Rapid dissolving device for pharmaceutical analysis

Abstract

The utility model relates to the technical field of drug analysis, and discloses a rapid dissolving device for drug analysis, which comprises a dissolving tank, a first mounting seat fixedly connected to the dissolving tank, a sealing cover fixedly connected to the first mounting seat, a lifting cylinder slidably connected in the sealing cover, and a piston fixedly connected to the bottom of the lifting cylinder and slidably connected in the dissolving tank. A water inlet penetrating through the piston is formed in the lifting cylinder, a first one-way sealing assembly is connected into the water inlet, a backflow opening is formed in the piston, a second one-way sealing assembly is connected into the backflow opening, a blocking net is fixedly connected into the lifting cylinder, and multiple sets of discharging holes located in the inner wall of the lifting cylinder are formed in the side, away from the water inlet, of the blocking net. According to the device, one-way pump pushing of a solvent is achieved through the arrangement of the piston and the one-way valve, medicine is arranged in the flowing channel of the solvent, then the medicine is flushed through the flowing solvent, and the solvent speed of the solvent to the medicine is increased.

Description

Technical Field

[0001] The utility model relates to the technical field of pharmaceutical analysis, in particular to a rapid dissolution device for pharmaceutical analysis. Background Technique

[0002] Pharmaceutical analysis requires the use of chemical, physical, biological, and microbiological methods and techniques to study chemical inspection of drugs, drug stability, bioavailability, clinical monitoring of drugs, and qualitative determination of active ingredients in Chinese herbal medicines. In pharmaceutical analysis experiments, whether it is the detection of finished drugs or raw materials, the dissolution of drugs is an essential process.

[0003] However, the existing drug dissolution devices have imperfect structures. After solid drugs are added to the device, they quickly sink to the bottom. During the stirring process of the existing devices, the crushing effect on the drugs at the bottom is small, resulting in a slow dissolution rate of the drugs at the bottom in the liquid, consuming more time in the drug dissolution process in the device and affecting the efficiency of the analysis experiment. Content of the Utility Model

[0004] The purpose of the utility model is to provide a rapid dissolution device for pharmaceutical analysis to solve the problems raised in the above background technique.

[0005] To achieve the above purpose, the utility model provides the following technical solutions:

[0006] A rapid dissolution device for pharmaceutical analysis includes a dissolution tank. A first mounting seat is fixedly connected to the dissolution tank, and a sealing cover is fixedly connected to the first mounting seat. A lifting cylinder is slidably connected inside the sealing cover. A piston slidably connected inside the dissolution tank is fixedly connected to the bottom of the lifting cylinder. A water inlet penetrating the piston is arranged inside the lifting cylinder, and a first one-way sealing assembly is connected inside the water inlet. A return port is arranged inside the piston, and a second one-way sealing assembly is connected inside the return port. A retaining net is fixedly connected inside the lifting cylinder, and a plurality of discharge holes located on the inner wall of the lifting cylinder are arranged on the side of the retaining net away from the water inlet. A clamping assembly is connected inside the lifting cylinder.

[0007] As a further scheme of the utility model: A stop block is fixedly connected to the outer wall of the lifting cylinder, and a handle is fixedly connected to the top of the lifting cylinder.

[0008] As a further scheme of the utility model: The first one-way sealing assembly includes a first control valve fixedly connected inside the water inlet. A first sealing ball is arranged inside the first control valve. A first fixing frame fixedly connected inside the first control valve is arranged on the side of the first sealing ball away from the bottom of the dissolution tank, and a first spring is arranged between the first fixing frame and the first sealing ball.

[0009] As a further solution of the present utility model: The second one-way sealing assembly includes a second control valve fixedly connected inside the reflux port. A second sealing ball is arranged inside the second control valve. A second fixing frame fixedly connected inside the second control valve is arranged on one side of the second sealing ball close to the bottom of the dissolution tank. A second spring is arranged between the second fixing frame and the second sealing ball.

[0010] As a further solution of the present utility model: The clamping assembly includes a second mounting seat fixedly connected to the top of the lifting cylinder. A mounting cover is threadedly connected inside the second mounting seat. The bottom of the mounting cover is fixedly connected with a fixed cylinder. One end of a telescopic rod is slidably connected inside the fixed cylinder. The other end of the telescopic rod passes through the fixed cylinder and is fixedly connected with a pressing block. A third spring is installed inside the fixed cylinder.

[0011] As a further solution of the present utility model: A knob is fixedly connected to the mounting cover.

[0012] Compared with the prior art, the beneficial effects of the present utility model are as follows: The present utility model realizes the one-way pumping of the solvent through the setting of the piston and the one-way valve, and arranges the drug in the flow channel of the solvent, and then flushes the drug through the flowing solvent, thereby accelerating the dissolution rate of the solvent to the drug. Description of the Drawings

[0013] Figure 1 It is a schematic structural diagram of a rapid dissolution device for drug analysis in the present utility model.

[0014] Figure 2 It is a schematic internal structure diagram of a rapid dissolution device for drug analysis in the present utility model.

[0015] Figure 3 It is a sectional view of a rapid dissolution device for drug analysis in the present utility model.

[0016] In the figure: 1 - dissolution tank, 2 - first mounting seat, 3 - sealing cover, 4 - lifting cylinder, 5 - piston, 6 - sealing ring, 7 - handle, 8 - stop block, 9 - retaining net, 10 - water inlet, 11 - discharge hole, 12 - first control valve, 13 - first sealing ball, 14 - first fixing frame, 15 - first spring, 16 - reflux port, 17 - second control valve, 18 - second sealing ball, 19 - second fixing frame, 20 - second spring, 21 - second mounting seat, 22 - mounting cover, 23 - knob, 24 - fixed cylinder, 25 - telescopic rod, 26 - third spring, 27 - pressing block. Detailed Embodiments

[0017] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0018] Referring to Figures 1 to 3 , in the embodiment of the present invention, a rapid dissolution device for drug analysis includes a dissolution tank 1. A first mounting seat 2 is fixedly connected to the dissolution tank 1. A sealing cover 3 is fixedly connected to the first mounting seat 2. A lifting cylinder 4 is slidably connected inside the sealing cover 3. A piston 5 that is slidably connected inside the dissolution tank 1 is fixedly connected to the bottom of the lifting cylinder 4. An inlet 10 that penetrates the piston 5 is provided inside the lifting cylinder 4. A first one-way sealing assembly is connected inside the inlet 10. A return port 16 is provided inside the piston 5. A second one-way sealing assembly is connected inside the return port 16. A retaining net 9 is fixedly connected inside the lifting cylinder 4. A plurality of discharge holes 11 located on the inner wall of the lifting cylinder 4 are provided on the side of the retaining net 9 away from the inlet 10. A clamping assembly is connected inside the lifting cylinder 4. A handle 7 is fixedly connected to the top of the lifting cylinder 4. In the present invention, the drug is first placed on the retaining net 9 along the lifting cylinder 4, and the drug on the retaining net 9 is elastically clamped by the clamping assembly. Then, the solvent is injected into the dissolution tank 1, the piston 5 is inserted into the dissolution tank 1, and the sealing cover 3 is screwed and installed on the dissolution tank 1. Then, through the setting of the handle 7, it is convenient to pull the lifting cylinder 4 to reciprocate up and down inside the dissolution tank 1. The lifting cylinder 4 drives the piston 5 to reciprocate up and down inside the dissolution tank 1. When the piston 5 descends inside the dissolution tank 1, the first one-way sealing assembly opens. At this time, the solvent inside the dissolution tank 1 enters the lifting cylinder 4 along the inlet 10. And under the action of pressure, the solvent quickly passes through the retaining net 9 to quickly wash the drug on the retaining net 9, thereby realizing the rapid dissolution of the drug. The solution then flows into the space between the piston 5 and the sealing cover 3 along the discharge holes 11. Then, when the piston 5 rises inside the dissolution tank 1, the second one-way sealing assembly opens. At this time, the solution then flows into the bottom of the dissolution tank 1 along the return port 16. Repeating this process can achieve the cyclic dissolution of the drug.

[0019] In one case of this embodiment, referring to Figures 1 to 3 , a retaining block 8 is fixedly connected to the outer wall of the lifting cylinder 4. In the present invention, through the setting of the retaining block 8, the relative position between the lifting cylinder 4 and the sealing cover 3 is limited.

[0020] In one case of this embodiment, referring to Figures 1 to 3, the first one-way sealing component includes a first control valve 12 fixedly connected inside the water inlet 10. A first sealing ball 13 is arranged inside the first control valve 12. On the side of the first sealing ball 13 away from the bottom of the dissolving tank 1, there is a first fixing frame 14 fixedly connected inside the first control valve 12. A first spring 15 is arranged between the first fixing frame 14 and the first sealing ball 13. The first one-way sealing component performs one-way sealing on the water inlet 10 through the arrangement of the first control valve 12 and the first sealing ball 13. When pressure pushes the first sealing ball 13 to move towards the first control valve 12, the water inlet 10 closes. On the contrary, when pressure pushes the first sealing ball 13 to move away from the first control valve 12, the first spring 15 is compressed. At this time, the first sealing ball 13 is away from the first sealing valve, and the water inlet 10 opens.

[0021] In one case of this embodiment, please refer to Figures 1 to 3 , the second one-way sealing component includes a second control valve 17 fixedly connected inside the return port 16. A second sealing ball 18 is arranged inside the second control valve 17. On the side of the second sealing ball 18 close to the bottom of the dissolving tank 1, there is a second fixing frame 19 fixedly connected inside the second control valve 17. A second spring 20 is arranged between the second fixing frame 19 and the second sealing ball 18. The second one-way sealing component performs one-way sealing on the return port 16 through the arrangement of the second control valve 17 and the second sealing ball 18. When pressure pushes the second sealing ball 18 to move towards the second control valve 17, the return port 16 closes. On the contrary, when pressure pushes the second sealing ball 18 to move away from the second control valve 17, the second spring 20 is compressed. At this time, the second sealing ball 18 is away from the second sealing valve, and the return port 16 opens.

[0022] In one case of this embodiment, please refer to Figures 1 to 3 , the clamping component includes a second mounting seat 21 fixedly connected to the top of the lifting cylinder 4. An installation cover 22 is threadedly connected inside the second mounting seat 21. The bottom of the installation cover 22 is fixedly connected with a fixed cylinder 24. One end of a telescopic rod 25 is slidably connected inside the fixed cylinder 24. The other end of the telescopic rod 25 passes through the fixed cylinder 24 and is fixedly connected with a pressing block 27. A third spring 26 is installed inside the fixed cylinder 24. A knob 23 is fixedly connected to the installation cover 22. After the clamping component places the medicine along the second mounting seat 21 inside the lifting cylinder 4, then inserts the pressing block 27 into the lifting cylinder 4, and tightens the installation cover 22 into the second mounting seat 21 by screwing the knob 23. At this time, the installation cover 22 drives the telescopic rod 25 to press down through the fixed cylinder 24, and elastically pushes the telescopic rod 25 through the setting of the third spring 26. The telescopic rod 25 drives the pressing block 27 to elastically press down, so as to elastically press down the medicine on the retaining net 9, thereby increasing the impact force of the water flow on the medicine, and further accelerating the dissolution rate of the water flow on the medicine.

[0023] The foregoing has shown and described the basic principles, main features and advantages of the present utility model. For those skilled in the art, it is obvious that the present utility model is not limited to the details of the above-described exemplary embodiments, and without departing from the spirit or basic features of the present utility model, the present utility model can be implemented in other specific forms. Therefore, from any point of view, the embodiments should be regarded as exemplary and non-limiting. The scope of the present utility model is defined by the appended claims rather than the above description. Therefore, all changes falling within the meaning and scope of the equivalent elements of the claims are intended to be embraced by the present utility model. Any reference signs in the claims should not be construed as limiting the claims involved.

[0024] The above are only the preferred embodiments of the present utility model and are not intended to limit the present utility model. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present utility model shall be included in the protection scope of the present utility model.

Claims

1. A rapid dissolution device for drug analysis, comprising a dissolution tank, characterized in that: A first mounting seat is fixedly connected to the dissolving tank, a sealing cover is fixedly connected to the first mounting seat, a lifting cylinder is slidably connected inside the sealing cover, a piston slidably connected inside the dissolving tank is fixedly connected to the bottom of the lifting cylinder, a water inlet penetrating the piston is provided in the lifting cylinder, a first one-way sealing component is connected in the water inlet, a reflux port is provided in the piston, a second one-way sealing component is connected in the reflux port, a blocking net is fixedly connected in the lifting cylinder, a plurality of discharge holes on the inner wall of the lifting cylinder are provided on the side of the blocking net away from the water inlet, and a clamping component is connected in the lifting cylinder.

2. A rapid dissolution device for drug analysis according to claim 1, characterized in that: A stopper is fixedly connected to the outer wall of the lifting cylinder, and a handle is fixedly connected to the top of the lifting cylinder.

3. A rapid dissolution device for drug analysis according to claim 1, characterized in that: The first one-way sealing assembly includes a first control valve fixedly connected to the water inlet, a first sealing ball is arranged in the first control valve, a first fixing frame fixedly connected to the first control valve is arranged on the side of the first sealing ball away from the bottom of the dissolution tank, and a first spring is arranged between the first fixing frame and the first sealing ball.

4. A rapid dissolution device for drug analysis according to claim 1, characterized in that: The second one-way sealing assembly includes a second control valve fixedly connected to the reflux port, a second sealing ball is arranged in the second control valve, a second fixing frame fixedly connected to the second control valve is arranged on the side of the second sealing ball close to the bottom of the dissolving tank, and a second spring is arranged between the second fixing frame and the second sealing ball.

5. A rapid dissolution device for drug analysis according to claim 1, characterized in that: The clamping assembly includes a second mounting seat fixedly connected to the top of the lifting cylinder, a mounting cover is threadedly connected to the second mounting seat, a fixing cylinder is fixedly connected to the bottom of the mounting cover, one end of the telescopic rod is slidably connected in the fixing cylinder, the other end of the telescopic rod passes through the fixing cylinder and is fixedly connected to a pressure block, and a third spring is installed in the fixing cylinder.

6. A rapid dissolution device for drug analysis according to claim 5, characterized in that: A knob is fixedly connected to the mounting cover.

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