Mouse brain tumor irradiation experiment mold

Abstract

The utility model discloses a mouse brain tumor irradiation experiment mold, and particularly relates to the technical field of animal experiment equipment, the mouse brain tumor irradiation experiment mold comprises an irradiation bearing piece and a mouse placing box, the irradiation bearing piece comprises an irradiation part and a plurality of bearing parts, a top plate, side plates and a bottom plate of the irradiation part enclose an accommodating space, an annular shielding layer is laid on the top plate, and the mouse placing box is arranged in the accommodating space. A plurality of first through holes enabling the containing space to be communicated with the outside are formed in the position, close to the side plates, of the top plate, all the bearing parts are installed on the outer sides of the side plates and used for bearing a mouse containing box, and a shielding layer used for shielding irradiation light is laid on the outer surface of the mouse containing box; the anesthetized mouse head in the mouse placing box can sequentially penetrate through the second through hole of the mouse placing box and the first through hole of the side plate to enter the containing space, and the annular shielding layer can shield irradiation light of the non-irradiation part of the mouse head. The mouse irradiation experiment device can be used for simultaneously carrying out irradiation experiments on a plurality of mice, and can shield irradiation light rays of non-irradiation parts of the mice, so that the death rate of the mice in irradiation is reduced.

Description

Technical Field

[0001] The utility model relates to the technical field of animal experimental equipment, in particular to a mouse brain tumor irradiation experimental mold. Background Art

[0002] The accelerator boron neutron capture therapy experimental device (BNCT for short) is a targeted, cell-level precision radiotherapy that combines radiation with drugs, and is one of the most advanced cancer treatments in the world. BNCT is an emerging radiotherapy method. A series of studies in the field of BNCT are inseparable from mice, the most commonly used experimental animals. However, there is currently no mature method for neutron irradiation of mice. Most researchers use acrylic plates to hang mice for irradiation. The whole body of the mice is irradiated by neutrons, and the mortality rate is high. Some other researchers use boron-containing polyethylene to partially shield the mice, which partially reduces the mortality rate of mice. However, the shielding method still exposes a large area of ​​mice and is not suitable for irradiation of in situ models of mouse brain tumors, especially the eyeballs close to the brain cannot be shielded. Mice are prone to blindness after high-dose irradiation, which increases the mortality rate of mice. Utility Model Content

[0003] The utility model aims to provide a mouse brain tumor irradiation experiment mold to solve the problems existing in the above-mentioned prior art. It can carry out irradiation experiments on multiple mice at the same time, and can shield the irradiation light of the non-irradiated parts of the mice, thereby reducing the mortality rate of mice irradiated.

[0004] To achieve the above purpose, the utility model provides the following solutions:

[0005] The utility model provides a mouse brain tumor irradiation experiment mold, comprising an irradiation support and a mouse placement box, wherein the irradiation support comprises an irradiation part and a plurality of support parts, wherein the irradiation part comprises a top plate, a bottom plate and a side plate, wherein the top plate is opposite to the bottom plate, the side plate is connected between the bottom plate and the top plate, and the top plate, the side plate and the bottom plate enclose a containing space, wherein irradiation light sequentially and vertically irradiates the top plate and the bottom plate, an annular shielding layer is laid on the top plate, and a plurality of first through holes are opened on the top plate near the side plate to connect the containing space with the outside world, Each of the supporting parts is fixedly mounted on the outer side of the side panel, and one of the through holes corresponds to one of the supporting parts, the supporting part is used to support the mouse placement box, the outer surface of the mouse placement box is paved with a shielding layer for shielding the irradiated light, and a second through hole is opened on a side panel of the mouse placement box. After the mouse placement box is placed on the supporting part, the head of the anesthetized mouse in the mouse placement box can pass through the second through hole and the first through hole in sequence to enter the accommodating space, and the annular shielding layer can shield the irradiated light on the non-irradiated part of the mouse's head.

[0006] Preferably, the annular shielding layer and the shielding layer are made of boron-containing polyethylene.

[0007] Preferably, the mouse placement box is provided with a third through hole, and the side wall where the third through hole is located is opposite to the side wall where the second through hole is provided, so that the tail of the mouse can extend out of the mouse placement box through the third through hole.

[0008] Preferably, the irradiation support is made of acrylic plate.

[0009] Preferably, the irradiation supporting member is a regular hexagonal prism, and the number of the supporting parts is six, and the six supporting parts correspond one-to-one to the six side surfaces of the regular hexagonal prism respectively.

[0010] Preferably, the annular shielding layer is a hexagonal annular shielding layer.

[0011] Preferably, the mouse placement box comprises a box body and a box cover, the interior of the box body can accommodate the mouse, the box body is provided with an opening for the mouse to enter and exit the box body, and the box cover is used to open and close the opening.

[0012] Compared with the prior art, the utility model has achieved the following technical effects:

[0013] The utility model provides a mouse brain tumor irradiation experiment mold, a plurality of mouse placement boxes can be placed on a plurality of supporting parts of an irradiation supporting member, a plurality of mice can be irradiated together, and the experimental efficiency is improved; the neutron beam is irradiated perpendicularly to the center of a top plate, and the intensity of the neutron beam gradually weakens from the center to the outside, a shielding layer laid on the outer surface of the mouse placement box can prevent other parts except the mouse head from being irradiated by the neutron beam, the annular shielding layer laid on the top plate can shield the irradiation light of the non-irradiated parts of the mouse head entering the accommodating space, especially the eyeball, the neutron beam can only irradiate the target position of the mouse brain tumor, avoid mouse blindness, and reduce the mortality rate of mouse irradiation. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0015] Figure 1 This is a schematic diagram of the structure of the mouse brain tumor irradiation experiment mold;

[0016] Figure 2 A partial perspective view of the mold used for mouse brain tumor irradiation experiments;

[0017] Figure 3 is a schematic diagram of the structure of the irradiation support;

[0018] Figure 4 Schematic diagram of the structure of the box for mice placement.

[0019] In the figure: 1-irradiation supporting member; 11-irradiation part; 12-supporting part; 13-annular shielding layer; 2-mouse placement box; 21-shielding layer; 22-second through hole; 23-third through hole; 3-mouse. DETAILED DESCRIPTION

[0020] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0021] The utility model aims to provide a mouse brain tumor irradiation experiment mold to solve the problems existing in the above-mentioned prior art. It can carry out irradiation experiments on multiple mice at the same time, and can shield the irradiation light of the non-irradiated parts of the mice, thereby reducing the mortality rate of mice irradiated.

[0022] In order to make the above-mentioned purposes, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0023] The utility model provides a mouse brain tumor irradiation experiment mold, such as Figure 1-4As shown, it includes an irradiation support member 1 and a mouse placement box 2, the irradiation support member 1 includes an irradiation portion 11 and a plurality of support portions 12, the irradiation portion 11 includes a top plate, a bottom plate and a side plate, the top plate is opposite to the bottom plate, the side plate is connected between the bottom plate and the top plate, and the top plate, the side plate and the bottom plate enclose a containing space, the irradiation light sequentially and vertically irradiates the top plate and the bottom plate, an annular shielding layer 13 is laid on the top plate, and a plurality of first through holes are opened on the top plate near the side plate to connect the containing space with the outside, and each support portion 12 is fixedly mounted on the outer side of the side plate. side, and a through hole corresponds to a supporting portion 12, the supporting portion 12 is used to support the mouse placement box 2, the outer surface of the mouse placement box 2 is paved with a shielding layer 21 for shielding the irradiated light, and a second through hole 22 is opened on a side panel of the mouse placement box 2. After the mouse placement box 2 is placed on the supporting portion 12, the head of the anesthetized mouse 3 in the mouse placement box 2 can pass through the second through hole 22 and the first through hole in sequence to enter the accommodating space, and the annular shielding layer 13 can shield the irradiated light on the non-irradiated part of the head of the mouse 3. A plurality of mouse placement boxes 2 can be placed on a plurality of supporting parts 12 of an irradiation support member 1, and a plurality of mice 3 can be irradiated together, thereby improving the experimental efficiency; the neutron beam is irradiated perpendicularly to the center of the top plate, and the intensity of the neutron beam gradually decreases from the center to the outside; the shielding layer 21 laid on the outer surface of the mouse placement box 2 can prevent other parts of the mouse 3 except the head from being irradiated by the neutron beam; the annular shielding layer 13 laid on the top plate can shield the non-irradiated parts of the head of the mouse 3 entering the accommodating space, especially the eyeballs, to prevent the mouse 3 from going blind; a gap is formed between the edge of the top plate and the outer edge of the annular shielding layer 13, and the part of the mouse 3 that needs to be irradiated is just exposed in the gap, so that the target position of the mouse 3 can be irradiated, thereby reducing the irradiation mortality rate of the mouse 3.

[0024] In the embodiment of the present invention, it is further preferred that the material of the annular shielding layer 13 and the shielding layer 21 is boron-containing polyethylene. Boron-containing polyethylene has a good effect of shielding neutron beams. The boron content in the boron-containing polyethylene is 10%.

[0025] In the embodiment of the utility model, it is further preferred that the mouse placement box 2 is provided with a third through hole 23 , and the side wall where the third through hole 23 is located is opposite to the side wall where the second through hole 22 is provided, so that the tail of the mouse 3 can extend out of the mouse placement box 2 through the third through hole 23 .

[0026] In the embodiment of the present invention, it is further preferred that the irradiation support member 1 is made of an acrylic plate.

[0027] In the embodiment of the present invention, it is further preferred that the irradiation support 1 is a regular hexagonal prism, the number of the support parts 12 is six, and the six support parts 12 correspond to the six sides of the regular hexagonal prism respectively. The neutron irradiation experiment can be performed on six mice 3 at a time, and the neutron beam can be uniformly irradiated on the six mice 3.

[0028] It is further preferred in the implementation manner of the present invention that the annular shielding layer 13 is a hexagonal annular shielding layer 13 .

[0029] In the embodiment of the utility model, it is further preferred that the mouse placement box 2 includes a box body and a box cover, the box body can accommodate the mouse 3, the box body is provided with an opening for the mouse 3 to enter and exit the box body, and the box cover is used to open and close the opening. When irradiating the mouse 3, the box cover is opened, the anesthetized mouse 3 is placed in the box body from the opening, and the head of the mouse 3 is taken out from the second through hole 22, and then the box cover is closed; after the irradiation experiment is completed, the mouse 3 is taken out from the mouse placement box 2.

[0030] The present invention uses specific examples to illustrate the principle and implementation of the present invention. The above examples are only used to help understand the method and core idea of ​​the present invention. At the same time, for those skilled in the art, according to the idea of ​​the present invention, there will be changes in the specific implementation and application scope. In summary, the content of this specification should not be understood as limiting the present invention.

Claims

1. A mouse brain tumor irradiation experimental mold, characterized in that: The invention comprises an irradiation support and a mouse placement box, wherein the irradiation support comprises an irradiation part and a plurality of supporting parts, wherein the irradiation part comprises a top plate, a bottom plate and a side plate, wherein the top plate is opposite to the bottom plate, the side plate is connected between the bottom plate and the top plate, and the top plate, the side plate and the bottom plate enclose a containing space, wherein irradiation light sequentially and vertically irradiates the top plate and the bottom plate, an annular shielding layer is laid on the top plate, a plurality of first through holes are opened on the top plate near the side plate so as to connect the containing space with the outside, each of the supporting parts is fixedly mounted on the outer side of the side plate, and one through hole corresponds to one supporting part, the supporting part is used to support the mouse placement box, a shielding layer for shielding irradiation light is laid on the outer surface of the mouse placement box, a second through hole is opened on one side plate of the mouse placement box, after the mouse placement box is placed on the supporting part, the head of the anesthetized mouse in the mouse placement box can sequentially pass through the second through hole and the first through hole to enter the containing space, and the annular shielding layer can shield the irradiation light of the non-irradiated part of the mouse head.

2. The mouse brain tumor irradiation experimental mold according to claim 1, characterized in that: The annular shielding layer and the shielding layer are made of boron-containing polyethylene.

3. The mouse brain tumor irradiation experimental mold according to claim 1, characterized in that: The mouse placement box is provided with a third through hole, and the side wall where the third through hole is located is opposite to the side wall where the second through hole is provided, and the tail of the mouse can extend out of the mouse placement box through the third through hole.

4. The mouse brain tumor irradiation experimental mold according to claim 1, characterized in that: The material of the irradiation support is an acrylic plate.

5. The mouse brain tumor irradiation experimental mold according to claim 1, characterized in that: The irradiation support is a regular hexagonal prism, and the number of the support parts is six, and the six support parts correspond to the six side surfaces of the regular hexagonal prism respectively.

6. The mouse brain tumor irradiation experimental mold according to claim 5, characterized in that: The annular shielding layer is a hexagonal annular shielding layer.

7. The mouse brain tumor irradiation experimental mold according to claim 1, characterized in that: The mouse placement box comprises a box body and a box cover. The inside of the box body can accommodate mice. The box body is provided with an opening for the mouse to enter and exit the box body, and the box cover is used to open and close the opening.

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