Simple device for manually drawing line on glass slide

Abstract

The utility model discloses a simple manual line drawing device for a glass slide, which relates to the technical field of line drawing devices for glass slides and comprises a bottom plate, limiting sleeves are mounted at four corners of the upper side surface of the bottom plate, a line drawing area is arranged in the center of the upper side surface of the bottom plate, and spring pressing sheets are mounted at four corners of the line drawing area. And a cover layer plate is arranged on the upper side of the bottom layer plate. Through the rectangular hole, the sliding groove, the graduated scale, the first sliding rail, the second sliding rail, the guide wheel and the spring pressing piece, four corners of a slide needing to be marked are pressed and fixed through the spring pressing piece, and then the moving positions of the first sliding rail and the second sliding rail in the sliding groove and the initial positions of the first sliding rail and the second sliding rail are adjusted according to the requirement for the marking area; the marking pen is used for drawing lines on the slide along the first sliding rail and the second sliding rail respectively, then the distance between the first sliding rail and the initial position and the distance between the second sliding rail and the initial position are adjusted according to the size of a line drawing area, the lines are drawn along the first sliding rail and the second sliding rail again after adjustment, the line drawing efficiency is improved, line drawing inclination can be avoided, and line drawing standardization is achieved.

Description

Technical Field

[0001] The utility model relates to the technical field of slide scribing devices, in particular to a simple device for manually scribing slides. Background Technique

[0002] In recent years, due to the progress of science and technology, the applied research of FFPE slides or fresh frozen tissue slides has been extended to the field of spatial omics. The spatial transcriptome sequencing technology can obtain gene expression data by sequencing technology while retaining the spatial position information of the sample, so as to analyze the tissue structure more comprehensively and intuitively. By analyzing the differences in expression patterns among different cell types, cell substructures or tissues, it is possible to analyze how these differences affect cell function, tissue development and biological processes. The spatial transcriptome technology plays a key role in re-understanding the structure of life, individual development, life evolution and defining diseases, and will promote the third technological revolution in the field of life science since the microscope and DNA sequencing technologies.

[0003] At present, different spatial transcriptome technical processes can all use FFPE slides for research, but the in-situ tissue areas of different technical processes are often different. For example, the effective area of the DSP technology is 36.2mm X 14.6mm, the effective area of the Xenium technology is 10.45mm x 22.45mm, and the effective area of the Cell DIVE technology is 45mm x 20mm. Therefore, it is necessary to draw lines on blank slides according to different regional areas. At present, generally, a ruler or multiple rulers are used to measure the scale and draw lines, which is very inefficient and prone to drawing crooked, and at the same time, standardization cannot be achieved. Therefore, a device that can draw lines efficiently and adapt to different scribing requirements is designed to solve the problems existing in the prior art. Content of the Utility Model

[0004] The technical problem to be solved by the utility model is to overcome the existing defects and provide a simple device for manually scribing slides. By setting a rectangular hole, a sliding groove, a scale, a first slide rail, a second slide rail, a guide wheel and a spring pressing piece, the four corners of the slide to be scribed are tightly fixed by the spring pressing piece, and then according to the requirements of the scribing area, the moving positions of the first slide rail and the second slide rail in the sliding groove are adjusted. At the starting positions of the first slide rail and the second slide rail, a marker pen is used to draw lines on the slide along the first slide rail and the second slide rail respectively, and then according to the size of the scribing area, the distance between the first slide rail and the second slide rail from the starting position is adjusted. After adjustment, lines are drawn along the first slide rail and the second slide rail again, which improves the scribing efficiency, can also avoid the lines from being drawn obliquely, and achieves the standardization of scribing, and can effectively solve the problems in the background technique.

[0005] To achieve the above object, the present utility model provides the following technical solution: A simple device for manually drawing lines on a glass slide, including a bottom plate. Four corners of the upper side of the bottom plate are provided with limit sleeves. The center of the upper side of the bottom plate is provided with a line-drawing area. Four corners of the line-drawing area are provided with spring pressing pieces. A cover plate is arranged on the upper side of the bottom plate. A rectangular hole is integrally formed in the center of the cover plate. A scale is pasted on the four sides of the rectangular hole. A second slide rail is horizontally arranged across the rectangular hole. A first slide rail is arranged above the second slide rail. Guide wheels are installed on the lower sides of both ends of the second slide rail and the first slide rail. Slide grooves are opened on the cover plate corresponding to the moving positions of both ends of the first slide rail and the second slide rail.

[0006] Further, limit posts are installed at the four corners of the lower side of the cover plate corresponding to the positions of the limit sleeves. The upper ends of the limit posts are glued to the cover plate.

[0007] Further, one end of the spring pressing piece is connected to the bottom plate by a rivet, and the lower end of the limit sleeve is glued to the bottom plate.

[0008] Further, both the first slide rail and the second slide rail are connected to the guide wheels by bearings, and the spring pressing pieces are all rotatably connected around one end.

[0009] Further, the cover plate is connected to the bottom plate through the limit posts and the limit sleeves, and the limit posts are inserted into the limit sleeves.

[0010] Further, both the first slide rail and the second slide rail are connected to the slide grooves through the guide wheels.

[0011] Compared with the prior art, the beneficial effects of the present utility model are:

[0012] 1. Through the rectangular hole, slide groove, scale, first slide rail, second slide rail, guide wheel and spring pressing piece provided by the utility model, the four corners of the glass slide to be drawn are tightly fixed by the spring pressing piece. Then, according to the requirement of the drawing area, the moving positions of the first slide rail and the second slide rail in the slide groove are adjusted. At the starting positions of the first slide rail and the second slide rail, a marker pen is used to draw lines on the glass slide along the first slide rail and the second slide rail respectively. Then, according to the size of the drawing area, the distance between the first slide rail and the second slide rail from the starting position is adjusted. After adjustment, lines are drawn along the first slide rail and the second slide rail again, which improves the drawing efficiency and can also prevent the lines from being drawn obliquely, achieving the standardization of drawing. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 is a schematic structural diagram of the present utility model in a separated state;

[0014] Figure 2 is the present utility model Figure 1Schematic enlarged structure diagram at position A in the [device name];

[0015] Figure 3 This is a side view structure diagram of the first slide rail in the present utility model.

[0016] In the figure: 1, bottom layer board; 2, cover layer board; 3, limit sleeve; 4, limit post; 5, drawing area; 6, spring pressing piece; 7, first slide rail; 8, second slide rail; 9, sliding groove; 10, rectangular hole; 11, scale; 12, guiding wheel. Specific embodiments

[0017] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present utility model.

[0018] Please refer to Figures 1-3 , this embodiment provides a technical solution: a simple device for manual drawing on a glass slide, including a bottom layer board 1, limit sleeves 3 are installed at the four corners of the upper side of the bottom layer board 1, a drawing area 5 is arranged at the center of the upper side of the bottom layer board 1, spring pressing pieces 6 are installed at the four corners of the drawing area 5, a cover layer board 2 is arranged on the upper side of the bottom layer board 1, a rectangular hole 10 is integrally formed at the center of the cover layer board 2, scales 11 are pasted on the four sides of the rectangular hole 10, a second slide rail 8 is horizontally arranged across the rectangular hole 10, a first slide rail 7 is arranged on the upper side of the second slide rail 8, guiding wheels 12 are installed at the lower sides of both ends of the second slide rail 8 and the first slide rail 7, and sliding grooves 9 are opened on the cover layer board 2 corresponding to the moving positions of both ends of the first slide rail 7 and the second slide rail 8.

[0019] As Figures 1-3 shown, when drawing a line, first press and fix the glass slide to be drawn on the drawing area 5 through the spring pressing piece 6, then insert the cover layer board 5 into the limit sleeve 3 through the limit post 4, so that the cover layer board 2 and the bottom layer board 1 are covered together, adjust the first slide rail 7 and the second slide rail 8 to the starting position, and then use a marker pen to draw a line mark on the glass slide along the first slide rail 7 and the second slide rail 8. According to the size of the marked area, adjust the distance between the first slide rail 7 and the second slide rail 8 at the initial position again to make the distance size meet the requirements, and then use a marker pen to draw a line on the glass slide along the first slide rail 7 and the second slide rail 8 again, improving the accuracy and efficiency of line drawing.

[0020] Limit posts 4 are installed at the four corners of the lower side of the cover layer board 2 corresponding to the positions of the limit sleeves 3, and the upper ends of the limit posts 4 are glued to the cover layer board 2.

[0021] As Figures 1-2As shown, the limit post 4 is inserted into the limit sleeve 3, so that a spacing is maintained between the cover layer plate 2 and the bottom layer plate 1, facilitating the fixation of glass slides of different sizes.

[0022] One end of the spring pressing piece 6 is connected to the bottom layer plate 1 by a rivet, and the lower end of the limit sleeve 3 is glued to the bottom layer plate 1.

[0023] Both the first slide rail 7 and the second slide rail 8 are connected to the guide wheel 12 through bearings, and the spring pressing piece 6 is rotatably connected around one end.

[0024] The cover layer plate 2 and the bottom layer plate 1 are connected by the limit post 4 and the limit sleeve 3, and the limit post 4 is inserted into the limit sleeve 3.

[0025] Both the first slide rail 7 and the second slide rail 8 are connected to the sliding groove 9 through the guide wheel 12.

[0026] The working principle of a simple device for manually drawing lines on a glass slide provided by the present utility model is as follows: As Figures 1-3 shown, during use, first, the glass slide to be drawn is tightly fixed on the drawing area 5 through the spring pressing piece 6, and then the cover layer plate 5 is inserted into the limit sleeve 3 through the limit post 4, so that the cover layer plate 2 and the bottom layer plate 1 are covered together. The first slide rail 7 and the second slide rail 8 are adjusted to the starting position, and then a marker pen is used to draw line marks on the glass slide along the first slide rail 7 and the second slide rail 8. According to the size of the marked area, the distance between the first slide rail 7 and the second slide rail 8 at the initial position is adjusted again so that the distance dimension meets the requirements, and then a marker pen is used to draw lines on the glass slide along the first slide rail 7 and the second slide rail 8 again, improving the accuracy and efficiency of line drawing.

[0027] The above are only the embodiments of the present utility model, and do not limit the patent scope of the present utility model accordingly. All equivalent structural or equivalent process transformations made by using the content of the specification and drawings of the present utility model, or directly or indirectly applied in other related technical fields, are equally included in the patent protection scope of the present utility model.

Claims

1. A simple device for manually drawing lines on a glass slide, comprising a bottom plate (1), characterized in that: Limiting sleeves (3) are installed at the four corners of the upper side of the bottom plate (1), a drawing area (5) is provided at the center of the upper side of the bottom plate (1), and spring pressing plates (6) are installed at the four corners of the drawing area (5). A cover plate (2) is provided on the upper side of the bottom plate (1), and a rectangular hole (10) is integrally formed at the center of the cover plate (2). A scale (11) is pasted on the four sides of the rectangular hole (10). A second slide rail (8) is arranged across the rectangular hole (10), and a first slide rail (7) is arranged on the upper side of the second slide rail (8). Guide wheels (12) are installed on the lower sides of both ends of the second slide rail (8) and the first slide rail (7), and a slide groove (9) is provided on the cover plate (2) corresponding to the moving positions of the two ends of the first slide rail (7) and the second slide rail (8).

2. A simple device for manually drawing lines on a glass slide according to claim 1, characterized in that: Limiting columns (4) are installed at the four corners of the lower side of the cover plate (2) corresponding to the positions of the limiting sleeves (3), and the upper ends of the limiting columns (4) are glued to the cover plate (2).

3. A simple device for manually drawing lines on a slide according to claim 1, characterized in that: One end of the spring pressing sheet (6) is connected to the bottom plate (1) via a rivet, and the lower end of the limiting sleeve (3) is glued to the bottom plate (1).

4. A simple device for manually drawing lines on a slide according to claim 1, characterized in that: The first slide rail (7) and the second slide rail (8) are both connected to the guide wheel (12) via bearings, and the spring pressing sheet (6) is both rotatably connected around one end.

5. A simple device for manually drawing lines on a glass slide according to claim 2, characterized in that: The cover plate (2) and the bottom plate (1) are connected via the limiting column (4) and the limiting sleeve (3), and the limiting column (4) and the limiting sleeve (3) are plugged into each other.

6. A simple device for manually drawing lines on a slide according to claim 1, characterized in that: The first slide rail (7) and the second slide rail (8) are both connected to the slide groove (9) via the guide wheel (12).

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