Acid-base property detection device for bioequivalence pre-test

Abstract

The utility model discloses an acid-base property detection device for bioequivalence pre-test, and relates to the technical field of acid-base property detection, the acid-base property detection device comprises a machine body and a connecting pipe, the inner side of the machine body is provided with a first air cylinder, one side of the first air cylinder is fixedly connected with a connecting box, and the connecting box is internally provided with a second air cylinder. According to the acid-base property detection device for the bioequivalence pre-test, a second air cylinder can drive a PH detection head to leave a sample barrel, then a first air cylinder continues to push a connecting box to move, when a connecting block on a water tank on one side of the connecting box makes contact with the inclined face of an inclined opening block, the connecting block moves downwards and drives a connecting rod to extrude a spring, and the connecting rod is driven to rotate; when a connecting rod moves downwards, a piston plate is driven to pressurize cleaning liquid in a water tank, a baffle is closed under the action of water pressure, the cleaning liquid enters a spray head through a hose and is sprayed out to clean the PH detection head, and the cleaning liquid after cleaning flows into a waste liquid tank to be collected.

Description

Technical Field

[0001] The utility model relates to the technical field of acid-base detection, in particular to an acid-base detection device for bioequivalence pre-testing. Background Technique

[0002] The acid-base detection device for bioequivalence pre-testing refers to the equipment used to detect the acidity and alkalinity of the solution involved in the dissolution, release or absorption process of pharmaceutical preparations in the body during the bioequivalence pre-testing process. Acidity and alkalinity have an important impact on the solubility and stability of drugs and their release behavior in the body.

[0003] When conducting bioequivalence pre-tests, it is necessary to detect pharmaceutical preparations through an acid-base detection device. When the existing acid-base detection device is in use, in order to ensure the accuracy of the detection, it is necessary to clean the pH detection head after each group of samples is detected. When cleaning, it is necessary to manually turn on the cleaning switch, which is not only troublesome but also easy to forget, thus affecting the detection results. Content of the Utility Model

[0004] The purpose of the utility model is to provide an acid-base detection device for bioequivalence pre-testing to solve the problem that the existing acid-base detection device is not convenient for cleaning the pH detection head proposed in the above background technique.

[0005] To achieve the above purpose, the utility model provides the following technical solution: an acid-base detection device for bioequivalence pre-testing, including: a body and a connecting pipe. A first cylinder is installed inside the body. A connecting box is fixedly connected to one side of the first cylinder. A second cylinder is installed inside the connecting box. A pH detection head is fixed to the bottom of the second cylinder.

[0006] The inside of the body is slidably connected to the connecting box through a sliding rod. A sample cylinder is arranged at the bottom of the second cylinder.

[0007] Preferably, the bottom of the sample cylinder is connected through a pipe to a fixing seat. The bottom of the fixing seat is fixedly connected to the body. One side of the fixing seat is connected through a connecting pipe to a waste liquid tank. The bottom of the waste liquid tank is fixedly connected to the body.

[0008] Preferably, an inclined mouth block is fixedly connected to one side of the body close to the waste liquid tank. A storage tank is fixedly connected to the top of the body. A water tank is fixedly connected to one side of the connecting box. The bottom of the water tank is connected through a hose to a spray head. One side of the spray head is fixedly connected to the connecting box through a bracket.

[0009] Preferably, one side of the water tank is connected to the storage tank through a hose. A cavity for the piston plate to slide is provided inside the water tank. A connecting rod is fixedly connected to the top of the piston plate. A sliding groove for the connecting rod to slide is provided at the top of the water tank. A spring is sleeved outside the connecting rod.

[0010] Preferably, the bottom of the spring is connected to the water tank. A connecting block is fixedly connected to the top of the connecting rod. A through groove is provided on one side of the water tank. A baffle is movably connected to the side of the water tank close to the through groove through a rotating shaft.

[0011] Preferably, a rack bar is fixedly connected to one side of the connection box. A gear body is meshed and connected to one side of the rack bar. A first synchronous pulley is fixedly connected to one side of the gear body.

[0012] Preferably, a synchronous belt is sleeved outside the first synchronous pulley. A second synchronous pulley is sleeved on one side of the synchronous belt. A first bevel gear is fixedly connected to one side of the second synchronous pulley.

[0013] Preferably, a second bevel gear is meshed and connected to the outside of the first bevel gear. A stirring rod is fixedly connected to one side of the second bevel gear. The outside of the stirring rod is movably connected to the sample cylinder through a bearing.

[0014] Compared with the prior art, the beneficial effects of the acid-base detection device for bioequivalence pre-tests are as follows: The first air cylinder can push the connection box to move. When the connection block on the water tank on one side of the connection box touches the inclined surface of the bevel block, it will move downward, and drive the connecting rod and the piston plate to pressurize the cleaning liquid in the water tank, so that the cleaning liquid is sprayed out through the nozzle to clean the pH detection head. When the connection box drives the pH detection head to move to the top of the sample cylinder, the rack bar will be meshed with the gear body, and drive the synchronous pulley set to rotate. The synchronous pulley set can drive the first bevel gear and the second bevel gear to be meshed, so as to drive the stirring rod to rotate and stir and mix the samples in the sample cylinder.

[0015] 1. When conducting bioequivalence pre-tests, it is necessary to detect the pharmaceutical preparations through an acid-base detection device. After the acid-base detection device has detected a group of samples, the second air cylinder can drive the pH detection head away from the sample cylinder. Then the first air cylinder will continue to push the connection box to move. When the connection block on the water tank on one side of the connection box touches the inclined surface of the bevel block, the connection block will move downward, and drive the connecting rod to squeeze the spring. When the connecting rod moves downward, it will drive the piston plate to pressurize the cleaning liquid in the water tank. Under the action of the water pressure, the baffle will be closed, and the cleaning liquid will enter the nozzle through the hose and be sprayed out to clean the pH detection head. The cleaned cleaning liquid will flow into the waste liquid tank for collection. Thus, through the above operations, it is convenient to automatically wash the pH detection head in the acid-base detection device.

[0016] 2. When conducting a pre - trial of bioequivalence, it is necessary to detect the pharmaceutical preparation through an acid - base detection device. When the connection box drives the pH detection head to move to the top of the sample cylinder, the rack bar will engage with the gear body and drive the first synchronous wheel to rotate. The first synchronous wheel can drive the second synchronous wheel to rotate through a synchronous belt. The second synchronous wheel can drive the first bevel gear to engage with the second bevel gear, thereby driving the stirring rod to rotate and mix the samples in the sample cylinder to prevent precipitation. Thus, through the above operations, it is convenient to automatically mix the detection samples in the acid - base detection device. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 is a three - dimensional schematic diagram of the present utility model;

[0018] Figure 2 is a three - dimensional sectional schematic diagram of the present utility model;

[0019] Figure 3 is a three - dimensional sectional schematic diagram of the water tank of the present utility model;

[0020] Figure 4 is an enlarged schematic diagram A of the present utility model;

[0021] Figure 5 is a three - dimensional schematic diagram of the gear of the present utility model.

[0022] In the figure: 1, the body; 2, the first cylinder; 3, the connection box; 4, the second cylinder; 5, the pH detection head; 6, the sample cylinder; 7, the fixed seat; 8, the connecting pipe; 9, the waste liquid tank; 10, the bevel - mouth block; 11, the water tank; 12, the spray head; 13, the storage tank; 14, the piston plate; 15, the connecting rod; 16, the spring; 17, the connecting block; 18, the baffle; 19, the rack bar; 20, the gear body; 21, the first synchronous wheel; 22, the synchronous belt; 23, the second synchronous wheel; 24, the first bevel gear; 25, the second bevel gear; 26, the stirring rod. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0023] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present utility model.

[0024] Please refer to Figures 1-4, the present utility model provides a technical solution: an acid-base detection device for bioequivalence pre-tests, comprising: a body 1 and a connecting pipe 8. A first cylinder 2 is installed inside the body 1. One side of the first cylinder 2 is fixedly connected to a connecting box 3. A second cylinder 4 is installed inside the connecting box 3. A PH detection head 5 is fixed to the bottom of the second cylinder 4.

[0025] The inside of the body 1 is slidably connected to the connecting box 3 through a slide bar. A sample cylinder 6 is arranged at the bottom of the second cylinder 4; the bottom of the sample cylinder 6 is connected through a pipe to a fixed seat 7, and the bottom of the fixed seat 7 is fixedly connected to the body 1. One side of the fixed seat 7 is connected through the connecting pipe 8 to a waste liquid tank 9, and the bottom of the waste liquid tank 9 is fixedly connected to the body 1; a beveled block 10 is fixedly connected to one side of the body 1 close to the waste liquid tank 9. A storage tank 13 is fixedly connected to the top of the body 1. One side of the connecting box 3 is fixedly connected to a water tank 11. The bottom of the water tank 11 is connected by a hose to a spray head 12, and one side of the spray head 12 is fixedly connected to the connecting box 3 through a bracket; one side of the water tank 11 is connected to the storage tank 13 through a hose. A cavity for the piston plate 14 to slide is provided inside the water tank 11. A connecting rod 15 is fixedly connected to the top of the piston plate 14. A chute for the connecting rod 15 to slide is provided at the top of the water tank 11. A spring 16 is sleeved on the outside of the connecting rod 15; the bottom of the spring 16 is connected to the water tank 11. A connecting block 17 is fixedly connected to the top of the connecting rod 15. A through groove is provided on one side of the water tank 11. A baffle 18 is movably connected to one side of the water tank 11 close to the through groove through a rotating shaft. The baffle 18 forms a rotating structure with the water tank 11 through the rotating shaft, and the connecting rod 15 forms a sliding structure with the water tank 11.

[0026] During specific implementation, when conducting bioequivalence pre-tests, it is necessary to detect pharmaceutical preparations through the acid-base detection device. After the acid-base detection device has completed the detection of a group of samples, the second cylinder 4 can drive the PH detection head 5 away from the sample cylinder 6, and then the first cylinder 2 will continue to push the connecting box 3 to move. When the connecting block 17 on the water tank 11 on one side of the connecting box 3 contacts the inclined surface of the beveled block 10, the connecting block 17 will move downward and drive the connecting rod 15 to squeeze the spring 16. When the connecting rod 15 moves downward, it will drive the piston plate 14 to pressurize the cleaning liquid in the water tank 11. Under the action of the water pressure, the baffle 18 will close, and the cleaning liquid will enter the spray head 12 through the hose and be sprayed out to clean the PH detection head 5. The cleaned cleaning liquid will flow into the waste liquid tank 9 for collection;

[0027] When it is necessary to detect the next group of samples, the first cylinder 2 is activated to pull the water tank 11 to reset. When the bevel block 10 disengages from the extrusion of the connecting block 17, the spring 16 will reset, driving the connecting rod 15 and the piston plate 14 to move upward. At this time, the cleaning liquid in the water tank 11 will flow into the water tank 11 through the hose, and the baffle 18 will open to complete the replenishment of the cleaning liquid in the water tank 11. When the sample in the sample cylinder 6 needs to be discharged, the valve connected to the bottom pipe of the sample cylinder 6 can be opened to allow the sample to flow into the fixed seat 7 and then into the waste liquid tank 9 through the connecting pipe 8. Thus, through the above operations, it is convenient to automatically flush the pH detection head 5 in the acid-base detection device.

[0028] Please refer to Figure 1 , Figure 2 and Figure 5 , one side of the connection box 3 is fixedly connected with a rack bar 19. One side of the rack bar 19 is meshed with a gear body 20. One side of the gear body 20 is fixedly connected with a first synchronous wheel 21; A synchronous belt 22 is sleeved on the outside of the first synchronous wheel 21. One side of the synchronous belt 22 is sleeved with a second synchronous wheel 23. One side of the second synchronous wheel 23 is fixedly connected with a first bevel gear 24; The outside of the first bevel gear 24 is meshed with a second bevel gear 25. One side of the second bevel gear 25 is fixedly connected with a stirring rod 26. The outside of the stirring rod 26 is movably connected to the sample cylinder 6 through a bearing. The first bevel gear 24 and the second bevel gear 25 form a meshing transmission structure.

[0029] During specific implementation, when conducting a bioequivalence pretest, it is necessary to detect the pharmaceutical preparation through an acid-base detection device. When detecting the sample in the acid-base detection device, in order to maintain the uniformity of the sample, a rack bar 19 is arranged on one side of the connection box 3. When the connection box 3 drives the pH detection head 5 to move to the top of the sample cylinder 6, the rack bar 19 will mesh with the gear body 20 and drive the first synchronous wheel 21 to rotate. The first synchronous wheel 21 can drive the second synchronous wheel 23 to rotate through the synchronous belt 22. The second synchronous wheel 23 can drive the first bevel gear 24 to mesh with the second bevel gear 25, thereby driving the stirring rod 26 to rotate and mixing the sample in the sample cylinder 6 to prevent precipitation. Thus, through the above operations, it is convenient to automatically mix the detected sample in the acid-base detection device.

[0030] In summary: When using the acid-base detection device for bioequivalence pretest, first add the sample into the sample cylinder 6, then activate the first cylinder 2 to drive the connection box 3 to move to the top of the sample cylinder 6, and then activate the second cylinder 4 to drive the pH detection head 5 to move down into the sample cylinder 6 to detect the acid-base property of the sample in the sample cylinder 6. These are the characteristics of the acid-base detection device for bioequivalence pretest. The content not described in detail in this specification belongs to the prior art well-known to those skilled in the art.

[0031] Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements on some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present utility model shall be included within the protection scope of the present utility model.

Claims

1. A bioequivalence preliminary test acid-base detection device, comprising: A machine body (1) and a connecting pipe (8), characterized in that a first cylinder (2) is installed on the inner side of the machine body (1), a connecting box (3) is fixedly connected to one side of the first cylinder (2), a second cylinder (4) is installed inside the connecting box (3), and a pH detection head (5) is fixed to the bottom of the second cylinder (4). The interior of the machine body (1) is slidably connected to the connection box (3) via a sliding rod, and a sample cylinder (6) is provided at the bottom of the second cylinder (4).

2. The acid-base detection device for bioequivalence pre-test according to claim 1, characterized in that: The bottom of the sample cylinder (6) is connected to a fixing seat (7) through a pipeline, and the bottom of the fixing seat (7) is fixedly connected to the machine body (1). One side of the fixing seat (7) is connected to a waste liquid tank (9) through a connecting pipe (8), and the bottom of the waste liquid tank (9) is fixedly connected to the machine body (1).

3. The acid-base detection device for bioequivalence pre-test according to claim 2, characterized in that: A bevel block (10) is fixedly connected to one side of the machine body (1) close to the waste liquid tank (9), a storage tank (13) is fixedly connected to the top of the machine body (1), a water tank (11) is fixedly connected to one side of the connection box (3), a nozzle (12) is connected to the bottom of the water tank (11) via a hose, and one side of the nozzle (12) is fixedly connected to the connection box (3) via a bracket.

4. The acid-base detection device for bioequivalence preliminary test according to claim 3, characterized in that: One side of the water tank (11) is connected to the storage box (13) via a hose, a cavity is provided inside the water tank (11) for the piston plate (14) to slide, a connecting rod (15) is fixedly connected to the top of the piston plate (14), a sliding groove is provided on the top of the water tank (11) for the connecting rod (15) to slide, and a spring (16) is sleeved on the outside of the connecting rod (15).

5. The acid-base detection device for bioequivalence preliminary test according to claim 4, characterized in that: The bottom of the spring (16) is connected to the water tank (11), the top of the connecting rod (15) is fixedly connected to a connecting block (17), a through slot is provided on one side of the water tank (11), and a baffle (18) is movably connected to the side of the water tank (11) close to the through slot via a rotating shaft.

6. The acid-base detection device for bioequivalence preliminary test according to claim 1, characterized in that: One side of the connection box (3) is fixedly connected to a rack rod (19), one side of the rack rod (19) is meshingly connected to a gear body (20), and one side of the gear body (20) is fixedly connected to a first synchronous wheel (21).

7. The acid-base detection device for bioequivalence preliminary test according to claim 6, characterized in that: A synchronous belt (22) is sleeved on the outer side of the first synchronous wheel (21), a second synchronous wheel (23) is sleeved on one side of the synchronous belt (22), and a first bevel gear (24) is fixedly connected to one side of the second synchronous wheel (23).

8. The acid-base detection device for bioequivalence preliminary test according to claim 7, characterized in that: The outer side of the first bevel gear (24) is meshingly connected to a second bevel gear (25), one side of the second bevel gear (25) is fixedly connected to a stirring rod (26), and the outer side of the stirring rod (26) is movably connected to the sample tube (6) via a bearing.

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