Micro-jet homogenizer for processing eye drops

Abstract

The utility model relates to a microjet homogenizer for processing eye drops, which comprises a power unit and a homogenizing working unit, the homogenizing working unit comprises a plunger pump, a sample injector, a diamond interaction cavity and a heat exchange tube, the plunger pump comprises a plunger pump shell and a plunger rod, a cooling jacket shell is arranged on the outer side of the plunger pump shell, and a cooling jacket is arranged on the outer side of the cooling jacket shell. A cooling water outlet is formed in the top of the cooling jacket shell, and a cooling water inlet is formed in the bottom of the cooling jacket shell. According to the utility model, the cooling structure is additionally arranged on the plunger pump to cool the plunger pump, so that a mixed solution is always in a proper temperature environment, and the condition that the product quality is influenced by metamorphism, precipitation and the like due to over-high temperature in the pressurization acceleration process is avoided; a three-way one-way valve and a Luer hose are used, so that when a product subjected to single-time homogenization needs to be continuously homogenized, the product can return to the sample injector through the Luer hose to be prepared to be continuously circularly treated.

Description

Technical Field

[0001] The utility model relates to the technical field of microfluidic homogenizers, in particular to a microfluidic homogenizer for processing eye drops. Background Technique

[0002] In a common preparation process of atropine eye drops, it is necessary to perform homogenization nanometer treatment on a protein lyophilized powder mixed solution, in which a microfluidic homogenizer is needed to process the mixed solution. Among them, the mixed solution needs to be kept in an environment of about 10 degrees Celsius as much as possible, and at least three homogenization treatments need to be carried out repeatedly. The existing microfluidic homogenizers generally only perform heat exchange treatment after homogenization treatment, and cannot ensure that the mixed solution is always in a suitable temperature environment. At the same time, the existing method of collecting finished products generally uses a syringe-type collection container. When multiple homogenization treatments need to be carried out on the mixed solution, multiple operations of collecting and adding the solution are required, resulting in waste of manpower. Content of the Utility Model

[0003] The utility model aims to solve the deficiencies of the prior art and provides a microfluidic homogenizer for processing eye drops.

[0004] To achieve the above object, the utility model adopts the following technical solutions: A microfluidic homogenizer for processing eye drops, comprising: a power unit and a homogenization working unit. The homogenization working unit includes: a plunger pump, a sampler, a diamond interaction chamber, and a heat exchange tube. The plunger pump includes a plunger pump housing, a plunger rod, and a cooling jacket housing. A high-pressure cylinder is provided in the plunger pump housing. The plunger rod is fixedly connected to the power unit and is placed inside the high-pressure cylinder. The plunger pump housing is provided with a feed channel and a discharge channel, both of which are communicated with the high-pressure cylinder. The feed channel is connected to the discharge port of the sampler, and a one-way valve is provided between the feed channel and the sampler. A cooling jacket housing is provided outside the plunger pump housing. A cooling water outlet is provided at the top of the cooling jacket housing, and a cooling water inlet is provided at the bottom of the cooling jacket housing.

[0005] Further, it further includes a three-way one-way valve. The discharge channel is connected to the feed port of the diamond interaction chamber. The discharge port of the diamond interaction chamber is connected to the feed port of the heat exchange tube. The discharge port of the heat exchange tube is connected to the bottom of the three-way one-way valve.

[0006] Further, the three-way one-way valve includes a valve body. A silica gel one-way valve core is provided in the inner cavity at the bottom of the valve body. A Luer connector is provided at the top of the valve body. A Luer connector sleeve is sleeved outside the Luer connector. A Luer hose connector is provided on the right side of the valve body.

[0007] Further, it also includes a Luer hose, the upper end of the Luer hose is connected to the Luer hose connector, and the lower end of the Luer hose leads into the feed port of the injector.

[0008] Further, an electric telescopic rod is provided in the power unit, and the movable end of the electric telescopic rod is fixedly connected to the plunger rod.

[0009] The beneficial effects of the present utility model are as follows: A cooling structure is added to the plunger pump of the present utility model to cool down the plunger pump, ensuring that the mixed solution is always in a suitable temperature environment and preventing the situation of product quality deterioration and precipitation due to excessive temperature during the pressurization and acceleration processes; The use of a three-way check valve and a Luer hose enables the product that has undergone single homogenization to return to the injector through the Luer hose when further homogenization processing is required, preparing for continuous circulation processing. Description of the Drawings

[0010] Figure 1 is a structural schematic diagram of the present utility model;

[0011] Figure 2 is a structural schematic diagram of the homogenization working unit;

[0012] Figure 3 is a structural schematic diagram of the three-way check valve;

[0013] In the figure: 1 - power unit; 10 - electric telescopic rod; 2 - plunger pump; 20 - plunger pump housing; 21 - plunger rod; 22 - cooling jacket housing; 23 - high-pressure cylinder; 24 - feed channel; 25 - discharge channel; 26 - cooling water outlet; 27 - cooling water inlet; 3 - injector; 30 - check valve; 4 - diamond interaction cavity; 5 - heat exchange tube; 6 - three-way check valve; 60 - valve body; 61 - silicone check valve core; 62 - Luer connector; 63 - Luer connector sleeve; 64 - Luer hose connector; 7 - Luer hose;

[0014] The drawings in the present utility model are all schematic diagrams, and their sizes do not represent actual sizes;

[0015] The following will be described in detail with reference to the embodiments of the present utility model with reference to the drawings. Specific Embodiments

[0016] The present utility model will be further described below with reference to the drawings and embodiments:

[0017] Such as Figures 1 to 3As shown in the figure, a microfluidic homogenizer for eye drop processing includes a power unit 1 and a homogenization working unit. The homogenization working unit includes a plunger pump 2, an injector 3, a diamond interaction chamber 4, and a heat exchange tube 5. The plunger pump 2 includes a plunger pump housing 20, a plunger rod 21, and a cooling jacket housing 22. A high-pressure cylinder 23 is provided inside the plunger pump housing 20. The plunger rod 21 is fixedly connected to the power unit 1 and is placed inside the high-pressure cylinder 23. A feed channel 24 and a discharge channel 25 are provided on the plunger pump housing 20. Both the feed channel 24 and the discharge channel 25 communicate with the high-pressure cylinder 23. The feed channel 24 is connected to the discharge port of the injector 3. A one-way valve 30 is provided between the feed channel 24 and the injector 3. A cooling jacket housing 22 is provided outside the plunger pump housing 20. A cooling water outlet 26 is provided at the top of the cooling jacket housing 22, and a cooling water inlet 27 is provided at the bottom of the cooling jacket housing 22. When the material passes through the high-pressure cylinder 23, cooling water is introduced from the cooling water inlet 27 to fill the inside of the cooling jacket housing 22, physically cooling the material, and finally discharging it from the cooling water outlet 26. The plunger rod 21 is a high-hardness zirconia wear-resistant plunger rod.

[0018] It further includes a three-way one-way valve 6. The discharge channel 25 is connected to the feed port of the diamond interaction chamber 4. The discharge port of the diamond interaction chamber 4 is connected to the feed port of the heat exchange tube 5. The discharge port of the heat exchange tube 5 is connected to the bottom of the three-way one-way valve 6. The three-way one-way valve 6 can realize two functions: collecting the processed material or continuing to circulate and process the material.

[0019] The three-way one-way valve 6 includes a valve body 60. A silica gel one-way valve core 61 is provided in the inner cavity at the bottom of the valve body 60. A Luer connector 62 is provided at the top of the valve body 60. A Luer connector sleeve 63 is sleeved outside the Luer connector 62. A Luer hose connector 64 is provided on the right side of the valve body 60. When the Luer connector sleeve 63 is sleeved, the material is circulated; when the Luer connector sleeve 63 is removed, the finished product is collected.

[0020] It further includes a Luer hose 7. The upper end of the Luer hose 7 is connected to the Luer hose connector 64, and the lower end of the Luer hose 7 leads into the feed port of the injector 3. When multiple homogenization treatment cycles are required, the material after a single homogenization treatment is automatically collected into the injector 3.

[0021] An electric telescopic rod 10 is provided inside the power unit 1. The movable end of the electric telescopic rod 10 is fixedly connected to the plunger rod 21. The electric telescopic rod 10 drives the plunger rod 21 to perform cyclic telescopic processing.

[0022] The usage steps of the present utility model are as follows: The power unit 1 drives the plunger rod 21 in the high-pressure cylinder 23 to reciprocate back and forth. When the plunger rod 21 retracts, it will form a negative pressure in the high-pressure cylinder 23, and the one-way valve 30 will open. The sample will enter the high-pressure cylinder 23 through the sampling channel 24. When the plunger rod 21 is pushed forward, the sample will not flow back from the feeding channel 24. Finally, the sample is pressurized and accelerated and enters the diamond interaction cavity 4. During this process, cooling water is connected at the cooling jacket housing 22. The material passes through the internal pipeline of the high-pressure cylinder 23, and the cooling water cools it physically from the outside to ensure that the sample is at an appropriate temperature. The sample passes through the diamond interaction cavity 4 to make the particle size of the sample nano-sized and uniformly refined, and is physically cooled again through the heat exchange tube, and finally enters the three-way one-way valve 6. When continuous homogenization cycle is required, the Luer connector sleeve 63 is used to block the Luer connector 62, and the Luer hose 7 is connected to the Luer hose connector 64. The processed material is automatically collected in the sampler 3 and waits for the next homogenization treatment; when multiple homogenization treatments are completed, the Luer hose 7 and the Luer connector sleeve 63 are removed, and the finished product is collected from the Luer connector 62 using a syringe-type container.

[0023] The present utility model has been described exemplarily above in conjunction with the accompanying drawings. Obviously, the specific implementation of the present utility model is not limited by the above-mentioned manner. As long as various improvements are made by adopting the method concept and technical solution of the present utility model, or directly applied to other occasions without improvement, they are all within the protection scope of the present utility model.

Claims

1. A microfluidizer for eye drops processing, characterized in that: include: A power unit (1) and a homogenizing working unit, wherein the homogenizing working unit comprises: a plunger pump (2), an injector (3), a diamond interaction chamber (4), and a heat exchange tube (5); the plunger pump (2) comprises a plunger pump housing (20), a plunger rod (21), and a cooling jacket housing (22); a high-pressure cylinder (23) is provided in the plunger pump housing (20); the plunger rod (21) is fixedly connected to the power unit (1); the plunger rod (21) is placed in the high-pressure cylinder (23); a feed passage is provided on the plunger pump housing (20); A feed channel (24) and a discharge channel (25), the feed channel (24) and the discharge channel (25) are both in communication with the high-pressure cylinder (23), the feed channel (24) is connected to the discharge port of the injector (3), a one-way valve (30) is provided between the feed channel (24) and the injector (3), a cooling jacket shell (22) is provided on the outside of the plunger pump shell (20), a cooling water outlet (26) is provided on the top of the cooling jacket shell (22), and a cooling water inlet (27) is provided on the bottom of the cooling jacket shell (22).

2. A microfluidizer for eye drops processing according to claim 1, characterized in that: It also includes a three-way one-way valve (6), the discharge channel (25) is connected to the feed port of the diamond interaction chamber (4), the discharge port of the diamond interaction chamber (4) is connected to the feed port of the heat exchange tube (5), and the discharge port of the heat exchange tube (5) is connected to the bottom of the three-way one-way valve (6).

3. A microfluidizer for eye drops processing according to claim 2, characterized in that: The three-way one-way valve (6) comprises a valve body (60), a silicone one-way valve core (61) is provided in the inner cavity at the bottom of the valve body (60), a Luer connector (62) is provided at the top of the valve body (60), a Luer connector sleeve (63) is sleeved on the outer side of the Luer connector (62), and a Luer hose connector (64) is provided on the right side of the valve body (60).

4. A microfluidizer for eye drops processing according to claim 3, characterized in that: It also includes a Luer hose (7), the upper end of which is connected to the Luer hose connector (64), and the lower end of which is connected to the feed port of the sample injector (3).

5. A microfluidizer for eye drops processing according to claim 1, characterized in that: An electric telescopic rod (10) is provided in the power unit (1), and the movable end of the electric telescopic rod (10) is fixedly connected to the plunger rod (21).

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