Atomization drug delivery box for mouse acute lung injury modeling

Abstract

The utility model discloses an atomization dosing box for mouse acute lung injury modeling, which belongs to the technical field of experimental modeling and comprises a buffer area, a box body and a conveyor belt component which are sequentially arranged from top to bottom, an atomizer connector is arranged at the upper end of the buffer area, holes are arranged on the periphery of the box body, and the upper end and the lower end of the box body are open. The lower end of the box body is connected with the conveying belt assembly, and the conveying belt assembly is used for driving mice placed in the box body to run. The buffer area is taken down from the upper portion of the box body, a mouse is placed into the box body from the upper portion of the box body, then the buffer area is placed at the upper end of the box body, the conveying belt assembly is started to enable the mouse to run on the conveying belt assembly, then medicine flows into the buffer area and the box body from the atomizer connector, and the use requirement for establishing a model through the mouse is met.

Description

Technical Field

[0001] The utility model belongs to the technical field of experimental modeling, and particularly relates to an atomizing drug delivery box for establishing a mouse acute lung injury model. Background Art

[0002] When developing drugs for treating acute lung injury, it is necessary to use rats or mice to establish animal models of the disease. At present, most of the drug delivery methods for modeling with lipopolysaccharide are tracheal intubation. This method is difficult to operate and the wound is prone to infection after drug delivery, thus affecting the experimental results. In view of the above deficiencies, an atomizing box is now proposed for drug delivery.

[0003] Most of the existing drug delivery devices on the market have the advantages of high efficiency and adjustable concentration, but they cannot control the uniformity of drug delivery. Often, due to the over-concentration of the atomized liquid, it is not conducive to achieving uniform drug intake by animals in the same device. Moreover, most of the mouse atomizing drug delivery devices use closed drug boxes, resulting in poor air circulation and a risk of hypoxia for mice. In addition, the closed box body cannot be disassembled, which is not conducive to thorough cleaning and disinfection. After a long time, pathogens may grow in its dead corners, leading to a risk of infection for experimental animals during the modeling process and affecting the modeling effect.

[0004] Chinese Patent with publication number CN215273583U and publication date December 24, 2021 discloses an experimental mouse atomizing drug delivery device, which includes an anti-overflow bottom plate, a drug delivery cover, a rhombic telescopic mechanism, an atomizing top plate, and suction cups. A fogging inlet is integrally formed in the middle of the upper surface of the drug delivery cover, and an atomizing top plate is arranged at the top inside the drug delivery cover. An atomizing buffer area is formed between the atomizing top plate and the inner top wall of the drug delivery cover. A plurality of atomizing nozzles are evenly spaced on the atomizing top plate. The anti-overflow bottom plate is located at the bottom of the drug delivery cover, and an anti-overflow ring groove is integrally formed on the anti-overflow bottom plate. The anti-overflow bottom plate is connected to the drug delivery cover through the rhombic telescopic mechanisms arranged at its four corners. Suction cups are also fixedly installed at the four corners of the bottom of the cover body. This device cannot make the mice move passively in the drug delivery device and cannot meet the needs of establishing a mouse acute lung injury model. This device cannot make the mice move passively in the drug delivery device, affecting the effect of establishing a mouse acute lung injury model. Content of the Utility Model

[0005] Aiming at the deficiencies of the prior art, the utility model provides an atomizing drug delivery box for establishing a mouse acute lung injury model. The buffer area is removed from above the box body, and the mice are placed into the box body from above the box body. Then, the buffer area is placed at the upper end of the box body. The conveyor belt assembly is started to make the mice run on the conveyor belt assembly. Subsequently, the drug flows into the buffer area and the box body from the atomizer connection port, meeting the needs of using mice to establish a model.

[0006] The purpose of the utility model is achieved through the following technical solutions:

[0007] An atomizing drug delivery box for establishing a mouse acute lung injury model, comprising a buffer area, a box body and a conveyor belt assembly arranged in sequence from top to bottom. An atomizer connection port is arranged at the upper end of the buffer area. Openings are arranged around the box body. Both the upper and lower ends of the box body are open. The lower end of the buffer area is open and connected to the upper end of the box body. The lower end of the box body is connected to the conveyor belt assembly. The conveyor belt assembly is used to drive the mice placed in the box body to run.

[0008] Preferably, a bracket is arranged at the lower part of the outer wall of the box body.

[0009] Preferably, the buffer area is in the shape of a frustum of a pyramid, and the box body is in the shape of a cuboid.

[0010] Preferably, a fine pore gauze is arranged at the opening at the lower end of the buffer area.

[0011] Preferably, the atomizer connection port is connected to the atomizer through a connecting pipe.

[0012] Preferably, one side of the lower end of the buffer area is hinged to one side of the upper end of the box body, and the other side of the lower end of the buffer area is connected to the other side of the upper end of the box body through a buckle.

[0013] Preferably, the conveyor belt assembly includes a conveyor belt, a driving shaft and a driven shaft. The conveyor belt is rotatably arranged on the driving shaft and the driven shaft. The driving shaft and the driven shaft are rotatably connected to the lower end of the box body through bearing seats.

[0014] Preferably, the driving shaft is connected to a driving member through a connecting member. The driving member drives the driving shaft to rotate, thereby driving the conveyor belt to rotate.

[0015] Preferably, both the buffer area and the box body are made of acrylic material.

[0016] The beneficial effects of this technical solution are as follows:

[0017] First, for an atomizing drug delivery box for establishing a mouse acute lung injury model provided by the present utility model, the buffer area is removed from above the box body, the mouse is placed into the box body from above the box body, and then the buffer area is placed at the upper end of the box body; the openings provided on the box body promote gas exchange, so that the animal is not short of oxygen during the modeling process; the conveyor belt assembly is started to make the mouse run on the conveyor belt assembly, and then the drug flows into the buffer area and the box body from the atomizer connection port, meeting the requirements for using the mouse to establish a model.

[0018] Second, for an atomizing drug delivery box for establishing a mouse acute lung injury model provided by the present utility model, the fine pore gauze arranged at the opening at the lower end of the buffer area makes the drug disperse more evenly and slows down the sinking of the drug.

[0019] III. A nebulization drug delivery box for establishing a mouse acute lung injury model provided by the present utility model. One side of the lower end of the buffer area is hinged to one side of the upper end of the box body, and the other side of the lower end of the buffer area is connected to the other side of the upper end of the box body through a buckle, making it more convenient to disassemble the buffer area from the box body, and also enabling the locking of the buffer area and the box body to prevent mice from escaping between the buffer area and the box body.

[0020] IV. A nebulization drug delivery box for establishing a mouse acute lung injury model provided by the present utility model. The driving member drives the driving shaft to rotate through the transmission member, thereby causing the conveyor belt to rotate on the driving shaft and the driven shaft, making the mice on the conveyor belt run, meeting the requirements for establishing a mouse acute lung injury model. On the one hand, it can enhance the breathing frequency and depth of mice, enabling them to inhale a larger amount of drugs per unit time and improving the success rate of the model. On the other hand, the running of the mice stirs the air in the nebulization box, promoting the flow of the nebulizing agent in the box and achieving a uniform distribution, so that the modeling effects on different experimental animals can be relatively consistent. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 is a schematic structural view of the present utility model Figure 1 ;

[0022] Figure 2 is a schematic structural view of the present utility model Figure 2 ;

[0023] Figure 3 is a schematic structural view of the conveyor belt assembly in the present utility model;

[0024] Wherein: 1. Buffer area; 11. Nebulizer connection port; 2. Box body; 21. Opening; 3. Conveyor belt assembly; 31. Conveyor belt; 32. Driving shaft; 33. Driven shaft; 4. Bracket. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0025] The following further describes the present utility model in detail with reference to the embodiments, but the embodiments of the present utility model are not limited thereto.

[0026] Embodiment 1

[0027] As Figure 1 and Figure 2 shown, a nebulization drug delivery box for establishing a mouse acute lung injury model includes a buffer area 1, a box body 2, and a conveyor belt assembly 3 arranged in sequence from top to bottom. The upper end of the buffer area 1 is provided with a nebulizer connection port 11. The periphery of the box body 2 is provided with openings 21. Both the upper and lower ends of the box body 2 are open. The lower end of the buffer area 1 is open and connected to the upper end of the box body 2. The lower end of the box body 2 is connected to the conveyor belt assembly 3. The conveyor belt assembly 3 is used to drive the mice placed in the rectangular box body 2 to run.

[0028] Embodiment 2

[0029] The difference between this embodiment and Embodiment 1 is that, as Figure 3 shown, a bracket 4 is provided at the lower part of the outer wall of the box body 2. Placing the bracket 4 on the working platform makes the atomizing drug delivery box more stable.

[0030] Among them, the buffer area 1 is in the shape of a frustum of a pyramid; the box body 2 is in the shape of a cuboid.

[0031] Among them, a fine pore gauze is provided at the lower end opening of the buffer area 1.

[0032] Among them, the atomizer connection port 11 is connected to the atomizer through a connecting pipe.

[0033] Among them, one side of the lower end of the buffer area 1 is hinged to one side of the upper end of the box body 2, and the other side of the lower end of the buffer area 1 is connected to the other side of the upper end of the box body 2 through a buckle.

[0034] Among them, the conveyor belt assembly 3 includes a conveyor belt 31, a driving shaft 32 and a driven shaft 33. The conveyor belt 31 is rotatably arranged on the driving shaft 32 and the driven shaft 33, and the driving shaft 32 and the driven shaft 33 are rotatably connected to the lower end of the box body 2 through bearing seats.

[0035] Among them, the driving shaft 32 is connected to the driving member through a connecting member, and the driving member drives the driving shaft 32 to rotate, thereby driving the conveyor belt 31 to rotate. The connecting member is a prior art, such as a belt; the driving member is a prior art, such as a driving motor.

[0036] Among them, both the buffer area 1 and the box body 2 are made of acrylic materials.

[0037] The beneficial effects of this technical solution are as follows:

[0038] First, for an atomizing drug delivery box for establishing a model of acute lung injury in rats provided by the present utility model, the buffer area 1 is removed from above the box body 2, the rats are placed into the box body 2 from above the box body 2, and then the buffer area 1 is placed on the upper end of the box body 2. The opening 21 provided on the box body 2 promotes gas exchange, so that the animals do not lack oxygen during the modeling process; the conveyor belt assembly 3 is started to make the rats run on the conveyor belt assembly 3, and then the drug flows into the buffer area 1 and the box body 2 from the atomizer connection port 11, meeting the requirements for using rats to establish a model.

[0039] Second, for an atomizing drug delivery box for establishing a model of acute lung injury in rats provided by the present utility model, the fine pore gauze provided at the lower end opening of the buffer area 1 makes the drug disperse more evenly and slows down the sinking of the drug.

[0040] III. A nebulizing drug delivery box for establishing a mouse acute lung injury model provided by the present utility model. One side of the lower end of the buffer area is hinged to one side of the upper end of the box body 2, and the other side of the lower end of the buffer area 1 is connected to the other side of the upper end of the box body 2 through a buckle, making it more convenient to disassemble the buffer area 1 and the box body 2, and enabling the locking of the buffer area 1 and the box body 2 to prevent mice from escaping between the buffer area 1 and the box body 2.

[0041] IV. A nebulizing drug delivery box for establishing a mouse acute lung injury model provided by the present utility model. The driving member drives the driving shaft 32 to rotate through the transmission member, so that the conveyor belt 31 rotates on the driving shaft 32 and the driven shaft 33, causing the mice on the conveyor belt to run, meeting the requirements for establishing a mouse acute lung injury model. On the one hand, it can increase the respiratory rate and depth of mice, enabling them to inhale a larger amount of drugs per unit time and improving the success rate of the model. On the other hand, the running of the mice stirs the air in the nebulizing box, promoting the flow of the nebulizing agent in the box and achieving a uniform distribution, so that the modeling effects on different experimental animals can be relatively consistent.

[0042] The above are only the preferred embodiments of the present utility model, and do not impose any formal limitations on the present utility model. Any simple modifications and equivalent changes made to the above embodiments based on the technical essence of the present utility model all fall within the protection scope of the present utility model.

Claims

1. An atomization drug delivery kit for rat acute lung injury modeling, characterized in that: The invention comprises a buffer zone (1), a box body (2) and a conveyor belt assembly (3) which are arranged in sequence from top to bottom. The upper end of the buffer zone (1) is provided with an atomizer connection port (11). The box body (2) is provided with openings (21) around its periphery. The upper and lower ends of the box body (2) are both open. The lower end of the buffer zone (1) is open and connected to the upper end of the box body (2). The lower end of the box body (2) is connected to the conveyor belt assembly (3). The conveyor belt assembly (3) is used to drive mice placed in the box body (2) to run.

2. The atomization drug delivery kit for rat acute lung injury modeling according to claim 1, characterized in that: A bracket (4) is provided at the lower part of the outer wall of the box body (2).

3. The atomization drug delivery kit for rat acute lung injury modeling according to claim 1, characterized in that: The buffer zone (1) is in the shape of a prism.

4. The atomization drug delivery kit for rat acute lung injury modeling according to claim 3, characterized in that: The buffer zone (1) is in the shape of a prism, and the box body (2) is in the shape of a rectangle.

5. The atomization drug delivery kit for rat acute lung injury modeling according to claim 1, characterized in that: A fine mesh screen is provided at the lower opening of the buffer zone (1).

6. The atomization drug delivery kit for rat acute lung injury modeling according to claim 1, characterized in that: The atomizer connection port (11) is connected to the atomizer via a connecting pipe.

7. The atomization drug delivery kit for rat acute lung injury modeling according to claim 1, characterized in that: One side of the lower end of the buffer zone (1) is hinged to one side of the upper end of the box body (2), and the other side of the lower end of the buffer zone (1) is connected to the other side of the upper end of the box body (2) via a buckle.

8. The atomization drug delivery kit for rat acute lung injury modeling according to claim 1, characterized in that: The conveyor belt assembly (3) comprises a conveyor belt (31), a driving shaft (32) and a driven shaft (33); the conveyor belt (31) is rotatably arranged on the driving shaft (32) and the driven shaft (33); the driving shaft (32) and the driven shaft (33) are rotatably connected to the lower end of the box body (2) via a bearing seat.

9. The atomization drug delivery kit for rat acute lung injury modeling according to claim 8, characterized in that: The driving shaft (32) is connected to the driving member via a connecting member, and the driving member drives the driving shaft (32) to rotate, thereby driving the conveyor belt (31) to rotate.

10. The atomization drug delivery kit for rat acute lung injury modeling according to claim 1, characterized in that: The buffer zone (1) and the box body (2) are both made of acrylic material.

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