Conical filtering adsorption tube, filtering adsorber and preserving fluid bottle

Abstract

The utility model provides a conical filtration adsorption tube, a filtration adsorber and a preservation liquid bottle, and relates to the technical field of medical sample collection, the conical filtration adsorption tube comprises a body and a filter element; the body is conical; the filter element comprises a filter membrane and a filter membrane bracket; the filter membrane bracket is a conical bracket consisting of a plurality of supporting rods arranged along the generatrix direction, is detachably mounted in the body and is used for supporting the filter membrane; the filtering membrane is arranged on the filtering membrane bracket in a sleeving manner, is tightly attached to the filtering membrane bracket, is conical and is used for filtering detected liquid and adsorbing and capturing cells in the detected liquid; according to the conical filtering adsorption tube, the filtering adsorber and the storage liquid bottle, the effective filtering area of the filtering membrane is increased, and the filtering membrane is not easy to block, so that the filtering efficiency is greatly improved, and meanwhile, the size is relatively small; and after the filtering membrane is taken out, cells on the filtering membrane can be washed and separated more quickly, so that the separation efficiency is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of medical sample collection, in particular to a conical filtration adsorption tube, a filtration adsorber and a preservation liquid bottle. Background Art

[0002] Body fluid examination is one of the common detection methods in clinical medicine, and it is usually necessary to obtain exfoliated cells contained in the body fluid for medical examination. At present, the common methods for obtaining exfoliated cells contained in body fluids include: sedimentation method, centrifugation method, filtration method, etc. These methods are applicable to body fluid specimens with a small specimen volume and a large cell content in the specimen. For body fluid specimens with a large specimen volume such as urine but a small cell content in the specimen, the common obtaining methods have certain defects. Since the specimen volume of the liquid to be detected is large but the cell content in the specimen is small, if the centrifugation method is used, multiple centrifugations are required, and multiple centrifuge tubes are needed during the centrifugation process, resulting in a large loss of cells in the liquid to be detected and affecting the subsequent test results; if the sedimentation method is used, a certain amount of time is required for sedimentation, which may cause cell degeneration and affect the accuracy of the test results. The filtration method has less impact on the test results compared to the sedimentation method and the centrifugation method. Therefore, currently, a filtration adsorber is mostly used to filter and adsorb the liquid to be detected, and then the cells in the liquid to be detected are collected for sampling analysis and medical examination.

[0003] The existing filtration adsorbers usually use a filtration membrane to filter the liquid to be detected and collect the cells in the liquid to be detected. In the prior art, the filtration membrane is usually horizontally unfolded or arranged in a funnel shape in the filtration adsorber, and these methods all have certain limitations. If the filtration membrane is horizontally unfolded, the filtration area of the filtration membrane is small and it is easy to be blocked, so the volume of the filtration adsorber needs to be large. However, a large volume of the filtration adsorber makes it very inconvenient to store and transport cells, and also occupies a large space in the subsequent test process. If the filtration membrane is arranged in a funnel shape, the liquid to be detected will be concentrated at the bottom of the funnel-shaped filtration membrane during detection, resulting in a small effective filtration area of the funnel-shaped filtration membrane, and the adsorbed and captured cells are concentrated at the bottom of the funnel-shaped filtration membrane, which is easy to be blocked. Summary of the Utility Model

[0004] The purpose of the utility model is to provide a conical filtration adsorption tube, a filtration adsorber and a preservation liquid bottle to solve at least one of the above technical problems existing in the prior art.

[0005] In a first aspect, to solve the above technical problems, a conical filtration adsorption tube provided by the utility model includes: a body and a filter core;

[0006] The body is conical;

[0007] The filter core includes a filtration membrane and a filtration membrane support;

[0008] The filter membrane support is a conical support composed of a plurality of support rods arranged along the generatrix direction, and is detachably installed in the body for supporting the filter membrane;

[0009] The filter membrane is sleeved on the filter membrane support and is in close fit with the filter membrane support, presenting a conical shape, and is used for filtering the liquid to be detected and adsorbing and capturing cells in the liquid to be detected; wherein, the liquid to be detected is usually a body fluid such as urine, sweat or saliva, or other liquids carrying target cells and substances to be detected;

[0010] During use, the liquid to be detected flows in from the upper end inlet of the body, rapidly flows downward along the surface of the filter membrane from the top of the filter membrane, flushing the entire filter membrane, filtering the liquid to be detected by the filter membrane, adsorbing and capturing cells in the liquid to be detected, and the liquid to be detected passing through the filter membrane flows out from the filter membrane support;

[0011] The filter membrane is connected to the filter membrane support and is used to take out the filter membrane from the body through the filter membrane support.

[0012] In this application, by arranging a conical filter membrane support in the conical filter adsorption tube, the filter membrane is closely attached to the filter membrane support and presents a conical shape, which facilitates the liquid to be detected to rapidly flow downward along the surface of the filter membrane from the top of the filter membrane, flushing the entire filter membrane, increasing the effective filtration area of the filter membrane and being not easily blocked, thereby greatly improving the filtration efficiency and ensuring that the volume of the conical filter adsorption tube is small; after the filter membrane is taken out, the cells on the filter membrane can be rinsed and separated more quickly, improving the separation efficiency.

[0013] Further, the filter element further includes a pressing ring;

[0014] A first annular groove is provided at the lower part of the filter membrane support, and the pressing ring is detachably inserted into the first annular groove and engages with the first annular groove, and is used to squeeze and fix the edge part of the filter membrane in the first annular groove of the filter membrane support, thereby sleeving the filter membrane on the filter membrane support and being in close fit with the filter membrane support; when taking out the filter membrane, the filter membrane is taken out from the body through the filter membrane support.

[0015] Optionally, the inner ring of the first annular groove is provided with a first internal tooth structure, and one tooth of the first internal tooth structure is provided between two adjacent support rods of the filter membrane support; the inner ring of the pressing ring is provided with a second internal tooth structure, and the second internal tooth structure is engaged with the first internal tooth structure. By engaging the second internal tooth structure of the pressing ring with the first internal tooth structure of the first annular groove, the filter membrane is folded inward along the contour of several teeth of the first internal tooth structure. While ensuring that the volume of the conical filter adsorption tube is small, the effective filtration area of the filter membrane is further increased, thereby improving the filtration efficiency;

[0016] Of course, the first annular groove may not be provided with the first internal tooth structure, and at the same time, the pressing ring may not be provided with the second internal tooth structure.

[0017] Further, the apex angle of the filter membrane support is 25° to 120°, and the apex angle of the filter membrane is the same as the apex angle of the filter membrane support; among them, the commonly used apex angles of the filter membrane support include but are not limited to 35°, 45°, 55°, and 75°.

[0018] Further, the effective filtration area of the filter membrane is 5 cm² to 95 cm², ensuring that the volume of the conical filter adsorption tube is small and not easily blocked; among them, the commonly used effective filtration areas of the filter membrane include but are not limited to 20 cm², 35 cm², 45 cm², and 75 cm².

[0019] Further, the pore size of the filter membrane is 1 μm to 0.9 mm;

[0020] Among them, when the pore size of the filter membrane is 1 μm to 10 μm, the filter membrane is used to capture cells with smaller particle sizes in the liquid to be detected, such as: lymphocytes;

[0021] When the pore size of the filter membrane is 10 μm to 100 μm, the filter membrane is used to capture cells with moderate particle sizes in the liquid to be detected, such as: epithelial cells, clustered lesion cells, etc.;

[0022] When the pore size of the filter membrane is 100 μm to 0.9 mm, the filter membrane is used to capture cells with larger particle sizes in the liquid to be detected, such as: clustered lesion cells with larger particle sizes.

[0023] Further, the thickness of the filter membrane is 0.3 μm to 0.9 mm, ensuring that the filter membrane is easy to press and fold while having high strength; among them, the commonly used thicknesses of the filter membrane include but are not limited to 10 μm, 50 μm, 0.1 mm, and 0.5 mm.

[0024] Further, the filter membrane is a polymer material, cotton and linen material, protein material, paper material or the like that has been ion-exchanged to carry a positive or negative charge;

[0025] A filter element made of materials such as polymer materials, cotton and linen materials, protein materials or paper materials can form the above-mentioned filter membrane with a positive or negative charge after being soaked in an ion exchanger; among them, the ion exchanger can be an inorganic or organic material, such as zeolite, sulfonated coal and ion exchange resin, etc.

[0026] Further, the lower end of the filter membrane support is connected to the lower end outlet of the body by means of plugging, clamping or threading, so that the filter membrane support is detachably installed in the body.

[0027] Further, the conical filter adsorption tube can be made of materials such as metal, plastic, glass or paper, except for the filter membrane.

[0028] In a second aspect, the present utility model also provides a filter adsorber, including: a liquid bag, a connecting pipe and the conical filter adsorption tube as described in the first aspect;

[0029] The liquid bag is used to collect and store the liquid to be detected;

[0030] Both ends of the connecting pipe are respectively communicated with the liquid outlet at the bottom of the liquid bag and the upper end inlet of the conical filter adsorption tube, and are used for the liquid to be detected in the liquid bag to flow into the conical filter adsorption tube through the connecting pipe.

[0031] Preferably, the conical filter adsorption tube further includes a stop clamp, and the stop clamp is detachably installed on the connecting pipe and is used for clamping the connecting pipe when collecting the liquid to be detected, preventing the liquid to be detected in the liquid bag from flowing into the conical filter adsorption tube through the connecting pipe, and further collecting the liquid to be detected in the liquid bag.

[0032] In a third aspect, the present utility model also provides a preservation liquid bottle for storing the filter core of the conical filter adsorption tube as described in the first aspect, including: a bottle body and a bottle cap;

[0033] The bottle body is used to store the filter core;

[0034] A first inverted conical structure is arranged in the bottle body, and a limiting structure is arranged at the upper end of the first inverted conical structure for limiting the position of the filter core in the bottle body;

[0035] The bottle cap is detachably installed on the bottle mouth of the bottle body for sealing the bottle body;

[0036] A second inverted conical structure is provided on the bottle cap, and a centrifugal flow channel is formed between the second inverted conical structure and the first inverted conical structure;

[0037] A second annular groove is further provided on the bottle cap for pressing the filter element in the bottle body, thereby fixing the filter element in the preservation liquid bottle;

[0038] During use, the filter element is placed upside down in the bottle body filled with cell preservation liquid, the bottle cap is covered, the lower end of the filter membrane support of the filter element is inserted into the second annular groove of the bottle cap, and the lower end of the filter membrane support of the filter element is pressed by the second annular groove of the bottle cap, pressing the filter element completely into the preservation liquid bottle, and pressing the pressing ring of the filter element against the limiting structure of the bottle body, thereby fixing the filter element in the preservation liquid bottle, preventing the filter element from shaking during centrifugation, and enabling the cells on the filter membrane of the filter element to be rinsed and separated more quickly, improving the separation efficiency.

[0039] Furthermore, a sampling hole is provided on the bottle cap. The sampling hole is provided at the lower end of the second inverted conical structure and is usually sealed with a plastic paper. During sampling, a sampling needle penetrates through the sampling hole for puncture sampling.

[0040] Adopting the above technical solution, the present utility model has the following beneficial effects:

[0041] A conical filter adsorption tube, a filter adsorber and a preservation liquid bottle provided by the present utility model increase the effective filtration area of the filter membrane and are not easily blocked, thereby greatly improving the filtration efficiency and ensuring a small volume at the same time; after the filter membrane is taken out, the cells on the filter membrane can be rinsed and separated more quickly, improving the separation efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0042] In order to more clearly illustrate the specific embodiments of the present utility model or the technical solutions in the prior art, the following will briefly introduce the drawings required for the description of the specific embodiments or the prior art. Obviously, the following drawings are some embodiments of the present utility model. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0043] Figure 1 It is a three-dimensional structural schematic diagram of the conical filter adsorption tube provided by the embodiment of the present utility model;

[0044] Figure 2 For Figure 1 The cross-sectional view of the shown conical filter adsorption tube;

[0045] Figure 3 For Figure 2Schematic perspective view of the filter element shown;

[0046] Figure 4 is Figure 3 Top view of the filter element shown;

[0047] Figure 5 is Figure 2 Schematic perspective view of the filter membrane support shown;

[0048] Figure 6 is Figure 5 Top view of the filter membrane support shown;

[0049] Figure 7 is Figure 2 Schematic perspective view of the compression ring shown;

[0050] Figure 8 is Figure 7 Bottom view of the compression ring shown;

[0051] Figure 9 Top view of the filter element of the conical filter adsorption tube provided by another embodiment of the present utility model;

[0052] Figure 10 is Figure 9 Top view of the filter membrane support shown;

[0053] Figure 11 is Figure 9 Bottom view of the compression ring shown;

[0054] Figure 12 Schematic perspective view of the filter adsorber provided by yet another embodiment of the present utility model;

[0055] Figure 13 is Figure 12 Schematic perspective view of the filter adsorber when unfolded;

[0056] Figure 14 Schematic perspective view of the preservation liquid bottle provided by yet another embodiment of the present utility model;

[0057] Figure 15 is Figure 14 Top view of the preservation liquid bottle shown;

[0058] Figure 16 is Figure 14 Cross-sectional view of the preservation liquid bottle shown;

[0059] Figure 17 is Figure 14 Schematic perspective view of the bottle body of the preservation liquid bottle shown.

[0060] Reference numerals:

[0061] 1 - Body; 2 - Filter element; 21 - Filter membrane; 22 - Filter membrane support; 221 - First annular groove; 222 - First internal tooth structure; 23 - Pressing ring; 231 - Second internal tooth structure; 3 - Liquid bag; 4 - Connecting pipe; 5 - Bottle body; 51 - First inverted conical structure; 52 - Limiting structure; 53 - Centrifugal flow channel; 6 - Bottle cap; 61 - Second inverted conical structure; 62 - Second annular groove; 63 - Sampling hole. Detailed implementation manners

[0062] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are part of the embodiments of the present utility model, rather than all of them. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present utility model without creative efforts shall fall within the protection scope of the present utility model.

[0063] In the description of the present utility model, it should be noted that the orientation or positional relationship indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to the present utility model. In addition, the terms "first", "second", "third" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance.

[0064] In the description of the present utility model, it should be noted that unless otherwise clearly specified and limited, the terms "installation", "connection", "connection" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected, or indirectly connected through an intermediate medium, and it can be the communication inside two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present utility model can be understood according to specific situations.

[0065] The present utility model will be further explained below in combination with specific implementation manners.

[0066] It should also be noted that the following specific embodiments or specific implementation manners are a series of optimized setting manners listed by the present utility model to further explain the specific content of the utility model, and these setting manners can be combined with each other or used in association with each other.

[0067] Embodiment 1

[0068] As Figure 1-8As shown in the figure, a conical filtering and adsorbing tube provided in this embodiment includes: a main body 1 and a filter core 2;

[0069] The main body 1 is conical;

[0070] The filter core 2 includes a filter membrane 21 and a filter membrane support 22; the filter membrane support 22 is a conical support composed of a plurality of support rods arranged along the generatrix direction, and is detachably installed in the main body 1 for supporting the filter membrane; the filter membrane 21 is sleeved on the filter membrane support 22 and is in close fit with the filter membrane support 22, presenting a conical shape, and is used for filtering the liquid to be detected and adsorbing and capturing cells in the liquid to be detected; wherein, the liquid to be detected is usually a body fluid such as urine, sweat or saliva, or other liquids carrying target cells and substances to be detected; the filter membrane 21 is usually a flat membrane;

[0071] During use, the liquid to be detected flows in from the upper end inlet of the main body 1 and rapidly flows downward along the surface of the filter membrane 21 from the top of the filter membrane 21, flushing the entire filter membrane 21. The filter membrane 21 is used to filter the liquid to be detected, adsorb and capture cells in the liquid to be detected, and the liquid to be detected passing through the filter membrane 21 flows out from the filter membrane support 22;

[0072] The filter membrane 21 is connected to the filter membrane support 22 and is used to take out the filter membrane 21 from the main body 1 through the filter membrane support 22.

[0073] In this application, by arranging a conical filter membrane support 22 in the conical filtering and adsorbing tube, the filter membrane 21 is closely attached to the filter membrane support 22 and presents a conical shape, which is convenient for the liquid to be detected to rapidly flow downward along the surface of the filter membrane 21 from the top of the filter membrane 21, flushing the entire filter membrane 21, increasing the effective filtering area of the filter membrane 21 and being not easily blocked, thereby greatly improving the filtering efficiency and at the same time ensuring that the volume of the conical filtering and adsorbing tube is small; after the filter membrane 21 is taken out, the cells on the filter membrane 21 can be rinsed and separated more quickly, improving the separation efficiency.

[0074] Refer to Figure 2-8As shown, on the basis of the above technical solution, further preferably, the filter element 2 further includes a pressing ring 23; a first annular groove 221 is provided at the lower part of the filter membrane support 22, and the pressing ring 23 is detachably inserted into the first annular groove 221 and engaged with the first annular groove 221, so as to squeeze and fix the edge part of the filter membrane 21 in the first annular groove 221 of the filter membrane support 22 through the pressing ring 23, and then the filter membrane 21 is sleeved on the filter membrane support 22 and closely attached to the filter membrane support 22; when the filter membrane 21 is taken out, the filter membrane 21 is taken out of the body 1 through the filter membrane support 22.

[0075] More preferably, the apex angle of the filter membrane support 22 is 25° - 120°, and the apex angle of the filter membrane 21 is the same as that of the filter membrane support 22; among them, the commonly used apex angles of the filter membrane support 22 include but are not limited to 35°, 45°, 55° and 75°.

[0076] More preferably, the effective filtration area of the filter membrane 21 is 5 cm² - 95 cm², ensuring that the volume of the conical filter adsorption tube is small and not easily blocked; among them, the commonly used effective filtration areas of the filter membrane 21 include but are not limited to 20 cm², 35 cm², 45 cm² and 75 cm². The pore size of the filter membrane 21 is 1 μm - 0.9 mm. Among them, when the pore size of the filter membrane 21 is 1 μm - 10 μm, the filter membrane 21 is used to capture cells with smaller particle sizes in the liquid to be detected, such as: lymphocytes; when the pore size of the filter membrane 21 is 10 μm - 100 μm, the filter membrane 21 is used to capture cells with moderate particle sizes in the liquid to be detected, such as: epithelial cells, clustered lesion cells, etc.; when the pore size of the filter membrane 21 is 100 μm - 0.9 mm, the filter membrane 21 is used to capture cells with larger particle sizes in the liquid to be detected, such as: clustered lesion cells with larger particle sizes. The thickness of the filter membrane 21 is 0.3 μm - 0.9 mm, ensuring that the filter membrane 21 is easy to press and fold while having high strength; among them, the commonly used thicknesses of the filter membrane 21 include but are not limited to 10 μm, 50 μm, 0.1 mm and 0.5 mm.

[0077] More preferably, the filter membrane 21 is a polymer material, cotton and linen material, protein material or paper material, etc. that has been ion-exchanged to carry a positive or negative charge; the filter element made of polymer material, cotton and linen material, protein material or paper material, etc. can form the above-mentioned filter membrane 21 with a positive or negative charge after being soaked with an ion exchanger; among them, the ion exchanger can be an inorganic or organic material, such as zeolite, sulfonated coal and ion exchange resin, etc.

[0078] In this embodiment, the lower end of the filter membrane support 22 is connected to the lower end outlet of the body 1 by means of plugging or clamping, so that the filter membrane support 22 is detachably installed in the body 1.

[0079] In addition, the conical filter adsorption tube can be made of materials such as metal, plastic, glass or paper, except for the filter membrane 21.

[0080] In the utility model, by arranging a conical filter membrane support 22 in the conical filter adsorption tube, the filter membrane 21 is closely attached to the filter membrane support 22 and is conical, which is convenient for the liquid to be detected to flow rapidly downward along the surface of the filter membrane 21 from the top of the filter membrane 21, flushing the whole filter membrane 21, increasing the effective filtration area of the filter membrane 21, and not easily blocked, thereby greatly improving the filtration efficiency and ensuring that the volume of the conical filter adsorption tube is small at the same time; after the filter membrane 21 is taken out, the cells on the filter membrane 21 can be rinsed and separated more quickly, improving the separation efficiency.

[0081] Embodiment 2

[0082] This embodiment is basically the same as Embodiment 1, except that:

[0083] As Figure 9-11 shown, in this embodiment, a first internal tooth structure 222 is arranged on the inner ring of the first annular groove 221, and one tooth of the first internal tooth structure 222 is arranged between two adjacent support rods of the filter membrane support 22; a second internal tooth structure 231 is arranged on the inner ring of the pressing ring 23, and the second internal tooth structure 231 is engaged and matched with the first internal tooth structure 222. By engaging the second internal tooth structure 231 of the pressing ring 23 with the first internal tooth structure 222 of the first annular groove 221, the filter membrane 21 is folded inward along the contour of several teeth of the first internal tooth structure 222. While ensuring that the volume of the conical filter adsorption tube is small, the effective filtration area of the filter membrane 21 is further increased, thereby improving the filtration efficiency.

[0084] In this embodiment, the lower end of the filter membrane support 22 is connected to the lower end outlet of the body 1 by means of a thread.

[0085] Embodiment 3

[0086] As Figure 12-13 shown, a filter adsorber provided in this embodiment includes: a liquid bag 3, a connecting pipe 4, and a conical filter adsorption tube as described in Embodiment 1; the liquid bag 3 is used for collecting and storing the liquid to be detected; both ends of the connecting pipe 4 are respectively communicated with the liquid outlet at the bottom of the liquid bag 3 and the upper end inlet of the conical filter adsorption tube, and are used for the liquid to be detected in the liquid bag 3 to flow into the conical filter adsorption tube through the connecting pipe 4.

[0087] More preferably, the length of the connecting tube 4 can be adjusted to adjust the pressure of the detected liquid flowing into the upper end inlet of the conical filtration adsorption tube on the filtration membrane 21. In this embodiment, the connecting tube 4 is a folding tube.

[0088] Further preferably, the conical filtration adsorption tube further includes a stop clamp (not shown in the figure), which is detachably installed on the connecting tube 4 and is used to clamp the connecting tube 4 when collecting the detected liquid to prevent the detected liquid in the liquid bag 3 from flowing into the conical filtration adsorption tube through the connecting tube 4, so as to collect the detected liquid in the liquid bag 3.

[0089] Example 4

[0090] As Figure 14-17 shown, a preservation liquid bottle for storing the filter core 2 of the conical filtration adsorption tube as described in Example 1 provided in this embodiment includes: a bottle body 5 and a bottle cap 6; the bottle body 5 is used to store the filter core 2; a first inverted conical structure 51 is arranged inside the bottle body 5, and a limiting structure 52 is arranged at the upper end of the first inverted conical structure 51 for limiting the position of the filter core 2 in the bottle body 5; the bottle cap 6 is detachably installed on the bottle mouth of the bottle body 5 for sealing the bottle body 5; a second inverted conical structure 61 is arranged on the bottle cap 6, and a centrifugal flow channel 53 is formed between the second inverted conical structure 61 and the first inverted conical structure 51; a second annular groove 62 is further arranged on the bottle cap 6 for pressing the filter core 2 in the bottle body 5, thereby fixing the filter core 2 in the preservation liquid bottle;

[0091] During use, the filter core 2 is placed upside down in the bottle body 5 filled with cell preservation liquid, the bottle cap 6 is covered, the lower end of the filter membrane support 22 of the filter core 2 is inserted into the second annular groove 62 of the bottle cap 6, and the lower end of the filter membrane support 22 of the filter core 2 is pressed by the second annular groove 62 of the bottle cap 6 to completely press the filter core 2 into the preservation liquid bottle, and the pressing ring 23 of the filter core 2 is pressed against the limiting structure 52 of the bottle body 5, thereby fixing the filter core 2 in the preservation liquid bottle and preventing the filter core 2 from shaking during centrifugation, so that the cells on the filter membrane 21 of the filter core 2 can be washed and separated more quickly, improving the separation efficiency.

[0092] Referring to Figure 15 、 Figure 16 shown, a sampling hole 63 is further arranged on the bottle cap 6, and the sampling hole 63 is arranged at the lower end of the second inverted conical structure 61 and is usually sealed by a plastic paper. During sampling, a sampling needle penetrates through the sampling hole 63 for puncture sampling.

[0093] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements on some or all of the technical features; and these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the various embodiments of the present invention.

Claims

1. A conical filter adsorption tube, characterized in that: include: Body and filter element; The body is conical; The filter element comprises a filter membrane and a filter membrane support; The filter membrane support is a conical support composed of a plurality of support rods arranged along the generatrix direction, which is detachably installed in the body and used to support the filter membrane; The filter membrane is sleeved on the filter membrane support, closely fits the filter membrane support, and is cone-shaped, and is used to filter the liquid to be detected and absorb and capture cells in the liquid to be detected.

2. The conical filter adsorption tube according to claim 1, characterized in that: The filter element further comprises a pressure ring; A first annular groove is provided at the lower portion of the filter membrane holder, and the pressure ring is detachably inserted into the first annular groove and engages with the first annular groove to squeeze and fix the edge of the filter membrane in the first annular groove of the filter membrane holder through the pressure ring; when taking out the filter membrane, the filter membrane is taken out of the body through the filter membrane holder.

3. The conical filter adsorption tube according to claim 2, characterized in that: The inner ring of the first annular groove is provided with a first internal tooth structure, and a tooth of the first internal tooth structure is provided between two adjacent support rods of the filter membrane support; the inner ring of the pressure ring is provided with a second internal tooth structure, and the second internal tooth structure is engaged with the first internal tooth structure. The filter membrane is folded inward along the contour of several teeth of the first internal tooth structure through the engagement of the second internal tooth structure of the pressure ring with the first internal tooth structure of the first annular groove.

4. The conical filter adsorption tube according to claim 1, characterized in that: The top angle of the filter membrane support is 25°~120°, and the top angle of the filter membrane is the same as the top angle of the filter membrane support.

5. The conical filter adsorption tube according to claim 1, characterized in that: The effective filtration area of ​​the filtration membrane is 5 cm²~95 cm², the pore size is 1 μm~0.9 mm, and the thickness is 0.3 μm~0.9 mm.

6. The conical filter adsorption tube according to claim 1, characterized in that: The filter membrane is a polymer material, cotton material, protein material or paper material with positive or negative charge after ion exchange.

7. The conical filter adsorption tube according to claim 1, characterized in that: The lower end of the filter membrane support is connected to the lower end outlet of the body by plugging, clamping or threading, so that the filter membrane support is detachably installed in the body.

8. The conical filter adsorption tube according to claim 1, characterized in that: The conical filtering adsorption tube is made of metal, plastic, glass or paper.

9. A filter adsorber comprising the conical filter adsorption tube according to any one of claims 1 to 8, characterized in that: Also includes: Flexitank and connecting tubes; The fluid bag is used to collect and store the detected liquid; The two ends of the connecting tube are respectively connected with the liquid outlet at the bottom of the liquid bag and the upper inlet of the conical filter adsorption tube, so that the detected liquid in the liquid bag flows into the conical filter adsorption tube through the connecting tube.

10. A storage liquid bottle for storing the filter element of the conical filter adsorption tube according to any one of claims 1 to 8, characterized in that: include: Bottle body and bottle cap; The bottle body is used to store the filter element; A first inverted cone structure is provided in the bottle body, and a limiting structure is provided at the upper end of the first inverted cone structure for limiting the position of the filter element in the bottle body; The bottle cap is detachably mounted on the bottle mouth of the bottle body and is used for sealing the bottle body; The bottle cap is provided with a second inverted cone structure, and a centrifugal flow channel is formed between the second inverted cone structure and the first inverted cone structure; The bottle cap is also provided with a second annular groove for squeezing the filter core into the bottle body, thereby fixing the filter core in the preservation liquid bottle.

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