Chromosome karyotype analysis dropping device

Abstract

The utility model belongs to the technical field of medical equipment, and discloses a chromosome karyotype analysis dropping device which comprises a mounting seat, a placement frame, an angle adjusting device, a moving device, a liquid absorber and a temperature and humidity adjusting device, the placing rack is provided with a placing position for placing a glass slide, the placing rack is arranged on the mounting seat, and the angle adjusting device is connected with the placing rack and can drive the placing rack to move to different inclination angles relative to the mounting seat; the liquid suction device is movably arranged on the mounting seat and suspended above the placement frame, and the moving device is connected with the liquid suction device and drives the liquid suction device to move in a three-dimensional space; the temperature and humidity adjusting device is arranged on the mounting base and located below the containing frame. According to the chromosome karyotype analysis dropping device, the dropping height, angle, humidity and temperature can be accurately controlled, and the influence on the chromosome dropping effect is effectively avoided, so that the produced chromosome is long and full.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical equipment, and particularly relates to a chromosome karyotype analysis dropping device. Background Art

[0002] In the medical field, chromosome karyotype analysis can diagnose genetic diseases caused by chromosome abnormalities, study genetic relationships, and explore species evolution, etc. Karyotype analysis can provide important basis for the research of cytogenetic classification, genetic relationships between species, and chromosome number and structure variations; at the same time, chromosome karyotype analysis is also an important indicator for the diagnosis, typing, prognosis judgment and follow-up monitoring of hematological diseases.

[0003] At present, the chromosome dropping operation directly uses an alcohol lamp, a wooden board, holds a wet glass slide by hand, and directly performs over-fire dropping after sucking cell suspension. Among them, when performing over-fire dropping, it is usually the user who holds the glass slide with a gripper for operation. This process has strong human factors and it is difficult to precisely control the height, angle, humidity and temperature of the environment where the dropping is performed, resulting in affecting the chromosome dropping effect. The prepared chromosomes will be short and small and there will be a non-dispersed situation. Summary of the Utility Model

[0004] The purpose of the utility model is to provide a chromosome karyotype analysis dropping device that can precisely control the height, angle and humidity of dropping.

[0005] The realization of the above purpose includes the following technical solutions.

[0006] The first aspect of the utility model provides a chromosome karyotype analysis dropping device, which includes a mounting base, a placement rack, an angle adjustment device, a moving device, a liquid suction device and a temperature and humidity adjustment device;

[0007] The placement rack is provided with a placement position for placing a glass slide. The placement rack is arranged on the mounting base, and the angle adjustment device is connected to the placement rack and can drive the placement rack to move relative to the mounting base to different inclination angles;

[0008] The liquid suction device is movably arranged on the mounting base and is suspended above the placement rack, and the moving device is connected to the liquid suction device and drives the liquid suction device to move in three-dimensional space;

[0009] The temperature and humidity adjustment device is arranged on the mounting base, and the temperature and humidity adjustment device is located below the placement rack.

[0010] In some of these embodiments, the angle adjustment device includes a fixed seat, a rotating shaft, and a knob portion; the rotating shaft is rotatably disposed through the fixed seat, the placement rack is disposed on the rotating shaft, the knob portion is disposed outside the fixed seat, and the knob portion is connected to the rotating shaft, and the knob portion can drive the rotating shaft to rotate relative to the fixed seat under the action of an external force.

[0011] In some of these embodiments, the angle adjustment device further includes a blocking member disposed on the fixed seat, and the blocking member intersects the rotation trajectory of the placement rack; when the placement rack rotates to the position of the blocking member, the blocking member prevents further rotation of the placement rack.

[0012] In some of these embodiments, there are multiple blocking members; along the rotation direction of the placement rack, a plurality of communication holes are sequentially formed on one side of the fixed seat, the blocking members are arranged in one-to-one correspondence with the communication holes, and the blocking members are movably disposed through the communication holes, and limiting rings are provided at opposite ends of the blocking members, and the radial length of the limiting rings is greater than the radial length of the communication holes.

[0013] In some of these embodiments, the fixed seat is provided with a water collecting tank, and the water collecting tank is located below the placement rack.

[0014] In some of these embodiments, the fixed seat includes a bottom plate, a first side plate, a second side plate, and a third side plate; the first side plate, the second side plate, and the third side plate are sequentially connected and are all disposed on the bottom plate, and the first side plate, the second side plate, and the third side plate enclose a side-opening enclosure structure, the rotating shaft is sequentially disposed through the first side plate and the third side plate, and the top end of the second side plate is inclined outwardly with respect to the fixed seat.

[0015] In some of these embodiments, the placement rack includes a plate body and a plurality of fixing columns disposed on the plate body, a placement position with a recessed and open top is formed between adjacent two of the fixing columns, and at least one blocking post is disposed in a region of the bottom of the placement rack corresponding to the placement position.

[0016] In some of these embodiments, the temperature and humidity adjustment device includes a water bath tank and a heater; the water bath tank includes a tank body and a tank cover disposed on the tank body, an air outlet hole is formed on the tank cover, and the heater is disposed inside the tank body.

[0017] In some of these embodiments, an air fan and a temperature and humidity detector are further disposed above the placement position corresponding to the mounting seat.

[0018] In some of these embodiments, a test tube rack is further provided on the mounting seat, and the test tube rack is magnetically adsorbed on the mounting seat.

[0019] The technical solution provided by the present utility model has the following advantages and effects:

[0020] By integrating the placement rack, angle adjustment device, moving device, liquid aspirator, and temperature and humidity adjustment device on the mounting base, the chromosome karyotype analysis dropping device facilitates the dropping operation for the operator. Among them, the angle adjustment device is connected to the placement rack. According to the required tilting angle of the glass slide during the dropping process, the tilting angle of the placement rack relative to the mounting base can be adjusted through the angle adjustment device, thereby adjusting the required tilting angle of the glass slide accordingly. The moving device controls the movement of the liquid aspirator above the placement rack, enabling precise control of the height of the liquid aspirator, and thus precisely controlling the height of the dropped liquid. The setting of the temperature and humidity adjustment device can increase the working humidity and temperature of the chromosome karyotype analysis dropping device. Therefore, the chromosome karyotype analysis dropping device can precisely control the height, angle, humidity, and temperature of the dropping, effectively avoiding affecting the dropping effect of the chromosome, and thus making the chromosomes produced in the preparation long and plump. Description of the Drawings

[0021] Figure 1 is the overall structural schematic diagram of the chromosome karyotype analysis dropping device according to the embodiment of the present utility model;

[0022] Figure 2 is the combined structural schematic diagram of the placement rack and the angle adjustment device according to the embodiment of the present utility model;

[0023] Figure 3 is the structural schematic diagram of the temperature and humidity adjustment device according to the embodiment of the present utility model.

[0024] Description of the Reference Numerals:

[0025] 100, chromosome karyotype analysis dropping device;

[0026] 1, mounting base; 2, placement rack; 21, placement position; 22, plate body; 23, fixing column; 24, blocking column; 3, angle adjustment device; 31, fixing seat; 311, water collecting tank; 312, bottom plate; 313, first side plate; 314, second side plate; 315, third side plate; 32, rotating shaft; 33, knob part; 34, blocking member; 341, limiting ring; 4, moving device; 5, liquid aspirator; 6, temperature and humidity adjustment device; 61, water bath tank; 62, air outlet; 7, test tube rack; 8, temperature and humidity detector; 9, air fan;

[0027] 200, glass slide. Detailed Embodiments

[0028] To facilitate the understanding of the present utility model, the following will describe the specific embodiments of the present utility model in more detail with reference to the accompanying drawings of the specification.

[0029] Unless otherwise specified or defined, the "first, second..." used herein is only for differentiating names and does not represent a specific quantity or order.

[0030] Unless otherwise specified or defined, the term "and / or" used herein includes any and all combinations of one or more of the related listed items.

[0031] It should be noted that "fixed to" and "connected to" in this article can be directly fixed or connected to an element, or indirectly fixed or connected to an element.

[0032] The embodiment of the present utility model provides a chromosome karyotype analysis dropping device 100, and the chromosome karyotype analysis dropping device 100 includes a mounting base 1, a placement rack 2, an angle adjustment device 3, a moving device 4, a liquid suction device 5, and a temperature and humidity adjustment device 6.

[0033] The placement rack 2 is provided with a placement position 21 for placing a glass slide 200. The placement rack 2 is arranged on the mounting base 1, and the angle adjustment device 3 is connected to the placement rack 2 and can drive the placement rack 2 to move relative to the mounting base 1 to different inclination angles; wherein, when chromosome dropping operation needs to be performed, the glass slide 200 is placed on the placement position 21 of the placement rack 2. According to the inclination angle required by the glass slide 200 during the dropping process, the inclination angle of the placement rack 2 relative to the mounting base 1 can be adjusted through the angle adjustment device 3, so as to adjust the inclination angle required by the glass slide 200 accordingly. Among them, when it is necessary to drop cell suspension onto the glass slide 200, the placement rack 2 can be adjusted to a horizontal or approximately horizontal state through the angle adjustment device 3, which is convenient for dropping cell suspension onto the glass slide 200. After dropping cell suspension onto the glass slide 200, it can be well carried on the glass slide 200. After the dropping is completed, the placement rack 2 is adjusted to an inclination angle through the angle adjustment device 3, specifically, it can be inclined at 15° to 25°, for example, it can be 15°, 20°, 25°, etc., and no special limitation is made here; at this time, the excess liquid on the glass slide 200 can spread and flow down along the inclined surface of the glass slide 200, so that the cells can be fully dispersed on the glass slide 200.

[0034] The liquid suction device 5 is movably arranged on the mounting base 1 and is suspended above the placement rack 2, and the moving device 4 is connected to the liquid suction device 5 and drives the liquid suction device 5 to move in three-dimensional space; the temperature and humidity adjustment device 6 is arranged on the mounting base 1, and the temperature and humidity adjustment device 6 is located below the placement rack 2. Among them, by controlling the movement of the liquid suction device 5 above the placement rack 2 through the moving device 4, the height of the liquid suction device 5 can be accurately controlled, so as to accurately control the height of the liquid dropping, and the setting of the temperature and humidity adjustment device 6 can control the working humidity and temperature of the chromosome karyotype analysis dropping device 100.

[0035] In summary, the chromosome karyotype analysis dropping device 100 integrates the placement rack 2, the angle adjustment device 3, the moving device 4, the liquid suction device 5 and the temperature and humidity adjustment device 6 on the mounting base 1, which facilitates the dropping operation for the operator. Among them, the angle adjustment device 3 is connected to the placement rack 2. According to the required tilting angle of the glass slide 200 during the dropping process, the tilting angle of the placement rack 2 relative to the mounting base 1 can be adjusted by the angle adjustment device 3, so as to adjust the required tilting angle of the glass slide 200 accordingly. The moving device 4 controls the movement of the liquid suction device 5 above the placement rack 2, which can accurately control the height of the liquid suction device 5, and thus accurately control the height of the liquid drop. The setting of the temperature and humidity adjustment device 6 can increase the working humidity and temperature of the chromosome karyotype analysis dropping device 100. Therefore, the chromosome karyotype analysis dropping device 100 can accurately control the height, angle, humidity and temperature of the dropping, effectively avoiding affecting the dropping effect of the chromosome, so that the chromosomes prepared are long and plump.

[0036] In some embodiments, the angle adjustment device 3 includes a fixed seat 31, a rotating shaft 32 and a knob part 33; the rotating shaft 32 is rotatably passed through the fixed seat 31, the placement rack 2 is arranged on the rotating shaft 32, the knob part 33 is arranged outside the fixed seat 31, and the knob part 33 is connected to the rotating shaft 32. The knob part 33 can drive the rotating shaft 32 to rotate relative to the fixed seat 31 under the action of an external force. Among them, by applying an external force to the knob part 33, the knob part 33 can be rotated to drive the rotating shaft 32 to rotate, so as to drive the placement rack 2 on the rotating shaft 32 and the glass slide 200 thereon to rotate to achieve the purpose of adjusting the tilting angle. The manual adjustment setting facilitates the user to flexibly adjust according to the progress of the dropping in real time. Of course, in other embodiments, a rotating motor can also be set to drive the rotating shaft 32 to rotate, which can achieve the purpose of automatically adjusting the tilting angle of the glass slide 200, and no special limitation is made here.

[0037] In some embodiments, the angle adjustment device 3 further includes a blocking member 34 arranged on the fixed seat 31, and the blocking member 34 intersects the rotation trajectory of the placement rack 2; when the placement rack 2 rotates to the position of the blocking member 34, the blocking member 34 prevents the further rotation of the placement rack 2. Among them, by arranging the blocking member 34 at the position corresponding to the rotation trajectory of the placement rack 2 on the fixed seat 31, when the knob part 33 is rotated to adjust the placement rack 2 and the glass slide 200 thereon to the position where the blocking member 34 is located, the blocking member 34 blocks the further rotation of the placement rack 2, thereby prompting that the placement rack 2 rotates in place, and the glass slide 200 can be accurately adjusted to the preset tilting angle.

[0038] In some embodiments, a plurality of blocking members 34 are provided; along the rotation direction of the placement rack 2, a plurality of communication holes are sequentially formed on one side of the fixed seat 31, the blocking members 34 are arranged in one-to-one correspondence with the communication holes, and the blocking members 34 are movably inserted through the communication holes. Limit rings 341 are provided at opposite ends of the blocking member 34, and the radial length of the limit ring 341 is greater than the radial length of the communication hole. Among them, by providing a plurality of blocking members 34 on the fixed seat 31, each blocking member 34 corresponds to an inclination angle of the placement rack 2. Therefore, the placement rack 2 can be rotated to different angles by different blocking members 34 protruding from the fixed seat 31. When it is necessary to adjust to other angles, the previous blocking member 34 is retracted along the communication hole of the fixed seat 31 to prevent the previous blocking member 34 from blocking the rotation of the placement rack 2, and another blocking member 34 corresponding to this angle is pulled out to block its further rotation when the placement rack 2 rotates in place, so that the slide 200 can be accurately adjusted to different inclination angles; among them, the limit rings 341 at opposite ends of the blocking member 34 are used to prevent the blocking member 34 from detaching from the fixed seat 31 when adjusting its own position.

[0039] In some embodiments, the fixed seat 31 is provided with a water collecting groove 311, and the water collecting groove 311 is located below the placement rack 2. Among them, the water collecting groove 311 is used to store the liquid flowing down from the slide 200, so as to facilitate collection and subsequent processing, and avoid splashing onto other areas and causing pollution. Preferably, the bottom surface of the water collecting groove 311 is of an inclined surface structure, so as to form a diversion surface to divert and collect the liquid flowing down from the slide 200.

[0040] In some embodiments, the fixed seat 31 includes a bottom plate 312, a first side plate 313, a second side plate 314, and a third side plate 315; the first side plate 313, the second side plate 314, and the third side plate 315 are sequentially connected and are all arranged on the bottom plate 312, and the first side plate 313, the second side plate 314, and the third side plate 315 enclose a side-opening enclosure structure. The rotating shaft 32 sequentially passes through the first side plate 313 and the third side plate 315, and the top end of the second side plate 314 is inclined outwardly with respect to the fixed seat 31. Among them, the opening of the enclosure structure faces the user, which is convenient for the user to observe and operate for dropping the liquid. Moreover, the cooperation structure of the bottom plate 312 and the three side plates can form a semi-closed liquid dropping area, effectively preventing pollution of other positions and other samples during the liquid dropping process. The inclined structure of the second side plate 314 can, on the one hand, block the liquid from polluting other positions during the liquid dropping process, and on the other hand, can form a larger placement space to facilitate the rotation of the placement rack 2 and avoid structural interference.

[0041] Specifically, in this embodiment, the placement rack 2 is made of wood. When a high-humidity environment is required, the placement rack 2 can be directly soaked, which is safer and more practical. Of course, in other embodiments, the placement rack 2 can also be made of other materials, and no special restrictions are imposed here.

[0042] In some embodiments, the placement rack 2 includes a plate body 22 and a plurality of fixing columns 23 arranged on the plate body 22. A placement position 21 with a depression and an open top is formed between two adjacent fixing columns 23. At least one retaining column 24 is arranged at the bottom of the placement rack 2 corresponding to the area of the placement position 21. Among them, the fixing column 23 and the retaining column 24 cooperate to form the placement position 21 with a depression and an open top, so that the glass slide 200 can be conveniently inserted downward from the open top of the placement position 21. The setting of the retaining column 24 can support the bottom of the glass slide 200 to prevent it from falling, and can facilitate the liquid on the glass slide 200 to flow out, avoiding the accumulation of liquid at the placement position 21 and affecting the dropping effect.

[0043] In some embodiments, the temperature and humidity adjustment device 6 includes a water bath box 61 and a heater; the water bath box 61 includes a box body and a box cover arranged on the box body. An air outlet hole 62 is opened on the box cover, and the heater is arranged inside the box body. Among them, water can be filled in the box body. By heating the water in the box body with the heater to form water vapor and spraying it out from the air outlet hole 62 of the box cover, operations of increasing or decreasing temperature and humidity can be performed according to the needs of dropping. Specifically, in this embodiment, conventional components such as a control panel, a display screen, a switch, and a power supply can be arranged on the mounting base 1, and no special restrictions are imposed here. The temperature and humidity can be controlled by operating the control panel.

[0044] In some embodiments, an air fan 9 and a temperature and humidity detector 8 are further arranged on the mounting base 1 corresponding to the upper side of the placement position 21. The function of the air fan 9 is to accelerate the air circulation inside the chromosome karyotype analysis dropping device 100 and ensure the constancy of temperature and humidity in each area. The temperature and humidity detector 8 is used to monitor the internal temperature and humidity of the chromosome karyotype analysis dropping device 100 in real time, so that the environmental temperature and humidity meet the dropping requirements. In addition, a distilled water bottle and the like are also arranged on the mounting base 1, and no special restrictions are imposed here.

[0045] In some embodiments, a test tube rack 7 is further provided on the mounting base 1, and the test tube rack 7 is magnetically adsorbed on the mounting base 1. Among them, the test tube rack 7 is used to store centrifuge tubes, and cell suspensions can be stored in the centrifuge tubes, which is convenient for the pipettor 5 to suck and drip the slices. Moreover, since the test tube rack 7 is magnetically adsorbed on the mounting base 1, the stable placement of the test tube rack 7 can be ensured, and the centrifuge tube can be vertically fixed. In addition, the test tube rack 7, the air fan 9, the temperature and humidity detector 8, the placement rack 2, the angle adjustment device 3, the moving device 4, and the pipettor 5 are integrated with the mounting base 1, and the slice dripping operation can be integrated and completed on the mounting base 1.

[0046] In some embodiments, the moving device 4 may be a three-axis moving platform formed by the cooperation of three linear slides, so as to automatically drive the pipettor 5 to move to a set position in three-dimensional space for the dripping operation. Of course, in other embodiments, the moving device 4 may also be an operating rod and a button cooperating with a robotic arm to control the movement of the pipettor 5, where the button controls the up and down movement of the pipettor 5, and the operating rod controls the left and right movement of the pipettor 5, so as to manually control the pipettor 5 to move to a set position in three-dimensional space for the dripping operation, and no special limitation is made here.

[0047] The above embodiments are not an exhaustive list based on the present invention. In addition, there may be multiple other embodiments not listed. Any substitution and improvement made without violating the concept of the present invention fall within the protection scope of the present invention.

Claims

1. A chromosome karyotype analysis droplet device, characterized in that: The chromosome karyotype analysis drop film device comprises a mounting seat, a placement rack, an angle adjustment device, a moving device, a liquid aspirator and a temperature and humidity adjustment device; The placement rack is provided with a placement position for placing a glass slide, the placement rack is arranged on the mounting seat, and the angle adjustment device is connected to the placement rack and can drive the placement rack to move to different inclination angles relative to the mounting seat; The pipette is movably arranged on the mounting seat and suspended above the placement rack, and the moving device is connected to the pipette and drives the pipette to move in a three-dimensional space; The temperature and humidity regulating device is arranged on the mounting seat, and the temperature and humidity regulating device is located below the placing rack.

2. The chromosome karyotype analysis droplet device according to claim 1, characterized in that: The angle adjustment device includes a fixed seat, a rotating shaft and a knob part; the rotating shaft is rotatably passed through the fixed seat, the placement frame is arranged on the rotating shaft, the knob part is arranged on the outside of the fixed seat, and the knob part is connected to the rotating shaft. The knob part can drive the rotating shaft to rotate relative to the fixed seat under the action of external force.

3. The chromosome karyotype analysis droplet device according to claim 2, characterized in that: The angle adjustment device also includes a blocking member arranged on the fixing seat, and the blocking member intersects with the rotation trajectory of the placement rack; when the placement rack rotates to the position of the blocking member, the blocking member prevents the placement rack from further rotating.

4. The chromosome karyotype analysis droplet device according to claim 3, characterized in that: There are multiple blocking members; along the rotation direction of the placement rack, one side of the fixed seat is sequentially opened with multiple connecting holes, the blocking members are arranged one by one corresponding to the connecting holes, and the blocking members are movably passed through the connecting holes, and limiting rings are arranged at the opposite ends of the blocking members, and the radial length of the limiting rings is greater than the radial length of the connecting holes.

5. The chromosome karyotype analysis droplet device according to claim 2, characterized in that: The fixing seat is provided with a water collecting tank, and the water collecting tank is located below the placing rack.

6. The chromosome karyotype analysis droplet device according to claim 2, characterized in that: The fixed seat includes a bottom plate, a first side plate, a second side plate and a third side plate; the first side plate, the second side plate and the third side plate are connected in sequence and are all arranged on the bottom plate, and the first side plate, the second side plate and the third side plate are enclosed to form a panel structure with an opening on one side, the rotating shaft is sequentially passed through the first side plate and the third side plate, and the top end of the second side plate is inclined toward the outside of the fixed seat.

7. The chromosome karyotype analysis droplet device according to any one of claims 1 to 6, characterized in that: The placement rack includes a plate body and a plurality of fixing columns arranged on the plate body, a placement position with a depression and an open top is formed between two adjacent fixing columns, and at least one blocking column is arranged at the bottom of the placement rack in an area corresponding to the placement position.

8. The chromosome karyotype analysis droplet device according to any one of claims 1 to 6, characterized in that: The temperature and humidity regulating device comprises a water bath and a heater; the water bath comprises a box body and a box cover arranged on the box body, the box cover is provided with air outlets, and the heater is arranged in the box body.

9. The chromosome karyotype analysis droplet device according to any one of claims 1 to 6, characterized in that: An air fan and a temperature and humidity detector are also arranged above the mounting seat corresponding to the placement position.

10. The chromosome karyotype analysis droplet device according to any one of claims 1 to 6, characterized in that: A test tube rack is also provided on the mounting seat, and the test tube rack is magnetically adsorbed on the mounting seat.

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