Mouse trachea cannula system

Abstract

The utility model provides a mouse tracheal intubation system, and belongs to the technical field of animal experiment instruments. The mouse tracheal intubation system comprises a tracheal intubation device, an air injection emptying device and a visual monitoring device. The mouse tracheal intubation system can be repeatedly used on the basis of performing tracheal intubation administration on a mouse, has the functions of monitoring whether the mouse is inserted into a trachea or not and promoting liquid medicine to be emptied, and can reduce the problem that liquid is left in a tracheal intubation needle; the problems of medicine loss, inaccurate experimental results caused by medicine crosstalk in different experimental groups and the like are reduced, the risk that a tracheal intubation needle is inserted into the esophagus can be reduced, and the risk that a mouse is subjected to laryngeal edema and suffocation death due to repeated tracheal intubation is reduced.

Description

Technical Field

[0001] The utility model belongs to the technical field of animal experiment instruments, and particularly relates to a mouse tracheal intubation system. Background Technique

[0002] Establishing a mouse tracheal intubation animal model is one of the commonly used technical means for studying lung diseases. Tracheal intubation is divided into two methods: blind intubation and intubation guided by a laryngoscope. Blind intubation is likely to insert into the esophagus, resulting in the failure of model establishment or drug administration because the drug solution does not reach the lungs. The success rate of intubation guided by a laryngoscope is higher than that of blind intubation, but the cost increases significantly at the same time.

[0003] Under the existing technology, the conventional tracheal intubation needle of Chinese Patent CN106620998A does not have the function of checking whether it is inserted into the trachea or misinserted into the esophagus. Therefore, Chinese Invention Patent CN118059363A, Chinese Utility Model Patent CN216417406U, and Chinese Utility Model Patent CN219251285U propose indicators and new tracheal intubation needles that can detect whether the position of the tracheal intubation is correct by observing the fluctuation of the water column. However, generally, the intubation needles for animal tracheal intubation and drug administration are reused, and it is not possible to use a new tracheal intubation needle for each mouse. Therefore, it is impossible to completely inhale the drug solution into the lungs by relying solely on the mouse's breathing after drug administration. It is necessary to forcefully eject the drug solution in the tracheal intubation needle before it can be used again. However, all the above types of tracheal intubation needles have the problem that liquid will remain in the tracheal intubation needle. The residual drug solution in the pipeline system will cause inaccurate drug dosage, increased drug loss, and drug crosstalk in different experimental groups, resulting in inaccurate experimental results.

[0004] Therefore, there is an urgent need for a tracheal intubation needle that can be reused and has monitoring and evacuation functions. Summary of the Utility Model

[0005] The utility model is carried out to solve the above problems, and the purpose is to provide a mouse tracheal intubation system.

[0006] The utility model provides a mouse tracheal intubation system, which has the following characteristics: including a tracheal intubation device, including a medicine liquid barrel and an intubation connected to the bottom of the medicine liquid barrel for inserting into the trachea of a mouse; an air injection evacuation device, connected and communicated with the medicine liquid barrel, for injecting air into the medicine liquid barrel to squeeze the medicine liquid in the medicine liquid barrel and fully introduce it into the lungs of the mouse through the intubation; and a visualization monitoring device, connected and communicated with the medicine liquid barrel, for indicating the air pressure change in the medicine liquid barrel to determine whether the intubation is connected to the lungs of the mouse. Among them, the liquid level of the medicine liquid in the medicine liquid barrel is below the connection between the air injection evacuation device and the medicine liquid barrel, and below the connection between the visualization monitoring device and the medicine liquid barrel.

[0007] In the mouse tracheal intubation system provided by the present utility model, it may further have the following features: wherein, the intubation material includes soft plastic or silica gel.

[0008] In the mouse tracheal intubation system provided by the present utility model, it may further have the following features: wherein, the tracheal intubation device further includes: a medicine injection port, opened above the medicine liquid barrel, for the operator to inject medicine liquid into the medicine liquid barrel; and a tracheal intubation needle, passing through the intubation and the medicine liquid barrel and extending upward through the medicine injection port, for supporting the soft intubation to assist its insertion into the trachea of the mouse, and the part of the tracheal intubation needle extending upward through the medicine injection port is for the operator to grasp and pull out the tracheal intubation needle after the intubation is inserted into the trachea of the mouse.

[0009] In the mouse tracheal intubation system provided by the present utility model, it may further have the following features: wherein, the mouse tracheal intubation system further includes a tube cap, which is matched with the medicine injection port and is used to close the medicine injection port with the tube cap after the operator pulls out the tracheal intubation needle.

[0010] In the mouse tracheal intubation system provided by the present utility model, it may further have the following features: wherein, the tracheal intubation device further includes a first extension section, which is a laterally and obliquely upwardly arranged tubular structure with a closed head end and communicated with the medicine liquid barrel on the medicine liquid barrel, and the air injection and evacuation device includes: an air injection hose, connected and communicated with the head end of the first extension section; and an air syringe, connected and communicated with the air injection hose and used for introducing air.

[0011] In the mouse tracheal intubation system provided by the present utility model, it may further have the following features: wherein, the air injection hose material includes soft plastic or silica gel, and a three-way valve is arranged on the air injection hose, and the three-way valve is used for the air syringe to extract air and inject it into the medicine liquid barrel.

[0012] In the mouse tracheal intubation system provided by the present utility model, it may further have the following features: wherein, the air syringe includes an air pump or a syringe barrel.

[0013] In the mouse tracheal intubation system provided by the present utility model, it may further have the following features: wherein, the tracheal intubation device further includes a second extension section, which is a laterally and obliquely upwardly arranged tubular structure with a closed head end and communicated with the medicine liquid barrel on the medicine liquid barrel, and the visualization monitoring device includes: a first hose, connected and communicated with the head end of the second extension section; a monitoring tube, which is a transparent tubular structure with narrow upper and lower ends and a wide middle in the vertical direction, and the bottom of the monitoring tube is connected and communicated with the first hose; and a second hose, connecting the top of the monitoring tube with the outside atmosphere and communicating.

[0014] In the mouse tracheal intubation system provided by the present utility model, it may further have the following features: wherein, the material of the first flexible tube or the second flexible tube includes soft plastic or silica gel, and a switchable blocking clip is provided on the first flexible tube and / or the second flexible tube. The blocking clip is used to clamp the first flexible tube or the second flexible tube in a switchable manner. When the blocking clip clamps the first flexible tube or the second flexible tube, the liquid medicine barrel is not communicated with the atmosphere through the visual monitoring device.

[0015] In the mouse tracheal intubation system provided by the present utility model, it may further have the following features: wherein, the horizontal position of the monitoring tube is below the horizontal position of the connection between the first flexible tube and the second extension section.

[0016] Functions and effects of the utility model

[0017] According to the mouse tracheal intubation system involved in the present utility model, because it includes: a tracheal intubation device, including a liquid medicine barrel and an intubation tube connected and communicated at its bottom for inserting into the trachea of a mouse; an air injection and evacuation device, connected and communicated with the liquid medicine barrel, for injecting air into the liquid medicine barrel to squeeze the liquid medicine in the liquid medicine barrel to be fully introduced into the lungs of the mouse through the intubation tube; and a visual monitoring device, connected and communicated with the liquid medicine barrel, for indicating the air pressure change in the liquid medicine barrel to determine whether the intubation tube is connected to the lungs of the mouse. Among them, the liquid level of the liquid medicine in the liquid medicine barrel is below the connection between the air injection and evacuation device and the liquid medicine barrel, and below the connection between the visual monitoring device and the liquid medicine barrel.

[0018] Therefore, the mouse tracheal intubation system of the present utility model has the functions of being reusable, monitoring whether it is inserted into the trachea, and promoting the evacuation of the liquid medicine on the basis of tracheal intubation and drug administration to a mouse. It can reduce the problem that liquid will remain in the tracheal intubation needle, reduce drug loss and problems such as inaccurate experimental results caused by drug crosstalk in different experimental groups, and can reduce the risk of the tracheal intubation needle inserting into the esophagus and the risk of suffocation and death caused by repeated tracheal intubation of the mouse. Description of the drawings

[0019] Figure 1 is a schematic structural diagram of a mouse tracheal intubation system in an embodiment of the present utility model;

[0020] Figure 2 is Figure 1 an enlarged view of part A in

[0021] Figure 3 is Figure 1 an enlarged view of part B in

[0022] Figure 4 is a perspective view of the tracheal intubation device of a mouse tracheal intubation system in an embodiment of the present utility model;

[0023] Figure 5 Stereogram of the tracheal intubation device of a mouse tracheal intubation system in an embodiment of the present utility model without the tracheal intubation needle;

[0024] Figure 6 is Figure 5 Enlarged view of part D in

[0025] Figure 7 Structural schematic diagram of the tracheal intubation needle in an embodiment of the present utility model;

[0026] Figure 8 Structural schematic diagram of the needle body and the intubation part of the tracheal intubation device of a mouse tracheal intubation system in an embodiment of the present utility model. Detailed implementation manners

[0027] In order to make the technical means, creative features, achieved purposes and effects realized by the present utility model easy to understand, the following embodiments will specifically describe a mouse tracheal intubation system of the present utility model in conjunction with the accompanying drawings.

[0028] <Embodiment>

[0029] Figure 1 Structural schematic diagram of a mouse tracheal intubation system in an embodiment of the present utility model.

[0030] As Figure 1 shown, the present utility model provides a mouse tracheal intubation system 100, including a tracheal intubation device 10, an air injection and evacuation device 20, and a visualization monitoring device 30.

[0031] Figure 2 is Figure 1 Enlarged view of part A in Figure 3 is Figure 1 Enlarged view of part B in Figure 4 Perspective view of the tracheal intubation device of a mouse tracheal intubation system in an embodiment of the present utility model; Figure 5 Stereogram of the tracheal intubation device of a mouse tracheal intubation system in an embodiment of the present utility model without the tracheal intubation needle; Figure 6 is Figure 5 Enlarged view of part D in

[0032] As Figures 1 to 6 shown, the tracheal intubation device 10 includes a liquid medicine barrel 11, a first extension section 12, a second extension section 13, an intubation 14, a medicine injection port 15, a tracheal intubation needle 16, and a tube cap (not shown in the figure).

[0033] In this embodiment, the liquid medicine barrel 11 is a barrel-shaped structure, the upper part of which is cylindrical and the lower part is a frustum-shaped structure with a wider top and a narrower bottom. The liquid medicine barrel 11 stores the liquid medicine to be introduced into the lungs of the mouse.

[0034] Both the first extension section 12 and the second extension section 13 are tubular structures with closed heads that are laterally and obliquely upwardly arranged on the liquid medicine barrel 11 and communicate with the liquid medicine barrel 11.

[0035] The intubation tube 14 is connected to and communicates with the bottom of the liquid medicine barrel 11 and is used to be inserted into the trachea of a mouse. In this embodiment, the intubation tube 14 is made of soft plastic.

[0036] The medicine injection port 15 is an opening formed at the top of the liquid medicine barrel 11 and is used for the operator to inject the liquid medicine into the liquid medicine barrel 11.

[0037] Figure 7 It is a schematic structural diagram of the tracheal intubation needle in the embodiment of the present utility model.

[0038] As Figures 1 to 7 shown, the tracheal intubation needle 16 includes a needle main body 161 and a gripping member 162.

[0039] Figure 8 It is a schematic structural diagram of the needle main body and the intubation part of the tracheal intubation device of a mouse tracheal intubation system in the embodiment of the present utility model.

[0040] As Figures 1 to 8 shown, the needle main body 161 passes through the intubation tube 14 and the liquid medicine barrel 11 and extends upward through the medicine injection port 15. The part of the needle main body 161 passing through the intubation tube 14 is used to support the soft intubation tube 14 to assist its insertion into the trachea of a mouse.

[0041] The gripping member 162 is arranged on the part of the needle main body 161 extending upward through the medicine injection port 15 and is used for the operator to grip after the intubation tube 14 is inserted into the trachea of a mouse to pull out the tracheal intubation needle 16. In this embodiment, the gripping member 162 and the needle main body 161 form a "T" - shaped structure.

[0042] The tube cap is matched with the medicine injection port 15 and is used to seal the medicine injection port 15 with the tube cap after the operator pulls out the tracheal intubation needle 16.

[0043] The air injection and evacuation device 20 includes an air syringe 21, an air injection hose 22, and a three - way valve 23.

[0044] The air syringe 21 is an injection syringe barrel.

[0045] The air injection hose 22 is made of soft plastic and includes an injection - end hose 221, an air - end hose 222, and a liquid - medicine - barrel - end hose 223.

[0046] The injection - end hose 221 is connected to and communicates with the air syringe 21.

[0047] One end of the air - end hose 222 is connected to and communicates with the injection - end hose 221, and the other end communicates with the atmosphere.

[0048] One end of the liquid medicine bucket end hose 223 is connected and communicated with the connection part of the injection end hose 221 and the air end hose 222, and the other end is connected and communicated with the head end of the first extension section 12.

[0049] The three-way valve 23 is rotatably arranged at the connection part of the injection end hose 221, the air end hose 222 and the liquid medicine bucket end hose 223, and is used to control the pairwise communication of the injection end hose 221, the air end hose 222 and the liquid medicine bucket end hose 223 respectively.

[0050] The visual monitoring device 30 includes a first hose 31, a monitoring tube 32, a second hose 33 and a blocking clip (not shown in the figure).

[0051] The first hose 31 is connected and communicated with the head end of the second extension section 13, and its material is soft plastic.

[0052] The monitoring tube 32 is a transparent tubular structure that is narrow at both the upper and lower ends and wide in the middle and is arranged vertically. The bottom of the monitoring tube 32 is connected and communicated with the first hose 31, and the horizontal position where the monitoring tube 32 is located is below the horizontal position of the connection part of the first hose 31 and the second extension section 13.

[0053] The second hose 33 is made of soft plastic, and it connects and communicates the top of the monitoring tube 32 with the outside atmosphere.

[0054] The blocking clip is arranged on the second hose 33 and is used to switchably close the second hose 33, and when closed, the liquid medicine bucket 11 is not connected and communicated with the outside atmosphere through the first hose 31, the monitoring tube 32 and the second hose 33.

[0055] The usage process of the mouse tracheal intubation system 100:

[0056] S01, inject an appropriate amount of liquid into the monitoring tube 32.

[0057] S02, use a curved forceps to open the airway of the mouse, insert the intubation 14 into the airway of the mouse under the support and guidance of the needle body 161 through which it passes, and then grasp the grasping part 162 to pull out the tracheal intubation needle 16.

[0058] S03, use a tube cap to seal the medicine injection port 15, observe the fluctuation of the water column inside the monitoring tube 32. If the water column fluctuates up and down with the breathing frequency of the mouse, it means that the intubation 14 has been inserted into the airway of the mouse.

[0059] S04, open and remove the tube cap, align a 100uL pipette gun with the medicine injection port 15, and thus inject the liquid medicine into the liquid medicine bucket 11.

[0060] S05, use a tube cap to seal the medicine injection port 15, and close the blocking clip on the second hose 33.

[0061] S06. Rotate the three-way valve 23 so that the b end of the three-way valve points to the injection end hose 221 and the c end points to the air end hose 222, thereby connecting the injection end hose 221 and the air end hose 222 and closing the liquid medicine barrel end hose 223. Then, use the air syringe 21 to draw a certain amount of air.

[0062] S07. Rotate the three-way valve 23 so that the a end of the three-way valve points to the liquid medicine barrel end hose 223, the c end points to the injection end hose 221, and the b end points in the direction opposite to the air end hose 222, thereby connecting the injection end hose 221 and the liquid medicine barrel end hose 223 and closing the air end hose 222. Then, use the air syringe 21 to release 100 - 200 uL of air into the liquid medicine barrel 11 to help the liquid be introduced into the mouse lungs, thereby emptying the liquid medicine in the liquid medicine barrel 11.

[0063] S08. After the liquid medicine is released, remove the entire mouse tracheal intubation system 100 and continue the experiment on the next mouse.

[0064] During the use process of this embodiment, the liquid level of the liquid medicine in the liquid medicine barrel 11 is controlled to be below the connection between the air injection hose 21 and the first extension section 12, and below the connection between the first hose 31 and the second extension section 13.

[0065] Function and Effect of the Embodiment

[0066] According to a mouse tracheal intubation system provided by this embodiment, because it includes: a tracheal intubation device, including a liquid medicine barrel and an intubation connected to the bottom of the liquid medicine barrel for inserting into the trachea of a mouse; an air injection and evacuation device, connected and communicated with the liquid medicine barrel, for injecting air into the liquid medicine barrel to squeeze the liquid medicine in the liquid medicine barrel to be fully introduced into the mouse lungs through the intubation; and a visualization monitoring device, connected and communicated with the liquid medicine barrel, for indicating the air pressure change in the liquid medicine barrel to determine whether the intubation is connected to the mouse lungs. Among them, the liquid level of the liquid medicine in the liquid medicine barrel is below the connection between the air injection and evacuation device and the liquid medicine barrel, and below the connection between the visualization monitoring device and the liquid medicine barrel.

[0067] Therefore, the mouse tracheal intubation system of this embodiment has the functions of being reusable, monitoring whether it is inserted into the trachea, and promoting the evacuation of the liquid medicine on the basis of tracheal intubation and drug administration to mice. It can reduce the problem that liquid will remain in the tracheal intubation needle, reduce drug loss and the problem of inaccurate experimental results caused by drug cross-talk in different experimental groups, and can reduce the risk of the tracheal intubation needle being inserted into the esophagus and the risk of mouse laryngeal edema and asphyxia death caused by repeated tracheal intubation.

[0068] Further, the tracheal intubation device further includes: a medicine injection port opened above the medicine liquid barrel for the operator to inject medicine liquid into the medicine liquid barrel; and a tracheal intubation needle passing through the intubation and the medicine liquid barrel and extending upward through the medicine injection port for supporting the soft intubation to assist in inserting it into the trachea of a mouse. The part of the tracheal intubation needle extending upward through the medicine injection port is used for the operator to grasp and pull out the tracheal intubation needle after the intubation is inserted into the trachea of the mouse. With such a setting, the intubation can be more conveniently inserted into the trachea of the mouse.

[0069] Further, the mouse tracheal intubation system further includes a tube cap that matches the medicine injection port and is used to close the medicine injection port with the tube cap after the operator pulls out the tracheal intubation needle. With such a setting, a closed space can be formed inside the medicine liquid barrel to test whether the intubation is inserted into the trachea of the mouse, and the medicine liquid can be extruded by air pressure and introduced into the lungs of the mouse through the intubation.

[0070] Further, the tracheal intubation device further includes a first extension section which is a tubular structure with a closed head end that is laterally and obliquely upwardly arranged on the medicine liquid barrel and is connected to the medicine liquid barrel. The air injection and evacuation device includes: an air injection hose connected and communicated with the head end of the first extension section; and an air syringe connected and communicated with the air injection hose for injecting air. With such a setting, the medicine liquid inside the medicine liquid barrel can be emptied and introduced into the lungs of the mouse.

[0071] Further, a three-way valve is provided on the air injection hose, and the three-way valve is used for the air syringe to draw air and inject it into the medicine liquid barrel. With such a setting, the air syringe can draw external air and inject it into the medicine liquid barrel without being removed (separated from the air injection hose), and it can prevent the medicine liquid in the medicine liquid barrel from flowing back repeatedly due to the respiration of the mouse.

[0072] Further, the tracheal intubation device further includes a second extension section which is a tubular structure with a closed head end that is laterally and obliquely upwardly arranged on the medicine liquid barrel and is connected to the medicine liquid barrel. The visualization monitoring device includes: a first hose connected and communicated with the head end of the second extension section; a monitoring tube which is a transparent tubular structure with narrow upper and lower ends and a wide middle in the vertical direction, and the bottom of the monitoring tube is connected and communicated with the first hose; and a second hose connecting the top of the monitoring tube to the external atmosphere and communicating. With such a setting, the air pressure condition inside the medicine liquid barrel after the intubation is inserted into the trachea of the mouse can be visualized according to the breathing frequency of the mouse.

[0073] Further, a switchable blocking clip is provided on the second hose, and the blocking clip is used to clamp the second hose in a switchable manner. When the blocking clip clamps the second hose, the medicine liquid barrel is not communicated with the atmosphere through the visualization monitoring device. With such a setting, the medicine liquid barrel can be closed, so as to facilitate the medicine liquid in the medicine liquid barrel to be introduced into the lungs of the mouse through air pressure extrusion via the intubation.

[0074] Furthermore, the horizontal position of the monitoring tube is below the horizontal position of the connection between the first flexible tube and the second extension section. Such an arrangement ensures that the liquid in the monitoring tube will not flow into the liquid medicine barrel.

[0075] Those skilled in the art should understand that the present utility model is not limited by the above embodiments. What is described in the above embodiments and the specification is only to illustrate the principle of the present utility model. Without departing from the spirit and scope of the present utility model, the present utility model will have various changes and improvements, and these changes and improvements all fall within the scope of the present utility model claimed. The scope of protection claimed by the present utility model is defined by the appended claims and their equivalents.

Claims

1. A mouse tracheal intubation system, characterized in that: include: The tracheal intubation device comprises a medicine liquid barrel and a cannula connected at the bottom thereof and used for inserting into the trachea of ​​a mouse; an air injection and emptying device, connected and communicated with the medicine liquid barrel, for injecting air into the medicine liquid barrel so as to squeeze the medicine liquid in the medicine liquid barrel and fully introduce it into the lungs of the mouse through the cannula; and A visual monitoring device is connected and communicated with the medicine liquid barrel, and is used to indicate the air pressure change in the medicine liquid barrel to determine whether the cannula is connected to the mouse lungs. Wherein, the liquid level of the medicine in the medicine barrel is located below the connection between the air injection and emptying device and the medicine barrel, and is located below the connection between the visual monitoring device and the medicine barrel.

2. The mouse endotracheal intubation system according to claim 1, characterized in that: in, The cannula material includes soft plastic or silicone.

3. The mouse endotracheal intubation system according to claim 1, Features: Wherein, the endotracheal intubation device further comprises: A medicine injection port is provided above the medicine liquid barrel and is used for the operator to inject the medicine liquid into the medicine liquid barrel; and The endotracheal intubation needle passes through the cannula and the medicine barrel and extends upward through the injection port, and is used to support the soft cannula to assist its insertion into the trachea of ​​the mouse. The part of the endotracheal intubation needle that passes through the injection port and extends upward is used for the operator to grasp and pull out the endotracheal intubation needle after the cannula is inserted into the trachea of ​​the mouse.

4. The mouse endotracheal intubation system according to claim 3, characterized in that: Also includes pipe caps, The tube cap matches the drug injection port and is used to seal the drug injection port after the operator pulls out the endotracheal intubation needle.

5. The mouse endotracheal intubation system according to claim 1, Features: The endotracheal intubation device further comprises a first extension section, which is a tubular structure with a closed head end and is disposed laterally and obliquely upward on the medicine liquid barrel and is connected to the medicine liquid barrel. The air injection and emptying device comprises: an air injection hose connected to and in communication with the head end of the first extension section; and An air syringe is connected and communicated with the air injection hose and is used for introducing air.

6. The mouse endotracheal intubation system according to claim 5, characterized in that: in, The air injection hose is made of soft plastic or silicone. The air injection hose is provided with a three-way valve, and the three-way valve is used for the air injector to extract air and inject it into the medicine liquid barrel.

7. The mouse endotracheal intubation system according to claim 5, characterized in that: in, The air injector includes an air pump or a syringe.

8. The mouse endotracheal intubation system according to claim 1, Features: in, The endotracheal intubation device further comprises a second extension section, which is a tubular structure with a closed head end and is disposed laterally and obliquely upward on the medicine liquid barrel and is connected to the medicine liquid barrel. The visual monitoring device comprises: a first hose connected to and in communication with the head end of the second extension section; The monitoring tube is a transparent tubular structure arranged in a vertical direction, which is narrow at the upper and lower ends and wide in the middle, and the bottom of the monitoring tube is connected and communicated with the first hose; and The second hose connects and communicates the top of the monitoring tube with the outside atmosphere.

9. The mouse endotracheal intubation system according to claim 8, characterized in that: in, The material of the first hose or the second hose includes soft plastic or silicone. The first hose and / or the second hose is provided with a switchable blocking clamp, The blocking clamp is used to clamp the first hose or the second hose in a switchable manner. When the blocking clamp clamps the first hose or the second hose, the medicine barrel is not connected to the atmosphere through the visual monitoring device.

10. The mouse endotracheal intubation system according to claim 8, characterized in that: in, The horizontal position of the monitoring pipe is below the horizontal position of the connection between the first hose and the second extension section.

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