Mixing and sample adding device for in-vitro diagnosis

Abstract

The utility model discloses a mixing and sample adding device for in vitro diagnosis, which comprises a centrifugal tube, and the centrifugal tube comprises a lower-section mixing tube body, a folding telescopic part, an upper-section mixing tube body and a liquid outlet tube which are connected in sequence; the folding telescopic part is telescopic, a diaphragm assembly and a diaphragm breaking assembly are respectively arranged on the inner walls of the centrifuge tubes at the lower end and the upper end of the folding telescopic part, the lower section of the mixing tube body below the diaphragm assembly is used for containing a reagent, and the diaphragm breaking assembly is used for breaking the diaphragm assembly to release the reagent; the outer walls of the centrifugal tubes at the lower end and the upper end of the folding telescopic part are in threaded connection with a lower threaded sleeve and an upper threaded sleeve respectively, and the lower threaded sleeve and the upper threaded sleeve are connected through a plurality of fracture pieces; and the pipe orifice of the liquid outlet pipe is plugged by a plug. According to the utility model, long-time contact with air in the whole sample adding process can be avoided, the steps of adding a reagent into a centrifugal tube and sucking a mixed sample from the centrifugal tube into a detection instrument by using a dropper are omitted, the operation steps are simplified, and the accuracy of a detection result is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of medical equipment, in particular to a mixing sample adding device for in vitro diagnosis. Background Art

[0002] In vitro diagnosis is one of the test items of the laboratory department. In routine operation, the reagents and samples need to be placed in centrifuge tubes in sequence, and then mixed thoroughly in a centrifuge to obtain a mixed sample. The sample is then drawn with a dropper and added to the test instrument for testing. Since most centrifuge tubes are hard glass tubes with open structures, the entire sample addition process will be in contact with the air for a long time, which will affect the accuracy of the test results to a certain extent. In addition, this traditional operation method is also cumbersome. Utility Model Content

[0003] The technical problem to be solved by the utility model is to provide a mixed sample adding device for in vitro diagnosis, aiming to solve the technical problems existing in the prior art that the traditional operation mode is relatively cumbersome, the entire sample adding process will be in contact with the air for a long time, and the accuracy of the test results will be affected to a certain extent.

[0004] The technical scheme of the utility model is: a mixing and adding sample device for in vitro diagnosis, comprising a centrifuge tube, wherein the centrifuge tube comprises a lower mixing tube body, a folding and telescopic part, an upper mixing tube body, and a liquid outlet pipe which are connected in sequence; the folding and telescopic part is telescopic, a diaphragm assembly is arranged on the inner wall of the centrifuge tube at the lower end of the folding and telescopic part, a membrane breaking assembly is arranged on the inner wall of the centrifuge tube at the upper end of the folding and telescopic part, the lower mixing tube body below the diaphragm assembly is used for containing reagents, the membrane breaking assembly is used for destroying the diaphragm assembly to release the reagents, a lower threaded sleeve and an upper threaded sleeve are respectively threadedly connected on the outer walls of the centrifuge tube at the lower end and the upper end of the folding and telescopic part, and the lower threaded sleeve and the upper threaded sleeve are connected by a plurality of breaking pieces; the pipe mouth of the liquid outlet pipe is blocked by a plug.

[0005] Furthermore, in the utility model, the bottom end of the lower mixing tube body is connected with a solid head, and the liquid outlet pipe is conical.

[0006] Furthermore, the solid head, the lower mixing tube body, the folding telescopic part, the upper mixing tube body and the liquid outlet pipe described in the utility model are integrally formed.

[0007] Furthermore, the diaphragm assembly in the utility model includes a lower fixing ring and a diaphragm body installed in the lower fixing ring, and the membrane breaking assembly includes an upper fixing ring and a pointed head connected to the upper fixing ring, and there is a gap between the upper fixing ring and the pointed head for the sample to flow downward.

[0008] Further, a connecting rod is provided inside the upper fixing ring of the present utility model. One end of the connecting rod is connected to the upper fixing ring, and the other end is connected with a supporting block. The pointed head is connected to the bottom of the supporting block.

[0009] Further, anti-slip bumps are distributed on the outer surfaces of the lower threaded sleeve and the upper threaded sleeve of the present utility model.

[0010] Further, the plug head of the present utility model is connected to the upper section mixing tube body through a connecting wire.

[0011] Compared with the prior art, the present utility model has the following advantages: The centrifuge tube of the present utility model is made of soft plastic, and the top is sealed with a plug head. The reagent is filled in the lower section mixing tube body. When the reagent is released, first, the upper and lower threaded sleeves are reversely screwed to restore the telescopic ability of the folding and telescopic part, and then the diaphragm body is damaged by cooperating with the membrane-breaking assembly; the human tissue sample can be injected through the liquid outlet tube to be mixed with the reagent, and then the centrifuge tube is placed in a centrifuge to fully mix the two. The mixed sample can be directly dropped into the detection instrument through the liquid outlet tube. In this way, it can avoid the long-term contact with air during the entire sample addition process, and can also save the steps of adding reagent to the centrifuge tube and sucking the mixed sample from the centrifuge tube to the detection instrument with a dropper, simplifying the operation steps and improving the accuracy of the test results. Description of the Drawings

[0012] Figure 1 is a schematic structural diagram of the present utility model;

[0013] Figure 2 is Figure 1 the A-A cross-sectional view of;

[0014] Figure 3 is Figure 2 the partial enlarged schematic view of part B in;

[0015] Figure 4 is a schematic structural diagram of the diaphragm assembly of the present utility model;

[0016] Figure 5 is a schematic structural diagram of the membrane-breaking assembly of the present utility model.

[0017] Wherein:

[0018] 1. Centrifuge tube; 101. Solid head; 102. Lower section mixing tube body; 103. Folding and telescopic part; 104. Upper section mixing tube body; 105. Liquid outlet tube;

[0019] 2. Diaphragm assembly; 201. Lower fixing ring; 202. Diaphragm body;

[0020] 3. Membrane-breaking assembly; 301. Upper fixing ring; 302. Connecting rod; 303. Support block; 304. Sharp tip

[0021] 4. Lower threaded sleeve; 5. Upper threaded sleeve; 6. Fracture piece; 7. Plug; 8. Connecting wire. Specific implementation manner

[0022] The following specifically describes the specific implementation manner of the present utility model in conjunction with the accompanying drawings.

[0023] Embodiment:

[0024] As shown in the accompanying drawings, the specific implementation manner of a hybrid sampling device for in vitro diagnosis of the present utility model is shown. Refer to Figure 1 、 Figure 2 , which mainly includes a centrifuge tube 1. The centrifuge tube 1 is made of soft plastic. The centrifuge tube 1 includes a solid head 101, a lower section mixing tube body 102, a folding and telescopic part 103, an upper section mixing tube body 104, and a liquid outlet tube 105 that are connected in sequence from bottom to top. The liquid outlet tube 105 is conical. The solid head 101, the lower section mixing tube body 102, the folding and telescopic part 103, the upper section mixing tube body 104, and the liquid outlet tube 105 are integrally formed. The solid head 101 can increase the weight of the entire centrifuge tube 1. The solid head 101 is spherical and is convenient for being placed in a centrifuge.

[0025] Refer to Figure 3 、 Figure 4 , on the inner wall of the centrifuge tube 1 at the lower end of the folding and telescopic part 103, a diaphragm assembly 2 is provided. The diaphragm assembly 2 includes a lower fixing ring 201. The outer wall of the lower fixing ring 201 is fixedly connected to the inner wall of the centrifuge tube 1. A diaphragm body 202 is installed inside the lower fixing ring 201. The diaphragm assembly 2 seals the lower section mixing tube body 102 below into an independent space for containing reagents. The diaphragm body 202 can be made of a polyethylene film.

[0026] Refer to Figure 3 、 Figure 5 , on the inner wall of the centrifuge tube 1 at the upper end of the folding and telescopic part 103, a membrane-breaking assembly 3 is provided. The membrane-breaking assembly 3 includes an upper fixing ring 301. The outer wall of the upper fixing ring 301 is fixedly connected to the inner wall of the centrifuge tube 1. A support block 303 is provided at the center of the upper fixing ring 301. The height of the support block 303 is lower than the height of the upper fixing ring 301. The support block 303 and the upper fixing ring 301 are connected by a plurality of connecting rods 302. The plurality of connecting rods 302 are equally angularly distributed around the center of the support block 303. One end of the connecting rod 302 is connected to the inner wall of the upper fixing ring 301 and the other end is connected to the outer wall of the support block 303. At the center of the bottom of the support block 303, a sharp tip 304 is provided. The sharp tip 304 is used to break the diaphragm body 202 of the diaphragm assembly 2 to release the reagent.

[0027] Refer to Figure 1 、Figure 3 On the outer wall of the centrifuge tube 1 at the lower end of the folding and telescopic part 103, a lower threaded sleeve 4 is threadedly connected. On the outer wall of the centrifuge tube 1 at the upper end of the folding and telescopic part 103, an upper threaded sleeve 5 is threadedly connected. Both the lower threaded sleeve 4 and the upper threaded sleeve 5 are sleeved on the centrifuge tube 1 and threadedly connected to the outer wall of the centrifuge tube 1, and the lower threaded sleeve 4 and the upper threaded sleeve 5 are of the same size. The lower threaded sleeve 4 and the upper threaded sleeve 5 are connected by a plurality of fracture pieces 6. The fracture pieces 6 are vertically arranged, and the plurality of fracture pieces 6 are equally angularly distributed around the centers of the lower threaded sleeve 4 and the upper threaded sleeve 5. The fracture pieces 6 can be made of plastic sheets. Anti-slip bumps are distributed on the outer surfaces of the lower threaded sleeve 4 and the upper threaded sleeve 5 to increase the friction force.

[0028] Refer to Figure 1 、 Figure 2 At the nozzle of the liquid outlet pipe 105, it is blocked by a plug 7. The lower end of the plug 7 is in the shape of an inverted frustum. After the inverted frustum-shaped lower end is inserted into the liquid outlet pipe 105, its top fits tightly with the inner wall of the nozzle of the liquid outlet pipe 105. The upper end of the plug 7 is in the shape of a round cake, and the size of the round cake-shaped upper end is larger than the size of the inverted frustum-shaped lower end. After the inverted frustum-shaped lower end is inserted into the liquid outlet pipe 105, the round cake-shaped upper end fits tightly with the nozzle end face of the liquid outlet pipe 105. The upper end of the plug 7 is connected to the top end of the upper mixing pipe body 104 through a connecting line 8, and the connecting line 8 can prevent the plug 7 from being lost.

[0029] When the specific work of the present utility model is carried out, first, hold the lower threaded sleeve 4 and the upper threaded sleeve 5 with two hands respectively, and rotate the lower threaded sleeve 4 and the upper threaded sleeve 5 in opposite directions with the two hands, so that the middle fracture pieces 6 are fractured, and the telescopic ability of the folding and telescopic part 103 is restored; then rotate the lower threaded sleeve 4 and the upper threaded sleeve 5 until they are separated from the threaded section of the centrifuge tube 1, and gently squeeze the centrifuge tube 1 to remove the lower threaded sleeve 4 and the upper threaded sleeve 5 from the centrifuge tube 1; then hold the tube wall of the centrifuge tube 1 at the lower fixing ring 201 of the diaphragm assembly 2 with one hand, and hold the tube wall of the centrifuge tube 1 at the upper fixing ring 301 of the membrane-breaking assembly 3 with the other hand, compress the folding and telescopic part 103, so that the pointed head 304 penetrates into the diaphragm body 202 to break the diaphragm body 202, and the reagent in the lower mixing pipe body 102 is released. Open the plug 7, inject the obtained human tissue sample into the centrifuge tube 1 through the liquid outlet pipe 105 to be mixed with the reagent, then install the plug 7, put the centrifuge tube 1 into the centrifuge, start the centrifuge to fully mix the reagent and the human tissue sample. After the mixing is completed, take out the centrifuge tube 1 and open the plug 7, and directly drip the mixed sample into the detection instrument through the liquid outlet pipe 105 to complete the detection.

[0030] Certainly, the above embodiments are only for illustrating the technical concept and features of the present utility model. The purpose is to enable those who are familiar with this technology to understand the content of the present utility model and implement it accordingly, and it should not be used to limit the protection scope of the present utility model. All modifications made according to the spirit and essence of the main technical solution of the present utility model should be covered within the protection scope of the present utility model.

Claims

1. A mixing and adding device for in vitro diagnosis, characterized in that: The invention comprises a centrifuge tube (1), wherein the centrifuge tube (1) comprises a lower mixing tube body (102), a folding and telescopic part (103), an upper mixing tube body (104), and a liquid outlet pipe (105) which are connected in sequence; the folding and telescopic part (103) is telescopic, a diaphragm assembly (2) is arranged on the inner wall of the centrifuge tube (1) at the lower end of the folding and telescopic part (103), a membrane rupture assembly (3) is arranged on the inner wall of the centrifuge tube (1) at the upper end of the folding and telescopic part (103), and the diaphragm assembly (2 ) is used for containing reagents, the membrane breaking assembly (3) is used for destroying the diaphragm assembly (2) to release the reagents, the outer walls of the centrifuge tube (1) at the lower and upper ends of the foldable telescopic portion (103) are respectively threadedly connected with a lower threaded sleeve (4) and an upper threaded sleeve (5), and the lower threaded sleeve (4) and the upper threaded sleeve (5) are connected by a plurality of breaking pieces (6); the pipe mouth of the liquid outlet pipe (105) is blocked by a plug (7).

2. The in vitro diagnostic mixing and adding device according to claim 1, characterized in that: The bottom end of the lower mixing tube body (102) is connected to a solid head (101), and the liquid outlet pipe (105) is conical.

3. The in vitro diagnostic mixing and adding device according to claim 2, characterized in that: The solid head (101), the lower mixing tube body (102), the folding and telescopic portion (103), the upper mixing tube body (104), and the liquid outlet pipe (105) are integrally formed.

4. The in vitro diagnostic mixing and adding device according to claim 1, characterized in that: The diaphragm assembly (2) comprises a lower fixing ring (201) and a diaphragm body (202) installed in the lower fixing ring (201); the membrane breaking assembly (3) comprises an upper fixing ring (301) and a pointed head (304) connected to the upper fixing ring (301); and a gap is provided between the upper fixing ring (301) and the pointed head (304) for the sample to flow downward.

5. The in vitro diagnostic mixing and adding device according to claim 4, characterized in that: A connecting rod (302) is provided inside the upper fixing ring (301), one end of the connecting rod (302) is connected to the upper fixing ring (301), and the other end is connected to a supporting block (303), and the pointed head (304) is connected to the bottom of the supporting block (303).

6. The in vitro diagnostic mixing and adding device according to claim 1, characterized in that: The outer surfaces of the lower threaded sleeve (4) and the upper threaded sleeve (5) are distributed with anti-slip convex points.

7. The in vitro diagnostic mixing and adding device according to claim 1, characterized in that: The plug (7) is connected to the upper mixing tube body (104) via a connecting line (8).

Images