High-voltage sine wave generating circuit and PFA high-voltage pulse ablation system

Abstract

The utility model discloses a high-voltage sine wave generating circuit and a PFA high-voltage pulse ablation system. The high-voltage sine wave generating circuit comprises a digital control module and more than two sine wave generating modules. The sine wave generation module comprises a sine wave generation assembly which is connected with a voltage input end and is used for generating pulses and generating sine waves by using the generated pulses; the output isolation assembly is connected with the output end of the sine wave generation assembly and used for voltage isolation and sine wave output; the digital control module controls the frequency of sine waves generated by the sine wave generation assembly. The output isolation assemblies of the more than two sine wave generation modules are connected in series to superpose generated sine waves, and high-voltage sine waves are obtained. The sine wave is generated under the low input voltage, the frequency and the amplitude of the sine wave are controlled and adjusted, the requirements of the high-voltage pulse ablation system for the ablation voltage, the ablation power and the working frequency are met, and the stable and safe ablation voltage is provided for the high-voltage pulse ablation system.

Description

Technical Field

[0001] The present application relates to the field of electronic circuits, and particularly to a high-voltage sine wave generating circuit and a PFA high-voltage pulse ablation system. Background Art

[0002] Cardiac atrial fibrillation ablation technology ablates myocardial cells in a specific area to destroy abnormal electrical conduction pathways, thereby treating arrhythmias such as atrial fibrillation.

[0003] In a pulsed field ablation (PFA) high-voltage pulse ablation system, there is a problem that abnormal electrical conduction pathways cannot be completely destroyed, resulting in incomplete ablation. In a period of time after ablation, the myocardial tissue that has not been completely destroyed may undergo a repair and remodeling process; during this process, new abnormal electrical conduction pathways may form, leading to recurrence of arrhythmias. In addition, during the ablation process, the contraction or fibrillation of muscles will cause the position of the ablation needle or electrode to change, thereby affecting the accuracy and efficiency of ablation, and also affecting the comfort of the patient and increasing the risk during the operation.

[0004] In an existing PFA high-voltage pulse ablation system, the circuit used to control the generation of ablation voltage has a low input voltage for the protection of patients and cannot generate a high ablation voltage to effectively destroy abnormal pathways during the treatment course, and it is difficult to avoid the risk caused by incomplete ablation during the ablation treatment process; in addition, the circuit for generating ablation voltage is affected by problems such as high-power consumption components and circuit aging, and its output voltage is prone to generate more harmonic components, which will affect the muscle tissue at the ablation site of the patient to varying degrees, causing muscle fibrillation in the patient during treatment and resulting in reduced treatment efficiency.

[0005] Therefore, there is a need to provide a voltage generating circuit for an existing PFA high-voltage pulse ablation system that can stably output an ablation voltage with a high voltage value and a low harmonic content. Summary of the Utility Model

[0006] To solve the problems in the prior art, the present application provides a high-voltage sine wave generating circuit and a PFA high-voltage pulse ablation system for providing a stable and adjustable high-voltage sine wave. The technical solution of the present application is as follows:

[0007] A high-voltage sine wave generating circuit, characterized by comprising:

[0008] A digital control module;

[0009] Two or more sine wave generating modules;

[0010] Wherein, the sine wave generating module comprises:

[0011] A sine wave generating component, which is connected to a voltage input terminal, is used to generate pulses and generate a sine wave using the generated pulses; an output isolation component, the input terminal of which is connected to the output terminal of the sine wave generating component, is used for voltage isolation and outputting a sine wave;

[0012] The digital control module controls the frequency of the pulses generated by the sine wave generating component;

[0013] The output terminals of the output isolation components of two or more of the sine wave generating modules are connected in series to output a sine wave.

[0014] According to an embodiment of the present application, the sine wave generating component includes a driving chip, a first switch, a second switch, an inductor group L1, and a capacitor group C1;

[0015] The first switch is connected to the voltage input terminal, and the second switch is connected in series with the first switch and grounded;

[0016] The inductor group L1 and the capacitor group C1 are connected in series and the whole is connected in parallel with the second switch;

[0017] Wherein, the digital control module can independently control the on-off of the first switch and the second switch through the driving chip.

[0018] According to an embodiment of the present application, the inductor group L1 is one inductor or multiple inductors connected in parallel; and / or,

[0019] The capacitor group C1 is one capacitor unit or multiple capacitor units connected in series, and each capacitor unit includes one capacitor or multiple capacitors connected in parallel.

[0020] According to an embodiment of the present application, at least one of the sine wave generating modules further includes:

[0021] An oscillation detection component, which includes: a voltage comparator, a resistor R1, a resistor R2, and an inductor L sn 1;

[0022] One end of the resistor R1 is connected in series with the resistor R2 and grounded, and the other end of the resistor R1 is connected to the first end of the inductor L sn 1;

[0023] The inductor L sn 1 is connected to the capacitor group C1, and the second end of the inductor L sn 1 is grounded;

[0024] The positive input terminal of the voltage comparator is connected between the resistor R1 and the resistor R2;

[0025] The inverting input terminal of the voltage comparator is connected to the second terminal of the inductor L sn 1; and

[0026] The output terminal of the voltage comparator is connected to the digital control module.

[0027] According to an embodiment of the present application, the output isolation component includes:

[0028] A transformer T1, the primary coil of the transformer T1 is connected in parallel with the capacitor bank C1, and both ends of the secondary coil of the transformer T1 are the output terminals of the output isolation component.

[0029] According to an embodiment of the present application, the output isolation component further includes:

[0030] Capacitors C2 and C3, the capacitor C2, the primary coil of the transformer T1, and the capacitor C3 are connected in series in sequence, and the whole is connected in parallel with the capacitor bank C1.

[0031] According to an embodiment of the present application, it further includes an output detection module, and the output detection module detects the voltage, current, and / or power of the sine wave output after the output isolation components are connected in series.

[0032] According to an embodiment of the present application, the output detection module includes:

[0033] A voltage detection component, and the digital control module detects the output voltage of the high-voltage sine wave generation circuit through the voltage detection component;

[0034] A current detection component, and the digital control module detects the output current of the high-voltage sine wave generation circuit through the current detection component;

[0035] A power detection component, and the digital control module detects the output power of the high-voltage sine wave generation circuit through the power detection component.

[0036] According to an embodiment of the present application, it further includes a balance module, and the digital control module controls the connection mode of the sine wave generation components through the balance module to make the sine waves generated by the sine wave generation components consistent.

[0037] According to an embodiment of the present application, the input terminals of the balance module are respectively connected between the inductor bank L1 and the capacitor bank C1 of each sine wave generation component, and the output terminal of the balance module is electrically connected to the digital control module.

[0038] According to an embodiment of the present application, it further includes an input voltage regulation module, and the input voltage regulation module controls the input voltage of the voltage input terminal.

[0039] According to an embodiment of the present application, the input voltage regulation module includes:

[0040] A buck-boost component, the buck-boost component including more than two buck-boost units; and

[0041] A regulation component, the regulation component changing the input voltage of the voltage input end by adjusting the connection mode of the output ends of more than two of the buck-boost units.

[0042] According to an embodiment of the present application, the buck-boost component includes a first buck-boost unit T2 and a second buck-boost unit T3. The input ends of the first buck-boost unit T2 and the second buck-boost unit T3 are respectively connected to a power supply and are used for boosting or bucking the voltage;

[0043] The regulation component includes a third switch and a fourth switch. The third switch and the fourth switch change the input voltage of the voltage input end by adjusting the connection mode of the output ends of the first buck-boost unit T2 and the second buck-boost unit T3.

[0044] According to an embodiment of the present application, the digital control module is electrically connected to the first buck-boost unit T2, the second buck-boost unit T3, the third switch, and the fourth switch respectively, and independently controls the buck / boost ratio of the first buck-boost unit T2 and the second buck-boost unit T3 and the on / off mode of the third switch and the fourth switch.

[0045] According to an embodiment of the present application, there is also provided a PFA high-voltage pulse ablation system, including the high-voltage sine wave generation circuit described in any one of the foregoing items.

[0046] Through a high-voltage sine wave generation circuit provided by the present application, including a digital control module and more than two of the sine wave generation modules; the sine wave generation modules are connected in parallel at the input end, and a voltage input end supplies voltage to the sine wave generation components of the sine wave generation modules. Therefore, by providing a single relatively low voltage input, multiple sine wave generation components can be driven, reducing the requirements of the circuit for the power supply, avoiding large power consumption of the circuit input load and large losses under long-term operation, extending the service life of the circuit, and reducing energy loss.

[0047] The sine wave generating modules are connected in series at the output end. The voltage output isolation component of the sine wave generating module isolates the sine wave generating component from the output end, and superimposes the generated sine waves in series to output a superimposed sine wave with a higher amplitude. This not only realizes the electrical isolation between the sine wave generating component and the voltage output end to protect the safety of the high-voltage sine wave generating circuit and the patient, but also further increases the output voltage through the superimposed sine wave to maintain the long-term pulse ablation treatment with high voltage requirements. By this way of obtaining a high output voltage through sine wave series superposition, the problem that the sine wave voltage generated by a single sine wave generating module in the existing pulse ablation system is too low to meet the ablation voltage requirement and cause incomplete ablation is solved.

[0048] Each sine wave generating module further includes a driving chip, which controls the on / off of the first switch and the second switch in the sine wave generating module where it is located. There is no need to drive other components, so it has sufficient driving energy and can achieve low-latency control driving, so that the sine waves generated by each sine wave generating module have similar phases at the same time. When superimposing sine waves, the influence of the phase difference on the waveform of the superimposed sine wave is reduced, making the superimposed sine wave have a regular waveform, effectively reducing the harmonic components in the output voltage, reducing the influence of the ablation voltage on the non-ablation parts of the patient, avoiding interference with image positioning due to muscle tremor during patient treatment, and improving the ablation treatment efficiency.

[0049] In addition, the high-voltage sine wave generating circuit of the present application further includes an output detection module. By detecting the voltage and power of the superimposed sine wave, the digital control module can adjust the magnitude of the input voltage to adjust the voltage and power of the output sine wave according to the needs of the output load, expanding the application scope of the high-voltage sine wave generating circuit in ablation treatment; and a balancing module. When problems such as aging and failure of internal components occur during the long-term operation of the high-voltage sine wave generating circuit, the balancing module forces the connection of each sine wave generating component to maintain the overall stability of the circuit, maintain the stability of the sine wave output by the sine wave generating module, improve the performance of the high-voltage sine wave generating circuit in the long-term operation state, and reduce the possibility of functional interruption or electrical failure of the circuit during the high-voltage pulse ablation process.

[0050] The above description is only an overview of the technical solution of the present application. In order to make the technical means of the present application clearer and to the extent that those skilled in the art can implement it according to the content of the specification, and in order to make the above and other purposes, features and advantages of the present application more obvious and understandable, the following takes the specific implementation manner of the present application as an example for illustration. Brief Description of the Drawings

[0051] Figure 1It is the circuit diagram of the high-voltage sine wave generating circuit of the present application in an embodiment;

[0052] Figure 2 It is the equivalent circuit diagram of the loop composed of the inductor group L1, capacitor group C1, inductor L sn 1 and the second switch of the sine wave generating component of the present application in an embodiment;

[0053] Figure 3 It is the circuit diagram of the input voltage regulating module of the present application in an embodiment;

[0054] Figure 4A It is the schematic diagram of the sine wave generating component of the present application generating a sine wave in a resonant state through a single pulse signal;

[0055] Figure 4B It is the schematic diagram of the sine wave generating component of the present application generating a sine wave in a resonant state through a double pulse signal;

[0056] Figure 4C It is the schematic diagram of the sine wave generating component of the present application generating a sine wave in a resonant state through a fixed-frequency pulse signal;

[0057] Figure 5 It is the circuit diagram of the high-voltage sine wave generating circuit including a balancing module of the present application in an embodiment. Detailed implementation manners

[0058] The following implementation manners of the present application are only used to illustrate the specific implementation manners of realizing the present application, and these implementation manners cannot be understood as limitations on the present application. Any other changes, modifications, substitutions, combinations, and simplifications made without departing from the spirit and principle of the present application shall be regarded as equivalent replacement manners and fall within the protection scope of the present application.

[0059] A high-voltage sine wave generating circuit described in this application includes a digital control module and more than two sine wave generating modules. Among them, the sine wave generating module includes a sine wave generating component. The sine wave generating component is connected to the voltage input terminal, and is used for generating pulses, and storing and releasing electric energy by using the generated pulses to generate a sine wave; the generated sine wave has an amplitude higher than the input voltage; therefore, through a lower voltage input, the sine wave generating component can generate a sine wave with a higher amplitude, realizing the improvement of the output voltage, and at the same time reducing the requirement of the circuit for the input voltage; in addition, since the input voltage is lower, the energy consumption generated by each component in the high-voltage sine wave generating circuit as an input load is also less, so the energy loss with a lower input voltage can be maintained. The sine wave generating module further includes an output isolation component. The input terminal of the output isolation component is connected to the output terminal of the sine wave generating component and is used for outputting voltage; the output isolation component also completely separates the sine wave generating component from the voltage output terminal, realizing the electrical isolation between the sine wave generating component and the voltage output terminal, so as to protect the safety of the high-voltage sine wave generating circuit and the patient, and improve the stability of the sine wave.

[0060] In this application, there is no specific limitation on the type of the digital control module, as long as it can be used to receive an electrical signal and process the electrical signal to control the operation of other electronic components. Specifically, examples can include a single-chip microcomputer, a DSP, an FPGA controller, etc. In this embodiment, a single-chip microcomputer is specifically used as the digital control module.

[0061] The digital control module controls the frequency of the pulses generated by the sine wave generating component, and can adjust the frequency of the sine wave generated by the sine wave generating component. By uniformly adjusting the pulse frequencies of the sine wave generating components of each of the sine wave generating modules at the same time, the sine wave generating components of the more than two sine wave generating modules can generate sine waves with the same frequency and initial phase, so as to facilitate the superposition of the more than two sine waves at the voltage output terminal. The output isolation components of the more than two sine wave generating modules are connected in series to output voltage, so that the sine waves with the same frequency and initial phase are superposed into a superimposed sine wave at the voltage output terminal. The amplitude of the superimposed sine wave is the sum of the amplitudes of each sine wave, realizing the further improvement of the output voltage to ensure the operation of a pulse ablation system with a higher voltage requirement.

[0062] In one embodiment, such as Figure 1As shown, the high-voltage sine wave generating circuit includes a digital control module and two sine wave generating modules. Among them, the sine wave generating component includes a driving chip (IC), a first switch, a second switch, an inductor group L1, and a capacitor group C1. The first switch and the second switch can be MOSFETs, triodes, thyristors, relays, etc.; preferably, the first switch and the second switch are transistors. Since transistors have the characteristics of small volume, fast on-off speed, and stable electrical performance, the first switch and the second switch are easy to be integrated into the sine wave generating component to provide an efficient switching on-off function; more preferably, the first switch and the second switch are MOS transistor Q1 and MOS transistor Q2 respectively. Since MOS transistors have a high input impedance and a small channel resistance in the conducting state, the MOS transistor Q1 and the MOS transistor Q2 have the advantages of low power consumption and low noise, with lower power loss for the input voltage, and improve the circuit signal-to-noise ratio, which is beneficial for the sine wave generating component to generate a regular sine wave.

[0063] The first switch is connected to the voltage input terminal, and the second switch is connected in series with the first switch and grounded; the inductor group L1 and the capacitor group C1 are connected in series and then the whole is connected in parallel with the second switch; among them, the digital control module can independently control the on-off of the first switch and the second switch through the driving chip. When the first switch and the second switch are MOS transistor Q1 and MOS transistor Q2 respectively, the drain of MOS transistor Q1 is connected to the voltage input terminal, the source of MOS transistor Q1 is connected to the drain of MOS transistor Q2, and the source of MOS transistor Q2 is grounded; the inductor group L1, the capacitor group C1, and the inductor L sn1 are connected in series in sequence and then are connected in parallel across both ends of MOS transistor Q2 as a whole; when MOS transistor Q1 is turned on and MOS transistor Q2 is turned off, a voltage signal starts to be input from the voltage input terminal. After a first fixed time, MOS transistor Q1 is turned off and MOS transistor Q2 is turned on, and the voltage input terminal stops inputting the voltage signal. That is, the voltage input terminal generates a first pulse voltage after one turn-on and turn-off of MOS transistor Q1, and inputs this pulse voltage into the loop composed of the inductor group L1, the capacitor group C1, and MOS transistor Q2. After a certain time, MOS transistor Q1 is turned on again, the voltage input terminal inputs the voltage signal again, and after a certain time, MOS transistor Q1 is turned off again, and the voltage input terminal stops inputting the voltage signal, generating a second pulse voltage. By repeating the above process of turning MOS transistor Q1 on and off within a certain time, multiple pulse signals with a fixed frequency or random intervals can be input into the loop composed of the inductor group L1, the capacitor group C1, and MOS transistor Q2. When a single or multiple pulse signals are applied to the inductor group L1 and the capacitor group C1 in the loop, the inductor group L1 starts to store / release magnetic field energy, the capacitor group C1 starts to store / release electric field energy, and the inductor group L1 and the capacitor group C1 continuously perform energy conversion in the loop, generating a voltage across the capacitor group C1. That is, a sine wave with a specific frequency is generated across the capacitor group C1.

[0064] The digital control module can independently control the on / off of the first switch and the second switch through the IC. Specifically, the digital control module is electrically connected to the IC of the sine wave generating component. The IC has a first port and a second port. The digital control module sends a power-on instruction to the IC, causing the first port and the second port of the IC to output a conduction voltage, including: the first port inputs a conduction voltage to the gate of MOS transistor Q1 to turn on MOS transistor Q1. After a first fixed time, the first port stops inputting the conduction voltage to the gate of MOS transistor Q1 to turn off MOS transistor Q1, generating a single pulse signal; and the second port inputs a conduction voltage to the gate of MOS transistor Q2 to turn on MOS transistor Q2, and the inductor group L1, the capacitor group C1, and MOS transistor Q2 form a loop.

[0065] By sending a power-on instruction from the digital control module to the IC to enable the IC to independently control the on / off of the first switch and the second switch, one or more pulse signals can be generated using the input voltage. The one or more pulse signals are input into a loop containing the inductor group L1 and the capacitor group C1, causing oscillations in the loop. The oscillations can be free resonance, such as Figures 4A - 4CAs shown, or forced oscillation; when the frequency of the one or more pulse signals is equal to or close to the resonant frequency of the inductor group L1 and the capacitor group C1, free resonance occurs in the circuit; when the frequency of the one or more pulse signals is not equal to and not close to the resonant frequency of the inductor group L1 and the capacitor group C1, the circuit generates forced oscillation under the drive of the continuous forced pulse signal.

[0066] In one embodiment, the equivalent circuit of the circuit composed of the inductor group L1, the capacitor group C1, and the MOS transistor Q2 is as Figure 2 shown. When the frequency of the pulse signal input to the circuit is equal to the resonant frequency of the inductor group L1 and the capacitor group C1, free resonance occurs in the circuit, as shown in the following formula:

[0067]

[0068] where F LC is the resonant frequency of the circuit, L 1 is the inductance of the inductor group L1, C 1 is the capacitance of the capacitor group C1. In the free resonance state, the resonant voltage generated across the capacitor group C1 has the maximum amplitude. Generating free resonance in the circuit containing the inductor group L1 and the capacitor group C1 by inputting a pulse signal helps to determine the frequency of the oscillation with the maximum amplitude generated by each of the sine wave generating components under external excitation, so as to facilitate understanding the oscillation characteristics of each of the sine wave generating components, provide the optimal pulse frequency for each of the sine wave generating components to generate a sine wave under pulse drive, and is beneficial to the superposition of multiple sine waves.

[0069] In one embodiment, the inductor group L1 is one inductor or multiple inductors connected in series or in parallel. Among them, after multiple inductors are connected in parallel, the inductance of their equivalent inductor is jointly determined by the multiple inductors. Therefore, by adjusting one or more inductors in the inductor group L1, the inductance of the inductor group L1 can be changed; in addition, by adjusting one or more inductors in the inductor group L1, the operating frequency range of the inductor group L1 can also be changed.

[0070] Therefore, when the resonant frequencies of the sine wave generating components are different or not close, by adjusting one or more inductors in the inductor group L1 of each of the sine wave generating components, the inductor group L1 of each of the sine wave generating components exhibits the same or similar inductance characteristics, and thus each of the sine wave generating components can exhibit the same or similar resonant frequencies.

[0071] The capacitor bank C1 is a single capacitor unit or multiple capacitor units connected in series or in parallel. Preferably, each capacitor unit includes a single capacitor or two or more capacitors connected in series or in parallel. Therefore, by adjusting the parallel capacitors in one or more capacitor units in the capacitor bank C1 and / or adjusting the number of capacitor units, the capacitance of the capacitor bank C1 can be changed; in addition, by adjusting one or more parallel capacitors in the capacitor bank C1, the operating frequency range of the capacitor bank C1 can also be changed.

[0072] Therefore, even if the inductor banks L1 of more than two sine wave generating modules and the capacitor bank C1 initially have the same specifications and the same number of inductors and capacitors respectively, since inductors / capacitors of the same specification usually have parameter errors within 5%, the resonance frequencies of each sine wave generating component will still be different. When the resonance frequencies of the sine wave generating components are different or not close to each other, by adjusting the capacitors in the capacitor bank C1 of each sine wave generating component, the capacitor bank C1 of each sine wave generating component exhibits the same or similar capacitance characteristics, and further each sine wave generating component exhibits the same or similar resonance frequencies.

[0073] By adjusting the inductor bank L1 and the capacitor bank C1 of the sine wave generating component to make the sine wave generating component have the same or similar resonance frequencies, it can be ensured that the sine waves generated by the sine wave generating component have the same or similar frequencies and amplitudes, so that the sine waves can be superimposed in amplitude after being connected in series by the output isolation component, and the superimposed sine wave generated after the superposition has the maximum amplitude, thereby realizing the output of a high-voltage sine wave.

[0074] In one embodiment, at least one of the sine wave generating modules further includes: an oscillation detection component, which can detect the frequency of the sine wave generated by the sine wave generating component and output the detection result to the digital control module. The oscillation detection component includes: a voltage comparator (CMP), a resistor R1, a resistor R2, and an inductor L sn 1; one end of the resistor R1 is connected to the ground in series with the resistor R2, and the other end is connected to the first end of the inductor L sn 1; the positive input terminal of the CMP is connected between the resistor R1 and the resistor R2; the negative input terminal of the CMP is connected to the second end of the inductor L sn 1; and the output terminal of the CMP is connected to the digital control module; the first end of the inductor L sn 1 is connected to the capacitor bank C1, and the second end is grounded.

[0075] In one embodiment, the inductor bank L1, the capacitor bank C1, the inductor L sn 1 and the MOS transistor Q2 form a loop, that is, the inductor L sn1 is connected in series with the inductor group L1 and the capacitor group C1 and is in parallel with the second switch. The inductor L sn 1 is used to reflect the current change in the loop. The current change in the loop forms a proportional voltage change across the inductor L sn 1, as shown in the following formula:

[0076]

[0077] Wherein, is the voltage across the inductor L sn 1, and L sn is the inductive reactance of the inductor L sn 1, is the change value of the current i sn in the loop over time t. Therefore, by setting the inductor L sn 1, when the current in the loop passes through the inductor L sn 1, a voltage change will be generated across the inductor L sn 1, which is beneficial to obtaining the voltage change situation of the loop in the oscillating state. That is, by monitoring the voltage across the inductor L sn 1, one or more of the oscillating state, resonant frequency, and forced oscillation frequency of the loop can be obtained.

[0078] It should be noted that the inductance of the inductor L sn 1 is 0.05%-5% of the inductance of the inductor group L1, and its influence on the resonance of the loop is much smaller than that of the inductor group L1; in addition, the parasitic impedance of the inductor L sn 1 is small, and the loss when the current passes through is very small. Therefore, the inductor L sn 1 can be ignored in the loop composed of the inductor group L1, the capacitor group C1, and the second switch.

[0079] After the sine wave generating component oscillates, a current passes through the inductor L sn 1, and a voltage is generated across the inductor L sn 1. Among them, the voltage at one end of the inductor L sn 1 reaches the positive input end of the CMP after being divided by the resistor R1. Its amplitude is much smaller than the amplitude of the sine wave generated by the sine wave generating component, which can avoid the loss of the CMP caused by high voltage; its phase and frequency are equal to the phase and frequency of the sine wave generated by the sine wave generating component. Therefore, the voltage frequency obtained at the positive input end of the CMP is the same as the frequency of the sine wave generated by the sine wave generating component.

[0080] When the sine wave generating component is in a resonant state, the voltage frequency obtained at the positive input terminal of the CMP is the resonant frequency of the sine wave generating component, and the voltage amplitude obtained at the positive input terminal of the CMP is small. When detecting the voltage frequency for a long time, it will not damage the CMP. The inverting input terminal of the CMP is connected to the other end of the inductor L sn 1 and grounded. Therefore, the voltage obtained at the inverting input terminal of the CMP is 0. When the voltage amplitude obtained at the positive input terminal of the CMP is greater than 0, its output terminal continuously outputs a high level to the digital control module; when the voltage amplitude obtained at the positive input terminal of the CMP is less than or equal to 0, its output terminal outputs a low level to the digital control module. Therefore, when the sine wave generating component oscillates and generates a sine wave, the output terminal of the CMP can output a detection pulse signal with the same frequency as the sine wave to the digital control module. The digital control module can obtain the sine wave frequency by calculating the frequency of the detection pulse signal, realizing the detection of the sine wave frequency generated by the sine wave generating component.

[0081] The oscillation detection component uses the CMP to compare the sine wave generated by the sine wave generating component with the 0 level and outputs a detection pulse signal to reflect the frequency of the sine wave amplitude change. Since the CMP has a fast response speed and a high input impedance to effectively reduce the noise interference in the sine wave, the oscillation detection component can quickly and accurately detect the frequency of the sine wave. In addition, the output terminal of the CMP usually outputs a digital signal, and the oscillation detection component can directly send the output pulse signal to the digital control module without an additional analog-to-digital conversion component, further improving the detection speed.

[0082] In one embodiment, the output isolation component includes: a transformer T1. The primary coil of the transformer T1 is connected in parallel with the capacitor bank C1, and the two ends of the secondary coil of the transformer T1 are the output terminals of the output isolation component. When the primary coil is connected in parallel across the two ends of the capacitor bank C1, the sine wave generated by the sine wave generating component passes through the primary coil, and a sine wave of the same frequency is induced in the secondary coil. During the process of the sine wave being induced from the primary coil to the secondary coil, the transformer T1 has the characteristic of a high insulation resistance, and there is good electrical isolation between the primary coil and the secondary coil, disconnecting the electrical connection between the output terminal of the sine wave and the sine wave generating component. Therefore, when the sine wave output by the secondary coil is connected to the output load, the output load is prevented from directly contacting the circuit, thereby reducing the risk of electric shock to the patient; in addition, when the sine wave output terminal of the secondary coil is subjected to an external current impact or is short-circuited, the sine wave generating component will not be affected, protecting the components in the circuit.

[0083] The transformer T1 also has the characteristic of low leakage inductance. During the process of the sine wave being induced in the secondary coil by the primary coil, the electromagnetic coupling between the primary coil and the secondary coil is weak. Therefore, it can reduce the generation of electromagnetic interference, effectively avoid energy loss of the sine wave, and reduce the energy loss of pulse ablation.

[0084] The secondary coils of the transformers T1 of each output isolation component are connected end to end, so that the sine waves induced by the secondary coils of each transformer T1 are superimposed at the same time, generating a superimposed sine wave with a high amplitude. Since the sine waves induced by the secondary coils of each transformer T1 have the same or similar frequencies and are generated simultaneously under the regulation of the digital control module, the waveform of the superimposed sine wave is regular and has fewer harmonic components.

[0085] The output isolation component further includes: a capacitor C2 and a capacitor C3. After the capacitor C2, the primary coil of the transformer T1, and the capacitor C3 are connected in series in sequence, the whole is connected in parallel with the capacitor bank C1. Capacitor C2 and capacitor C3 are connected to the two connection segments of the transformer T1 and the capacitor bank C1 respectively. The purpose is to isolate the DC part in the sine wave generated by the capacitor bank C1 of the sine wave generating component, so that the sine wave reaching the primary coil of the transformer T1 is prevented from being distorted by the DC component interference, ensuring the high quality of the sine wave and reducing the harmonic components.

[0086] In one embodiment, the high-voltage sine wave generating circuit further includes an output detection module, and the output detection module is used to detect the voltage, current, and / or power of the sine wave output after the output isolation components are connected in series. The output detection module includes:

[0087] A voltage detection component, and the digital control module detects the output voltage of the high-voltage sine wave generating circuit through the voltage detection component;

[0088] A current detection component, and the digital control module detects the output current of the high-voltage sine wave generating circuit through the current detection component;

[0089] A power detection component, and the digital control module detects the output power of the high-voltage sine wave generating circuit through the power detection component.

[0090] Specifically, in this embodiment, as Figure 1As shown, in the voltage detection component, one end of the series connection of resistor R3 and resistor R4 is grounded, and the other end is connected to the secondary coil of the transformer T1; the primary coil of the voltage transformer is connected in parallel across both ends of resistor R4. The sine wave output by the voltage output isolation component can pass through resistor R3 for voltage reduction and then pass through the primary coil of the voltage transformer. After being stepped down by the voltage transformer, it is output from its secondary coil to the digital control module. The digital control module calculates the voltage value of the sine wave based on the step-down ratio of the voltage transformer and the impedance ratio of resistor R3 and resistor R4. In this way, the digital control module can continuously monitor the amplitude of the sine wave output by the sine wave generation module, so as to adjust the sine wave voltage according to the demand and provide flexibility for ablation treatment.

[0091] In the current detection component, the primary winding of the current transformer is connected to the secondary coil of the transformer T1. The current of the sine wave output by the voltage output isolation component passes through the primary winding of the current transformer, and a current with a smaller amplitude is induced in its secondary winding and output to the digital control module. The digital control module calculates the current value of the sine wave based on the rated current ratio of the current transformer.

[0092] In the power detection component, the input end of the power detection component is respectively connected to the secondary coil of the voltage transformer and the secondary winding of the current transformer. It can calculate the output power value of the sine wave through the voltage and current detected by the voltage transformer and the current transformer, and send the calculation result to the digital control module. In this way, the digital control module can continuously monitor the power of the sine wave output by the sine wave generation module, so as to adjust the power of the sine wave by adjusting the voltage of the sine wave according to the ablation demand. Specifically, the power detection component used in this embodiment can be exemplified as a single-chip microcomputer, DSP, FPGA, multi-quadrant multiplier, etc.

[0093] In one embodiment, the high-voltage sine wave generation circuit further includes an input voltage regulation module, such as Figure 3As shown, the input voltage regulation module is used to control the input voltage of the voltage input terminal, and includes: a buck-boost component, the buck-boost component includes more than two buck-boost units, and the buck-boost component may include a first buck-boost unit T2 and T2 and a second buck-boost unit T3. The input ends of the first buck-boost unit T2 and the second buck-boost unit T3 are respectively connected to the power supply for stepping up / down the voltage. Therefore, the first buck-boost unit T2 and the second buck-boost unit T3 may be a transformer or an isolated power supply module. The output ends of the first buck-boost unit T2 and the second buck-boost unit T3 are connected, and the connection method is series connection or parallel connection, and then connected to the input end of the sine wave generating component for serving as the voltage input terminal. Therefore, when the current ablation voltage cannot meet the ablation requirement, the magnitude of the input voltage of the voltage input terminal can be changed by changing the buck-boost ratio of the first buck-boost unit T2 and the second buck-boost unit T3 and the connection method of the output ends, so as to change the amplitude of the sine wave generated by the sine wave generating component and maintain the effectiveness of the ablation treatment.

[0094] In addition, the input voltage regulation module further includes an adjustment component, the adjustment component includes a third switch and a fourth switch. One end of the third switch is connected to the output end of the first buck-boost unit T2, the other end of the third switch is connected to the output end of the second buck-boost unit T3, and the fourth switch is connected to the output end of the second buck-boost unit T3. The third switch may be a double-control switch, one end of which is connected to the lower end of the secondary coil of the first buck-boost unit T2, and the other end may be connected to the upper end or the lower end of the secondary coil of the first buck-boost unit T2. Therefore, when the third switch is connected to the lower end of the secondary coil of the first buck-boost unit T2 and the fourth switch is connected, the first buck-boost unit T2 is connected in parallel with the secondary coil of the first buck-boost unit T2, and the voltage value at the voltage output terminal is the voltage value output by any one of the secondary coils; when the third switch is connected to the upper end of the secondary coil of the first buck-boost unit T2 and the fourth switch is disconnected, the first buck-boost unit T2 is connected in series with the secondary coil of the first buck-boost unit T2, and the voltage value at the voltage output terminal is the sum of the voltage values output by the two secondary coils.

[0095] By changing the step-up / step-down ratios of the first buck-boost unit T2 and the second buck-boost unit T3, and by changing the connection mode of the output end of the adjustment component, the input voltage adjustment module can provide a wide range of input voltage adjustment for the sine wave generation component. When the voltage requirement of the sine wave is high, increase the step-up ratios of the first buck-boost unit T2 and the second buck-boost unit T3, and connect the output ends of the first buck-boost unit T2 and the second buck-boost unit T3 in series so that the output voltages are superimposed, so as to provide a higher input voltage for the sine wave generation component to generate a sine wave with a higher amplitude through oscillation; when the voltage requirement of the sine wave decreases, increase the step-down ratios of the first buck-boost unit T2 and the second buck-boost unit T3, and connect the output ends of the first buck-boost unit T2 and the second buck-boost unit T3 in parallel, so as to provide a lower input voltage for the sine wave generation component to reduce the amplitude of the sine wave. Therefore, by adjusting the amplitude of the sine wave through the input voltage adjustment module, the sine wave output under different voltage requirements can be satisfied, so that the high-voltage sine wave generation circuit can adapt to various output loads and meet the voltage drive requirements of various types of electronic devices.

[0096] In one embodiment, the digital control module is electrically connected to the first buck-boost unit T2, the second buck-boost unit T3, the third switch and the fourth switch respectively, and independently controls the step-up / step-down ratios of the first buck-boost unit T2 and the second buck-boost unit T3 and the on / off modes of the third switch and the fourth switch.

[0097] Regarding the digital control module, it can be exemplified as a single-chip microcomputer, DSP, FPGA, etc.

[0098] In one embodiment, there is also provided a PFA high-voltage pulse ablation system, including the high-voltage sine wave generation circuit in any of the foregoing embodiments. In the PFA high-voltage pulse ablation system, the high-voltage sine wave generation circuit is used to generate the ablation voltage required for ablation treatment, and the PFA high-voltage pulse ablation system outputs the ablation voltage to the ablation treatment site of the patient.

[0099] The high-voltage sine wave generation circuit described in this application includes two or more of the sine wave generation modules. The sine wave generation modules are connected in parallel at the input end, and a unified voltage input end provides an input voltage for the sine wave generation components of the sine wave generation modules; the sine wave generation modules are connected in series at the output end, and the voltage output isolation components of the sine wave generation modules superimpose the generated sine waves into a high-amplitude superimposed sine wave through series connection. By this way of sine wave series superposition to obtain a high output voltage, the problem that the sine wave amplitude generated by a single sine wave generation module in the existing pulse ablation system is small and cannot output a high voltage for effective ablation treatment is solved.

[0100] In addition, the voltage input terminal does not need to provide a high input voltage. On the one hand, it can avoid large power consumption of the first switch and the second switch, reduce the loss of the first switch and the second switch during long-term operation, so as to extend the circuit life. On the other hand, circuit components such as inductors, capacitors and transformers required to generate high-voltage sine waves are evenly distributed to multiple sine wave generating modules. Therefore, their energy consumption is also evenly distributed to multiple sine wave generating modules. In this way, not only can the selectivity of circuit components be increased, no special high-voltage-resistant components need to be customized to reduce the circuit construction cost, but also the temperature of circuit components during power-on can be reduced, the life and reliability of the circuit can be improved, and further the life and reliability of the ablation system where the circuit is located can be improved. Each sine wave generating module includes an IC, and the IC only needs to control the on / off of the first switch and the second switch in the sine wave generating module where it is located, without driving other components. Therefore, it has sufficient driving energy and can achieve low-latency control driving, so that the sine waves generated by each sine wave generating module have similar phases at the same time, reduce the influence of phase difference on the waveform of the superimposed sine waves when superimposing sine waves, make the superimposed sine waves have regular waveforms, and improve the comfort and treatment efficiency of patients during the ablation treatment process.

[0101] Finally, by detecting the voltage and power of the superimposed sine wave, the digital control module can adjust the magnitude of the input voltage by controlling the input voltage adjustment module, so as to adjust the voltage and power of the output sine wave according to different ablation modes, and expand the application scope of the high-voltage sine wave generating circuit in the ablation treatment system.

[0102] In one embodiment, the high-voltage sine wave generating circuit further includes a balancing module, as Figure 5 shown, the balancing module is respectively connected to the midpoints of the inductor group L1 and the capacitor group C1 of the sine wave generating assembly, and is used to connect the sine wave generating assembly to make the hardware of the sine wave generating assembly consistent. Specifically, the balancing module includes a balancing bridge relay, and both ends of the balancing bridge relay are respectively connected to the midpoints of the inductor group L1 and the capacitor group C1 of the sine wave generating assembly; when the sine waves generated by the sine wave generating module cannot be superimposed at the output end, the balancing bridge relay closes, and the sine wave generating assembly is connected through the balancing bridge relay, so that the circuits of the sine wave generating assembly are forced to be consistent, and then the sine waves generated by the sine wave generating assembly have the same frequency and phase, can be well superimposed at the output end, reduce the harmonic components in the sine wave, and improve the ablation treatment comfort and treatment efficiency of the system under long-term operation conditions.

[0103] When the high-voltage sine wave generating circuit operates for a long time, problems such as aging and faults may occur in its internal components. The sine wave generated under the drive of the drive pulse signal may not have the frequency specified by the digital control module, or the frequency is unstable, the waveform jitters greatly in a short time, and there are large noise harmonics. Therefore, by closing the balance bridge relay, the internal components of the circuit can be forced to be connected to maintain the overall stability of the circuit and the stability of the sine wave output by the sine wave generating module, so as to improve the performance of the high-voltage sine wave generating circuit in the long-term operating state and reduce the possibility of functional interruption or electrical faults in the ablation treatment system. The digital control module is electrically connected to the balance module and controls the closing or opening of the balance bridge relay of the balance module to adjust the hardware states of the sine wave generating components of two or more sine wave generating modules.

[0104] Although the embodiments of the present application have been described above, the present application is not limited to the above specific embodiments and application fields. The above specific embodiments are merely illustrative and guiding, rather than restrictive. Those of ordinary skill in the art can also make many forms under the inspiration of this specification and without departing from the scope protected by the claims of the present application, and these all belong to the scope required to be protected by the present application.

Claims

1. A high voltage sine wave generating circuit, characterized in that: include: Digital control module; More than two sine wave generating modules; Wherein, the sine wave generating module comprises: A sine wave generating component, the sine wave generating component is connected to the voltage input terminal and is used to generate pulses and generate sine waves using the generated pulses; an output isolation component, the input terminal of the output isolation component is connected to the output terminal of the sine wave generating component and is used for voltage isolation and outputting sine waves; The digital control module controls the frequency of the pulses generated by the sine wave generating component; The output ends of the output isolation components of more than two sine wave generating modules are connected in series and then output sine waves.

2. A high voltage sine wave generating circuit according to claim 1, characterized in that: The sine wave generating component includes a driving chip, a first switch, a second switch, an inductor group L1, and a capacitor group C1; The first switch is connected to the voltage input terminal, and the second switch is connected in series with the first switch and is grounded; The inductor group L1 and the capacitor group C1 are connected in series and then connected in parallel with the second switch as a whole; The digital control module can independently control the on and off of the first switch and the second switch through the driving chip.

3. A high voltage sine wave generating circuit according to claim 2, characterized in that: The inductor group L1 is one inductor or a plurality of inductors connected in series or in parallel; and / or, The capacitor group C1 is a capacitor unit or a plurality of capacitor units connected in series or in parallel, and each of the capacitor units includes a capacitor or a plurality of capacitors connected in series or in parallel.

4. A high voltage sine wave generating circuit according to claim 2, characterized in that: At least one of the sine wave generating modules further includes: an oscillation detection component, wherein the oscillation detection component includes: Voltage comparator, resistor R1, resistor R2 and inductor L sn 1; One end of the resistor R1 is connected in series with the resistor R2 and then grounded. The other end of the resistor R1 is connected to the inductor L sn The first end of 1 is connected; The inductance L sn The first end of 1 is connected to the capacitor group C1, and the inductor L sn The second end of 1 is grounded; The positive input terminal of the voltage comparator is connected between the resistor R1 and the resistor R2; The inverting input of the voltage comparator is connected to the inductor L sn 1 is connected to the second end; and The output end of the voltage comparator is connected to the digital control module.

5. A high voltage sine wave generating circuit according to claim 1, characterized in that: The output isolation component comprises: Transformer T1, the primary coil of the transformer T1 is connected in parallel with the capacitor group C1, and the two ends of the secondary coil of the transformer T1 are the output ends of the output isolation component.

6. A high voltage sine wave generating circuit according to claim 5, characterized in that: The output isolation component also includes: Capacitor C2 and capacitor C3, the capacitor C2, the primary coil of the transformer T1, and the capacitor C3 are sequentially connected in series and then the whole is connected in parallel with the capacitor group C1.

7. A high voltage sine wave generating circuit according to claim 1, characterized in that: It also includes an output detection module, which detects the voltage, current and / or power of the sinusoidal wave output by the output isolation components after being connected in series.

8. A high voltage sine wave generating circuit according to claim 7, characterized in that: The output detection module comprises: A voltage detection component, through which the digital control module detects the output voltage of the high-voltage sine wave generating circuit; A current detection component, through which the digital control module detects the output current of the high-voltage sine wave generating circuit; A power detection component, wherein the digital control module detects the output power of the high-voltage sine wave generating circuit through the power detection component.

9. A high voltage sine wave generating circuit according to claim 2, characterized in that: It also includes a balancing module, and the digital control module controls the connection mode of the sine wave generating component through the balancing module to make the sine waves generated by the sine wave generating component consistent.

10. A high voltage sine wave generating circuit according to claim 9, characterized in that: The input end of the balancing module is respectively connected between the inductance group L1 and the capacitance group C1 of each of the sine wave generating components, and the output end of the balancing module is electrically connected to the digital control module.

11. A high voltage sine wave generating circuit according to claim 1, characterized in that: It also includes an input voltage regulating module, which controls the input voltage of the voltage input terminal.

12. A high voltage sine wave generating circuit according to claim 11, characterized in that: The input voltage regulation module comprises: A buck-boost assembly, the buck-boost assembly comprising two or more buck-boost units; and A regulating component, wherein the regulating component changes the input voltage of the voltage input terminal by adjusting the connection mode of the output terminals of more than two buck-boost units.

13. A high voltage sine wave generating circuit according to claim 12, characterized in that: The buck-boost component includes a first buck-boost unit T2 and a second buck-boost unit T3, wherein the input ends of the first buck-boost unit T2 and the second buck-boost unit T3 are respectively connected to a power source for increasing or decreasing voltage; The regulating component includes a third switch and a fourth switch. The third switch and the fourth switch change the input voltage of the voltage input terminal by regulating the connection mode between the output terminals of the first buck-boost unit T2 and the second buck-boost unit T3.

14. A high voltage sine wave generating circuit according to claim 13, characterized in that: The digital control module is electrically connected to the first buck-boost unit T2, the second buck-boost unit T3, the third switch and the fourth switch, respectively, and independently controls the step-up / step-down ratio of the first buck-boost unit T2 and the second buck-boost unit T3 and the on / off mode of the third switch and the fourth switch.

15. A PFA high-voltage pulse ablation system, characterized in that: A high voltage sine wave generating circuit comprising any one of claims 1-14.

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