Auxiliary device for laboratory mouse medical image imaging

Abstract

The utility model provides an auxiliary device for medical imaging of laboratory mice, which comprises a main body part with a through hole on the surface and a fixed sleeve detachably arranged in the through hole of the main body part in a penetrating manner, and the main body part is hollow. The animal imaging device has the advantages that the animal imaging device can be used for simultaneously carrying out imaging experiments on one or more animals, experiment time is saved, liquid is evenly distributed around each mouse, scanned echo signals can be enhanced, magnetic fields on the body surfaces of the mice are made to be more even, and therefore the influence on a main magnetic field is reduced, and the experiment efficiency is improved. The accuracy of an experiment detection result is improved.

Description

Technical Field

[0001] The utility model belongs to the technical field of imaging examinations, and particularly relates to an auxiliary device for medical imaging of experimental mice. Background Art

[0002] In recent years, imaging examinations have been increasingly widely used in related experimental fields such as medicine due to their advantages of non-invasiveness, objectivity, and good repeatability. Among them, magnetic resonance examination has good soft tissue resolution and can be applied to functional imaging and molecular imaging, and the demand for its application in animal experiments is gradually increasing. Mice are the most common experimental animals, but they are prone to shaking during medical imaging scans, resulting in inaccurate images. Therefore, during animal imaging scans, it is necessary to fix the experimental animals for experiments. Currently, most of these experimental fixation methods use rubber tubes or ropes to directly tie up small animals. Although it can achieve the effect of fixation, however, such a method will have different defects caused by the tightness of the binding. For example, sometimes tying too tightly will affect the breathing and normal physiological limits of small animals and even pinch their limbs, and tying not tightly enough will cause displacement or escape during the experiment, resulting in the inability to complete the experiment. Of course, there are also conventional animal body position fixation devices that can fix a single animal body position, but this kind of device cannot fix multiple animals simultaneously. And the application of such body position fixation devices is also very limited. For example, during nuclear magnetic resonance scanning, a single animal cannot detect signals under a large-bore nuclear magnetic resonance, and basically all such body position fixation devices expose the animals in an air medium. Due to the uneven magnetic field on the animal body surface, it has a greater impact on the main magnetic field during scanning, resulting in inaccurate final scanning results. Summary of the Utility Model

[0003] In order to solve the deficiencies of the prior art, the utility model provides an auxiliary device for medical imaging of experimental mice, which can perform the required imaging examinations for a single or multiple animals simultaneously, improving work efficiency.

[0004] The purpose of the utility model is achieved through the following technical solutions:

[0005] An auxiliary device for medical imaging of experimental mice includes a main body portion with through holes formed on its surface, and a fixing sleeve detachably inserted into the through holes of the main body portion. The interior of the main body portion is hollow.

[0006] Preferably, the through holes are evenly distributed on the surface of the main body portion.

[0007] Preferably, the hollow interior of the main body portion is filled with liquid.

[0008] Preferably, the fixing sleeve is cylindrical, one end of which is provided with breathing holes for gas circulation, and the other end of the fixing sleeve is provided with an end cap.

[0009] Preferably, a serial number for identifying and marking the through hole is correspondingly provided on the side of the through hole.

[0010] Preferably, a liquid injection port is provided at the top of the main body, and a support base for facilitating the standing and positioning of the main body is provided at the bottom of the main body.

[0011] Preferably, the material of the auxiliary device is a polymer material.

[0012] Preferably, the fixed sleeve is transparent.

[0013] Preferably, the cross-section of the main body is circular, the outer diameter of the outer circle is 5 - 18 cm, and the thickness is 10 - 20 cm.

[0014] Preferably, a positioning ring is provided on the outer circle at the front end of the fixed sleeve, and the outer diameter of the positioning ring is greater than the diameter of the through hole.

[0015] The beneficial effects of the present utility model are embodied in that the present utility model can simultaneously conduct imaging experiments on single or multiple animals, saving experimental time. Moreover, the liquid evenly distributed around each mouse can enhance the echo signal of the scan and make the magnetic field on the surface of the mouse more uniform, thereby reducing the influence on the main magnetic field and improving the accuracy of the experimental detection results. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the following drawings are some embodiments of the present utility model. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0017] Figure 1 : Schematic three-dimensional structure diagram of the main body of the present utility model.

[0018] Figure 2 : Schematic structure diagram of the fixed sleeve of the present utility model. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0019] The present utility model discloses an auxiliary device for medical imaging of experimental mice. In order to make the purpose, technical solutions and advantages of the present utility model clearer, the following will further describe the present utility model in detail with reference to the Figure 1 - Figure 2 drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present utility model and are not used to limit the present utility model.

[0020] An auxiliary device for medical imaging of experimental mice, comprising a main body part 1 with through holes 11 formed on its surface, and a fixing sleeve detachably inserted into the through holes of the main body part. The fixing sleeve is used to place the mice to be experimented. During use, the mice are placed in the fixing sleeve, and then the fixing sleeve is placed in the through hole 11 of the main body part. The number of mice can be adjusted according to needs, so as to achieve the purpose of conducting experiments on multiple mice simultaneously and save experimental time.

[0021] The interior of the main body part 1 is hollow, and the hollow interior is filled with a liquid. Usually, water can be used as the liquid. Its function is that when scanning with the device, when there is a liquid evenly distributed around each mouse, it can enhance the echo signal and make the magnetic field on the mouse body surface more uniform, thereby reducing the influence on the main magnetic field and improving the accuracy of the detection results.

[0022] In this embodiment, the cross-section of the main body part is circular, with an outer diameter of 5 - 18 cm and a thickness of 10 - 20 cm. The through holes 11 are evenly distributed on the surface of the main body part 1, and serial numbers for identifying and marking the through holes are correspondingly set beside the through holes 11. A liquid injection port 12 is provided at the top of the main body part 1, and a support base 13 for facilitating the standing and positioning of the main body part is provided at the bottom of the main body part 1. The liquid injection port 12 is equipped with a silica gel plug to prevent liquid leakage during use.

[0023] To facilitate the observation of the mice, the fixing sleeve is made transparent, for example, made of transparent resin material. The fixing sleeve is a cylindrical main body 2, and one end thereof is provided with a breathing hole for facilitating gas circulation. The breathing hole can ensure smooth breathing of the mice in a closed space and can also be connected to a gas anesthesia machine for facilitating the anesthesia of the mice. The other end of the fixing sleeve is provided with an end cap, and of course, it can also be directly in a closed form. Since the noise is relatively large during nuclear magnetic resonance scanning, by fixing the mice in a relatively airtight sleeve, the noise interference received by the mice can be reduced, making it not easy to wake up and facilitating the progress of the experiment.

[0024] In this embodiment, the breathing hole appears in the form of a front end cap 21, that is, the breathing hole 22 is placed on the front end cap 21. After the mice enter the cylindrical main body 2, the front end cap 21 can be plugged to complete the assembly. A positioning ring 23 is provided on the outer circle of the front end of the fixing sleeve, and the outer diameter of the positioning ring 23 is larger than the diameter of the through hole 11. When the fixing sleeve is placed in the through hole, the front end of its positioning ring 23 will extend outside the through hole of the main body structure. Through the setting of this structure, it is convenient to insert and remove the fixing sleeve.

[0025] The material of the auxiliary device is a polymer material, which is an MR-compatible material without metal components. It does not affect the magnetic field during MR sim imaging and has no artifacts during CT sim imaging, enabling the registration of the two types of images. The size of the auxiliary device of the present utility model can be directly applied to the magnetic resonance with a clinical bore and is compatible with a conventional head coil. It has good economy and wide applicability.

[0026] Finally, it should be noted that the orientation or positional relationship indicated by the terms "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. is based on the orientation shown in the drawings or the positional relationship in general use, and is only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the present utility model. In addition, the terms "first", "second", "third", etc., when used for description purposes only, should not be construed as indicating or implying relative importance.

[0027] Moreover, the above embodiments are only used to illustrate the technical solutions of the present utility model and are not intended to limit it; although the present utility model has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions described in the foregoing embodiments or perform equivalent replacements for some of the technical features; and these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present utility model.

Claims

1. An auxiliary device for medical imaging of experimental mice, characterized in that: It includes a main body with a through hole on the surface, and a fixed sleeve that is detachably inserted into the through hole of the main body. The interior of the main body is hollow and the hollow interior of the main body is filled with liquid. The fixed sleeve is cylindrical and has a breathing hole at one end for gas circulation. The other end of the fixed sleeve is provided with an end cap.

2. The auxiliary device for medical imaging of experimental mice according to claim 1, characterized in that: The through holes are evenly distributed on the surface of the main body.

3. The auxiliary device for medical imaging of experimental mice according to claim 2, characterized in that: The through hole edges are correspondingly provided with serial numbers for identifying and marking the through holes.

4. The auxiliary device for medical imaging of experimental mice according to claim 3, characterized in that: The top of the main body is provided with a liquid injection port, and the bottom of the main body is provided with a support seat for facilitating the standing and positioning of the main body.

5. The auxiliary device for medical imaging of experimental mice according to claim 4, characterized in that: The auxiliary device is made of polymer material.

6. The auxiliary device for medical imaging of experimental mice according to claim 5, characterized in that: The fixing sleeve is transparent.

7. The auxiliary device for medical imaging of experimental mice according to claim 6, characterized in that: The main body has a circular cross section, an outer diameter of 5-18 cm, and a thickness of 10-20 cm.

8. The auxiliary device for medical imaging of experimental mice according to claim 7, characterized in that: A positioning ring is arranged on the front outer ring of the fixing sleeve, and the outer diameter of the positioning ring is larger than the diameter of the through hole.

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