Cell filtering connector of injector
By designing a cell filtration linker in the syringe and filtration of the drug solution using a screen, the problem that conventional syringes cannot filter cell clumps is solved, and the safety and effectiveness of cell therapy drug administration is improved.
Patent Information
- Application Number
- CN202421710322.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-07-18
- Publication Date
- 2025-06-13
- Estimated Expiration
- 2034-07-18
AI Technical Summary
During the administration of cell therapy drugs, conventional syringes lack filtration function, resulting in cell clumps entering mice, which may lead to embolization and unknown death.
A syringe cell filtration connector is designed, including a housing and a conversion valve, the housing has a liquid inlet and a liquid outlet hole, and a first and second pipes are provided in the conversion valve, respectively, and the second screen is used to realize the secondary filtration of the drug liquid.
Through the use of filtration linkers, cells can be effectively filtered to treat cell clumps in the drug solution, reduce the risk of embolization, and improve the safety and effectiveness of administration.
Smart Images

Figure CN222968696U_ABST
Abstract
Description
Technical Field
[0001] The utility model belongs to the field of injection devices, and particularly relates to a syringe cell filtration adapter. Background Art
[0002] Before the formal clinical trial of cell therapy drugs, safety evaluation is required, and animal experiments are particularly important. Taking the common mouse experiment as an example, intravenous administration is required. In conventional experiments, a common syringe is used to directly aspirate the cell drug suspension and inject it into the mouse. However, since the cells in the cell therapy drug are prone to cell aggregation during transportation and storage, the conventional syringe has a relatively large needle hole and no filtering function. During drug administration, these cell clumps directly enter the mouse body, which may cause embolism and then lead to the unknown death of the mouse due to factors other than the cell drug. Based on the disadvantages of traditional syringes for cell drug administration, it is urgent to improve the injection device. Content of the Utility Model
[0003] In view of the problems existing in the above-mentioned prior art, the utility model provides a syringe cell filtration adapter. The technical problem to be solved by the utility model is that the filtration adapter is installed between the syringe and the needle, and the filtration of cell therapy liquid medicine or ordinary liquid medicine is realized through the filtration adapter.
[0004] To achieve the above object, the utility model adopts the following technical solutions:
[0005] A syringe cell filtration adapter includes: a housing and a switching valve. The housing is of a barrel structure and has a liquid inlet hole and a liquid outlet hole. The switching valve has a first pipeline and a second pipeline inside. One end of the first pipeline is provided with a first screen, and the other end of the first pipeline is provided with a second screen. The switching valve is hermetically connected to the housing, and the switching valve rotates along the central axis of the housing.
[0006] Further, the housing is further provided with a rotation limit card, which is located at the bottom of the housing. There is a round hole in the middle of the bottom of the housing. Through the round hole, the switching valve is connected to the rotation limit card, and the rotation limit card rotates synchronously with the switching valve.
[0007] Further, the bottom of the housing has a fan-shaped groove, which is engaged with the rotation limit card. The projection of the central connection line between the liquid inlet hole and the liquid outlet hole on the bottom of the housing coincides with one side of the fan-shaped groove, and the fan-shaped angle of the fan-shaped groove is 90°.
[0008] Further, the first screen has a preset first aperture, and the second screen has a preset second aperture, and the first aperture is larger than the second aperture.
[0009] Further, the central axes of the liquid inlet hole and the liquid outlet hole coincide. The housing is provided with a first identifier, which is respectively located on one side of the liquid outlet hole and at a position 90° deviated from the liquid outlet hole in the direction of the liquid inlet hole. The upper surface of the switching valve is provided with a second identifier.
[0010] Further, both the first identifier and the second identifier include one or more combinations of letters, characters, shapes, and symbols.
[0011] Further, the first identifier is a letter, and the second identifier is a triangular arrow with the arrow pointing in the circumferential direction.
[0012] Further, the end of the first pipeline provided with the first screen has the same height and size as the liquid inlet hole; the end of the first pipeline provided with the second screen has the same height and size as the liquid outlet hole;
[0013] One end of the second pipeline has the same height and size as the liquid inlet hole, and one end of the second pipeline has the same height and size as the liquid outlet hole.
[0014] Further, the housing includes a barrel wall, a liquid inlet pipe, and a liquid outlet pipe. The liquid inlet pipe and the liquid outlet pipe are both connected to the barrel wall. The central axes of the liquid inlet pipe and the liquid outlet pipe coincide. The liquid inlet hole is located at the exposed end of the liquid inlet pipe, and the liquid outlet hole is located at the exposed end of the liquid outlet pipe;
[0015] Both the liquid inlet pipe and the liquid outlet pipe have a taper. The liquid inlet pipe is connected to a syringe, and the liquid outlet pipe is connected to a needle. The diameters of the liquid inlet pipe and the liquid outlet pipe gradually decrease from the end where the liquid inlet pipe is connected to the syringe to the end where the liquid outlet pipe is connected to the needle.
[0016] Further, the first pipeline and the second pipeline are perpendicular to each other and communicate with each other.
[0017] The principle of the present utility model is as follows:
[0018] 1. During use, connect the syringe to the liquid inlet pipe and the needle to the liquid outlet pipe;
[0019] 2. Twist the rotary handle so that the second pipeline in the switching valve communicates with the liquid inlet hole and the liquid outlet hole respectively, and suck the cell therapy liquid medicine or the ordinary liquid medicine;
[0020] 3. Twist the rotary handle again so that the first pipeline in the switching valve communicates with the liquid inlet hole and the liquid outlet hole respectively. Push the piston of the syringe, and the cell therapy liquid medicine or the ordinary liquid medicine in the syringe passes through the two-stage filtration of the first screen and the second screen via the liquid inlet pipe, the liquid inlet hole, the first screen, the first pipeline, the second screen, the liquid outlet hole, the liquid outlet pipe, and the needle, and is injected into the recipient's body.
[0021] Compared with the prior art, the utility model has the following beneficial effects:
[0022] 1. The filter joint is installed between the syringe and the needle, and the filtration of cell therapy liquid medicine or ordinary liquid medicine is realized through the filter joint;
[0023] 2. Through the rotation limit card, the rotation angle of the switching valve is limited to avoid the first pipeline being inverted, so that the second screen is connected to the liquid inlet hole and the first screen is connected to the liquid outlet hole;
[0024] 3. The first aperture of the first screen is larger than the second aperture of the second screen, realizing two-stage filtration;
[0025] 4. The switching valve has a first pipeline and a second pipeline. Through the switching of the switching valve, the suction of liquid medicine does not require filtration, and the filtration link only exists when injecting liquid medicine. BRIEF DESCRIPTION OF THE DRAWINGS
[0026] Figure 1 is a schematic diagram of the overall structure of a syringe cell filter joint of the utility model;
[0027] Figure 2 is a perspective view of a syringe cell filter joint of the utility model;
[0028] Figure 3 is a top view of the switching valve of a syringe cell filter joint of the utility model;
[0029] Figure 4 is a top view of the housing of a syringe cell filter joint of the utility model, where A and B in the figure are a kind of marks.
[0030] The list of components represented by each label in the figure is as follows:
[0031] 1 - housing, 2 - switching valve, 3 - rotation limit card, 4 - liquid inlet hole, 5 - liquid outlet hole, 6 - first screen, 7 - second screen, 8 - first mark, 9 - second mark, 10 - rotation handle, 11 - barrel wall, 12 - liquid inlet pipe, 13 - liquid outlet pipe, 14 - fan-shaped groove. DETAILED DESCRIPTION OF THE EMBODIMENTS
[0032] The technical solutions of the utility model will be described clearly and completely below with reference to the accompanying drawings.
[0033] Embodiment 1
[0034] As shown in the attached Figures 1-4 figure, the following technical solutions are provided in this embodiment:
[0035] A syringe cell filtration adapter, comprising: a housing 1 and a switching valve 2, wherein the housing 1 is of a barrel structure, the housing 1 has a liquid inlet hole 4 and a liquid outlet hole 5, the switching valve 2 has a first pipeline and a second pipeline therein, one end of the first pipeline is provided with a first screen 6, the other end of the first pipeline is provided with a second screen 7, the switching valve 2 is sealingly connected to the housing 1, and the switching valve 2 rotates along the central axis of the housing 1.
[0036] Further, the first screen 6 has a preset first pore diameter, the second screen 7 has a preset second pore diameter, and the first pore diameter is larger than the second pore diameter.
[0037] Further, the central axes of the liquid inlet hole 4 and the liquid outlet hole 5 coincide, the housing 1 is provided with a first mark 8, the first mark 8 is respectively on one side of the liquid outlet hole 5 and at a position 90° deviated from the liquid outlet hole 5 in the direction of the liquid inlet hole 6, and the upper surface of the switching valve 2 is provided with a second mark 9.
[0038] Further, the switching valve 2 is further provided with a rotating handle 10, the rotating handle 10 is parallel to the second pipeline, and the connection line between the second mark 9 and the center of the upper surface of the switching valve 2 is perpendicular to the rotating handle 10.
[0039] Further, both the first mark 8 and the second mark 9 include one or more combinations of letters, characters, shapes, and symbols.
[0040] Further, the first mark 8 is a letter, and the second mark 9 is a triangular arrow with the arrow pointing in the circumferential direction.
[0041] Further, the end of the first pipeline provided with the first screen 6 is the same in height and size as the liquid inlet hole 4; the end of the first pipeline provided with the second screen 7 is the same in height and size as the liquid outlet hole 5;
[0042] One end of the second pipeline is the same in height and size as the liquid inlet hole 4, and one end of the second pipeline is the same in height and size as the liquid outlet hole 5.
[0043] Further, the housing 1 includes a barrel wall 11, a liquid inlet pipe 12, and a liquid outlet pipe 13. The liquid inlet pipe 12 and the liquid outlet pipe 13 are both connected to the barrel wall 11. The central axes of the liquid inlet pipe 12 and the liquid outlet pipe 13 coincide. The liquid inlet hole 4 is located at the exposed end of the liquid inlet pipe 12, and the liquid outlet hole 5 is located at the exposed end of the liquid outlet pipe 13;
[0044] The liquid inlet pipe 12 and the liquid outlet pipe 13 both have a taper. The liquid inlet pipe 12 is connected to a syringe, and the liquid outlet pipe 13 is connected to a needle. The diameters of the liquid inlet pipe 12 and the liquid outlet pipe 13 gradually decrease from the end where the liquid inlet pipe 12 is connected to the syringe to the end where the liquid outlet pipe 13 is connected to the needle. Through the change in diameter, the pressure on the needle side during injection is increased.
[0045] Furthermore, the first pipe and the second pipe are perpendicular to each other and communicate with each other.
[0046] Embodiment 2
[0047] The difference from Embodiment 1 is that in this embodiment, the housing further includes a rotation limit card 3. The rotation limit card 3 is located at the bottom of the housing 1. There is a circular hole in the middle of the bottom of the housing 1. Through the circular hole, the switching valve 2 is connected to the rotation limit card 3, and the rotation limit card 3 rotates synchronously with the switching valve 2.
[0048] In some preferred embodiments of this embodiment, the bottom of the housing 1 has a fan-shaped groove 14. The fan-shaped groove 14 engages with the rotation limit card 3. The projection of the central connection line between the liquid inlet hole 4 and the liquid outlet hole 5 on the bottom of the housing 1 coincides with one side of the fan-shaped groove 14, and the fan angle of the fan-shaped groove 14 is 90°.
[0049] Through the rotation limit card 3, the rotation angle of the switching valve 2 is restricted, avoiding the situation where the first pipe is inverted and the second screen 7 is connected to the liquid inlet hole 4 while the first screen 6 is connected to the liquid outlet hole 5.
[0050] The above are only the preferred embodiments of the present utility model and are not used to limit the present utility model. For those skilled in the art, the present utility model can have various modifications and changes. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present utility model are included in the protection scope of the present utility model.
Claims
1. A syringe cell filtration connector, characterized in that: include: A shell and a conversion valve, wherein the shell is a barrel-shaped structure, the shell has a liquid inlet hole and a liquid outlet hole, the conversion valve has a first pipe and a second pipe inside, a first screen is arranged at one end of the first pipe, and a second screen is arranged at the other end of the first pipe, the conversion valve is sealed and connected to the shell, and the conversion valve rotates along the central axis of the shell.
2. The syringe cell filtration connector according to claim 1, characterized in that The shell is also provided with a rotation limit card, which is located at the bottom of the shell. A circular hole is provided in the middle of the bottom of the shell. The conversion valve is connected to the rotation limit card through the circular hole, and the rotation limit card rotates synchronously with the conversion valve.
3. The syringe cell filtration connector according to claim 2, characterized in that The shell bottom has a fan-shaped groove, which is engaged with the rotation limit card. The projection of the center connecting line of the liquid inlet and the liquid outlet on the shell bottom coincides with one side of the fan-shaped groove, and the fan angle of the fan-shaped groove is 90°.
4. The syringe cell filtration connector according to claim 1, characterized in that The first screen has a preset first aperture, and the second screen has a preset second aperture, and the first aperture is larger than the second aperture.
5. The syringe cell filtration connector according to claim 1, characterized in that The central axes of the liquid inlet and the liquid outlet coincide with each other, the shell is provided with a first mark, the first mark is respectively located on one side of the liquid outlet and at a position where the liquid outlet deviates 90° from the liquid inlet, and the upper surface of the conversion valve is provided with a second mark.
6. The syringe cell filtration connector according to claim 5, characterized in that The first identification and the second identification both include one or more combinations of letters, words, shapes, and symbols.
7. The syringe cell filtration connector according to claim 6, characterized in that The first mark is a letter, and the second mark is a triangular arrow, with the arrow pointing in the circumferential direction.
8. The syringe cell filtration connector according to claim 1, characterized in that The height and size of one end of the first pipe provided with the first screen are consistent with the liquid inlet hole; the height and size of one end of the first pipe provided with the second screen are consistent with the liquid outlet hole; One end of the second pipe is consistent with the height and size of the liquid inlet hole, and one end of the second pipe is consistent with the height and size of the liquid outlet hole.
9. The syringe cell filtration connector according to claim 1, characterized in that: The shell comprises a barrel wall, a liquid inlet pipe and a liquid outlet pipe, the liquid inlet pipe and the liquid outlet pipe are both connected to the barrel wall, the central axes of the liquid inlet pipe and the liquid outlet pipe coincide, the liquid inlet hole is located at the exposed end of the liquid inlet pipe, and the liquid outlet hole is located at the exposed end of the liquid outlet pipe; The liquid inlet tube and the liquid outlet tube both have a taper, the liquid inlet tube is connected to the syringe, and the liquid outlet tube is connected to the needle. The diameters of the liquid inlet tube and the liquid outlet tube decrease successively from the end where the liquid inlet tube is connected to the syringe to the end where the liquid outlet tube is connected to the needle.
10. The syringe cell filtration connector according to claim 1, characterized in that The first pipeline and the second pipeline are perpendicular to each other and communicated with each other.