Coupling reaction device in preparation of sartan biphenyl
By setting up a treatment tank and heating layer in the coupling reaction device to activate the palladium catalyst and providing an inert gas environment, the problem of palladium catalyst failure to achieve the optimal active state is solved, the reaction efficiency and selectivity are improved, and the effective separation and recovery of the catalyst is achieved.
Patent Information
- Application Number
- CN202421993003.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-16
- Publication Date
- 2025-05-30
- Estimated Expiration
- 2034-08-16
AI Technical Summary
When the existing coupling reaction device is added to the palladium catalyst for reaction, the palladium catalyst is prone to fail to reach the optimal active state, which affects the efficiency and selectivity of the coupling reaction.
A coupling reaction device in the preparation of sartan biphenyl is designed, including a treatment tank and a heating layer, for activating the palladium catalyst to achieve an optimal active state before adding to the reaction system. At the same time, through the gas storage tank, gas separation valve, delivery pipe and jet pipe, an inert gas environment is provided to prevent catalyst oxidation, and solid-liquid separation is achieved through the filter tank, filter plate and scraper.
By activating the palladium catalyst and providing an inert gas environment, catalytic efficiency is improved, the yield and selectivity of the reaction is enhanced, and the efficient separation and recovery of the catalyst is achieved.
Smart Images
Figure CN222918649U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of the preparation of sartan biphenyl, and particularly relates to a coupling reaction device in the preparation of sartan biphenyl. Background Technique
[0002] In the synthesis of sartan drugs such as valsartan and losartan, the coupling reaction is one of the key steps, especially in the synthesis route involving the biphenyl structure. The coupling reaction usually uses palladium-catalyzed or other transition metal-catalyzed cross-coupling reactions, such as Suzuki coupling, Stille coupling, Negishi coupling, etc. In the Suzuki coupling reaction, this usually requires the participation of a palladium catalyst.
[0003] In the coupling reaction, the activity of the palladium catalyst is directly affected by its treatment method. Traditional treatment methods may not be able to ensure that the catalyst reaches the optimal activity state before being added to the reaction system, resulting in low reaction efficiency or an increase in by-products. Therefore, this application provides a coupling reaction device in the preparation of sartan biphenyl to meet the requirements. Content of the Utility Model
[0004] The technical problem to be solved by the utility model is to provide a coupling reaction device in the preparation of sartan biphenyl to solve the problem that in the existing coupling reaction device, when adding a palladium catalyst for reaction, the palladium catalyst is likely to fail to reach the optimal activity state, affecting the coupling reaction.
[0005] To solve the above technical problem, the utility model provides the following technical solutions:
[0006] A coupling reaction device in the preparation of sartan biphenyl, comprising: a tank body; a treatment tank, which is connected and arranged at the top of the tank body, and the treatment tank comprises: a housing, which is connected and arranged at the top of the tank body; a heating layer, which is arranged inside the housing; a storage tank, which is connected and arranged above the treatment tank; a gas storage tank, which is arranged on the tank body; a spray pipe, which is arranged inside the storage tank, and the spray pipe is spiral; a conveying pipe, one end of which is connected and arranged at the top of the gas storage tank, and the other end penetrates through the storage tank and is connected to the spray pipe; the tank body is usually made of stainless steel such as stainless steel or special alloy, and sometimes glass lining or enamel material is used. Stainless steel has good corrosion resistance and mechanical strength and can withstand the high temperature and high pressure environment in chemical reactions, while the glass lining or enamel can prevent certain strongly corrosive media from eroding the metal tank body; the heating layer uses electric heating elements such as resistance wires wrapped in insulating materials to make the reaction medium reach the required temperature.
[0007] It further comprises: a gas distribution valve, which is arranged on the conveying pipe; a connecting pipe is arranged on the gas distribution valve, and the connecting pipe is connected to the tank body.
[0008] It further includes: a filter tank, disposed at the bottom of the tank body; a scraping bar, disposed inside the filter tank.
[0009] It further includes: a filter plate, detachably disposed inside the filter tank, and the top of the filter plate is in contact with the scraping bar; the scraping bar is composed of wear-resistant and corrosion-resistant plastics or metals, etc., to help remove solid deposits on the filter plate.
[0010] It further includes: a shunt valve, communicatively disposed at the bottom of the filter tank.
[0011] It further includes: a driving frame, disposed at the top of the tank body; a driving motor, disposed at the top of the driving frame; a rotating rod, rotatably disposed inside the tank body, and the bottom of the rotating rod is U-shaped; the top of the rotating rod penetrates through the driving frame and is connected to the output end of the driving motor.
[0012] It further includes: two auxiliary rods, rotatably disposed inside the tank body; the tops of the two auxiliary rods extend into the driving frame; two pulley groups, respectively disposed on the auxiliary rods and the rotating rod, and connected by a belt.
[0013] Compared with the prior art, the present utility model has at least the following beneficial effects:
[0014] In the above solution, by providing a treatment tank and a heating layer, the palladium catalyst can be activated to ensure its best active state before being added to the reaction system, improve its catalytic efficiency, and thus improve the reaction yield and selectivity.
[0015] By providing a gas storage tank, a gas distribution valve, a delivery pipe, and a spray pipe, an inert gas environment can be provided for the stored palladium catalyst and the tank body, preventing the catalyst from being oxidized when exposed to air, maintaining its activity, and providing an oxygen-free state during the coupling reaction to ensure the coupling reaction.
[0016] By providing a filter tank, a filter plate, and a scraping bar, solid by-products, unreacted raw materials, or catalyst particles generated during the reaction can be separated from the liquid. The reaction liquid and other substances can be discharged separately through the shunt valve, facilitating subsequent unified treatment. Description of the Drawings
[0017] Figure 1 It is a schematic diagram of the coupling reaction device in the preparation of sartan biphenyl.
[0018] Figure 2 It is a schematic diagram of the structure of the gas storage tank.
[0019] Figure 3 It is a cross-sectional view of the structure of the storage tank.
[0020] Figure 4 It is a cross-sectional view of the structure of the tank body.
[0021] Figure 5 It is a sectional view of the drive frame structure.
[0022] Figure 6 It is a top view of the filter plate structure.
[0023] Figure 7 It is a sectional view of a partial structure of the heating layer.
[0024] [Reference Signs]
[0025] 1. Tank body; 2. Storage tank; 3. Drive frame; 4. Filter tank; 5. Filter plate; 6. Diverting valve; 7. Gas storage tank; 8. Gas distributing valve; 9. Delivery pipe; 10. Processing tank; 11. Jet pipe; 12. Auxiliary rod; 13. Rotating rod; 14. Pulley set; 15. Drive motor; 16. Scraping strip; 101. Outer shell; 102. Heating layer.
[0026] As shown in the figure, in order to clearly show the structure of the embodiments of the present invention, specific structures and devices are marked in the figure, but this is only for schematic purposes and is not intended to limit the present invention to this specific structure, device and environment. According to specific needs, those of ordinary skill in the art can adjust or modify these devices and environments, and the adjustments or modifications still fall within the scope of the appended claims. Detailed Embodiments
[0027] The following describes in detail a polymer material injection molding device provided by the present invention with reference to the accompanying drawings and specific embodiments. At the same time, it should be noted here that in order to make the embodiments more detailed, the following embodiments are the best and preferred embodiments. For some well-known technologies, those skilled in the art can also adopt other alternative methods for implementation; moreover, the accompanying drawings are only for more specifically describing the embodiments and are not intended to specifically limit the present invention.
[0028] As Figure 1 - Figure 7 shown, an embodiment of the present invention provides a coupling reaction device in the preparation of sartan biphenyl, including: a tank body 1; a processing tank 10, communicatively arranged at the top of the tank body 1, and the processing tank 10 includes: an outer shell 101, communicatively arranged at the top of the tank body 1; a heating layer 102, arranged inside the outer shell 101; a storage tank 2, communicatively arranged above the processing tank 10; a gas storage tank 7, arranged on the tank body 1; a jet pipe 11, arranged inside the storage tank 2, and the jet pipe 11 is spiral; a delivery pipe 9, one end of which is communicatively arranged at the top of the gas storage tank 7, and the other end penetrates through the storage tank 2 and is communicatively connected to the jet pipe 11.
[0029] By setting up the storage tank 2, palladium catalysts or other catalysts can be stored. At the same time, a first control valve and a sensor are provided on the storage tank 2. The first control valve is used to control the delivery of the palladium catalyst in the storage tank 2 into the treatment tank 10. The sensor is mainly used to monitor various parameters in the storage tank 2 in real time, such as temperature, pressure, gas concentration, etc., to ensure that the conditions for catalyst pretreatment are precisely controlled. By setting up the treatment tank 10, it is mainly used for pretreating palladium catalysts, especially palladium catalysts, to ensure that they reach the optimal active state before being added to the reaction system. Then, the palladium catalyst is heated by the heating layer 102, which can remove impurities or oxide layers on the surface of the palladium catalyst and improve its catalytic efficiency. A second control valve is provided on the treatment tank 10, and the second control valve is used to control the delivery of the treated palladium catalyst in the treatment tank 10 into the tank body 1.
[0030] It further includes: a gas distribution valve 8, which is arranged on the delivery pipe 9; a connecting pipe is provided on the gas distribution valve 8, and the connecting pipe is connected to the tank body 1. By setting up the tank body 1, a coupling reaction is carried out. An inlet valve and a discharge pipe are provided on the tank body 1, and an electromagnetic valve is provided on the discharge pipe. By setting up the gas distribution valve 8, it is used to control the delivery amount and flow direction of the inert gas in the gas storage tank 7 to the tank body 1 and the storage tank 2, and can adjust the flow rate and pressure of the gas according to needs to ensure the stability of the gas environment in the reaction system.
[0031] It further includes: a filter tank 4, which is arranged at the bottom of the tank body 1; a scraping bar 16, which is arranged in the filter tank 4. By setting up the filter tank 4, it is mainly used to filter and separate the products after the reaction is completed, remove solid catalyst particles, unreacted raw materials and other impurities, and achieve the effective separation of the products and the catalyst, which is convenient for the recycling and reuse of the catalyst.
[0032] It further includes: a filter plate 5, which is detachably arranged in the filter tank 4, and the top of the filter plate 5 is in contact with the scraping bar 16. By setting up the filter plate 5, it is used to separate solid particles from the reaction mixture and liquid or gas to ensure that the purified product meets the required purity standards. The filter plate 5 can be installed on the filter tank 4 by means of bolts, buckles or magnetic attraction, etc. By setting up the scraping bar 16, it is mainly used to remove the solid residues or condensates that may accumulate on the surface of the filter plate 5 to prevent these substances from blocking the filter channels or affecting the filtration efficiency.
[0033] It further includes: a shunt valve 6, which is connected and arranged at the bottom of the filter tank 4. By setting up the shunt valve 6, it controls the separate discharge of the reaction liquid and residues, which is convenient for subsequent unified treatment.
[0034] It further includes: a driving frame 3, which is arranged at the top of the tank body 1; a driving motor 15, which is arranged at the top of the driving frame 3; a rotating rod 13, which is rotatably arranged in the tank body 1, and the bottom of the rotating rod 13 is U-shaped; the top of the rotating rod 13 penetrates through the driving frame 3 and is connected to the output end of the driving motor 15.
[0035] By setting the rotating rod 13 to be U-shaped, it is mainly to enhance the stirring effect, especially in the bottom area of the tank body 1, to promote the turning and rising of the bottom materials, avoid material deposition or caking, and ensure the uniform mixing of reactants in various parts of the tank body 1.
[0036] It also includes: two auxiliary rods 12 rotatably arranged in the tank body 1; the tops of the two auxiliary rods 12 extend into the driving frame 3; two pulley groups 14 are respectively arranged on the auxiliary rods 12 and the rotating rod 13 and are connected by belts.
[0037] By setting the auxiliary rods 12, a rotating piece is arranged at the bottom of the auxiliary rod 12. Driven by the rotation of the auxiliary rod 12, the rotating piece stirs the upper part in the tank body 1, creating an additional fluid circulation in the upper part of the tank body 1. The rotating piece can help improve the mass transfer efficiency of the materials; the pulley group 14 includes pulleys sleeved on the rotating rod 13 and the auxiliary rods 12 respectively, and the pulleys are connected by belts to distribute the power generated by the driving motor 15 to the auxiliary rods 12.
[0038] The technical solution provided by the present utility model uses an external controller to open the gas distribution valve 8, and inert gas is transported from the gas storage tank 7 to the tank body 1 and the storage tank 2 respectively through the spray pipe 11 and the connecting pipe to exclude air. Reactants are added to the tank body 1 through the feed valve. At the same time, the first control valve is opened to drop the palladium catalyst in the storage tank 2 into the treatment tank 10. The external controller is used to open the heating layer 102 to heat-treat the palladium catalyst so that the palladium catalyst reaches the optimal active state. The second control valve is opened to operate, and the palladium catalyst is put into the tank body 1. The external controller is used to open the driving motor 15 to operate, driving the rotating rod 13 to rotate, and driving the two auxiliary rods 12 to rotate through the pulley group 14 to carry out the coupling reaction. After the reaction is completed, it enters the filter tank 4 through the discharge pipe and is filtered by the filter plate 5. The filtered reaction liquid is discharged through the flow dividing valve 6; when the filter plate 5 needs to be cleaned, the filter plate 5 is pulled outwards. During the pulling-out process, the residual palladium catalyst on the surface of the filter plate 5 is cleaned by the scraping strip 16 and discharged outwards through the flow dividing valve 6.
[0039] The present utility model covers any substitutions, modifications, equivalent methods and solutions made on the essence and scope of the present utility model. In order to enable the public to have a thorough understanding of the present utility model, specific details are described in detail in the above preferred embodiments of the present utility model. However, those skilled in the art can fully understand the present utility model without these detailed descriptions. In addition, in order to avoid unnecessary confusion to the essence of the present utility model, well-known methods, processes, procedures, elements and circuits are not described in detail.
[0040] The above are only the preferred embodiments of the present utility model. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present utility model, several improvements and modifications can be made, and these improvements and modifications should also be regarded as the protection scope of the present utility model.
Claims
1. A coupling reaction device for preparing sartan biphenyl, characterized in that: include: Tank (1); A processing tank (10) is arranged in communication with the top of the tank body (1), and the processing tank (10) comprises: An outer shell (101) is arranged in communication with the top of the tank body (1); A heating layer (102) is arranged inside the outer shell (101); A storage tank (2) arranged above the processing tank (10) in communication with the processing tank; A gas storage tank (7) arranged on the tank body (1); An air jet pipe (11) is arranged in the storage tank (2), and the air jet pipe (11) is spiral-shaped; A delivery pipe (9) has one end connected to the top of the gas storage tank (7) and the other end passing through the storage tank (2) and connected to the injection pipe (11).
2. The coupling reaction device for preparing sartan biphenyl according to claim 1, characterized in that: Also includes: An air separation valve (8) is arranged on the delivery pipe (9); The gas separation valve (8) is provided with a connecting pipe, and the connecting pipe is connected to the tank body (1).
3. The coupling reaction device for preparing sartan biphenyl according to claim 1, characterized in that: Also includes: A filter tank (4) arranged at the bottom of the tank body (1); A scraper strip (16) is arranged in the filter tank (4).
4. The coupling reaction device for preparing sartan biphenyl according to claim 3, characterized in that: Also includes: A filter plate (5) is detachably arranged in the filter tank (4), and the top of the filter plate (5) is in contact with the scraper strip (16).
5. The coupling reaction device for preparing sartan biphenyl according to claim 3, characterized in that: Also includes: A diverter valve (6) is arranged in communication with the bottom of the filter tank (4).
6. The coupling reaction device for preparing sartan biphenyl according to claim 1, characterized in that: Also includes: A driving frame (3) arranged on the top of the tank body (1); A driving motor (15) arranged on the top of the driving frame (3); A rotating rod (13) is rotatably disposed in the tank body (1), and the bottom of the rotating rod (13) is U-shaped; The top of the rotating rod (13) passes through the driving frame (3) and is connected to the output end of the driving motor (15).
7. The coupling reaction device for preparing sartan biphenyl according to claim 6, characterized in that: Also includes: Two auxiliary rods (12) rotatably disposed in the tank body (1); The tops of the two auxiliary rods (12) extend into the driving frame (3); Two pulley sets (14) are respectively arranged on the auxiliary rod (12) and the rotating rod (13), and are connected by a belt.