ray source bracket; 6, ray source; 7, collimator; 8, flat panel detector; 9, detector baffle; 10, CCD camera; 11, mirror; 12, filter; 21, X-axis linear slide module; 22, Y-axis linear slide module; 23, Z-axis linear slide module; 24, slide module fixing plate; 25, Z-axis rotation assembly; 81, lead screw; 82, slide motor; 83, detector fixing plate; 84, moving plate; 200, cabinet; a, horizontal axis. Detailed implementation manners

[0037] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present utility model.

[0038] For the convenience of understanding, here in conjunction with the accompanying drawings, the specific structure and working mode of the present utility model are further described as follows:

[0039] The specific structure of the present utility model is referred to Figures 1-11 As shown, its main structure includes a base 1, a load unit installed on the base 1, a detection unit and an irradiation mechanism for CT imaging of organisms on the load unit, an optical imaging unit for biological optical imaging, and a collimator 7 detachably installed at the irradiation end of the irradiation mechanism and used for biological irradiation.

[0040] Among them, as Figure 1As shown in the figure, the loading unit and the detection unit are sequentially arranged on the base 1 along a horizontal irradiation path coaxial with the irradiation end of the irradiation mechanism; the imaging path of the bio-optical imaging unit points to the loading unit, and the imaging path intersects with the detection path of the detection unit, so as to realize non-interfering bio-optical imaging operations and CT imaging operations.

[0041] It is worth mentioning that during the CT imaging process, the collimator 7 needs to be removed from the irradiation end of the irradiation mechanism, and the irradiation end of the irradiation mechanism is directly used to emit rays towards the organisms in the loading unit, and the projection images are collected by the detection unit to perform CT imaging work. During bio-irradiation, the collimator 7 needs to be installed at the irradiation end of the irradiation mechanism, and rays are emitted by the irradiation mechanism, and under the action of the collimator 7, a radiation field with a certain shape contour is formed to perform precise radiotherapy on the lesion site.

[0042] To improve the accuracy of the irradiation process, as Figure 1 shown, the irradiation mechanism includes a mounting plate 4 fixed on the base 1. A ray source support 5 is rotatably fitted on the mounting plate 4 around a horizontal axis a, and the horizontal axis a is perpendicular to the horizontal irradiation path. A ray source 6 is installed on the ray source support 5, and the beam outlet of the ray source 6 constitutes the irradiation end. By rotating the ray source support 5 around the horizontal axis a, the ray source 6 is driven to rotate synchronously, that is, the irradiation angle of the ray source 6 is adjusted to perform irradiation treatment from a better angle.

[0043] In actual implementation, the angle adjustment of the ray source 6 can also adopt other implementation methods, such as structures that can adjust the irradiation angle of the ray source 6 through existing universal ball joints or multi-axis robotic arms, etc.

[0044] On the above basis, as Figure 1 shown, the detection unit includes a flat panel detector 8 whose plate surface is distributed perpendicular to the horizontal irradiation path. A detector baffle 9 that can block the detection plate surface is movably arranged between the detection plate surface of the flat panel detector 8 and the loading unit. During the irradiation treatment process, the detection surface of the flat panel detector 8 is blocked by the detector baffle 9 to prevent the rays of the irradiation treatment from irradiating the detection surface of the flat panel detector 8. During CT imaging, the detector baffle 9 is movably removed or moved away so that the detection surface of the flat panel detector 8 is exposed for CT imaging acquisition.

[0045] Specifically, as Figures 7-10As shown, the flat panel detector 8 is fixed to the base 1 through the detector fixing plate 83, and a screw slider mechanism is installed on the detector fixing plate 83 to drive the detector baffle 9 to slide back and forth in the vertical direction, thereby realizing the detector baffle 9 to block or release the detection surface of the flat panel detector 8. In specific implementation, the screw slider mechanism includes a lead screw 81, a slide motor 82 and a moving plate 84, the moving plate 84 slides on the detector fixing plate 83 along the vertical axis, and the moving plate 84 is fixedly connected to the detector baffle 9; the output end of the slide motor 82 is connected to the lead screw 81 through a belt, and the moving plate 84 is movably connected to the lead screw 81, the slide motor 82 drives the lead screw 81 to rotate, and the moving plate 84 moves on the lead screw 81, driving the detector baffle 9 to move up and down.

[0046] Bioluminescence imaging and molecular fluorescence imaging are two imaging methods in bioluminescence imaging.

[0047] The principle of bioluminescence imaging is that the chemical reaction inside the imaging object comes from the enzymatic reaction in the organism, which is the spontaneous fluorescence in the animal body. The enzyme that catalyzes this reaction is called luciferase. The common method is to construct an expression vector of the luciferase gene to transfect the target cells and transplant them into the target organ of the recipient. When observing, inject exogenous luciferin, and the target cells will react to produce fluorescence. Then, a highly sensitive in vivo bio-optical imaging system can be used to achieve real-time monitoring of the expression of target cells or target molecules.

[0048] On the basis of the above, if Figure 1 As shown, the biological optical imaging unit includes a CCD camera 10, and a filter 12 is arranged at the front end of the lens of the CCD camera 10. The cooperation between the CCD camera 10 and the filter 12 can realize the collection of biological luminescence imaging.

[0049] Further, such as Figure 1 and Figure 2 As shown, the CCD camera 10 and the detection unit are arranged side by side, and the bio-optical imaging unit also includes a reflector 11. The bio-light is reflected by the reflector 11 and then input into the collection end of the CCD camera 10; the passage path of the bio-light constitutes the imaging path of the bio-optical imaging unit, and a section of the optical path of the bio-light before entering the reflector 11 intersects with the detection path. Preferably, the collection path of the CCD camera 10 is parallel to the detection path of the detection unit. In a top-down perspective, the reflecting surface of the reflector 11 and the collection path of the CCD camera 10 are inclined at 45°, so that a section of the optical path of the bio-light before entering the reflector 11 intersects vertically with the detection path. The imaging path is bent by the reflector 11, so that a parallel layout is formed between the detection unit, the irradiation mechanism, and the optical imaging unit of the biological CT imaging. Compared with the intersecting layout structure, it occupies less space and improves the compactness of the overall layout of the device.

[0050] Of course, in actual implementation, the mirror 11 may not be provided, and the acquisition path of the CCD camera 10 can be directly used as the imaging path of the bio-optical imaging unit. In addition, the cross-arrangement between the acquisition path of the CCD camera 10 and the detection path of the detection unit is preferably a perpendicular cross, as long as the independent imaging between the CCD camera 10 and the detection unit is not affected.

[0051] In addition, at least two filter plates 12 are provided, and at least two filter plates 12 can be respectively and actively switched to the front end of the lens of the CCD camera 10, so that different filter plates 12 can be adjusted and replaced according to the bio-optical imaging requirements for filtering operations.

[0052] To further enhance the polymorphism of the bio-optical imaging function, the acquisition of molecular fluorescence imaging can also be realized in this application. Compared with bioluminescence imaging, an additional excitation laser is required to irradiate the organism to excite the fluorescence molecules carried by the organism to generate emitted fluorescence. In actual implementation, the bio-optical imaging unit further includes an excitation light source, which is used to irradiate the organism on the loading unit and cause the fluorescence molecules in the organism to generate emitted fluorescence.

[0053] On the above basis, as Figure 1 shown, the loading unit includes a loading platform 3 and a four-axis module 2 for adjusting the spatial position of the loading platform 3. It can not only adjust the position of the organism in the three-dimensional space coordinate system according to the image acquisition and irradiation treatment requirements, but also rotate the organism around the vertical axis to realize the multi-angle image acquisition of the organism. In addition, the multi-angle rotation of the organism around the vertical axis can be used in cooperation with the rotation of the radiation source 6 driven by the radiation source bracket 5 around the horizontal axis a, so that the radiation source 6 can realize the multi-angle adjustment in the horizontal and vertical directions to facilitate finding a better irradiation treatment angle.

[0054] To realize the adjustment of the spatial position of the above-mentioned loading platform 3, specifically, as Figures 3-6 shown, the four-axis module 2 includes a Z-axis rotation component 25 installed on the base 1. A slide table module fixing plate 24 is fixed on the rotation power end of the Z-axis rotation component 25. A Z-axis linear slide table module 23 is installed on the slide table module fixing plate 24. A Y-axis linear slide table module 22 is installed on the sliding end of the Z-axis linear slide table module 23. An X-axis linear slide table module 21 is provided on the sliding end of the Y-axis linear slide table module 22. The X-axis linear slide table module 21, the Y-axis linear slide table module 22, and the Z-axis linear slide table module 23 respectively realize the movement adjustment of the organism on the X, Y, and Z axes, and the Z-axis rotation component 25 realizes the rotation adjustment of the organism along the Z axis.

[0055] In addition, as Figure 11 shown, the multi-modal image-guided irradiation device is arranged in the cabinet 200 to provide a dark environment for the device to work and reduce the interference of external light on the acquisition and irradiation work.

[0056] The working principle of a multi-modal image-guided irradiation device of the present utility model is as follows:

[0057] Before starting work, the organism is fixed on the loading platform 3. Among them, the four-axis module 2 is driven by a motor and can move in multiple directions to adjust the spatial position of the organism, facilitating subsequent imaging and irradiation experiments:

[0058] When performing CT imaging, the organism needs to be scanned from multiple angles. At this time, the ray source support 5 is flipped to the horizontal position, so that the beam outlet of the ray source 6 is vertically aligned with the flat panel detector 8. At the same time, the detector baffle 9 moves downward, so that the flat panel detector 8 is exposed for signal detection. In addition, the four-axis module 2 drives the organism to rotate, the rays emitted by the ray source 6 irradiate the organism, and the flat panel detector 8 is used to collect projection images. During this process, the flat panel detector 8 collects projection images from multiple angles, which can be used for subsequent three-dimensional CT image reconstruction.

[0059] When performing biological optical imaging, the entire device is kept in a dark environment. Specifically:

[0060] When performing bioluminescence imaging, the processed organism is also fixed on the loading platform 3. The light emitted by the organism is reflected by the mirror 11, passes through the corresponding filter 12 for filtering, and is finally captured by the CCD camera 10 with an optical lens, thereby completing the image acquisition of bioluminescence imaging.

[0061] When performing molecular fluorescence imaging, the excitation light source emits excitation light to irradiate the organism, thereby exciting the fluorescent molecules carried by the organism to generate emission fluorescence. The fluorescence emitted by the organism is also reflected by the mirror 11, passes through the corresponding filter 12 for filtering, and is finally captured by the CCD camera 10 with an optical lens, thereby completing the image acquisition of molecular fluorescence imaging. Whether it is molecular fluorescence imaging or bioluminescence imaging, the biological light can be processed by the filter or not, depending on the actual acquisition needs.

[0062] When performing irradiation treatment, the four-axis module 2 moves the organism to a suitable position and adjusts the area to be irradiated to the center of the field of view; during this process, the position of the detector baffle 9 needs to be adjusted so that the detector baffle 9 moves upward to block the flat panel detector 8, and a collimator 7 is manually or automatically mounted at the beam outlet of the ray source 6. Under the action of the collimator 7, the ray source 6 emits a radiation field with a certain shape and contour to perform precise radiotherapy on the lesion. Among them, the irradiation angle of the ray source 6 can be adjusted by flipping the ray source support 5 to perform irradiation treatment from a better angle.

[0063] The multi-modal image-guided irradiation device of the present utility model can achieve CT imaging and bioluminescence imaging of live animals through an integrated structure. The four-axis module 2 adjusts the tumor site to a suitable position, and uses the same radiation source in cooperation with the rotatable radiation source bracket 5 to complete CT imaging and biological irradiation operations, which can ensure the three-dimensional precise positioning of the area to be irradiated and the accurate delivery of radiotherapy dose during treatment, avoid radiation damage to normal tissues while ensuring irradiation accuracy, and improve the treatment effect.

[0064] It is worth mentioning that the present utility model is also equipped with a central control system. The pictures collected in various scenarios can be registered after being processed by the software provided in the central control system, and finally a highly accurate fused image is presented. The main structural components involved in the CT imaging, bioluminescence imaging, rotation or position angle of the loading platform 3, position of the detector baffle 9, etc. of the present utility model can be intelligently controlled by the provided software.

[0065] Certainly, for those skilled in the art, the present utility model is not limited to the details of the above exemplary embodiments, but also includes the same or similar structures that can be implemented in other specific forms without departing from the spirit or basic characteristics of the present utility model. Therefore, from any point of view, the embodiments should be regarded as exemplary and non-restrictive. The scope of the present utility model is defined by the appended claims rather than the above description. Therefore, all changes falling within the meaning and scope of the equivalent elements of the claims are intended to be included in the present utility model. Any reference signs in the claims should not be regarded as limiting the claimed rights.

[0066] In addition, it should be understood that although this specification is described according to embodiments, not every embodiment only contains an independent technical solution. This narrative way of the specification is only for clarity. Those skilled in the art should regard the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

[0067] The technologies, shapes, and structures not described in detail in the present utility model are all well-known technologies.

Claims

1. A multimodal image-guided irradiation device, characterized in that: The invention comprises a base (1), an irradiation mechanism is mounted on the base (1), a carrier unit and a detection unit are arranged in sequence along a coaxial horizontal irradiation path of an irradiation end of the irradiation mechanism on the base (1), a bio-optical imaging unit is also arranged on the base (1), an imaging path of the bio-optical imaging unit points to the carrier unit, the imaging path and the detection path of the detection unit intersect each other, and a collimator (7) is detachably mounted on the irradiation end of the irradiation mechanism.

2. The multimodal image-guided irradiation device according to claim 1, characterized in that: The irradiation mechanism comprises a mounting plate (4) fixed on a base (1), a ray source bracket (5) being arranged on the mounting plate (4) to rotate around a horizontal axis (a), and the horizontal axis (a) is perpendicular to the horizontal irradiation path, a ray source (6) is mounted on the ray source bracket (5), and the irradiation end is formed by a beam outlet of the ray source (6).

3. A multimodal image-guided irradiation device according to claim 1 or 2, characterized in that: The detection unit comprises a flat panel detector (8) whose plate surface is perpendicular to the horizontal irradiation path, and a detector baffle (9) capable of shielding the detection plate surface is movably arranged between the detection plate surface of the flat panel detector (8) and the object-carrying unit.

4. The multimodal image-guided irradiation device according to claim 3, characterized in that: The flat panel detector (8) is fixed to the base (1) via a detector fixing plate (83), and a screw slider mechanism is installed on the detector fixing plate (83) for driving the detector baffle (9) to slide back and forth in a vertical direction.

5. A multimodal image-guided irradiation device according to claim 1 or 2, characterized in that: The bio-optical imaging unit comprises a CCD camera (10), and a filter (12) is arranged at the front end of the lens of the CCD camera (10).

6. The multimodal image-guided irradiation device according to claim 5, characterized in that: The CCD camera (10) and the detection unit are arranged side by side, and the bio-optical imaging unit further comprises a reflector (11), and the bio-light is reflected by the reflector (11) and then input into the collection end of the CCD camera (10); the passage path of the bio-light constitutes the imaging path of the bio-optical imaging unit, and a section of the optical path of the bio-light before entering the reflector (11) forms an intersection with the detection path.

7. The multimodal image-guided irradiation device according to claim 5, characterized in that: The optical filters (12) are arranged in a number of at least two, and the at least two optical filters (12) can be movably switched to the front end of the lens of the CCD camera (10) respectively.

8. The multimodal image-guided irradiation device according to claim 5, characterized in that: The biological optical imaging unit also includes an excitation light source, which is used to irradiate the organism on the carrier unit and make the fluorescent molecules in the organism emit fluorescence.

9. A multimodal image-guided irradiation device according to claim 1 or 2, characterized in that: The object carrying unit comprises an object carrying platform (3) and a four-axis module (2) for adjusting the spatial position of the object carrying platform (3).

10. The multimodal image-guided irradiation device according to claim 9, characterized in that: The four-axis module (2) includes a Z-axis rotating assembly (25) installed on a base (1); a slide module fixing plate (24) is fixed on the rotating power end of the Z-axis rotating assembly (25); a Z-axis linear slide module (23) is installed on the slide module fixing plate (24); a Y-axis linear slide module (22) is installed on the sliding end of the Z-axis linear slide module (23); and an X-axis linear slide module (21) is arranged on the sliding end of the Y-axis linear slide module (22).

Images