Particle size grading device for non-Newtonian fluid soft rubber microsphere suspension

Abstract

The utility model discloses a particle size grading device for a non-Newtonian fluid soft rubber microsphere suspension. The device comprises particle size grading vibration equipment, a magnetic scrap iron removing device, a suction filtration barrel, a bag type filter, a storage tank front-back multi-stage centrifugal pump and a liquid storage tank, the multi-stage centrifugal pump behind the storage tank is connected with upper and lower diluent spraying pipelines; upper and lower screens are arranged in the particle size grading vibration equipment; the non-Newtonian fluid flexible glue microsphere suspension is diluted to form microsphere homogenate, the particle size grading vibration equipment performs grading filtration on the microsphere homogenate, the diluent is extracted from the liquid storage tank and conveyed to the upper and lower diluent spraying pipelines, and the spraying pipelines spray the screen; the large-particle-size microspheres remain on the upper-layer screen, the medium-particle-size microspheres remain on the lower-layer screen, homogenate containing the small-particle-size microspheres flows into the suction filtration barrel after passing through the magnetic scrap iron removal device, then enters the liquid storage tank after being subjected to impurity removal through the bag type filter, and circulation is carried out. Different target particle size distribution can be achieved by carrying out primary particle size grading on the non-Newtonian fluid soft rubber microsphere suspension.

Description

Technical Field

[0001] The utility model relates to a method for grading the particle size of microspheres, in particular to a device for grading the particle size of a non-Newtonian fluid soft gel microsphere suspension. Background Art

[0002] A non-Newtonian fluid refers to a fluid that does not satisfy Newton's viscosity experimental law, that is, a fluid in which the shear stress and the shear strain rate are not linearly related. Most biological fluids belong to the defined non-Newtonian fluids. The particle size distribution range of an agarose soft gel microsphere suspension or a chitosan soft gel microsphere suspension prepared by the emulsification-curing method is relatively wide. If microspheres within a specific particle size range are to be obtained, the microspheres above the upper limit and below the lower limit of the particle size range need to be separated. Since the surface of agarose soft gel microspheres is rich in a large number of hydrophilic functional groups and the internal pores are occupied by a large amount of free water, the interaction force between the microspheres is relatively large. If the method of screening solid microspheres with a conventional filter screen is used, while the filtrate in the suspension is filtered out, the microspheres gradually transform from a flowing state to a non-Newtonian fluid state, and the interaction force between the microspheres causes particle adhesion and accumulation. Even with the addition of vibration or air blowing, the screening and grading efficiency is almost zero, and there is currently no reported method for efficiently grading the particle size of soft gel microspheres. Therefore, there is an urgent need to develop an efficient and energy-saving method for grading the particle size of non-Newtonian fluid soft gel microspheres.

[0003] Patent CN109794414 discloses a screening method for polydisperse polymer microspheres. By using the methods of multiple sedimentation and freezing in a plastic tube and finally cutting and dividing the plastic tube, microspheres with different particle size distributions are obtained. However, this method is not suitable for large-scale screening and grading of microsphere particle sizes. Patent CN113824241 discloses a vibrating screening machine. This method is suitable for solid-liquid separation or the separation of particles with no interaction force between particles, but is not suitable for microspheres with strong interaction force between particles. Patent CN219965753 discloses a device for cleaning and screening microspheres, which is used for screening adhered polystyrene microspheres. However, it uses a kind of screen as an effective grading and screening means. If it is used for multi-stage screening, the screen needs to be replaced for re-screening, which is time-consuming and consumes a large amount of washing pure water; the process of sampling the target microspheres is also prone to residue; in addition, a large amount of deionized water is consumed during the screening and grading process, and if it is not recycled, it will also cause a large amount of waste.

[0004] In summary, the prior art has the following deficiencies: the grading effect of the particle size of soft gel microspheres with strong interaction between particles is poor, the operation is slightly complicated, the microsphere structure can be damaged, and the energy consumption is relatively high. Therefore, there is an urgent need to develop an efficient and energy-saving method for grading the particle size of non-Newtonian fluid soft gel microsphere suspensions. Summary of the Utility Model

[0005] Purpose of the utility model: A particle size grading device for a non-Newtonian fluid soft gel microsphere suspension of the present utility model can achieve different target particle size distributions of 121 - 180 μm, 47 - 120 μm, and 25 - 46 μm through a single particle size grading of the non-Newtonian fluid soft gel microsphere suspension.

[0006] Technical solution: A particle size grading device for a non-Newtonian fluid soft gel microsphere suspension of the present utility model includes a particle size grading vibration device, a magnetic iron filings removal device, and a suction filtration barrel connected in sequence according to the transmission direction of the microsphere homogeneous slurry.

[0007] An upper sieve mesh and a lower sieve mesh are arranged inside the particle size grading vibration device from top to bottom; among them, the aperture of the upper sieve mesh is larger than that of the lower sieve mesh.

[0008] An upper dilution liquid spray pipe is arranged above the upper sieve mesh, and a lower dilution liquid spray pipe is arranged above the lower sieve mesh.

[0009] The non-Newtonian fluid soft gel microsphere suspension is diluted with a dilution liquid to form a microsphere homogeneous slurry. The particle size grading vibration device is used for grading and filtering the microsphere homogeneous slurry. The upper dilution liquid spray pipe and the lower dilution liquid spray pipe are used to spray the dilution liquid onto the upper sieve mesh and the lower sieve mesh to weaken the interaction force between the microspheres.

[0010] Furthermore, the output end of the suction filtration barrel is connected to a bag filter, a multi-stage centrifugal pump before the storage tank, a liquid storage tank, and a multi-stage centrifugal pump after the storage tank. Among them, the output end of the multi-stage centrifugal pump after the storage tank is connected to the upper dilution liquid spray pipe and the lower dilution liquid spray pipe; the multi-stage centrifugal pump after the storage tank is used to extract the dilution liquid from the liquid storage tank during the grading and filtering process and transport it to the upper dilution liquid spray pipe and the lower dilution liquid spray pipe.

[0011] Furthermore, an adjustment mechanism is fixedly arranged at the bottom of the particle size grading vibration device. The adjustment mechanism rotates under the drive of a motor, thereby driving the particle size grading vibration device to rotate.

[0012] The adjustment mechanism includes an upper flower plate and a lower flower plate, and a connecting member connected between the upper flower plate and the lower flower plate; an upper eccentric block is concentrically arranged on the upper surface of the upper flower plate, and a lower eccentric block is concentrically arranged on the lower surface of the lower flower plate. The included angle center line of the upper eccentric block corresponds to the 0° position of the lower eccentric block.

[0013] Furthermore, the flow mode of the microsphere homogeneous slurry is controlled by adjusting the included angle formed by the included angle center line of the upper eccentric block and the included angle center line of the lower eccentric block; the up and down amplitude of the adjustment mechanism is adjusted by adjusting the included angle of the lower eccentric block.

[0014] Furthermore, the suction filtration barrel is equipped with a lining filter bag, and the multi-stage centrifugal pump before the storage tank provides a pressure difference for the extraction of the filtrate.

[0015] A sampling port is provided on the side wall of the particle size classification vibration device between the upper sieve and the lower sieve;

[0016] The aperture of the upper sieve is selected to be 107 - 120 μm, and the aperture of the lower sieve is selected to be 47 - 52 μm, which can screen out three types of microspheres with large, medium and small particle sizes of 121 - 180 μm, 47 - 120 μm, and 25 - 46 μm.

[0017] Furthermore, the pressure of the upper diluent spray pipe is controlled at 0.05 - 0.20 Mpa, and the pressure of the lower diluent spray pipe is controlled at 0.25 - 0.40 Mpa. The diluent can effectively increase the distance between microspheres and weaken the interaction between microspheres; by adjusting the flow mode of the microsphere homogenate on the upper and lower sieves, it is possible to prevent the microspheres from accumulating in the middle of the sieve edge or moving around the sieve edge, and try to increase the contact area between the diluent and the microspheres; by controlling the pressure of the upper and lower diluent pipes, the microspheres can pass through the sieve in the form of single particles. The pressure of the upper pipe is lower than that of the lower pipe because the large - particle - size microspheres in the upper layer are more likely to deform under the pressure of the diluent. Through this method, the soft - gel microspheres can pass through the sieve more efficiently to achieve the effect of particle size classification.

[0018] The principle of the present utility model is as follows: The interaction force between non - Newtonian fluid soft - gel microspheres is relatively large, and the adhesion between particles in the flowing state is very serious. Moreover, there are very few iron filings in the synthesized soft - gel microspheres that need to be removed. Considering the load - bearing capacity of the grading sieve, the present invention provides an intermittent feeding method to obtain soft - gel microspheres with relatively large, medium, and small particle sizes for different purposes in one - time grading. For example, for the agarose soft - gel microsphere suspension with its unique self - properties, a large amount of diluent is required to weaken the interaction force between microspheres before particle size grading. During the screening process, as the diluted filtrate separates from the system, the flowing state of the soft - gel microspheres will also change. Therefore, it is necessary to use a pressure - controlled spray liquid to avoid this situation. Another function of the pressure - controlled spray is to prevent the structure of the soft - gel microspheres from being damaged or the large - sized microspheres from deforming and passing through the sieve. The particle size classification vibration device controls the vibration amplitude of the microspheres and the vibration flow mode of the homogenate on the sieve by adjusting the motor frequency and the angles of the upper and lower counterweight disks, so as to perform particle size classification more efficiently. The filtrate of the homogenate enters the filter cylinder after removing the difficult - to - filter iron filings through a strong magnet. The multi - stage centrifugal pump pumps the filtrate out of the suction filter cylinder, and removes the microspheres with extremely small particle sizes through a bag - type filter. The diluted filtrate is pumped into the storage tank and recycled for the diluted spray of the particle size classification of the microspheres, and the cycle repeats to achieve the purpose of the particle size classification of the soft - gel microspheres.

[0019] Advantageous effects: Compared with the prior art, the technical solution of the present utility model has the following advantageous effects:

[0020] The particle size classification vibration equipment of this solution can achieve different target particle size distributions of 121 - 180μm, 47 - 120μm, and 25 - 46μm in one - time particle size classification for the non - Newtonian fluid soft gel microsphere suspension; greatly improving the particle size classification efficiency and having simple operation;

[0021] In this solution, the homogenate containing small - sized microspheres finally enters the storage tank, which is used as the diluent for microsphere particle size classification, enabling the washing diluent to be reused, saving energy and being environmentally friendly;

[0022] The equipment occupies a small area and has low costs. Multiple classification devices can share the diluent circulation system, meeting the requirements of industrial production. Brief Description of the Drawings

[0023] Figure 1 It is a schematic structural diagram of the present utility model;

[0024] Figure 2 It is a schematic diagram of the adjusting mechanism in the present utility model;

[0025] Figure 3 It is a flow direction diagram of the microsphere homogenate on the sieve of the particle size classification vibration equipment. Detailed Embodiments

[0026] The technical solutions of the present utility model will be introduced in detail below in combination with the detailed embodiments and the drawings in the specification.

[0027] As Figure 1 shown, a non - Newtonian fluid soft gel microsphere suspension particle size classification device of the present utility model involves the following components: particle size classification vibration equipment, pressure gauge 1, upper - layer diluent regulating ball valve 2, lower - layer diluent regulating ball valve 3, upper - layer sieve 4, lower - layer sieve 5, sampling port 6, counterweight eccentric block 7, magnetic iron - chip removing device 8, suction filter bucket 9, upper - layer diluent spraying pipeline 10, lower - layer diluent spraying pipeline 11, bag - type filter 12, multi - stage centrifugal pump 13 in front of the storage tank, storage tank 14, multi - stage centrifugal pump 15 behind the storage tank, partition 16. The connection methods between each component are as follows:

[0028] The particle size classification vibration equipment, magnetic iron - chip removing device 8, suction filter bucket 9, bag - type filter 12, multi - stage centrifugal pump 13 in front of the storage tank, storage tank 14, and multi - stage centrifugal pump 15 behind the storage tank are connected in sequence. The output end of the multi - stage centrifugal pump 15 behind the storage tank is connected to the upper - layer diluent spraying pipeline 10 and the lower - layer diluent spraying pipeline 11. Pressure gauges 1 for monitoring the pipeline pressure are arranged on both the upper - layer diluent spraying pipeline 10 and the lower - layer diluent spraying pipeline 11. The upper - layer diluent regulating ball valve 2 is arranged on the upper - layer diluent spraying pipeline 10, and the lower - layer diluent regulating ball valve 3 is arranged on the lower - layer diluent spraying pipeline 11. The upper - layer diluent regulating ball valve 2 and the lower - layer diluent regulating ball valve 3 are used to adjust the pressure of the pipeline where they are located.

[0029] In this embodiment, the upper dilution liquid regulating ball valve 2 controls the pressure of the upper dilution liquid spraying pipeline 10 within the range of 0.05 - 0.20 Mpa, and the lower dilution liquid regulating ball valve 3 controls the pressure of the lower dilution liquid spraying pipeline 11 within the range of 0.25 - 0.40 Mpa. After the dilution liquid removes waste microspheres or minute impurities through a bag filter, it enters the liquid storage tank for reuse.

[0030] Inside the particle size classification vibration device, an upper screen 4, a lower screen 5, and a partition 16 are arranged from top to bottom, and a counterweight eccentric block 7 is arranged below the partition 16; among them, the aperture of the upper screen 4 is larger than that of the lower screen 5. The upper dilution liquid spraying pipeline 10 extends above the upper screen 4, and the lower dilution liquid spraying pipeline 11 passes through the particle size classification vibration device and extends above the lower screen 5.

[0031] The non-Newtonian fluid soft gel microsphere suspension is diluted by the dilution liquid to form a microsphere homogeneous slurry. The particle size classification vibration device is used for grading and filtering the microsphere homogeneous slurry. The multi-stage centrifugal pump 15 behind the storage tank is used to extract the dilution liquid from the liquid storage tank 14 and transport it to the upper dilution liquid spraying pipeline 10 and the lower dilution liquid spraying pipeline 11 during the grading and filtering process. The upper dilution liquid spraying pipeline 10 and the lower dilution liquid spraying pipeline 11 are used to spray the dilution liquid onto the upper screen 4 and the lower screen 5.

[0032] Large particle size microspheres with a size of 121 - 180 μm are retained on the upper screen 4, medium particle size microspheres with a size of 47 - 120 μm are retained on the lower screen 5, and the homogeneous slurry containing small particle size microspheres with a size of 25 - 46 μm flows into the suction filter bucket 9 after removing difficult-to-filter iron filings through the magnetic iron removal device 8. The homogeneous slurry containing small particle size microspheres coming out of the suction filter bucket 9 enters the liquid storage tank 14 under the action of the multi-stage centrifugal pump 13 in front of the storage tank after removing waste microspheres or minute impurities through the bag filter 12. The dilution liquid used for microsphere particle size classification circulates repeatedly to achieve the purpose of soft gel microsphere particle size classification. The magnetic iron removal device 8 can adopt a container equipped with a magnetic bar, which can adsorb iron filings in the homogeneous slurry. In this embodiment, there are 5 magnetic bars with a magnetic strength greater than 10000 Gs inside the magnetic iron removal device 8.

[0033] In this embodiment, the particle size classification vibration device rotates driven by an electric motor, and the vibration amplitude of the microspheres in the microsphere homogeneous slurry and the rotational flow mode of the homogeneous slurry on the upper screen 4 and the lower screen 5 are controlled by adjusting the electric motor frequency and the angle of the upper and lower counterweight disks of the counterweight eccentric block 7. Specifically as follows:

[0034] Such as Figures 1-3As shown, an adjusting mechanism 7 is fixedly arranged at the bottom of the particle size grading vibration device. The adjusting mechanism 7 rotates under the drive of a motor, thereby driving the particle size grading vibration device to rotate. The adjusting mechanism 7 includes an upper flower disc 71 and a lower flower disc 72, and a connecting member 73 connected between the upper flower disc 71 and the lower flower disc 72. An upper eccentric block 74 is concentrically arranged on the upper surface of the upper flower disc 71, and a lower eccentric block 75 is concentrically arranged on the lower surface of the lower flower disc 72. The included angle center line of the upper eccentric block 74 corresponds to the 0° position of the lower eccentric block 75. The flow mode of the microsphere homogenate is controlled by adjusting the included angle formed by the included angle center line of the upper eccentric block 74 and the included angle center line of the lower eccentric block 75; specifically, it controls whether the microsphere homogenate converges or diverges. When the included angle α formed by the included angle center line of the upper eccentric block 74 and the included angle center line of the lower eccentric block 75 is larger, the material tends to be denser in the middle.

[0035] The up-and-down amplitude of the adjusting mechanism 7, including the vibration intensity and whether the material splashes out, is adjusted by adjusting the included angle β of the lower eccentric block 75. By adjusting the included angle β of the lower eccentric block 75, the smaller the included angle, the larger the amplitude.

[0036] In this embodiment, the suction filtration bucket 9 is equipped with a lined filter bag and is attached with vacuum suction. The lined filter bag attached to the suction filtration bucket 9 is 600 mesh. The suction filtration bucket 9 is provided with the differential pressure for separating small particle size soft rubber microspheres and filtrate by the multi-stage centrifugal pump 13 in front of the storage tank.

[0037] In this embodiment, a sampling port 6 is opened on the side wall of the particle size grading vibration device between the upper screen 4 and the lower screen 5 for sampling medium particle size soft rubber microspheres. The lower side of the sampling port for medium particle size soft rubber microspheres is 5 cm higher than the lower screen 5.

[0038] In this embodiment, the aperture of the upper screen 4 is selected to be 107 - 120 μm, and the aperture of the lower screen 5 is selected to be 47 - 52 μm.

[0039] In this solution, before particle size grading, the soft rubber microsphere suspension is diluted and stirred with a diluent to change its rheological properties. The particle size grading vibration device is equipped with upper and lower two-stage different aperture screens determined by the target particle size range. Diluent pipelines for controlling the flow rate are assembled at the upper parts of the two-stage screens. The diluted microsphere homogenate is placed on the upper screen 4, and the flow state of the microsphere homogenate in the particle size grading vibration device is controlled by adjusting the motor frequency and the angles of the upper and lower counterweight discs; during the grading process, two diluent pipelines, upper and lower, are required to spray diluent to prevent the interaction between microspheres and affect the grading effect. Large particle size microspheres are retained on the upper screen 4, small particle size microspheres flow into the suction filtration bucket through permanent magnet rust removal, and the sample on the lower screen 5 is medium particle size microspheres. The diluent can be recycled through special treatment, and soft rubber microspheres with different particle size dimensions can be used as base balls for different products.

Claims

1. A non-Newtonian fluid soft gel microsphere suspension particle size classification device, characterized in that: It comprises a particle size classification vibration device, a magnetic iron chip removal device (8), and a suction filter barrel (9) which are connected in sequence according to the transmission direction of the microsphere homogenate liquid; An upper screen (4) and a lower screen (5) are arranged inside the particle size classification vibration device from top to bottom; wherein the aperture of the upper screen (4) is larger than the aperture of the lower screen (5); An upper dilution liquid spraying pipeline (10) is arranged above the upper screen (4), and a lower dilution liquid spraying pipeline (11) is arranged above the lower screen (5); The non-Newtonian fluid soft gel microsphere suspension is diluted with a diluent to form a microsphere homogenate. The particle size classification vibration device is used to grade and filter the microsphere homogenate. The upper diluent spraying pipe (10) and the lower diluent spraying pipe (11) are used to spray the diluent on the upper screen (4) and the lower screen (5) to weaken the interaction force between the microspheres.

2. The non-Newtonian fluid soft gel microsphere suspension particle size classification device according to claim 1, characterized in that: The output end of the suction filter barrel (9) is connected to a bag filter (12), a multi-stage centrifugal pump (13) before the storage tank, a liquid storage tank (14), and a multi-stage centrifugal pump (15) after the storage tank, wherein the output end of the multi-stage centrifugal pump (15) after the storage tank is connected to an upper dilution liquid spraying pipeline (10) and a lower dilution liquid spraying pipeline (11); The multi-stage centrifugal pump (15) after the storage tank is used to extract diluent from the liquid storage tank (14) during the graded filtration process and transport the diluent to the upper diluent spray pipeline (10) and the lower diluent spray pipeline (11).

3. The non-Newtonian fluid soft gel microsphere suspension particle size classification device according to claim 1, characterized in that: An adjusting mechanism (7) is fixedly arranged at the bottom of the particle size classification vibration device, and the adjusting mechanism (7) rotates under the drive of a motor, thereby driving the particle size classification vibration device to rotate.

4. The non-Newtonian fluid soft gel microsphere suspension particle size classification device according to claim 3, characterized in that: The adjustment mechanism (7) comprises an upper faceplate (71) and a lower faceplate (72), and a connecting member (73) connected between the upper faceplate (71) and the lower faceplate (72); An upper eccentric block (74) is coaxially arranged on the upper surface of the upper faceplate (71), and a lower eccentric block (75) is coaxially arranged on the lower surface of the lower faceplate (72), wherein the center line of the angle of the upper eccentric block (74) corresponds to the 0° position of the lower eccentric block (75).

5. The non-Newtonian fluid soft gel microsphere suspension particle size classification device according to claim 4, characterized in that: The flow mode of the microsphere homogenate is controlled by adjusting the angle formed by the angle center line of the upper eccentric block (74) and the angle center line of the lower eccentric block (75).

6. The non-Newtonian fluid soft gel microsphere suspension particle size classification device according to claim 4, characterized in that: The upper and lower amplitudes of the regulating mechanism (7) are adjusted by adjusting the included angle of the lower eccentric block (75).

7. The non-Newtonian fluid soft gel microsphere suspension particle size classification device according to claim 1, characterized in that: The suction filter barrel (9) is equipped with a lined filter bag and a multi-stage centrifugal pump (13) in front of the storage tank provides a pressure difference for extracting the filtrate; A sampling port (6) is provided on the side wall of the particle size classification vibration device between the upper screen (4) and the lower screen (5); The aperture of the upper screen (4) is selected to be 107-120 μm, and the aperture of the lower screen (5) is selected to be 47-52 μm.

8. The non-Newtonian fluid soft gel microsphere suspension particle size classification device according to claim 1, wherein the pressure of the upper diluent spray pipe (10) is controlled at 0.05-0.20 MPa, and the pressure of the lower diluent spray pipe (11) is controlled at 0.25-0.40 MPa.

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