Separation and purification device for medicine impurities

Abstract

The utility model discloses a medicine impurity separation and purification device, belongs to the technical field of medicine impurity utilization auxiliary equipment, and aims to solve the problem that the purpose of impurity separation and purification is difficult to achieve due to the fact that part of impurities and medicine solid raw materials are stacked at the bottom in the conventional direct mixing distillation mode. Through the stirring mechanism, the filtering assembly, the stirring mechanism, a heating plate and an electric telescopic rod, the mixing efficiency of a medicine raw material and a solution is improved through the stirring mechanism, a mixed solution is filtered through the filtering assembly, impurities in the medicine raw material are separated from the mixed solution, and the mixed solution is purified by starting the heating plate; steam enters a collecting box through an air outlet and a connecting pipe, liquid is conveniently collected, an electric telescopic rod is started, solid crystals precipitated in residual mixed liquid are pushed out of a discharging opening through a push plate, and filtering is conducted in advance through a pretreatment box; the purity of later-stage solid-liquid separation is improved; and the quality of medicine impurity separation and purification is effectively improved.

Description

Technical Field

[0001] The utility model relates to the technical field of auxiliary equipment for the utilization of drug impurities, and particularly relates to a separation and purification device for drug impurities. Background Art

[0002] The separation and purification of drug impurities is a very important link in the pharmaceutical industry. During the synthesis process of drugs, some by-products or unreacted raw materials are often generated, which are all called impurities. To ensure the safety and effectiveness of drugs, these impurities must be removed to an acceptable level. Chinese Patent Authorization Publication No. CN213853125U discloses a separation and purification device for drug synthesis, including an outer frame. The outer frame is in a hollow cylindrical shape, and a cover plate is arranged on the top of the outer frame. The cover plate is movably connected to the top wall surface of the outer frame. A diversion plate is arranged inside the outer frame, and a heating device is arranged inside the outer frame. The side wall of the heating device is fixedly connected to the bottom end of the inner side wall of the outer frame. A motor is arranged at the bottom of the outer frame, and the output end of the motor extends into the inner part of the outer frame through the heating device. In the utility model, for the separation and purification device for drug synthesis, the motor is started to work. The output shaft of the motor drives the suspension rod to rotate. A stirring rod is fixedly installed on the side wall of the suspension rod. The drug is stirred through the suspension rod and the stirring rod. There are multiple outer rings on the side wall of the stirring rod. The side wall of the outer ring is arc-shaped, reducing the resistance received by the outer ring. By the outer ring, the activity range of the drug at the bottom is increased, achieving the effect of improving the evaporation efficiency. The above-mentioned prior art solutions have the following deficiencies: during the use of the separation and purification device, separation and purification are carried out through heating. Since the internal impurities of different drugs are different, the treatment methods and the obtained results are also different. For example, tepotinib, a small molecule MET kinase inhibitor used to treat non-small cell lung cancer carrying MET gene alterations, the solid residues at the bottom are collected by distillation during the purification process. The direct distillation method will cause some impurities to accumulate at the bottom together with the solid raw materials of tepotinib, making it difficult to achieve the purpose of impurity separation and purification. Therefore, it is necessary to design a separation and purification device for drug impurities to solve the above problems. Summary of the Utility Model

[0003] The purpose of the utility model is to provide a separation and purification device for drug impurities to solve the problem proposed in the above background art that the direct mixing and distillation method will cause some impurities to accumulate at the bottom together with the drug solid raw materials, making it difficult to achieve the purpose of impurity separation and purification.

[0004] To achieve the above object, the present utility model provides the following technical solutions: A separation and purification device for drug impurities, comprising a separation box. An installation groove is opened inside the separation box, and a heating plate is installed inside the installation groove. A connection port is opened at the top of the separation box. A pretreatment box is provided at the top of the separation box. A stirring mechanism is provided at the top inside the pretreatment box. Mixing grooves and filtration grooves are respectively provided at both ends inside the pretreatment box. A feeding groove is provided inside the pretreatment box. The mixing groove is communicated with the inside of the filtration groove through the feeding groove. A solenoid valve is provided inside the feeding groove. A filtration component is provided inside the filtration groove. The inside of the filtration groove is communicated with the inside of the connection port. A discharge port is provided at the bottom on one side of the separation box, and a sealing door is provided at one end of the discharge port. The discharge port is located below the heating plate. An air outlet is provided at the top on one side of the separation box. A connecting pipe is fixedly connected to one side of the separation box, and the connecting pipe is communicated with the inside of the separation box through the air outlet. A collection box is provided on one side of the separation box, and the collection box is located below the connecting pipe. The inside of the collection box is communicated with the inside of the connecting pipe. A condensing pipe is provided inside the collection box. A feeding port is provided at the top of the pretreatment box. A liquid inlet pipe is provided at the top on one side of the pretreatment box. A receiving groove is provided on the side of the separation box away from the discharge port, and an electric telescopic rod is fixed inside the receiving groove. The telescopic end of the electric telescopic rod is fixedly connected with a push plate, and the bottom end of the push plate is in contact with the bottom end inside the separation box. A control panel is provided at one end of the separation box.

[0005] Preferably, the stirring mechanism includes a rotating shaft provided at the top inside the pretreatment box. Connecting rods are fixed on the outer side of the rotating shaft, and scraping plates are fixed on the outer side of the connecting rods. Stirring rods are fixed on the outer side of the connecting rods. A driving motor is provided at the top of the pretreatment box, and the output shaft of the driving motor is fixedly connected with the rotating shaft.

[0006] Preferably, the outer sides of the scraping plates are all in contact with the inner wall of the mixing groove, and the cross-section of the scraping plates is triangular.

[0007] Preferably, the filtration component includes an installation frame slidably connected inside the filtration groove. A sealing plate is fixed on one side of the installation frame, and the side of the sealing plate is in contact with the outer wall of the pretreatment box. A moving groove is provided inside the installation frame, and a spring is fixed at the bottom end inside the moving groove. A filtration frame is fixed at the top of the spring, and the outer wall of the filtration frame is in contact with the inner wall of the moving groove.

[0008] Preferably, through holes are provided inside the filtration frame. A limiting rod is fixedly connected inside the moving groove, and the limiting rod penetrates through the through hole and the inside of the spring.

[0009] Preferably, a diversion plate A is fixed to the bottom end of the filter box, and the cross-section of the diversion plate A is inclined, and the diversion plate A is symmetrically arranged about the central axis of the filter box.

[0010] Preferably, a diversion plate B is fixed to the top end inside the separation box, and the cross-section of the diversion plate B is inclined. A connecting column is fixed to one side of the diversion plate B, and the side of the connecting column away from the diversion plate B is fixedly connected to the inner wall of the separation box. The higher side of the diversion plate B is located above the air outlet.

[0011] Adopting the technical solution provided by the present utility model, compared with the prior art, it has the following beneficial effects: By pre-treating the mixed solution, through the stirring mechanism, the drug raw materials and the solution are mixed to accelerate the mixing speed and improve the mixing efficiency. After the solution and the drug raw materials are mixed evenly, the solenoid valve is used to open the blanking groove, so that the mixed solvent enters the inside of the filter tank. The mixed solution is filtered through the filter assembly to separate the impurities in the solution in advance, which is convenient for the subsequent purification operation of the drug; Under the guiding action of the diversion plate B, the vapor enters the inside of the collection box through the air outlet for condensation, which is convenient for collecting the liquid. The solid crystals precipitated from the remaining mixed solution are pushed out of the discharge port by the push plate through the electric telescopic rod. Whether the drug is finally collected in a liquid form or in a solid crystal form can be carried out. Description of the Drawings

[0012] In order to more clearly illustrate the technical solutions in the embodiments of the present utility model or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the following drawings are some embodiments of the present utility model. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0013] Figure 1 It is a front-sectional structure diagram of the present utility model;

[0014] Figure 2 It is a three-dimensional structure diagram of the stirring mechanism of the present utility model;

[0015] Figure 3 It is a front-sectional three-dimensional structure diagram of the filter assembly of the present utility model;

[0016] Figure 4 It is a three-dimensional structure diagram of the separation box of the present utility model.

[0017] Description of the reference numerals in the figures: 1. Stirring mechanism; 101. Driving motor; 102. Rotating shaft; 103. Scraper; 104. Stirring rod; 105. Connecting rod; 2. Pretreatment tank; 3. Mixing tank; 4. Feeding chute; 5. Filter assembly; 501. Installation frame; 502. Moving groove; 503. Spring; 504. Limiting rod; 505. Filter frame; 506. Deflector A; 507. Sealing plate; 6. Filter tank; 7. Separation tank; 8. Connecting column; 9. Heating plate; 10. Sealing door; 11. Pushing plate; 12. Electric telescopic rod; 13. Collection box; 14. Condensing pipe; 15. Connecting pipe; 16. Deflector B; 17. Solenoid valve; 18. Connecting port; 19. Control panel. Detailed implementation manners

[0018] To make the objectives, technical solutions and advantages of the embodiments of the present utility model clearer, the technical solutions in the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model. Apparently, the described embodiments are some, but not all, of the embodiments of the present utility model. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present utility model without creative efforts shall fall within the protection scope of the present utility model.

[0019] Please refer to Figures 1-4 , an embodiment provided by the present utility model: A device for separating and purifying drug impurities, comprising a separation tank 7. An installation groove is formed inside the separation tank 7, and a heating plate 9 is installed inside the installation groove. A connecting port 18 is formed at the top of the separation tank 7. A pretreatment tank 2 is arranged at the top of the separation tank 7. A stirring mechanism 1 is arranged at the top inside the pretreatment tank 2; The stirring mechanism 1 includes a rotating shaft 102 arranged at the top inside the pretreatment tank 2. A connecting rod 105 is fixed to the outer side of the rotating shaft 102, and a scraper 103 is fixed to the outer side of the connecting rod 105. Stirring rods 104 are fixed to the outer sides of the connecting rods 105. A driving motor 101 is arranged at the top of the pretreatment tank 2, and the output shaft of the driving motor 101 is fixedly connected to the rotating shaft 102; The outer sides of the scrapers 103 are all in contact with the inner wall of the mixing tank 3, and the cross-section of the scraper 103 is triangular; Specifically, as Figure 1 and Figure 2As shown in the figure, the stirring mechanism 1 is used to mix the drug raw materials and the solution, accelerating the mixing speed and improving the mixing efficiency. At both ends inside the pretreatment tank 2, a mixing tank 3 and a filtering tank 6 are respectively arranged. Inside the pretreatment tank 2, a feeding chute 4 is arranged. The mixing tank 3 is connected to the inside of the filtering tank 6 through the feeding chute 4. An electromagnetic valve 17 is arranged inside the feeding chute 4, and a filtering component 5 is arranged inside the filtering tank 6. The filtering component 5 includes a mounting frame 501 slidably connected inside the filtering tank 6. One side of the mounting frame 501 is fixed with a sealing plate 507, and one side of the sealing plate 507 is in contact with the outer wall of the pretreatment tank 2. A moving groove 502 is arranged inside the mounting frame 501, and a spring 503 is fixed at the bottom end inside the moving groove 502. The top end of the spring 503 is fixed with a filtering frame 505, and the outer wall of the filtering frame 505 is in contact with the inner wall of the moving groove 502. Through holes are arranged inside the filtering frame 505. A limiting rod 504 is fixedly connected inside the moving groove 502, and the limiting rod 504 passes through the through holes and into the inside of the spring 503. A diversion plate A506 is fixed at the bottom end of the filtering frame 505, and the cross-section of the diversion plate A506 is arranged in an inclined shape. The diversion plate A506 is symmetrically arranged about the central axis of the filtering frame 505. Specifically, as Figure 1 and Figure 3 shown, the filtering component 5 filters the mixed liquid, separating the impurities in the solution in advance, which is convenient for the later purification operation of the drug. The inside of the filtering tank 6 is connected to the inside of the connection port 18. At the bottom of one side of the separation tank 7, there is a discharge port, and one end of the discharge port is provided with a sealing door 10. The discharge port is located below the heating plate 9. At the top of one side of the separation tank 7, there is an air outlet. At the top inside the separation tank 7, a diversion plate B16 is fixed. The cross-section of the diversion plate B16 is arranged in an inclined shape. One side of the diversion plate B16 is fixed with a connecting column 8, and the side of the connecting column 8 away from the diversion plate B16 is fixedly connected to the inner wall of the separation tank 7. The higher side of the diversion plate B16 is located above the air outlet. Specifically, as Figure 1 shown, through the diversion plate B16, not only can the filtered mixed liquid be diverted, but also the steam can be diverted. One side of the separation tank 7 is fixedly connected with a connecting pipe 15, and the connecting pipe 15 is connected to the inside of the separation tank 7 through the air outlet. A collection tank 13 is arranged on one side of the separation tank 7, and the collection tank 13 is located below the connecting pipe 15. The inside of the collection tank 13 is connected to the inside of the connecting pipe 15. A condensing pipe 14 is arranged inside the collection tank 13. At the top of the pretreatment tank 2, there is a feeding port. At the top of one side of the pretreatment tank 2, there is a liquid inlet pipe. On the side of the separation tank 7 away from the discharge port, there is a receiving groove, and an electric telescopic rod 12 is fixed inside the receiving groove. The telescopic end of the electric telescopic rod 12 is fixedly connected with a push plate 11, and the bottom end of the push plate 11 is in contact with the bottom end inside the separation tank 7. A control panel 19 is arranged at one end of the separation tank 7.

[0020] Working principle: When in use, when it is necessary to separate and purify the impurities in the medicine, after closing the feeding chute 4 by controlling the solenoid valve 17 through the control panel 19, the medicine raw materials are added into the interior of the pretreatment tank 2 through the feeding seat, and the matching solution is introduced through the liquid inlet pipe. Then, the driving motor 101 is started to drive the rotating shaft 102 to rotate, and the medicine raw materials are stirred through the stirring rod 104 and the connecting rod 105 to improve the mixing efficiency of the medicine raw materials and the solution. After the solution and the medicine raw materials are mixed evenly, the solenoid valve 17 is opened to allow the mixed solvent to enter the interior of the filtering tank 6, and the mixed liquid is filtered through the filtering frame 505, so that the impurities in the medicine raw materials are separated from the mixed liquid. Under the elastic telescopic action of the spring 503, the filtering frame 505 vibrates up and down, to a certain extent avoiding the situation of blockage of the filtering frame 505. The filtered mixed liquid enters the interior of the separation tank 7, and by starting the heating plate 9, the mixed liquid is purified. The vapor, under the guiding action of the guiding plate B16, enters the interior of the collection tank 13 through the air outlet and the connecting pipe 15, and is condensed by the condenser pipe 14 to facilitate the collection of the liquid. The solid crystals precipitated from the remaining mixed liquid are pushed out of the discharge port by starting the electric telescopic rod 12 and the push plate 11. For the whole device, by filtering in advance through the pretreatment tank 2, the purity of the subsequent solid-liquid separation is improved. Whether the medicine is finally collected in a liquid form or in a solid crystal form can be achieved, effectively improving the quality of the separation and purification of medicine impurities.

[0021] In the description of the present utility model, it should be noted that unless otherwise clearly defined and limited, the terms "installed", "connected" and "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present utility model can be understood according to specific situations.

[0022] The device embodiments described above are only illustrative. The units described as separation components may or may not be physically separated, and the components shown as units may or may not be physical units, that is, they can be located in one place or distributed to multiple network units. Some or all of the modules can be selected according to actual needs to achieve the purpose of the solution of this embodiment. Those of ordinary skill in the art can understand and implement it without creative labor.

[0023] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements on some of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the various embodiments of the present invention.

Claims

1. A device for separating and purifying drug impurities, comprising a separation box (7), characterized in that: The separation box (7) is provided with an installation groove inside, and a heating plate (9) is installed inside the installation groove. The top of the separation box (7) is provided with a connection port (18). The top of the separation box (7) is provided with a pretreatment box (2). The top of the pretreatment box (2) is provided with a stirring mechanism (1). The two ends of the pretreatment box (2) are provided with a mixing tank (3) and a filter tank (6) respectively. The pretreatment box (2) is provided with a feed trough (4). The mixing tank (3) is connected to the inside of the filter tank (6) through the feed trough (4). The feed trough (4) is provided with a solenoid valve (17). The filter tank (6) is provided with a filter assembly (5). The inside of the filter tank (6) is connected to the inside of the connection port (18). A discharge port is provided at the bottom of one side of the separation box (7), and a sealing door (10) is provided at one end of the discharge port. The discharge port is located below the heating plate (9). An air outlet is provided at the top of one side of the box (7); a connecting pipe (15) is fixedly connected to one side of the separation box (7), and the connecting pipe (15) is connected to the interior of the separation box (7) through the air outlet; a collecting box (13) is provided at one side of the separation box (7), and the collecting box (13) is located below the connecting pipe (15); the interior of the collecting box (13) is connected to the interior of the connecting pipe (15); a condensing pipe (14) is provided inside the collecting box (13); a feed port is provided at the top of the pretreatment box (2); a liquid inlet pipe is provided at the top of one side of the pretreatment box (2); a receiving groove is provided at the side of the separation box (7) away from the discharge port, and an electric telescopic rod (12) is fixed inside the receiving groove; the telescopic end of the electric telescopic rod (12) is fixedly connected to a push plate (11), and the bottom end of the push plate (11) is in contact with the bottom end of the interior of the separation box (7); and a control panel (19) is provided at one end of the separation box (7).

2. The device for separating and purifying drug impurities according to claim 1, characterized in that: The stirring mechanism (1) comprises a rotating shaft (102) arranged at the top end of the pretreatment box (2), a connecting rod (105) is fixed on the outside of the rotating shaft (102), a scraper (103) is fixed on the outside of the connecting rod (105), and a stirring rod (104) is fixed on the outside of the connecting rod (105). A driving motor (101) is arranged at the top end of the pretreatment box (2), and the output shaft of the driving motor (101) is fixedly connected to the rotating shaft (102).

3. The device for separating and purifying drug impurities according to claim 2, characterized in that: The outer sides of the scrapers (103) are in contact with the inner wall of the mixing tank (3), and the cross-section of the scrapers (103) is arranged in a triangular shape.

4. The device for separating and purifying drug impurities according to claim 1, characterized in that: The filter assembly (5) comprises a mounting frame (501) slidably connected to the inside of the filter tank (6); a sealing plate (507) is fixed to one side of the mounting frame (501), and one side of the sealing plate (507) is in contact with the outer wall of the pretreatment box (2); a movable groove (502) is provided inside the mounting frame (501), and a spring (503) is fixed to the bottom end of the movable groove (502); a filter frame (505) is fixed to the top end of the spring (503), and the outer wall of the filter frame (505) is in contact with the inner wall of the movable groove (502).

5. The device for separating and purifying drug impurities according to claim 4, characterized in that: A through hole is provided inside the filter frame (505), a limiting rod (504) is fixedly connected inside the movable groove (502), and the limiting rod (504) passes through the through hole and the inside of the spring (503).

6. The device for separating and purifying drug impurities according to claim 4, characterized in that: A guide plate A (506) is fixed to the bottom end of the filter frame (505), and the cross-section of the guide plate A (506) is arranged in an inclined shape. The guide plate A (506) is symmetrically arranged with respect to the central axis of the filter frame (505).

7. The device for separating and purifying drug impurities according to claim 1, characterized in that: A guide plate B (16) is fixed to the top of the interior of the separation box (7), and the cross-section of the guide plate B (16) is arranged in an inclined shape. A connecting column (8) is fixed to one side of the guide plate B (16), and the side of the connecting column (8) away from the guide plate B (16) is fixedly connected to the inner wall of the separation box (7), and the higher side of the guide plate B (16) is located above the air outlet.

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