Full-automatic treponema pallidum experiment detection system

Abstract

The utility model provides a full-automatic treponema pallidum experiment detection system, relates to the full-automatic treponema pallidum experiment detection equipment field, and comprises a work bench, the top of the work bench is fixedly connected with a protective cover, the front end of the top of the work bench is provided with a suction head replacement part, the suction head replacement part comprises a through groove and a groove, and the through groove and the groove are communicated with each other. A collecting box is arranged in an inner cavity of the workbench. The effect of extracting sample liquid and reagents is achieved by arranging the pipetting assembly, the effect of recycling the suction head is achieved by arranging the suction head replacing part and the collecting box, the suction head can be replaced by matching the three-axis moving assembly, the pipetting assembly and the suction head replacing part, and the suction head replacing part is convenient to use. And the collection box can collect the suction heads, so that the working efficiency of the full-automatic enzyme immunoassay analyzer is improved.

Description

Technical Field

[0001] The utility model belongs to the field of full-automatic syphilis spirochete experimental detection equipment, in particular to a full-automatic syphilis spirochete experimental detection system. Background Art

[0002] Treponema pallidum is one of the pathogens that cause syphilis infection. This bacterium is a spiral-shaped microorganism whose morphological characteristics can be seen under a microscope, so it is often called a spirochete. Syphilis is a sexually transmitted disease. After a patient is infected with Treponema pallidum, he or she may experience a variety of symptoms, including ulcers and rashes at the site of infection. If not treated in time, it may cause serious complications, including damage to the cardiovascular and nervous systems.

[0003] In order to determine whether a patient is infected with Treponema pallidum, one of the commonly used methods is to use a fully automatic enzyme immunoassay analyzer for testing. This instrument can quickly and accurately detect the presence of Treponema pallidum-related antibodies in the sample. The test is usually based on serum samples and determines the infection by measuring the content of specific antibodies. This method is generally regarded as a reliable diagnostic method that can help doctors diagnose patients' syphilis infection in a timely manner and take appropriate treatment measures.

[0004] The existing fully automatic ELISA analyzer can achieve automatic detection and obtain test results, avoiding the problems of large deviations in manual judgment results, increased workload, low efficiency, and safety hazards. Since the ELISA analyzer needs to use a pipette to suck the reagent and drip it into the sample, and then form multiple samples into batches for simultaneous testing, the number of samples in each batch is large, and the process of dripping the reagent for the entire batch of samples needs to be repeated multiple times. During this process, the reagent pipette tip is easily contaminated, resulting in contamination of the reagent when the reagent is repeatedly sucked, which ultimately leads to inaccurate test results. Summary of the invention

[0005] The utility model provides a full-automatic Treponema pallidum experimental detection system to solve the technical problem that a reagent pipette tip is easily contaminated, which causes the reagent to be contaminated when the reagent is repeatedly sucked, and finally causes inaccurate detection results.

[0006] The utility model provides a workbench, on which a protective cover is arranged;

[0007] A tip replacement unit, the tip replacement unit is arranged on the top of the workbench, the tip replacement unit comprises a first through slot and a second through slot, the first through slot and the second through slot both pass through the workbench surface in the up-down direction, and the second through slot is connected to the first through slot;

[0008] A collection box is arranged below the workbench where the tip replacement unit is located;

[0009] A three-axis motion assembly A, wherein the three-axis motion assembly A is arranged in a protective cover; the three-axis motion assembly A and the three-axis motion assembly B both include an X-axis, a Y-axis and a Z-axis and are perpendicular to each other, the X-axis is fixedly mounted on the protective cover, the Y-axis is arranged on the X-axis, the Z-axis is arranged on the Y-axis, and the Z-axis is arranged in a vertical direction;

[0010] A pipetting assembly, wherein the pipetting assembly is arranged on the Z axis of the three-axis motion assembly A, and the pipetting assembly comprises a pipetting pump, a connecting pipe and a first electric push rod, wherein the connecting pipe is connected to the pipetting pump via a hose, and the end of the connecting pipe is used to sleeve a suction head to form a suction portion; the outer diameter of the suction portion is smaller than the inner diameter of the first through groove and larger than the inner diameter of the second through groove, and the outer diameter of the connecting pipe is smaller than the inner diameter of the second through groove; the first electric push rod is fixedly connected to the connecting pipe so that the connecting pipe can move in the up and down directions;

[0011] A suction head rack is arranged on the workbench, and a plurality of suction heads are arranged on the suction head rack.

[0012] Furthermore, the second through groove is U-shaped, and the opening of the U-shape is connected to the first through groove.

[0013] Furthermore, the first electric push rod is fixed on the pipetting pump.

[0014] Furthermore, the pipetting assembly also includes a support plate, the support plate is fixed to the output end of the first electric push rod, and the connecting tube is installed at the bottom of the support plate.

[0015] Furthermore, it also includes a gripping assembly and a three-axis motion assembly B, the structure of the three-axis motion assembly B is the same as that of the three-axis motion assembly A; the gripping assembly includes a second electric push rod and a manipulator, the gripping assembly is installed on the Z-axis of the three-axis motion assembly B, and the manipulator is fixedly connected to the output end of the second electric push rod.

[0016] Furthermore, the workbench is provided with a sample rack, an oscillator and a reagent rack, the sample rack is provided with a plurality of sample label plates, and the reagent rack is provided with a plurality of reagent test tubes.

[0017] Furthermore, a revolving door is provided on the front side of the protective cover, and a visual window is provided on the revolving door.

[0018] Furthermore, a disinfection component is arranged above the collection box.

[0019] Furthermore, the disinfection component is a UV-C lamp.

[0020] Furthermore, the X-axis, Y-axis and Z-axis all include motors and ball screw structures.

[0021] Beneficial effects: The utility model has the following beneficial effects:

[0022] The utility model has the effect of driving the liquid transfer component to move by arranging the three-axis motion component A. By arranging the liquid transfer component and the tip replacement part, new and clean tips can be used to suck up the reagents one by one and then drip them into the samples until the reagents are added to multiple samples in a batch, thereby ensuring that the samples do not affect each other, making the analysis results of the full-automatic enzyme immunoassay analyzer more accurate. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 This is a schematic diagram of the main structure of the fully automatic Treponema pallidum experimental detection system of the embodiment of the utility model;

[0024] Figure 2 This is a schematic diagram of the main structure of the workbench of an embodiment of the utility model;

[0025] Figure 3 This is a schematic diagram of the connection state of the three-axis motion component A and the pipetting component of the embodiment of the utility model;

[0026] Figure 4 It is a structural schematic diagram of the separation state of the three-axis motion component B and the gripping component of the embodiment of the utility model.

[0027] In the figure:

[0028] 1. Workbench; 2. Protective cover; 3. Tip replacement unit; 301. First through slot; 302. Second through slot; 4. Collection box; 5. Three-axis motion assembly A; 6. Three-axis motion assembly B; 7. Pipetting assembly; 701. Pipetting pump; 702. First electric push rod; 703. Support plate; 704. Connecting tube; 8. Grasping assembly; 801. Second electric push rod; 802. Manipulator; 9. Oscillator; 10. Sample rack; 11. Tip rack; 12. Reagent rack. DETAILED DESCRIPTION

[0029] In order to better understand the technical content of the utility model, specific embodiments are cited and described as follows in conjunction with the accompanying drawings. In this disclosure, various aspects of the utility model are described with reference to the accompanying drawings, and many illustrative embodiments are shown in the accompanying drawings. The embodiments of the present disclosure are not necessarily defined to include all aspects of the utility model. It should be understood that the various concepts and embodiments introduced above, as well as those described in more detail below, can be implemented in any of many ways, because the concepts and embodiments disclosed in the utility model are not limited to any implementation method. In addition, some aspects disclosed in the utility model can be used alone, or used in any appropriate combination with other aspects disclosed in the utility model.

[0030] Example 1

[0031] like Figure 1-4 As shown in the figure, it is the first embodiment of the utility model, which provides a fully automatic syphilis treponema experimental detection system, including a workbench 1, a protective cover 2 is fixedly connected to the top of the workbench 1, and the workbench 1 and the protective cover 2 cooperate to form an area for placing various equipment. Figure 1 As shown, in this embodiment, the protective cover 2 has a visible window for observing the area. In some preferred embodiments, the visible window is a movable window, which can be opened to expose the area when needed, such as for maintenance.

[0032] In order to facilitate the recycling of discarded tips, a tip replacement unit 3 is provided on one side of the workbench 1, and the tip replacement unit 3 includes a first through slot 301 and a second through slot 302, both of which penetrate the workbench 1 in the up-down direction, and the second through slot 302 is connected to the first through slot 301. Figure 4 As shown, in this embodiment, the first through slot 301 is a rectangular slot, and the second through slot 302 includes a plurality of U-shaped slots arranged parallel to each other, and the openings of the U-shaped slots are connected to the long sides of the first through slot 301 .

[0033] The collecting box 4 is arranged below the workbench 1 where the tip replacement part 3 is located. The collecting box 4 is used to collect the tips dropped from the tip replacement part 3 .

[0034] The three-axis motion assembly A5 and the three-axis motion assembly B6 are both arranged in the protective cover 2. The three-axis motion assembly A5 and the three-axis motion assembly B6 each include an X-axis, a Y-axis and a Z-axis and are mutually perpendicular. The X-axis is fixedly mounted on the protective cover 2, the Y-axis is arranged on the X-axis, the Z-axis is arranged on the Y-axis, and the Z-axis is arranged in the vertical direction.

[0035] The X-axis, Y-axis and Z-axis all include motors and ball screw structures. The motors use stepper motors or servo motors to drive axial movement. Stepper motors have precise positioning capabilities and are suitable for applications that require high precision, but their speed is relatively low, while servo motors can provide higher speeds and better dynamic responsiveness, and are suitable for scenarios with higher speed requirements. The ball screw structure is a mechanical transmission device used to achieve efficient rotation and linear motion. It has the advantages of high transmission efficiency, high speed, high precision and high rigidity. It is suitable for occasions that require precise control and stable motion, and can ensure the accurate positioning and motion stability of the robotic arm. By combining the motor with the ball screw, precise control and positioning of the X-axis, Y-axis and Z-axis can be achieved. Therefore, the above-mentioned three-axis motion assembly A5 and the three-axis motion assembly B6 can drive the objects mounted thereon to perform multi-dimensional motion.

[0036] Liquid transfer assembly 7, the liquid transfer assembly 7 is arranged on the Z axis of the three-axis motion assembly A5, the liquid transfer assembly 7 includes a liquid transfer pump 701, a connecting pipe 704 and a first electric push rod 702, the connecting pipe 704 and the liquid transfer pump 701 are connected by a hose, in this embodiment, the liquid transfer pump 701 uses ADP10, which can provide highly accurate liquid transfer operation. The end of the connecting pipe 704 is used to set the suction head to form a suction part; the outer diameter of the suction part is smaller than the inner diameter of the first through groove 301 and larger than the inner diameter of the second through groove 302, and the outer diameter of the connecting pipe is smaller than the inner diameter of the second through groove 302. The first electric push rod 702 is fixed on the liquid transfer pump 701. The first electric push rod 702 is fixedly connected to the connecting pipe 704 so that the connecting pipe 704 can move in the up and down direction. The liquid transfer assembly 7 uses the liquid transfer pump 701 to perform negative pressure suction on the connecting pipe 704, so that the connecting pipe 704 can suck the corresponding liquid through the suction head. The pipetting assembly 7 is arranged on the Z-axis of the three-axis motion assembly A5 and can move in the protective cover 2 driven by the three-axis motion assembly A5.

[0037] The tip rack 11 is arranged on the workbench 1. A plurality of tips are arranged on the tip rack 11. The tip rack 11 is provided with a support corresponding to each tip. The lower end of the tip wraps around the support so that the upper end of the tip is in a vertical state. The tips on the tip rack 11 are all clean tips. The material of the upper end of the tip is harder than that of the lower end of the tip. The mouth of the connecting tube 704 contacts the upper part of the tip. The connecting tube 704 can wrap around the tip on the connecting tube 704 under a certain downward pressure and the negative pressure of the pipette pump 701.

[0038] In the above embodiment, the pipetting assembly 7 further includes a support plate 703, the support plate 703 is fixed to the output end of the first electric push rod 702, and the connecting tube 704 is installed at the bottom of the support plate 703. The support plate 703 can support each connecting tube 704, so that the positions of each connecting tube 704 are relatively fixed, and the combination of each connecting tube 704 forms a rectangular parallelepiped structure so as to fit with the first through slot 301, and each connecting tube 704 also fits with the second through slot 302.

[0039] In the above embodiment, it also includes a gripper assembly 8 and a three-axis motion assembly B6, the structure of the three-axis motion assembly B6 is the same as that of the three-axis motion assembly A5; the gripper assembly 8 includes a second electric push rod 801 and a manipulator 802, the gripper assembly 8 is installed on the Z axis of the three-axis motion assembly B6, and the manipulator 802 is fixedly connected to the output end of the second electric push rod 801. After the entire batch has completed dripping the reagent into the sample, the gripper assembly 8 can grab the samples of the batch driven by the three-axis motion assembly B6 and send them for inspection.

[0040] Therefore, in the present embodiment, the workbench 1 is provided with an ELISA instrument, a sample rack 10, an oscillator 9 and a reagent rack 12, the sample rack 10 is provided with a plurality of sample label plates, and the reagent rack 12 is provided with a plurality of reagent test tubes. In the present embodiment, the sample rack 10 and the reagent rack 12 both include multiple columns, and the number of test tubes placed in each column is consistent with the number of the connecting tubes 704, and each time the reagent is drawn and the reagent is added, it is carried out in a one-time manner to complete one column. Therefore, after the addition of one column is completed, it is necessary to synchronously replace the suction tip on the connecting tube 704 at the same time, and then install a new suction tip at the same time. The oscillator 9 is used to oscillate the sample label plate before the formal detection so as to fully fuse the sample and the reagent so as to be sent to the ELISA instrument for detection so that the result is more accurate.

[0041] In some preferred embodiments, a revolving door is provided on the front side of the protective cover 2 for opening the revolving door when necessary to update and maintain consumables. In some preferred embodiments, a visual window is provided on the revolving door for easy observation.

[0042] For disinfection, a disinfection component is arranged above the collection box 4, wherein the disinfection component uses a UV-C lamp, and the disinfection component UV-C lamp is installed in the workbench 1. The UV-C lamp can emit ultraviolet rays of a specific wavelength, which has sterilization and disinfection effects.

[0043] During use, after the pipetting component 7 completes the dripping of a row of reagents, the X-axis, Y-axis and Z-axis of the three-axis motion component A5 cooperate to drive the pipetting component 7 to move above the tip replacement part 3, and the output end of the first electric push rod 702 extends to push the support plate 703 to move downward, so that the connecting tube 704 extends to the inner cavity of the first through groove 301, and makes the upper edge of the connecting tube 704 at the position corresponding to the tip lower than the lower surface of the first through groove 301 and the second through groove 302 as a whole.

[0044] Then, the Z axis of the three-axis motion assembly A5 drives the liquid transfer assembly 7 to move toward the second through slot 302, so that the connecting tube 704 extends into the inner cavity of the second through slot 302. At this time, the output end of the first electric push rod 702 contracts to drive the connecting tube 704 to move upward, so that the suction head on the surface of the connecting tube 704 rubs against the inner wall of the second through slot 302, so that the suction head can fall off the surface of the connecting tube 704 and fall into the collection box 4. Then, the X axis, Y axis and Z axis of the three-axis motion assembly A5 cooperate to drive the liquid transfer assembly 7 to move above the suction head rack 11, and the output end of the first electric push rod 702 extends to push the support plate 703 to move downward and enable the connecting tube 704 to penetrate into the suction head and achieve connection with the suction head under the pressure and the negative pressure of the liquid transfer pump 701, so as to achieve the effect of automatic suction head replacement.

[0045] In this embodiment, a batch of samples shares one sample rack 10. When all samples on a sample rack have completed the reagent filling, subsequent oscillation and testing can be performed. At this time, the three-axis motion component B6 drives the gripping component 8 to move, so that the gripping component 8 can grab the sample label plate on the sample rack 10, which is convenient for oscillating and testing the samples. Specifically, the output end of the second electric push rod 801 extends to push the manipulator 802 to move downward, and the manipulator 802 grabs the sample label plate, places the sample label plate in the oscillator 9 for oscillation, and then grabs it again and sends it to the ELISA instrument for analysis and testing.

[0046] The standard parts used in this application document can all be purchased from the market and can be customized according to the description in the specification and drawings. The specific connection methods of each part adopt conventional means such as mature bolts, rivets, welding, etc. in the prior art. The machinery, parts and equipment all adopt conventional models in the prior art. The control method is automatic control through a controller. The control circuit of the controller can be implemented through simple programming by technicians in this field, which is common knowledge in the field. This application is mainly used to protect mechanical devices, so this application no longer explains the control method and circuit connection in detail.

[0047] Although the present invention has been disclosed as above with preferred embodiments, it is not intended to limit the present invention. A person with ordinary knowledge in the technical field to which the present invention belongs may make various changes and modifications without departing from the spirit and scope of the present invention. Therefore, the protection scope of the present invention shall be determined by the definition of the claims.

Claims

1. A fully automatic Treponema pallidum experimental detection system, characterized in that: include: A workbench (1), wherein a protective cover (2) is arranged on the workbench (1); A suction tip replacement part (3), the suction tip replacement part (3) being arranged on the top of the workbench (1), the suction tip replacement part (3) comprising a first through groove (301) and a second through groove (302), the first through groove (301) and the second through groove (302) both passing through the surface of the workbench (1) in the up-down direction, the second through groove (302) being in communication with the first through groove (301); A collection box (4) is arranged below the workbench (1) where the tip replacement unit (3) is located; A three-axis motion assembly A (5), wherein the three-axis motion assembly A (5) is disposed in the protective cover (2); A three-axis motion assembly B (6), wherein the structure of the three-axis motion assembly B (6) is the same as that of the three-axis motion assembly A (5); The three-axis motion assembly A (5) and the three-axis motion assembly B (6) both include an X-axis, a Y-axis and a Z-axis, and are perpendicular to each other. The X-axis is fixedly mounted on the protective cover (2), the Y-axis is arranged on the X-axis, the Z-axis is arranged on the Y-axis, and the Z-axis is arranged in the vertical direction; A liquid transfer assembly (7), wherein the liquid transfer assembly (7) is arranged on the Z axis of the three-axis motion assembly A (5), and the liquid transfer assembly (7) comprises a liquid transfer pump (701), a connecting pipe (704) and a first electric push rod (702); the connecting pipe (704) and the liquid transfer pump (701) are connected via a hose, and the end of the connecting pipe (704) is used to cover a suction head to form a suction portion; the outer diameter of the suction portion is smaller than the inner diameter of the first through groove (301) and larger than the inner diameter of the second through groove (302), and the outer diameter of the connecting pipe is smaller than the inner diameter of the second through groove (302); the first electric push rod (702) and the connecting pipe (704) are fixedly connected so that the connecting pipe (704) can move in an up and down direction; A suction head rack (11) is arranged on the workbench, and a plurality of suction heads are arranged on the suction head rack (11).

2. The fully automatic Treponema pallidum experimental detection system as claimed in claim 1, characterized in that: The second through groove (302) is U-shaped, and the opening of the U-shape is connected to the first through groove (301).

3. The fully automatic Treponema pallidum experimental detection system as claimed in claim 1, characterized in that: The first electric push rod is fixed on the liquid transfer pump.

4. The fully automatic Treponema pallidum experimental detection system as claimed in claim 3, characterized in that: The pipetting assembly (7) further comprises a support plate (703), wherein the support plate (703) is fixed to the output end of the first electric push rod (702), and the connecting tube (704) is installed at the bottom of the support plate (703).

5. The fully automatic Treponema pallidum experimental detection system as claimed in claim 1, characterized in that: Also includes a gripper assembly (8); The gripping assembly (8) comprises a second electric push rod (801) and a manipulator (802). The gripping assembly (8) is mounted on the Z axis of the three-axis motion assembly B (6). The manipulator (802) is fixedly connected to the output end of the second electric push rod (801).

6. The fully automatic Treponema pallidum experimental detection system as claimed in claim 1, characterized in that: The workbench (1) is provided with a sample rack (10), an oscillator (9) and a reagent rack (12); the sample rack (10) is provided with a plurality of sample plates; and the reagent rack (12) is provided with a plurality of reagent test tubes.

7. The fully automatic Treponema pallidum experimental detection system as claimed in claim 1, characterized in that: A revolving door is arranged on the front side of the protective cover (2), and a visual window is arranged on the revolving door.

8. The fully automatic Treponema pallidum experimental detection system as claimed in claim 1, characterized in that: A disinfection component is arranged above the collection box (4).

9. The fully automatic Treponema pallidum experimental detection system as claimed in claim 8, characterized in that: The disinfection component is a UV-C lamp.

10. The fully automatic Treponema pallidum experimental detection system as claimed in claim 1, characterized in that: The X-axis, Y-axis and Z-axis all include motors and ball screw structures.

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