Dialysis device

Abstract

The utility model relates to the technical field of dialysis equipment, and provides a dialysis device which comprises a connecting pipe with two open ends. One end of the sample tube is open, and the opening of the sample tube is detachably connected to one end of the connecting tube in a sealing manner; an opening is formed in one end of the dialysate tube, and the opening of the dialysate tube is detachably connected to the other end of the connecting tube in a sealed mode; the dialysis membrane is clamped between the sample tube and the connecting tube; substances to be separated in sample liquid in the sample tube can enter the dialysate tube through the dialysis membrane and the connecting tube. The dialysis bag can solve the problems that in the dialysis process of an existing dialysis bag, operation is tedious, pollution is likely to be caused, and sample liquid loss is likely to be caused.

Description

Technical Field

[0001] The utility model relates to the technical field of dialysis equipment, in particular to a dialysis device. Background Art

[0002] Dialysis technology is one of the commonly used separation and purification methods in biomedical and chemical experiments, especially suitable for steps that require the removal of small molecule impurities such as nanoparticles. At present, common dialysis equipment is mostly dialysis bags or similar traditional devices. These devices are usually made of semi-permeable membrane materials. The mixture is placed inside the bag and immersed in a large amount of buffer solution or water, so that small molecules diffuse through the membrane into the external solvent, thereby achieving the removal of impurities.

[0003] However, traditional dialysis bags have some limitations in practical applications. Traditional dialysis bags are often sealed with strings, rubber bands or dialysis bag clips. This method is not only cumbersome to operate, but also prone to contamination and sample loss. These problems have limited the use efficiency and reliability of traditional dialysis equipment to a certain extent, especially in precision experiments, these problems will be more prominent. Therefore, it is necessary to develop a more efficient and safe dialysis device to meet the purification requirements of samples such as nanoparticles. Summary of the Utility Model

[0004] The purpose of the utility model is to provide a dialysis device to solve the problems of cumbersome operation, easy contamination and sample liquid loss existing in the existing dialysis process using dialysis bags.

[0005] The above technical purpose of the utility model is mainly achieved through the following technical solutions:

[0006] The utility model provides a dialysis device, which includes:

[0007] A connecting pipe with openings at both ends;

[0008] A sample tube with one end open, and the opening of the sample tube is detachably and sealingly connected to one end of the connecting pipe;

[0009] A dialysis liquid tube with one end open, and the opening of the dialysis liquid tube is detachably and sealingly connected to the other end of the connecting pipe;

[0010] A dialysis membrane, clamped between the sample tube and the connecting pipe;

[0011] Wherein, the substance to be separated in the sample liquid in the sample tube can enter the dialysis liquid tube through the dialysis membrane and the connecting pipe.

[0012] In a preferred embodiment of the utility model, the connecting pipe is threadedly connected to the sample tube; and / or, the connecting pipe is threadedly connected to the dialysis liquid tube.

[0013] In a preferred embodiment of the present utility model, the two ends of the connecting pipe are open and provided with internal threads, the opening of the sample pipe is provided with an external thread, and the opening of the dialysis solution pipe is also provided with an external thread.

[0014] In a preferred embodiment of the present utility model, at least a part of the dialysis membrane is clamped in the thread pair formed between the external thread on the sample pipe and the internal thread on the connecting pipe, and at least another part of the dialysis membrane separates the inner cavity of the sample pipe from the inner cavity of the connecting pipe.

[0015] In a preferred embodiment of the present utility model, the helix directions of the internal threads at both ends of the connecting pipe are opposite.

[0016] In a preferred embodiment of the present utility model, elastic interfaces are provided at both open ends of the connecting pipe, the outer diameters of the sample pipe and the dialysis solution pipe are both larger than the inner diameter of the elastic interface, and the openings of the sample pipe and the dialysis solution pipe are respectively inserted into the two elastic interfaces.

[0017] In a preferred embodiment of the present utility model, the connecting pipe is a straight pipe made of an elastic material.

[0018] In a preferred embodiment of the present utility model, at least a part of the dialysis membrane is clamped in the interference socket pair formed between the opening on the sample pipe and the elastic interface on the connecting pipe, and at least another part of the dialysis membrane separates the inner cavity of the sample pipe from the inner cavity of the connecting pipe.

[0019] In a preferred embodiment of the present utility model, a base is provided at one end of the sample pipe away from its upper opening; and / or, a base is provided at one end of the dialysis solution pipe away from its upper opening.

[0020] In a preferred embodiment of the present utility model, the base includes a plurality of legs distributed in a radial pattern, and each leg is formed at the end of the sample pipe and / or the end of the dialysis solution pipe.

[0021] Compared with the prior art, the technical solution of the present utility model has the following characteristics and advantages:

[0022] When performing dialysis operations, the operation is simple, has good sealing performance, and is not easy to contaminate and lose the sample solution. Description of the Drawings

[0023] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings. In the drawings:

[0024] The drawings described herein are for illustrative purposes only and are not intended to limit the scope of the disclosure of the present invention in any way. Additionally, the shapes and proportional dimensions of the components in the drawings are only schematic and are used to assist in understanding the present invention, rather than specifically defining the shapes and proportional dimensions of the components of the present invention. Those skilled in the art can, under the teaching of the present invention, select various possible shapes and proportional dimensions according to specific circumstances to implement the present invention.

[0025] Figure 1 Schematic diagram of the disassembled structure of the dialysis device described in the present invention;

[0026] Figure 2 is Figure 1 the cross-sectional structure diagram in;

[0027] Figure 3 Schematic diagram of the assembled structure of the dialysis device described in the present invention.

[0028] Explanation of reference numerals:

[0029] 10. Connecting tube; 20. Sample tube; 30. Dialysate tube; 40. Dialysis membrane; 50. Support leg. Detailed implementation manners

[0030] In order to enable those skilled in the art to better understand the technical solutions in the present invention, the following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the drawings in the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, rather than all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0031] It should be noted that when an element is referred to as "disposed on" another element, it can be directly on the other element or there can also be an intermediate element. When an element is considered to be "connected" to another element, it can be directly connected to the other element or there may be an intermediate element at the same time. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are only for illustrative purposes and do not represent the only embodiments.

[0032] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the technical field to which this utility model belongs. The terms used in the description of this utility model herein are only for the purpose of describing specific embodiments and are not intended to limit this utility model. The term "and / or" used herein includes any and all combinations of one or more of the related listed items.

[0033] As Figures 1 to 3 shown, this utility model provides a dialysis device, which includes: a connecting tube 10 with openings at both ends; a sample tube 20 with an opening at one end, and the opening of the sample tube 20 is detachably and sealingly connected to one end of the connecting tube 10; a dialysis solution tube 30 with an opening at one end, and the opening of the dialysis solution tube 30 is detachably and sealingly connected to the other end of the connecting tube 10; a dialysis membrane 40, clamped between the sample tube 20 and the connecting tube 10; wherein, the substance to be separated in the sample solution in the sample tube 20 can enter the dialysis solution tube 30 through the dialysis membrane 40 and the connecting tube 10.

[0034] For the dialysis device described in this utility model, during the dialysis operation, the operation is simple, it has good sealing performance, and it is not easy to contaminate and lose the sample solution.

[0035] The following will detail the specific structures of each part of the dialysis device described in this utility model and the connection relationships between the parts.

[0036] As Figure 1 and Figure 2 shown, the dialysis device described in this utility model is mainly assembled by three parts: a connecting tube 10, a sample tube 20, and a dialysis solution tube 30.

[0037] The connecting tube 10 is a straight tube with openings at both ends, and it can be a rigid tube or a flexible tube with a certain elasticity.

[0038] The sample tube 20 is a straight tube with an opening at one end and a closed end, such as a glass test tube, centrifuge tube, cryopreservation tube, etc. commonly used in laboratories. The sample tube 20 is used to hold the sample solution to be dialyzed. The end of the sample tube 20 with the opening can be sealingly connected to one end of the connecting tube 10, thereby making the two communicate. The connection method between the sample tube 20 and the connecting tube 10 can be interference socket connection, threaded connection, snap connection, etc. No specific limitation is made here, as long as the sealing effect between the two is ensured.

[0039] The dialysis liquid tube 30 is similar to the sample tube 20. It is also a straight tube with one end open and the other end closed, such as the glass test tubes, centrifuge tubes, cryopreservation tubes, etc. commonly used in laboratories. The dialysis liquid tube 30 is used to hold dialysis liquid. The open end of the dialysis liquid tube 30 can be hermetically connected to the other end of the connecting tube 10, thereby enabling the two to communicate. That is to say, the sample tube 20 and the dialysis liquid tube 30 are respectively connected to both ends of the connecting tube 10. The connection method between the dialysis liquid tube 30 and the connecting tube 10 can be interference socket connection, threaded connection, snap connection, etc. There is no specific limitation here, as long as the sealing effect between the two is ensured.

[0040] Furthermore, as Figure 3 shown, a dialysis membrane 40 is clamped at the interface between the sample tube 20 and the connecting tube 10. The dialysis membrane 40 is usually a semipermeable membrane. Small molecules (substances to be separated) in the sample liquid in the sample tube 20 can pass through the semipermeable membrane and then diffuse into the dialysis liquid in the dialysis liquid tube 30. Semipermeable membranes with different cut-off molecular weight specifications can be replaced according to different requirements.

[0041] The operation steps of the dialysis device described in the present utility model for dialysis operation are as follows:

[0042] After sucking the sample liquid, put it into the sample tube 20, cover the dialysis membrane 40 on the opening of the sample tube 20, align one end of the connecting tube 10 with the opening of the sample tube 20 and connect the two together; after the dialysis liquid tube 30 is filled with dialysis liquid, align the other end of the connecting tube 10 with the opening of the dialysis liquid tube 30 and connect the two together. During the connection process, the opening of the dialysis liquid tube 30 needs to be facing upward or obliquely upward to prevent the dialysis liquid from flowing out during connection; place the connected device on the roller instrument to start dialysis. When the dialysis liquid needs to be replaced during dialysis, turn the opening of the dialysis liquid tube 30 upward or obliquely upward and remove it from the connecting tube 10, and repeat the steps of loading the dialysis liquid and connecting the device. After dialysis is completed, first remove the dialysis liquid tube 30, and then remove the connecting tube 10 and the dialysis membrane 40 from the sample tube 20 to take out the dialyzed sample liquid.

[0043] According to an embodiment of the present utility model, as Figures 1 to 3 shown, the connecting tube 10 is threadedly connected to the sample tube 20, and the connecting tube 10 is threadedly connected to the dialysis liquid tube 30.

[0044] Specifically, internal threads are provided at the openings at both ends of the connecting tube 10, external threads are provided at the opening of the sample tube 20, and external threads are also provided at the opening of the dialysis liquid tube 30; the circumferential edge area of the dialysis membrane 40 is clamped between the external threads on the sample tube 20 and the internal threads on the connecting tube 10 to form a thread pair, and the middle area of the dialysis membrane 40 separates the inner cavity of the sample tube 20 from the inner cavity of the connecting tube 10. Of course, in other embodiments of the present utility model, the positions of the internal threads and the external threads can be interchanged.

[0045] Preferably, the internal threads at both ends of the connecting tube 10 are screwed in opposite directions; the sample tube 20 and the dialysate tube 30 are screwed into the connecting tube 10 from two opposite directions, which facilitates the operator to connect the three and avoids loosening of the sample tube 20 when screwing in the dialysate tube 30.

[0046] According to one embodiment of the utility model, both end openings of the connecting tube 10 are provided with elastic interfaces, the outer diameter of the sample tube 20 and the outer diameter of the dialysate tube 30 are both larger than the inner diameter of the elastic interfaces, and the opening of the sample tube 20 and the opening of the dialysate tube 30 are respectively inserted into the two elastic interfaces.

[0047] Specifically, in one embodiment, the connecting tube 10 is a straight tube made of an elastic material, which may be rubber; the above-mentioned elastic interface is formed at both ends of the straight tube, the end of the sample tube 20 with an opening can stretch out the elastic interface and then connect to the connecting tube 10, and the end of the dialysate tube 30 with an opening can also stretch out the elastic interface and then connect to the connecting tube 10. The circumferential edge area of ​​the dialysis membrane 40 is clamped in the elastic interference sleeve formed between the opening on the sample tube 20 and the elastic interface on the connecting tube 10, and the middle area of ​​the dialysis membrane 40 separates the inner cavity of the sample tube 20 from the inner cavity of the connecting tube 10. In other embodiments of the utility model, the connecting tube 10 can also be made of a hard material, and elastic interfaces made of elastic material are installed in the openings at both ends of the connecting tube 10.

[0048] According to one embodiment of the present utility model, Figures 1 to 3 As shown, a base is provided at one end of the sample tube 20 away from the upper opening, and a base is also provided at one end of the dialysate tube 30 away from the upper opening; the provision of the base can facilitate the sample tube 20 and the dialysate tube 30 to stand upright, thereby freeing the operator's hands and facilitating the operator to perform other operations.

[0049] Specifically, Figure 1 As shown, in this embodiment, the base includes a plurality of legs 50 distributed radially, and each leg 50 is formed at the end of the sample tube 20 and the end of the dialysate tube 30. In other embodiments of the utility model, the base can also be made into a separate placement seat, which is sleeved on the bottom of the sample tube 20 and the bottom of the dialysate tube 30.

[0050] The specific embodiments described above further illustrate the purpose, technical solutions and beneficial effects of the utility model in detail. It should be understood that the above description is only a specific embodiment of the utility model and is not intended to limit the scope of protection of the utility model. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the utility model should be included in the scope of protection of the utility model.

Claims

1. A dialysis device, characterized in that: include: A connecting pipe (10) with openings at both ends; A sample tube (20) with an opening at one end, wherein the opening of the sample tube (20) is detachably sealed and connected to one end of the connecting tube (10); a dialysate tube (30) with an opening at one end, wherein the opening of the dialysate tube (30) is detachably sealed and connected to the other end of the connecting tube (10); A dialysis membrane (40) is sandwiched between the sample tube (20) and the connecting tube (10); The substances to be separated in the sample liquid in the sample tube (20) can enter the dialysate tube (30) through the dialysis membrane (40) and the connecting tube (10).

2. The dialysis device according to claim 1, characterized in that The connecting tube (10) is threadedly connected to the sample tube (20); and / or the connecting tube (10) is threadedly connected to the dialysate tube (30).

3. The dialysis device according to claim 2, characterized in that The openings at both ends of the connecting tube (10) are provided with internal threads, the opening of the sample tube (20) is provided with external threads, and the opening of the dialysate tube (30) is also provided with external threads.

4. The dialysis device according to claim 3, characterized in that At least a portion of the dialysis membrane (40) is sandwiched within a thread pair formed between the external thread on the sample tube (20) and the internal thread on the connecting tube (10), and at least another portion of the dialysis membrane (40) separates the inner cavity of the sample tube (20) from the inner cavity of the connecting tube (10).

5. The dialysis device according to claim 2, characterized in that The internal threads at both ends of the connecting pipe (10) have opposite rotation directions.

6. The dialysis device according to claim 1, characterized in that Both end openings of the connecting tube (10) are provided with elastic interfaces, the outer diameter of the sample tube (20) and the outer diameter of the dialysate tube (30) are both larger than the inner diameter of the elastic interfaces, and the opening of the sample tube (20) and the opening of the dialysate tube (30) are respectively inserted into the two elastic interfaces.

7. The dialysis device according to claim 6, characterized in that The connecting pipe (10) is a straight pipe made of elastic material.

8. The dialysis device according to claim 6, characterized in that At least a portion of the dialysis membrane (40) is sandwiched in an interference fit formed between the opening on the sample tube (20) and the elastic interface on the connecting tube (10), and at least another portion of the dialysis membrane (40) separates the inner cavity of the sample tube (20) from the inner cavity of the connecting tube (10).

9. The dialysis device according to claim 1, characterized in that The sample tube (20) has a base at one end away from the upper opening thereof; and / or the dialysate tube (30) has a base at one end away from the upper opening thereof.

10. The dialysis device according to claim 9, characterized in that The base comprises a plurality of legs (50) distributed in a radial shape, and each of the legs (50) is formed at an end of the sample tube (20) and / or an end of the dialysate tube (30).

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