Sealing device of chromatographic column

Abstract

The utility model discloses a sealing device of a chromatographic column, which relates to the technical field of mounting equipment and comprises a chromatographic column main body and a liquid inlet fixed on one side of the chromatographic column main body. Through the arrangement of the sealing mechanism arranged on one side of the liquid inlet and the connecting mechanism arranged on one side of the liquid outlet, when the connector is connected, the connector and the sealing ring sleeved on the surface of the connector are inserted into the adapter on one side together, then the threaded pipe on the surface of the adapter slides to a proper position, and then the threaded pipe is rotated, so that the connector is connected with the liquid outlet. According to the connecting device, the threaded pipe is arranged in the threaded hole formed in the surface of the connecting opening, so that the connecting opening is in butt joint, and the stability of equipment connection is improved; the threaded holes in the flange plate A and the flange plate B on one side of the liquid outlet are aligned, and the threaded column is adopted for connection and fixation; and sealing gaskets arranged in the flange plate A and the flange plate B are matched, so that the sealing performance of the device can be effectively improved.

Description

Technical Field

[0001] The utility model relates to the technical field of chromatographic columns, and specifically relates to a sealing device for a chromatographic column. Background Technique

[0002] Chromatographic columns are widely used in the biopharmaceutical industry to separate drugs and bulk drugs from raw materials and by-products. Generally, the finally produced drugs directly act on human blood, which requires accurate separation of the chromatographic column to achieve extremely high cleanliness and biocompatibility of the products. Chromatographic analysis is an important chemical analysis technique and is widely used in fields such as medicine, environmental monitoring, and food safety. During the chromatographic analysis process, as a key component, the internal sealing device of the chromatographic column plays a crucial role. The sealing device not only affects the accuracy and sensitivity of the analysis but also directly affects the chromatographic separation effect and the stability of the instrument.

[0003] However, the existing sealing devices of chromatographic columns have poor sealing performance and lack an anti-backflow function inside the sealing device, which can improve the accuracy and reproducibility of the analysis and is particularly important for chromatographic analysis applications that require high precision and sensitivity. Content of the Utility Model

[0004] The utility model provides a sealing device for a chromatographic column to solve the problems of poor existing sealing performance and lack of an anti-backflow function inside the sealing device.

[0005] The utility model provides the following technical scheme: A sealing device for a chromatographic column includes a chromatographic column main body and a liquid inlet fixed on one side of the chromatographic column main body, and further includes: a sealing mechanism arranged on one side of the liquid inlet, the sealing mechanism includes a connection port, a sealing ring, and a threaded pipe; a swivel joint arranged on the inner wall of the threaded pipe, one side of the swivel joint is fixedly connected with a flow pipe, the surface of the flow pipe is fixedly connected with a fixed cylinder, and one side of the fixed cylinder is fixedly connected with an anti-backflow mechanism, the anti-backflow mechanism includes a torsion spring, a rotating rod, and a rubber plate; a liquid outlet arranged on the back of the flow pipe, one side of the liquid outlet is fixedly connected with a connection mechanism, and the connection mechanism includes a flange A, a flange B, and a sealing gasket.

[0006] As a preferred technical scheme of the utility model, the connection port is fixedly connected to one side of the liquid inlet, the surface of the connection port is sleeved with a sealing ring, the surface of the connection port is provided with a threaded hole, and the threaded hole is internally threaded with a threaded pipe.

[0007] As a preferred technical scheme of the utility model, the torsion spring is fixedly connected to one side of the fixed cylinder, one side of the torsion spring is fixedly connected with a rotating rod, and the bottom of the rotating rod is fixedly connected with a rubber plate.

[0008] As a preferred technical solution of the present utility model, the flange A is fixedly connected to one side of the liquid outlet, the surface of the flange A is threadedly connected with a flange B, and a gasket is installed inside the flange A and the flange B.

[0009] As a preferred technical solution of the present utility model, a plurality of threaded holes are formed on the surfaces of the flange A and the flange B, and threaded posts are threadedly connected inside the threaded holes.

[0010] As a preferred technical solution of the present utility model, two groups of handles are fixedly connected to the surface of the flow pipe, and an anti-slip sleeve is sleeved on the surface of the handle.

[0011] As a preferred technical solution of the present utility model, an observation window is formed on one side of the flow pipe, and the observation window is made of acrylic.

[0012] As a preferred technical solution of the present utility model, a filter groove is formed inside the flow pipe, and a filter screen is installed inside the filter groove.

[0013] Compared with the prior art, the present utility model provides a sealing device for a chromatographic column, which has the following beneficial effects:

[0014] 1. For the sealing device of the chromatographic column, through the setting of the sealing mechanism on one side of the liquid inlet and the connection mechanism on one side of the liquid outlet, when connecting the interfaces, the connection port and the sealing ring sleeved on the surface are inserted into the internal of the adapter on one side together. Then, after sliding the threaded pipe on the surface of the adapter to the appropriate position, the threaded pipe is rotated, so that the threaded pipe rotates inside the threaded hole formed on the surface of the connection port to achieve the docking of the connection port, improving the connection stability of the device. Secondly, align the threaded holes on the flange A and the flange B on one side of the liquid outlet, and use threaded posts for connection and fixation. With the gaskets arranged inside the flange A and the flange B, the sealing performance of the device can be effectively improved.

[0015] 2. For the sealing device of the chromatographic column, through the setting of the anti-backflow mechanism inside the flow pipe, when transporting liquid, the rubber plate arranged inside the flow pipe changes its angle due to the liquid pressure, and at this time, a passage is formed inside the flow pipe. When there is no pressure to push the rubber plate, the rubber plate returns to the starting position under the reverse acting force provided by the torsion spring at the top, and seals the internal space of the flow pipe, thus achieving the effect of preventing backflow, ensuring that the liquid can only flow in the predetermined direction and cannot flow reversely, thereby ensuring the accuracy and reliability of the analysis. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a schematic diagram of the overall structure of the present utility model;

[0017] Figure 2 Structural schematic diagram of the sealing mechanism of the present utility model;

[0018] Figure 3 Structural schematic diagram of the anti-backflow mechanism of the present utility model;

[0019] Figure 4 Structural schematic diagram of the connection mechanism of the present utility model.

[0020] In the figure: 1, chromatographic column main body; 2, liquid inlet; 3, sealing mechanism; 301, connection port; 302, sealing ring; 303, threaded pipe; 4, adapter; 5, flow pipe; 6, fixed cylinder; 7, anti-backflow mechanism; 701, torsion spring; 702, rotating rod; 703, rubber plate; 8, liquid outlet; 9, connection mechanism; 901, flange A; 902, flange B; 903, sealing gasket; 10, threaded column; 11, handle; 12, observation window; 13, filter screen. Specific embodiments

[0021] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present utility model.

[0022] Please refer to Figures 1-4 , the present utility model discloses a sealing device for a chromatographic column, including a chromatographic column main body 1 and a liquid inlet 2 fixed on one side of the chromatographic column main body 1, and further including: a sealing mechanism 3 provided on one side of the liquid inlet 2, the sealing mechanism 3 including a connection port 301, a sealing ring 302 and a threaded pipe 303; an adapter 4 provided on the inner wall of the threaded pipe 303, one side of the adapter 4 is fixedly connected with a flow pipe 5, the surface of the flow pipe 5 is fixedly connected with a fixed cylinder 6, one side of the fixed cylinder 6 is fixedly connected with an anti-backflow mechanism 7, the anti-backflow mechanism 7 including a torsion spring 701, a rotating rod 702 and a rubber plate 703; a liquid outlet 8 provided on the back of the flow pipe 5, one side of the liquid outlet 8 is fixedly connected with a connection mechanism 9, the connection mechanism 9 including a flange A 901, a flange B 902 and a sealing gasket 903.

[0023] Specifically, the connection port 301 is fixedly connected to one side of the liquid inlet 2, the surface of the connection port 301 is sleeved with a sealing ring 302, a threaded hole is provided on the surface of the connection port 301, and a threaded pipe 303 is threadedly connected inside the threaded hole.

[0024] In this implementation scheme, the connection port 301 and the sealing ring 302 sleeved on the surface are inserted into the adapter 4 on one side together. Then, after sliding the threaded tube 303 on the surface of the adapter 4 to a proper position, the threaded tube 303 is rotated so that the threaded tube 303 rotates inside the threaded hole opened on the surface of the connection port 301 to realize the docking of the connection port 301.

[0025] Specifically, when the torsion spring 701 is fixedly connected to one side of the fixed cylinder 6, a rotating rod 702 is fixedly connected to one side of the torsion spring 701, and a rubber plate 703 is fixedly connected to the bottom of the rotating rod 702.

[0026] In this implementation scheme, the rubber plate 703 arranged inside the flow pipe 5 is caused to change its angle due to the liquid pressure, and at this time, a passage is formed inside the flow pipe 5. When there is no pressure to push the rubber plate 703, the rubber plate 703 is subjected to the reverse acting force provided by the top torsion spring 701, so that the rubber plate 703 returns to the starting position and seals the internal space of the flow pipe 5.

[0027] Specifically, a flange A901 is fixedly connected to one side of the liquid outlet 8, a flange B902 is threadedly connected to the surface of the flange A901, and a gasket 903 is installed inside the flange A901 and the flange B902.

[0028] In this implementation scheme, the threaded holes on the flange A901 and the flange B902 on one side of the liquid outlet 8 are aligned, and the threaded column 10 is used for connection and fixation.

[0029] Specifically, a plurality of threaded holes are opened on the surfaces of the flange A901 and the flange B902, and the threaded column 10 is threadedly connected inside the threaded holes.

[0030] Specifically, two groups of handles 11 are fixedly connected to the surface of the flow pipe 5, and an anti-slip sleeve is sleeved on the surface of the handles 11.

[0031] In this implementation scheme, the threaded column 10 is convenient for improving the stability of the flange A901 and the flange B902, and the handle 11 is convenient for carrying the device.

[0032] Specifically, an observation window 12 is opened on one side of the flow pipe 5, and the material of the observation window 12 is acrylic.

[0033] Specifically, a filter tank is opened inside the flow pipe 5, and a filter screen 13 is installed inside the filter tank.

[0034] Working principle and usage process of the present utility model: When making an interface connection, insert the connection port 301 and the sealing ring 302 sleeved on the surface together into the adapter 4 on one side. Then, slide the threaded tube 303 on the surface of the adapter 4 to a proper position, and then rotate the threaded tube 303 so that the threaded tube 303 rotates inside the threaded hole formed on the surface of the connection port 301 to achieve the docking of the connection port 301, improving the stability of the device connection. Secondly, align the threaded holes on the flange A 901 and the flange B 902 on one side of the liquid outlet 8 and use the threaded column 10 for connection and fixation.

[0035] When conducting liquid transportation, the rubber plate 703 arranged inside the flow pipe 5 undergoes an angular change due to the liquid pressure, and at this time, a passage is formed inside the flow pipe 5. When there is no pressure to push the rubber plate 703, the rubber plate 703 returns to its starting position under the reverse force provided by the torsion spring 701 at the top, and seals the internal space of the flow pipe 5.

[0036] In summary, for the sealing device of this chromatographic column, through the sealing mechanism 3 arranged on one side of the liquid inlet 2 and the connection mechanism 9 arranged on one side of the liquid outlet 8, and in cooperation with the sealing gasket 903 arranged inside the flange A 901 and the flange B 902, the sealing performance of the device can be effectively improved. Through the anti-backflow mechanism 7 arranged inside the flow pipe 5, it is ensured that the liquid can only flow in a predetermined direction and cannot flow backward, thereby ensuring the accuracy and reliability of the analysis.

[0037] It should be noted that in this article, terms such as "including", "comprising" or any other variant thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. Without further limitations, an element defined by the statement "including one..." does not exclude the existence of additional identical elements in the process, method, article or device including the said element.

[0038] Although the embodiments of the present utility model have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principle and spirit of the present utility model. The scope of the present utility model is defined by the appended claims and their equivalents.

Claims

1. A sealing device for a chromatographic column, comprising a chromatographic column body (1) and a liquid inlet (2) fixed on one side of the chromatographic column body (1), characterized in that: Also includes: A sealing mechanism (3) disposed on one side of the liquid inlet (2), the sealing mechanism (3) comprising a connecting port (301), a sealing ring (302) and a threaded tube (303); An adapter (4) is arranged on the inner wall of the threaded tube (303), one side of the adapter (4) is fixedly connected to a flow tube (5), a surface of the flow tube (5) is fixedly connected to a fixed cylinder (6), one side of the fixed cylinder (6) is fixedly connected to an anti-backflow mechanism (7), and the anti-backflow mechanism (7) comprises a torsion spring (701), a rotating rod (702) and a rubber plate (703); A liquid outlet (8) is provided on the back of the circulation tube (5), and a connecting mechanism (9) is fixedly connected to one side of the liquid outlet (8), wherein the connecting mechanism (9) comprises a flange A (901), a flange B (902) and a sealing gasket (903).

2. The sealing device for a chromatographic column according to claim 1, characterized in that: The connection port (301) is fixedly connected to one side of the liquid inlet (2); a sealing ring (302) is sleeved on the surface of the connection port (301); a threaded hole is provided on the surface of the connection port (301); and a threaded pipe (303) is threadedly connected to the interior of the threaded hole.

3. The sealing device for a chromatographic column according to claim 1, characterized in that: The torsion spring (701) is fixedly connected to one side of the fixed cylinder (6), and a rotating rod (702) is fixedly connected to one side of the torsion spring (701), and a rubber plate (703) is fixedly connected to the bottom of the rotating rod (702).

4. The sealing device for a chromatographic column according to claim 1, characterized in that: The flange A (901) is fixedly connected to one side of the liquid outlet (8), the surface of the flange A (901) is threadedly connected to the flange B (902), and sealing gaskets (903) are installed inside the flange A (901) and the flange B (902).

5. The sealing device for a chromatographic column according to claim 1, characterized in that: The surfaces of the flange A (901) and the flange B (902) are both provided with a plurality of threaded holes, and the internal threads of the threaded holes are connected to threaded columns (10).

6. The sealing device for a chromatographic column according to claim 1, characterized in that: Two groups of handles (11) are fixedly connected to the surface of the circulation tube (5), and anti-slip sleeves are sleeved on the surfaces of the handles (11).

7. The sealing device for a chromatographic column according to claim 1, characterized in that: An observation window (12) is provided on one side of the circulation tube (5), and the material of the observation window (12) is acrylic.

8. The sealing device for a chromatographic column according to claim 1, characterized in that: A filter tank is provided inside the circulation pipe (5), and a filter screen (13) is installed inside the filter tank.

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