Continuous reaction equipment for preparing sartan biphenyl

Abstract

The utility model provides continuous reaction equipment for preparing sartan biphenyl and belongs to the technical field of reaction equipment. Comprising a support frame; the Grignard reaction cabin is stably mounted on the supporting frame and is used for carrying out a preparation reaction of a Grignard reagent; the coupling reaction cabin is stably mounted on the support frame and is used for carrying out coupling reaction to generate the sartan biphenyl; and the cooling part is stably mounted on the supporting frame. Through cooperation of the Grignard reaction cabin, the coupling reaction cabin and the cooling part, the temperature requirement of the coupling reaction is met under the condition of not additionally arranging heating equipment, the energy consumption and the cost are reduced, and meanwhile through structural cooperation of a pressure relief opening formed in one side of the gas storage cabin, an internal sealing plug, a spring and a plurality of gas inlet channels, the pressure relief opening is formed in the other side of the gas storage cabin. And the pressure can be automatically relieved when the air pressure in the air storage bin is too high.

Description

Technical Field

[0001] The utility model relates to the technical field of reaction equipment, in particular to a continuous reaction equipment for preparing sartan biphenyl. Background Technique

[0002] Sartan biphenyl is an important class of organic compounds and has wide applications in the pharmaceutical field, especially as a key intermediate for sartan anti-hypertensive drugs; with the continuous development of the pharmaceutical industry, the demand for sartan biphenyl is increasing day by day, and its efficient and high-quality preparation process has become a research hotspot.

[0003] At present, in the preparation of sartan biphenyl, a large amount of hot gas is generated during the Grignard reaction; in the prior art, these hot gases are either directly discharged, resulting in energy waste and environmental heat pollution; or there is a lack of effective recovery and utilization means, resulting in the need to additionally install heating equipment during the subsequent palladium-catalyzed coupling reaction to increase its reaction rate, thereby increasing energy consumption and costs. Content of the Utility Model

[0004] The technical problem to be solved by the utility model is to provide a continuous reaction equipment for preparing sartan biphenyl, so as to solve the energy waste caused by improper treatment of the hot gas during the Grignard reaction in the prior art. At the same time, due to the large temperature change during the Grignard reaction, the air pressure inside the gas storage chamber will be affected, which in turn affects the work and use of the cooling part.

[0005] Technical solution: To achieve the above objectives, the present utility model is realized through the following technical solutions: A continuous reaction device for preparing sartan biphenyl, comprising: a support frame; a Grignard reaction chamber stably installed on the support frame for carrying out the preparation reaction of Grignard reagent; a coupling reaction chamber stably installed on the support frame for carrying out the coupling reaction to generate sartan biphenyl; a cooling part stably installed on the support frame, the cooling part is connected between the Grignard reaction chamber and the coupling reaction chamber, and the cooling part is used to adjust the temperature of the hot gas generated during the operation of the Grignard reaction chamber; a gas guide groove is opened in the coupling reaction chamber, and the gas guide groove is spiral, the inlet end of the gas guide groove is stably connected to the cooling part, and the outlet end is used to externally connect a gas purification device, and the gas guide groove is used to transfer the gas after cooling treatment to provide a suitable temperature environment for the coupling reaction chamber, wherein the Grignard reaction chamber is equipped with an advanced stirring system and a precise temperature control system, and the chamber body adopts a double-layer jacket structure for heat preservation; the addition of materials during the reaction process is precisely controlled by a high-precision metering pump, its stirring speed can be steplessly adjusted within the range of 50 - 500 revolutions per minute, the temperature control accuracy is ±0.5 °C, and the metering error of the metering pump does not exceed ±1%; a special catalyst fixing device and an efficient mixing structure are provided inside the coupling reaction chamber to improve the reaction efficiency and product selectivity; at the same time, the chamber wall has good heat conduction performance; the fixing efficiency of the catalyst is not less than 95%, the deviation of the mixing uniformity does not exceed 5%, and the thermal conductivity of the chamber wall is not less than 20 W / (m·K).

[0006] In a further embodiment, a gas storage chamber is opened in the cooling part, and the gas storage chamber is used to store the hot gas generated during the operation of the Grignard reaction chamber; a cooling chamber is opened in the cooling part, and the cooling chamber is used to cool the hot gas; a heat preservation chamber is opened in the cooling part, and the heat preservation chamber is used to store the hot gas after temperature adjustment, wherein the gas storage chamber has a large volume to adapt to the production requirements of different scales; the chamber body adopts a pressure-resistant design and is equipped with a pressure monitoring device.

[0007] In a further embodiment, a condenser tube is stably installed in the cooling chamber, and the condenser tube is used to define the flow path of the condensate; a gas guide tube is wound around the condenser tube, and the gas guide tube is stably installed in the cooling chamber, the inlet of the gas guide tube is communicated with the gas storage chamber, and the outlet of the gas guide tube is communicated with the heat preservation chamber, wherein the condenser tube can adopt a copper tube fin structure to increase the heat exchange area; the gas guide tube adopts a high-temperature resistant stainless steel corrugated tube, which has good flexibility and sealing performance.

[0008] In a further embodiment, a pressure relief port is provided on one side of the gas storage chamber. The pressure relief port is used for relieving pressure in the gas storage chamber. A sealing plug is slidably connected inside the pressure relief port. The sealing plug is used to seal the pressure relief port. A spring is installed inside the pressure relief port. One end of the spring is stably connected to the sealing plug, and the other end is stably connected to a bracket inside the pressure relief port. There are multiple intake channels, and the multiple intake channels are opened inside the pressure relief port. The intake channels are used for gas to enter the pressure relief port. Among them, the design of the pressure relief port has undergone strict hydrodynamics calculations to ensure rapid and safe pressure relief when the pressure is too high. The materials of the sealing plug and the spring are carefully selected to ensure long-term reliable operation. The material of the sealing plug can be high-temperature resistant polytetrafluoroethylene, and the service life of the spring is not less than 10,000 working cycles.

[0009] In a further embodiment, an external interface is provided on the gas storage chamber. One end of the external interface is stably connected to the gas storage chamber, and a valve is stably installed at the other end. The external interface is used for connecting an external pipeline. Among them, the external interface adopts a standard quick-connect fitting, which is convenient for quick connection and disassembly with the external pipeline. The valve adopts an electric control valve, which can realize remote control and precise flow regulation.

[0010] In a further embodiment, the intake channel is arranged in a U shape, and the inlet of the intake channel is close to the sealing plug, and the outlet is close to the bracket. A filter screen is arranged at the inlet, and the mesh diameter is not more than 1 mm.

[0011] In a further embodiment, the outlet of the pressure relief port is externally connected to a gas purification device to avoid air pollution. Among them, the pressure relief rate of the pressure relief port needs to be adapted to the intake rate of the intake pipeline, so as to ensure rapid and stable pressure relief.

[0012] In a further embodiment, a temperature detector is stably installed on the gas storage chamber for detecting the gas temperature inside the gas storage chamber. Among them, the temperature detector on the gas storage chamber can adopt an intelligent digital sensor, which has the characteristics of high precision and fast response. The detection data is transmitted to the control system in real time to realize automatic monitoring.

[0013] Beneficial effects: 1. Through the structural cooperation of stably installing the Grignard reaction chamber, the coupling reaction chamber and the cooling part on the support frame, an integrated continuous reaction system is formed. The hot gas generated in the Grignard reaction chamber can directly enter the cooling part for temperature adjustment, and then be transmitted to the coupling reaction chamber through the air guide groove, providing a suitable temperature environment for the coupling reaction. This structural design achieves the purpose of making full use of the hot gas generated by the Grignard reaction and reducing energy waste. It realizes meeting the temperature requirements of the coupling reaction without additionally installing heating equipment, reduces energy consumption and costs, and improves the energy utilization efficiency of the entire preparation process at the same time.

[0014] 2. The structural cooperation of the pressure relief port provided on one side of the gas storage chamber, the internal sealing plug, the spring, and multiple intake channels can automatically relieve pressure when the air pressure in the gas storage chamber is too high; when the pressure exceeds the set value, the sealing plug slides under the action of gas pressure, overcoming the spring resistance, opening the pressure relief port, and the gas is discharged through the intake channels, thus ensuring the stable pressure in the gas storage chamber; achieving the purpose of ensuring the safe operation of the equipment and preventing danger caused by excessive pressure; realizing the effect of automatically adjusting the pressure and protecting the safety of the equipment and personnel when the gas pressure fluctuates due to the change of temperature in the Grignard reaction. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] In order to more clearly illustrate the technical solutions in the embodiments of the present utility model or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only some embodiments of the present utility model. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0016] Figure 1 It is a schematic structural diagram of the present utility model.

[0017] Figure 2 It is Figure 1 the main sectional structural diagram of

[0018] Figure 3 It is Figure 1 the side sectional structural diagram of

[0019] Figure 4 It is Figure 1 the top sectional structural diagram of

[0020] Figure 5 It is the structural diagram of the cooling part.

[0021] Figure 6 It is Figure 2 the structural diagram of the A position of

[0022] Figure 7 It is Figure 4 the structural diagram of the B position of

[0023] The reference numerals in the drawings are: 1, support frame; 2, Grignard reaction chamber; 3, coupling reaction chamber; 301, air guide groove; 4, cooling part; 401, gas storage chamber; 4011, pressure relief port; 4012, intake channel; 402, cooling chamber; 403, heat preservation chamber; 5, external interface; 6, condensing pipe; 7, air duct; 8, sealing plug; 9, spring. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0024] To make the objectives, technical solutions, and advantages of the present utility model embodiment clearer, the technical solutions in the present utility model embodiment will be clearly and completely described. Apparently, the described embodiments are part of the embodiments of the present utility model, rather than all of them. All other embodiments obtained by those of ordinary skill in the art based on the embodiments in the present utility model without creative efforts belong to the scope of protection of the present utility model.

[0025] By providing a continuous reaction device for preparing sartan biphenyl in an embodiment of the present application, the technical problem in the prior art of energy waste caused by improper treatment of the hot gas in the Grignard reaction during the preparation of sartan biphenyl is solved; at the same time, due to the large temperature change in the Grignard reaction, the air pressure inside the gas storage chamber will be affected, which in turn affects the operation and use of the cooling part. In actual use, efficient energy utilization and stable operation of the cooling part are achieved.

[0026] To better understand the above technical solutions, the above technical solutions will be described in detail below in conjunction with the accompanying drawings of the specification and specific embodiments.

[0027] Refer to Figures 1-7 , a continuous reaction device for preparing sartan biphenyl, comprising: a support frame 1; a Grignard reaction chamber 2 stably installed on the support frame 1 for carrying out the preparation reaction of Grignard reagent; a coupling reaction chamber 3 stably installed on the support frame 1 for carrying out a coupling reaction to generate sartan biphenyl; a cooling part 4 stably installed on the support frame 1, the cooling part 4 is connected between the Grignard reaction chamber 2 and the coupling reaction chamber 3, and the cooling part 4 is used to adjust the temperature of the hot gas generated during the operation of the Grignard reaction chamber; a gas guide groove 301 opened in the coupling reaction chamber 3, and the gas guide groove 301 is spiral, the inlet end of the gas guide groove 301 is stably connected to the cooling part 4, and the outlet end is used to externally connect a gas purification device, and the gas guide groove 301 is used to transfer the gas after temperature reduction treatment to provide a suitable temperature environment for the coupling reaction chamber 3.

[0028] Through the cooperation of the support frame 1, the Grignard reaction chamber 2, the coupling reaction chamber 3, and the cooling part 4, the cooling part 4 is used to adjust the temperature of the hot gas generated by the Grignard reaction chamber 2 to provide a suitable temperature environment for the coupling reaction chamber 3.

[0029] A gas storage chamber 401 opened in the cooling part 4, and the gas storage chamber 401 is used to store the hot gas generated during the operation of the Grignard reaction chamber; a cooling chamber 402 opened in the cooling part 4, and the cooling chamber 402 is used for cooling the hot gas; a heat preservation chamber 403 opened in the cooling part 4, and the heat preservation chamber 403 is used to store the hot gas after temperature adjustment.

[0030] By setting up the cooperation of the gas storage bin 401, the cooling bin 402 and the heat preservation bin 403 in the cooling part 4, the hot gas generated by the Grignard reaction chamber 2 is stored, cooled, and the cooled hot gas is stored again, so as to meet the temperature requirements of subsequent reactions.

[0031] The condensing pipe 6 is stably installed in the cooling bin 402, and the condensing pipe 6 is used to define the flowing path of the condensate; the gas guiding pipe 7 is wound around the condensing pipe 6, and the gas guiding pipe 7 is stably installed in the cooling bin 402. The air inlet of the gas guiding pipe 7 is communicated with the gas storage bin 401, and the air outlet of the gas guiding pipe 7 is communicated with the heat preservation bin 403.

[0032] Through the cooperation of the condensing pipe 6 and the gas guiding pipe 7 wound around it, the hot gas entering the cooling bin 402 is efficiently cooled, and the cooled gas is transported to the heat preservation bin 403.

[0033] The pressure relief port 4011 is on one side of the gas storage bin 401. The pressure relief port 4011 is used for the gas storage bin 401 to relieve pressure; the sealing plug 8 is slidably connected in the pressure relief port 4011, and the sealing plug 8 is used to seal the pressure relief port 4011; the spring 9 is installed in the pressure relief port 4011, and one end of the spring 9 is stably connected to the sealing plug 8, and the other end is stably connected to the bracket in the pressure relief port 4011; there are multiple air inlet channels 4012, and the multiple air inlet channels 4012 are opened in the pressure relief port 4011. The air inlet channel 4012 is used for gas to enter the pressure relief port 4011.

[0034] Through the cooperation of the pressure relief port 4011, the sealing plug 8, the spring 9 and the air inlet channel 4012, the gas storage bin 401 automatically relieves pressure when the pressure is too high, ensuring the safe operation of the gas storage bin 401.

[0035] The external interface 5 is on the gas storage bin 401. One end of the external interface 5 is stably connected to the gas storage bin 401, and a valve is stably installed at the other end. The external interface 5 is used for connecting to an external pipeline.

[0036] Through the cooperation of the external interface 5 and the valve, the gas storage bin 401 can be conveniently connected to an external pipeline, and the on / off and flow rate of the external pipeline are controlled by the valve.

[0037] The air inlet channel 4012 is set in a U shape, and the inlet of the air inlet channel 4012 is close to the sealing plug 8, and the outlet is close to the bracket.

[0038] By setting the air inlet channel 4012 in a U-shaped structure, the gas in the gas storage bin 401 can enter the pressure relief port 4011 through the air inlet channel 4012. At the same time, buffering and stability during air intake are achieved, as well as a reasonable guiding of gas flow.

[0039] The air outlet of the pressure relief port 4011 is externally connected to a gas purification device to avoid air pollution.

[0040] Through the setting of externally connecting a gas purification device to the pressure relief port 4011, the effect of avoiding air pollution caused by the gas discharged when the gas storage bin 401 is depressurized is achieved.

[0041] A temperature detector is stably installed on the gas storage bin 401 for detecting the gas temperature inside the gas storage bin 401.

[0042] By installing a temperature detector on the gas storage bin 401, the gas temperature inside the gas storage bin 401 can be detected in real time so as to timely master and adjust the temperature condition.

[0043] During the use process, when using this continuous reaction device for preparing sartan biphenyl, first put the raw materials into the Grignard reaction chamber 2 stably installed on the support frame 1 to carry out the preparation reaction of Grignard reagent. The hot gas generated by the reaction enters the cooling part 4 connected between the Grignard reaction chamber 2 and the coupling reaction chamber 3. Inside the cooling part 4, the hot gas is first stored in the gas storage bin 401, and then enters the cooling bin 402, and is efficiently cooled through the cooperation of the condensation pipe 6 and the air guide pipe 7 wound around it. The cooled gas is transported to the heat preservation bin 403 for storage. When the air pressure in the gas storage bin 401 is too high, the gas is depressurized through the pressure relief port 4011 on one side of the gas storage bin 401. When depressurizing, the sealing plug 8 slides under the action of the gas pressure to overcome the resistance of the spring 9 and opens the pressure relief port 4011, and the gas is discharged through a plurality of air inlet channels 4012 to ensure the stable pressure of the gas storage bin 401. At the same time, the air inlet channel 4012 is set in a U shape to achieve air inlet buffering and stable gas flow guiding. The gas processed by the cooling part 4 is transmitted to the coupling reaction chamber 3 through the air guide groove 301 to provide a suitable temperature environment for the coupling reaction. In addition, one end of the external interface 5 is stably connected to the gas storage bin 401, and the valve installed at the other end can control the on-off and flow rate of the external pipeline, and provides a connection position for the subsequent possibly added external pipeline. Moreover, the air outlet of the pressure relief port 4011 is externally connected to a gas purification device to avoid air pollution caused by the gas discharged when the gas storage bin 401 is depressurized. The temperature detector stably installed on the gas storage bin 401 can detect the gas temperature inside the gas storage bin 401 in real time, which is convenient for timely mastering and adjusting the temperature condition.

[0044] Among them, the required feeding equipment, stirring equipment, gas treatment equipment, material conveying equipment between the Grignard reaction chamber and the coupling reaction chamber, etc. all belong to the prior art and are non-essential technical features in this application, so they are not described and drawn in the documents and drawings of this application. The various data mentioned in the above specification are all example data, which have reference value, but are not absolute standards and fixed and unchangeable. The actual data need to be selected according to the actual production requirements and working environment.

[0045] In summary, compared with the prior art, the following beneficial effects are achieved: an integrated continuous reaction system is formed, making full use of the hot gas generated by the Grignard reaction, reducing energy waste, meeting the temperature requirements of the coupling reaction without the need to additionally install heating equipment, reducing energy consumption and costs, and significantly improving the energy utilization efficiency of the entire preparation process; at the same time, through the coordinated cooperation of the gas storage bin, cooling bin, heat preservation bin, etc., the hot gas is effectively stored, cooled and temperature-controlled, meeting the temperature requirements of subsequent reactions and ensuring the stability of reaction conditions; and through the structures such as the pressure relief port, sealing plug, spring and air inlet channel provided, the pressure can be automatically relieved when the air pressure in the gas storage bin is too high, ensuring the safe operation of the equipment, effectively preventing the danger caused by excessive pressure, realizing automatic pressure regulation when the air pressure fluctuates due to the temperature change of the Grignard reaction, and protecting the safety of the equipment and personnel; and because the air inlet channel is designed in a U shape, air inlet buffering and stable gas flow guiding are achieved.

[0046] The present utility model covers any substitutions, modifications, equivalent methods and solutions made on the essence and scope of the present utility model. In order to enable the public to have a thorough understanding of the present utility model, specific details are described in detail in the above preferred embodiments of the present utility model, and those skilled in the art can fully understand the present utility model without the description of these details. In addition, in order to avoid unnecessary confusion to the essence of the present utility model, well-known methods, processes, procedures, components and circuits, etc. are not described in detail.

[0047] The above description is only a preferred embodiment of the present utility model. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present utility model, several improvements and refinements can be made, and these improvements and refinements should also be regarded as the protection scope of the present utility model.

Claims

1. A continuous reaction device for preparing sartan biphenyl, characterized in that: include: Support frame (1); A Grignard reaction chamber (2) is stably mounted on the support frame (1) and is used for performing a preparation reaction of a Grignard reagent; A coupling reaction chamber (3) is stably mounted on the support frame (1) and is used for performing a coupling reaction to generate sartan biphenyl; A cooling part (4) is stably mounted on the support frame (1), the cooling part (4) is connected between the Grignard reaction chamber (2) and the coupling reaction chamber (3), and the cooling part (4) is used to adjust the temperature of hot air generated when the Grignard reaction chamber is working; The gas guide groove (301) is provided in the coupling reaction chamber (3), and the gas guide groove (301) is spiral-shaped. The gas inlet end of the gas guide groove (301) is stably connected to the cooling portion (4), and the gas outlet end is used for connecting to an external gas purification device. The gas guide groove (301) is used to transfer gas that has been subjected to a cooling treatment, so as to provide a suitable temperature environment for the coupling reaction chamber (3).

2. The continuous reaction equipment for preparing sartan biphenyl according to claim 1, characterized in that: The cooling unit (4) comprises: A gas storage bin (401) is provided in the cooling portion (4), and the gas storage bin (401) is used to store hot gas generated when the format reaction chamber is working; A cooling chamber (402) is provided in the cooling portion (4), and the cooling chamber (402) is used for cooling hot air; The heat preservation chamber (403) is disposed in the cooling portion (4), and the heat preservation chamber (403) is used to store the temperature-adjusted hot air.

3. The continuous reaction equipment for preparing sartan biphenyl according to claim 2, characterized in that: Also includes: A condenser tube (6) is stably installed in the cooling chamber (402), and the condenser tube (6) is used to limit the flow path of the condensate; The air guide pipe (7) is wound around the condensing pipe (6), and the air guide pipe (7) is stably installed in the cooling chamber (402), the air inlet of the air guide pipe (7) is connected to the air storage chamber (401), and the air outlet of the air guide pipe (7) is connected to the heat preservation chamber (403).

4. The continuous reaction equipment for preparing sartan biphenyl according to claim 2, characterized in that: Also includes: A pressure relief port (4011) is located at one side of the gas storage bin (401), and the pressure relief port (4011) is used to relieve pressure in the gas storage bin (401); A sealing plug (8) is slidably connected to the pressure relief port (4011), and the sealing plug (8) is used to seal the pressure relief port (4011); A spring (9) is installed in the pressure relief port (4011), and one end of the spring (9) is stably connected to the sealing plug (8), and the other end of the spring (9) is stably connected to the bracket in the pressure relief port (4011); A plurality of air inlet channels (4012) are provided, and the plurality of air inlet channels (4012) are opened in the pressure relief port (4011), and the air inlet channels (4012) are used for gas to enter the pressure relief port (4011).

5. The continuous reaction equipment for preparing sartan biphenyl according to claim 2, characterized in that: Also includes: The external interface (5) is located on the gas storage bin (401), one end of the external interface (5) is stably connected to the gas storage bin (401), and the other end is stably installed with a valve, and the external interface (5) is used to connect an external pipeline.

6. The continuous reaction equipment for preparing sartan biphenyl according to claim 4, characterized in that: The air inlet channel (4012) is arranged in a U shape, with an inlet of the air inlet channel (4012) close to the sealing plug (8) and an outlet close to the bracket.

7. The continuous reaction equipment for preparing sartan biphenyl according to claim 4, characterized in that: The gas outlet of the pressure relief port (4011) is externally connected to a gas purification device to avoid air pollution.

8. The continuous reaction equipment for preparing sartan biphenyl according to claim 2, characterized in that: A temperature detector is stably mounted on the gas storage bin (401) for detecting the temperature of the gas in the gas storage bin (401).

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