Modularly designed high-flux parallel chemical reaction device

Abstract

The utility model discloses a high-flux parallel chemical reaction device with modular design. The device comprises a vertical magnetic stirring and mixing platform, a temperature control module, a sample reaction tube module, an electrochemical reaction module and a photochemical reaction module. According to the device, a vertical magnetic stirring and mixing platform adopting a vertical magnetic stirring and mixing technology is adopted as a basic platform of a reactor, and is combined with a temperature control module capable of performing a precise temperature control technology, a photochemical reaction module adopting a light source power control technology and an electrochemical reaction module adopting a direct / alternating current power supply control technology; a modular design technology is adopted, the device completely follows international SLAS / SBS laboratory automation specifications and standards, and high-throughput chemical experiments such as temperature control type chemical reactions, photochemical reactions, electrochemical reactions and the like can be conveniently, flexibly and freely combined.

Description

Technical Field

[0001] The utility model relates to the technical field of laboratories, and particularly relates to a high-throughput parallel chemical reaction device with modular design. Background Art

[0002] The high-throughput experimental technology originated in the 1980s and has since developed rapidly in the field of biological science experimental technology. Especially with the rapid development of laboratory automation technology, it has greatly promoted biological science research such as high-throughput gene sequencing, high-throughput cell screening, high-throughput nucleic acid virus purification, high-throughput synthetic biology, and high-throughput ELISA detection.

[0003] The basic principle of high-throughput experimental technology is to conduct multiple experiments (usually dozens, hundreds, or even thousands) simultaneously in a parallel processing manner to explore the relationships between various variable parameters. Today's high-throughput experimental technology is developing towards the direction of "automation, miniaturization, and scale-up", aiming to obtain "the most data" with "the fastest speed, the highest efficiency, and the lowest cost", and this goal is also closely combined with the current scientific trends of artificial intelligence and machine learning. Specifically for high-throughput chemical synthesis technology, it usually requires "conducting hundreds or thousands of parallel chemical reactions simultaneously in 1-2 ml reaction tubes (such as 96 or 384-well plate mode)", so that the cost of a single chemical reaction can be minimized (with the least amount of reaction raw materials), and the chemical reactions are operated automatically, thus greatly improving the speed and reducing the time cost to the lowest level.

[0004] The high-throughput test method based on porous plates (24 / 48 / 96 / 384-well plates) in accordance with the SLAS / SBS standard specifications is common in the field of biological high-throughput, with low cost and easy implementation. However, it is extremely challenging in the field of chemical synthesis: Firstly, the chemical reaction conditions are much more severe than those of biological reactions. Most biological high-throughput experiments are under mild experimental conditions, and the commonly used 96 / 384-well plates are usually made of "plastic material" that is biocompatible and simply cannot meet the usual "high temperature and high pressure" experimental conditions of chemical reactions. Most high-throughput chemical reaction experiments are under severe experimental conditions and require to be carried out in glass reaction tubes with "temperature and pressure resistance", and the glass reaction tubes need to be placed in an aluminum metal block to meet the temperature control requirements of "rapid and uniform heat conduction". Secondly, the physical and chemical properties of chemical reaction reagent materials are also very different from those of biological reaction reagent materials. Biological reactions are usually carried out among aqueous biological reagents, with the characteristics of "single homogeneous phase, very low viscosity, easy mixing, and short reaction time"; the characteristics of chemical reactions are "multiple phases with solid-liquid coexistence, high viscosity, strong stirring and mixing required, and long reaction time". Therefore, the commonly used "oscillation mixing and aspiration mixing" in biological high-throughput experiments cannot meet the experimental requirements of high-throughput automation of chemical reactions.

[0005] Today's chemical reaction technology is far from reaching the true high-throughput experimental level. It still remains at the stage of "simultaneously conducting several parallel reactions", and usually conducts experiments at the level of "reaction scales from dozens to hundreds of milliliters". This is far from the goal of "modern high-throughput chemical experiments": firstly, the number of single experiments is too small, resulting in "slow speed and low efficiency"; secondly, "the scale of a single reaction is too large", leading to "high consumption of raw materials and high cost for each reaction". These cannot meet the goal requirements of large-scale machine learning for "low-cost big data".

[0006] Currently, technologies and devices with a truly modular high-throughput chemical reaction device are extremely rare. More or less, there are some problems with similar parallel chemical reaction devices. For example, the utility model patent with the authorization number CN 220371009U discloses "a photochemical parallel reactor device", which usually can only conduct parallel operations of less than 10 photochemical reaction experiments at a time, and the scale of a single reaction is all above "30ml reaction tubes"; the utility model patent with the authorization number CN 215611455U discloses "a parallel reactor", which usually can only conduct parallel operations of 10 chemical reaction experiments at a time, and the scale of a single reaction is all in "25ml Schlenk reaction tubes"; the invention patent with the application publication number CN 111167361A can achieve "simultaneous magnetic stirring of 0 - 200 small-capacity liquids of 5ml to 20ml, and many sets of stirring experiments can be done at one time, and precise and stable stirring can be carried out, and precise gradient temperature control can be achieved, with a wide temperature range of use (-20°C to 100°C)". However, this design is extremely complex. Due to physical space limitations, the 5ml glass tube is already the limit, so it is impossible to meet the high-throughput automation requirements of a "96-well 1ml glass tube reaction block" laboratory, and its large volume is also difficult to integrate into an automated experimental platform; the invention patent with the application publication number CN 118076439A discloses a device of "an integrated system for chemical, biochemical or molecular biology reactions in a microplate", and the content includes "uniformity high-precision modular temperature control" technology, but it is only suitable for mild biochemical reactions and not suitable for high-throughput chemical synthesis reactions. Summary of the Utility Model

[0007] In order to achieve a truly "modern high-throughput automatic chemical reactor", the present utility model provides a high-throughput parallel chemical reaction device with a modular design. This device adopts modular design technology and fully complies with international SLAS / SBS laboratory automation specifications and standards, and can conveniently and flexibly conduct high-throughput chemical experiments with free combinations of various reaction scales and various reaction types (temperature-controlled chemical reactions, photochemical reactions, electrochemical reactions).

[0008] The technical solution provided by the present utility model is as follows:

[0009] A modular designed high-throughput parallel chemical reaction device, comprising a vertical magnetic stirring and mixing platform, a temperature control module, and one or more of a sample reaction tube module, an electrochemical reaction module, and a photochemical reaction module provided on the temperature control module;

[0010] The vertical magnetic stirring and mixing platform is internally provided with a vertical magnetic line generating module, the vertical magnetic line generating module is arranged along the extending direction of the temperature control module, the vertical magnetic line generating module includes a magnetic pole group, and the magnetic lines emitted by the magnetic pole group are perpendicular to the top of the vertical magnetic stirring and mixing platform;

[0011] The temperature control module is arranged on the top of the vertical magnetic stirring and mixing platform for temperature control;

[0012] The sample reaction tube module is arranged on the temperature control module for fixing sample containers;

[0013] The electrochemical reaction module is arranged on the temperature control module, and includes an electrode module and an electrochemical reaction sample tube module. The electrochemical reaction sample tube module is uniformly stirred under the action of the magnetic lines provided by the vertical magnetic line generating module, and the electrode module controls the samples in the electrochemical reaction sample tube module to perform high-throughput chemical reactions;

[0014] The photochemical reaction module is arranged on the temperature control module, and includes a light source module and a photoreaction sample tube module. The photoreaction sample tube module is uniformly stirred under the action of the magnetic lines provided by the vertical magnetic line generating module, and the light source module controls the samples in the photoreaction sample tube module to perform photochemical reactions.

[0015] Further, the electrode module includes an electrode, an electrode mounting substrate, and an electrode control bus;

[0016] The electrochemical reaction sample tube module includes a metal heat conducting block base;

[0017] The metal heat conducting block base is arranged on the temperature control module, and a plurality of first reaction bottles are placed on the metal heat conducting block base, and a strong magnetic stirrer one is placed in each first reaction bottle;

[0018] The electrode mounting substrate is arranged corresponding to the metal heat conducting block base on the top of the first reaction bottle. One ends of a plurality of electrodes are mounted on the electrode mounting substrate, and the other ends respectively extend into the corresponding first reaction bottles, and the electrodes are energized through the electrode control bus.

[0019] Further, the light source module includes a dot matrix light source board, a light source control bus, and light source lamp beads;

[0020] The photoreaction sample tube module includes a metal base;

[0021] The metal base is disposed on the dot matrix light source board, and a plurality of second reaction bottles are placed on the metal base. A strong magnetic stirrer two is placed in each of the second reaction bottles. Light source beads are disposed on the dot matrix light source board at positions corresponding to each of the second reaction bottles, and the light source beads are used to irradiate the chemical reagents in the second reaction bottles.

[0022] Further, a microchannel one is built in the metal base, and a coolant inlet and outlet are provided on the side wall of the metal base. The coolant inlet and outlet are used to introduce a heat-conducting or heat-insulating fluid, and the heat-conducting or heat-insulating fluid controls the temperature of the photoreaction in the second reaction bottle through the microchannel one;

[0023] A microchannel two is built in the dot matrix light source board, and a coolant inlet and outlet are provided on the side wall of the dot matrix light source board. The coolant inlet and outlet are used to introduce a coolant, and the coolant enters the microchannel two to cool the light source beads.

[0024] Further, the temperature control module includes a temperature control base. A plurality of the temperature control bases are located directly above the vertical magnetic force generation module and are arranged in sequence along the direction where the vertical magnetic force generation module is located. The temperature control base is connected to a temperature controller.

[0025] Further, the outer dimensions of the sample reaction tube module, the metal heat-conducting block base, and the metal base are consistent with the well plate dimensions of the SLAS / SBS standard, and the interiors are all designed in specifications of 96 wells of 1 ml, 48 wells of 2 ml, 24 wells of 4 ml, or 8 ml.

[0026] Further, the vertical magnetic force generation module further includes a fixing frame;

[0027] The fixing frame is disposed outside the magnetic pole group and is used to fix the magnetic pole group;

[0028] The magnetic pole group includes a connecting frame and one or more magnets;

[0029] The connecting frame is disposed inside the fixing frame and is parallel to the plane where the bottom surface of the temperature control module is located;

[0030] One of the magnets is fixed to the connecting frame alone; or a plurality of the magnets are evenly fixed to the connecting frame at equal intervals, and the connection line between the two magnetic poles of each magnet is perpendicular to the bottom surface of the temperature control module.

[0031] Furthermore, a driving module is also provided inside the vertical magnetic stirring and mixing platform. The driving module is connected to the vertical magnetic field generating module and is used to drive the vertical magnetic field generating module to rotate within a plane perpendicular to the bottom surface of the temperature control module.

[0032] Furthermore, the driving module includes a driving motor, a coupling, and a speed controller.

[0033] The output shaft of the driving motor is connected to the connecting frame. The speed controller is connected to the driving motor, and the connecting frame is connected to the output end of the driving motor through the coupling.

[0034] Furthermore, the vertical magnetic stirring and mixing platform further includes a main control screen, which is arranged on the front of the vertical magnetic stirring and mixing platform.

[0035] The magnet is a neodymium iron boron magnet.

[0036] Compared with the prior art, the beneficial effects of the present utility model are as follows:

[0037] 1. The high-throughput parallel chemical reaction device with modular design provided by the present utility model can be freely combined and modularly assembled as needed to carry out various high-throughput chemical reactions. For the stirring and mixing of various types of chemical reactions, all magnetic stirrers are driven by the high-speed rotation of the vertical magnetic field generating module to rotate vertically with the horizontal line as the rotation axis, while ordinary magnetic stirrers rotate with the vertical line as the rotation axis, achieving the uniform stirring and mixing effect required for each reaction.

[0038] 2. The high-throughput parallel chemical reaction device with modular design provided by the present utility model uses the "vertical magnetic stirring and mixing technology" as the basic platform of the reactor, combines precise temperature control technology (heating or cooling), light source power control technology, and direct / alternating current power supply control technology. According to the modular design principle, based on the international laboratory automation SLAS / SBS standard specifications, on one platform device, "high-throughput temperature-controlled chemical reactions, high-throughput photochemical reactions, and high-throughput electrochemical reactions" can be carried out separately or in combination. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] Figure 1 It is a schematic structural diagram of the high-throughput parallel chemical reaction device with modular design provided by the present utility model;

[0040] Figure 2 It is a schematic structural diagram of the electrochemical reaction module in an embodiment of the present utility model;

[0041] Figure 3 It is a sectional view of the electrochemical reaction module in an embodiment of the present utility model;

[0042] Figure 4 It is a schematic structural diagram of the photoreaction module in the embodiment of the present utility model;

[0043] Figure 5 It is a sectional view of the photoreaction module in the embodiment of the present utility model;

[0044] Figure 6 It is a schematic structural diagram of the vertical magnetic field line generation module and the drive module in the embodiment of the present utility model.

[0045] The reference numerals are as follows:

[0046] 1 - vertical magnetic stirring and mixing platform, 101 - main machine control screen, 102 - fixing rack, 103 - connecting rack, 104 - magnet, 105 - drive motor, 108 - coupling, 2 - temperature control module, 3 - electrochemical reaction module, 301 - metal heat conduction block base, 302 - first reaction bottle, 303 - strong magnetic stirrer 1, 304 - electrode installation substrate, 305 - electrode, 306 - electrode control bus, 307 - first sealing cover, 4 - photoreaction module, 401 - metal base, 402 - second reaction bottle, 403 - dot matrix light source board, 404 - strong magnetic stirrer 2, 405 - coolant inlet and outlet, 406 - light source control bus, 407 - second sealing cover, 408 - light source lamp bead, 5 - sample reaction tube module. Specific embodiments

[0047] To make the objectives, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application. Obviously, the embodiments described below are some, but not all, of the embodiments of the present application. The components of the embodiments of the present application usually described and illustrated in the drawings here can be arranged and designed in various different configurations.

[0048] Therefore, the detailed description of the embodiments of the present application provided below with reference to the accompanying drawings is only intended to represent the selected embodiments of the present application, and does not limit the scope claimed by the present application. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present application without creative efforts fall within the scope of protection of the present application.

[0049] It should be understood that in the description of the embodiments of the present invention, the orientation or positional relationship indicated by terms such as "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc. is based on the orientation or positional relationship shown in the drawings. It is only for the convenience of describing the embodiments of the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, it should not be construed as a limitation to the embodiments of the present invention. In addition, the terms "first" and "second" are only used for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include one or more of the said features. In the description of the embodiments of the present invention, the meaning of "plurality" is two or more unless otherwise specifically defined.

[0050] In the description of the embodiments of the present invention, it should be noted that unless otherwise clearly specified and limited, the terms "set", "install", "connect", and "couple" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, an electrical connection, or a connection that can communicate with each other; it can be directly connected, or indirectly connected through an intermediate medium, and can be the internal communication of two elements or the interaction relationship between two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the embodiments of the present invention can be understood according to specific circumstances.

[0051] Referring to Figure 1 , the present invention provides a modular high-throughput parallel chemical reaction device, which includes a vertical magnetic stirring and mixing platform 1, a temperature control module 2, an electrochemical reaction module 3, a photochemical reaction module 4, and a sample reaction tube module 5.

[0052] The vertical magnetic stirring and mixing platform 1 is internally provided with a vertical magnetic field generation module, and the vertical magnetic field generation module is used to emit magnetic lines perpendicular to the top of the vertical magnetic stirring and mixing platform 1. The vertical magnetic field generation module built into the vertical magnetic stirring and mixing platform 1 adopts vertical magnetic stirring and mixing technology, and the vertical magnetic stirring and mixing platform 1 is also the basic platform of the device.

[0053] The temperature control module 2 is arranged on the top of the vertical magnetic stirring and mixing platform 1 for temperature control.

[0054] The sample reaction tube module 5 is arranged on the temperature control module 2 for fixing the sample container.

[0055] The electro-chemical reaction module 3 is arranged on the temperature control module 2 and includes an electrode module and an electro-chemical reaction sample tube module. The electro-chemical reaction sample tube module is uniformly stirred under the action of the magnetic field lines provided by the vertical magnetic field line generation module, and the electrode module controls the samples in the electro-chemical reaction sample tube module to perform high-throughput chemical reactions.

[0056] The photo-chemical reaction module 4 is arranged on the temperature control module 2 and includes a light source module and a photo-reaction sample tube module. The photo-reaction sample tube module is uniformly stirred under the action of the magnetic field lines provided by the vertical magnetic field line generation module, and the light source module controls the samples in the photo-reaction sample tube module to perform photo-chemical reactions.

[0057] It should be noted that the above-mentioned multiple modules can be arbitrarily combined as needed, and high-throughput chemical experiments of temperature-controlled chemical reactions, photo-chemical reactions, and electro-chemical reactions can be conveniently and flexibly carried out. Among them, the temperature-controlled chemical reaction is carried out by combining the temperature control module 2 with the sample reaction tube module 5, the electro-chemical reaction is carried out by the electro-chemical reaction module 3, and the photo-chemical reaction is carried out by the photo-chemical reaction module 4. The temperature-controlled chemical reaction, photo-chemical reaction, and electro-chemical reaction can be carried out simultaneously or only one or two of the high-throughput chemical experiments as needed.

[0058] As Figure 2 、 Figure 3 shown, the electrode module includes an electrode 305, an electrode mounting substrate 304, and an electrode control bus 306.

[0059] The electro-chemical reaction sample tube module includes a metal heat-conducting block base 301.

[0060] The metal heat-conducting block base 301 is arranged on the temperature control module 2, and a plurality of first reaction bottles 302 are placed on the metal heat-conducting block base 301, and a strong magnetic stirrer 303 is placed in each first reaction bottle 302.

[0061] The electrode mounting substrate 304 is arranged corresponding to the metal heat-conducting block base 301 at the top of the first reaction bottle 302. One end of a plurality of electrodes 305 is mounted on the electrode mounting substrate 304, and the other ends respectively extend into the corresponding first reaction bottles 302. The electrodes 305 are externally connected to a multi-channel DC or AC power supply through the electrode control bus 306.

[0062] As Figure 4 、 Figure 5 shown, the light source module includes a dot matrix light source board 403, a light source control bus 406, and light source lamp beads 408.

[0063] The photoreaction sample tube module includes a metal base 401, the metal base 401 is arranged on the dot matrix light source board 403, a plurality of second reaction bottles 402 are placed on the metal base 401, and a strong magnetic stirrer two 404 is placed in each second reaction bottle 402. A light source lamp bead 408 is arranged on the dot matrix light source board 403 at a position corresponding to each second reaction bottle 402, and the light source lamp bead 408 is used to irradiate the chemical reagent in the second reaction bottle 402.

[0064] Optionally, the metal base 401 is internally provided with a first microporous channel, and a coolant inlet and outlet 405 is arranged on the side wall of the metal base 401. The coolant inlet and outlet 405 is used to introduce a heat-conducting or heat-conducting fluid, and the heat-conducting or heat-conducting fluid controls the temperature of the photoreaction in the second reaction bottle 402 through the first microporous channel.

[0065] The dot matrix light source board 403 is internally provided with a second microporous channel, and a coolant inlet and outlet 405 is arranged on the side wall of the dot matrix light source board 403. The coolant inlet and outlet 405 is used to introduce a coolant, and the coolant enters the second microporous channel to cool the light source lamp bead 408.

[0066] Specifically, the dot matrix light source board 403 of the light source module is assembled with light source lamp beads 408 of various wavelengths according to Figure 4 、 Figure 5 shown. The coolant enters the second microporous channel to cool the light source lamp bead 408 and takes away the heat generated when the light source lamp bead 408 works. One or more light source lamp beads 408 are externally connected to a power regulator as needed to achieve real-time adjustment and control. The bottom of the metal base 401 penetrates or is provided with high-transparency quartz glass or similar materials at a position corresponding to the second reaction bottle 402 to ensure that the light source lamp bead 408 of the light source module can perform a light reaction on the chemical reagent in the second reaction bottle 402. The first microporous channel built into the photoreaction sample tube module can introduce a heat-conducting or heat-conducting fluid to ensure precise temperature control of the photoreaction.

[0067] Optionally, the temperature control module 2 includes a temperature control base. A plurality of temperature control bases are located directly above the vertical magnetic field generation module and are arranged in sequence along the direction where the vertical magnetic field generation module is located. The temperature control base is connected to a temperature controller.

[0068] It should be noted that the temperature control module 2 adopted by the present utility model can perform temperature-controlled chemical reactions, and can also heat or cool the electrochemical reaction module 3 and the photoreaction module 4. The temperature control module 2 adopts the existing technology, and it can be heated by the principle of resistance wire heating. When refrigeration is required, ice water can be introduced into the temperature control module 2 to achieve the refrigeration effect. When the temperature control module 2 adopted can perform temperature-controlled chemical reactions, the sample reaction tube module 5 needs to be placed on the temperature control module 2, and then the sample tube is installed at the corresponding position in the sample reaction tube module 5. A strong magnetic stirrer (not shown in the figure) is also placed in the sample tube.

[0069] Optionally, the outer dimensions of the sample reaction tube module 5, the metal heat conduction block base 301 and the metal base 401 are the same as the orifice plate dimensions of the SLAS / SBS standard, and their interiors are all designed in specifications of 96 holes of 1 ml, 48 holes of 2 ml, 24 holes of 4 ml or 8 ml.

[0070] Specifically, the sample reaction tube module 5, the metal heat conduction block base 301 and the metal base 401 are processed from metal aluminum blocks or other metal materials with excellent thermal conductivity. Their outer dimensions are the size of the orifice plate of the SLAS / SBS standard (about 127.6 mm x 85.4 mm) to ensure compatibility with commercial platforms. The metal heat conduction block base 301 and the metal base 401 are processed into a 96-hole plate that can accommodate 1-ml glass reaction tubes, a 48-hole plate that can accommodate 2-ml glass reaction tubes, a 24-hole plate that can accommodate 4-ml or 8-ml glass reaction tubes (with the same diameter), etc. according to requirements. A micro stirrer magnet of a suitable size is placed in each reaction tube. Driven by the strong vertical rotating magnetic field of the vertical magnetic field generation module in the vertical magnetic stirring and mixing platform 1, the magnet in the reaction tube is driven to rotate, achieving the effect of stirring and mixing. Figure 2 and Figure 4 Shown is the structural diagram of a 24-hole plate that can accommodate 4-ml or 8-ml glass reaction tubes (with the same diameter).

[0071] As Figure 6 shown, the vertical magnetic field generation module includes a magnetic pole group and a fixing frame 102. The fixing frame 102 is arranged outside the magnetic pole group and is used to fix the magnetic pole group. The magnetic pole group includes a connecting frame 103 and one or more magnets 104. The connecting frame 103 is arranged inside the fixing frame 102 and is parallel to the plane where the bottom surface of the temperature control module 2 is located.

[0072] If the number of magnets 104 is one, one magnet 104 is fixed on the connecting frame 103 alone.

[0073] If the number of magnets 104 is multiple, multiple magnets 104 are evenly fixed on the connecting frame 103 at equal intervals. The connection line between the two magnetic poles of each magnet 104 is perpendicular to the bottom surface of the temperature control module 2.

[0074] Optionally, a driving module is further provided inside the vertical magnetic stirring and mixing platform 1. The driving module is connected to the vertical magnetic line generating module and is used to drive the vertical magnetic line generating module to rotate within the plane of the bottom surface of the vertical temperature control module 2.

[0075] Optionally, the driving module includes a driving motor 105, a coupling 108, and a speed controller.

[0076] The output shaft of the driving motor 105 is connected to the connecting frame 103. The speed controller is connected to the driving motor 105. The connecting frame 103 is connected to the output end of the driving motor 105 through the coupling 108.

[0077] Optionally, the vertical magnetic stirring and mixing platform 1 further includes a main control screen 101, and the main control screen 101 is arranged on the front surface of the vertical magnetic stirring and mixing platform 1.

[0078] In this embodiment, the main control screen 101 is connected to the driving motor 105 and is used to adjust the rotation speed of the driving motor 105, so that the strong magnetic stirrer one 303 and the strong magnetic stirrer two 404 are suspended in the sample. The driving motor 7 can be a horizontally arranged rotary motor. During actual use, the rotation speed of the driving motor 105 can be adjusted through the main control screen 101 according to the viscosities of different samples.

[0079] The vertical magnetic stirring and mixing platform 1 uses a neodymium iron boron magnet with a high magnetic energy product and good high-temperature performance as the magnetic pole of the magnetic pole group, and maintains the distance between the driving motor 105 and the magnetic pole group through the coupling 1088, which can effectively avoid the interference of the magnetic field of the driving motor 105 on the magnetic lines.

[0080] In order to achieve a better sealing effect and prevent the sample in the reaction bottle from leaking out of the bottle mouth, a first sealing cover 307 and a second sealing cover 407 can be respectively arranged at the bottle mouths of the first reaction bottle 302 and the second reaction bottle 402.

[0081] The high-throughput parallel chemical reaction device with modular design provided by the present utility model can be freely combined and modularly assembled as required to carry out various high-throughput chemical reactions. For the stirring and mixing of various types of chemical reactions, all magnetic stirrers are driven by the high-speed rotation of the vertical magnetic line generating module in the vertical magnetic stirring and mixing platform 1 to rotate vertically with the horizontal line as the rotation axis, while ordinary magnetic stirrers rotate with the vertical line as the rotation axis, achieving the uniform stirring and mixing effect required for each reaction; the temperature, light, and current required for various types of chemical reactions are provided and executed by their respective functional modules. Moreover, the device of the present utility model can be integrated with an automated platform to realize automatic feeding, sampling, detection, and other automated operations for each reaction tube, achieving a truly fully automated high-throughput chemical reaction. Furthermore, due to the modular design based on the SLAS / SBS standard specifications, it is also very easy to achieve automated integration.

[0082] In this field, the implementation principles of all magnetic stirring devices are the same. They all form a changing magnetic field by rotating a driving magnet, and the stirring magnetic particle follows the magnetic field rotation under the action of the attractive force - repulsive force in the changing magnetic field, thereby realizing the stirring and mixing function. However, in this solution, the "vertical magnetic stirring and mixing technology" is adopted. The vertical magnetic line generating module generates a vertical magnetic field. When the driving module controls the vertical magnetic line generating module to rotate in the vertical direction, the magnetic field will rotate with the rotation of the vertical magnetic line generating module, and a driving field of vertical rotating magnetic lines can be formed outside the vertical magnetic line generating module. When the magnetic particle is located in this driving field, the magnetic particle will rotate with the rotation of the magnetic line, and the macroscopic manifestation of this process is that the magnetic particle rotates in the driving field in the same way as the vertical magnetic line generating module.

[0083] The present utility model adopts a unique "vertical magnetic stirring and mixing technology" as the basic platform of the reactor, combines precise temperature control technology (heating or refrigeration), light source power control technology, and direct / alternating current power supply control technology, and according to the modular design principle, based on the international laboratory automation SLAS / SBS standard specifications, on a platform device, "high-throughput temperature-controlled chemical reactions, high-throughput photochemical reactions, and high-throughput electrochemical reactions" can be carried out separately or in combination.

[0084] The high-throughput parallel chemical reaction device with modular design provided by the present utility model adopts modular design technology and fully complies with the international SLAS / SBS laboratory automation specifications and standards, and can conveniently and flexibly carry out high-throughput chemical experiments with free combinations of various reaction scales and various reaction types (temperature-controlled chemical reactions, photochemical reactions, electrochemical reactions).

[0085] As described above, it is only the optimal specific implementation manner of the present application, but the protection scope of the present application is not limited thereto. Any changes or substitutions within the technical scope disclosed in the present application shall be covered within the protection scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims described.

Claims

1. A modular high-throughput parallel chemical reaction device, characterized in that: It includes a vertical magnetic stirring mixing platform, a temperature control module, and one or more of a sample reaction tube module, an electrochemical reaction module, and a photochemical reaction module arranged on the temperature control module; The vertical magnetic stirring mixing platform has a built-in vertical magnetic force line generating module, which is arranged along the extension direction of the temperature control module. The vertical magnetic force line generating module includes a magnetic pole group, and the magnetic force lines emitted by the magnetic pole group are perpendicular to the top of the vertical magnetic stirring mixing platform; The temperature control module is arranged on the top of the vertical magnetic stirring mixing platform for temperature control; The sample reaction tube module is arranged on the temperature control module and is used to fix the sample container; The electrochemical reaction module is arranged on the temperature control module, and comprises an electrode module and an electrochemical reaction sample tube module. The electrochemical reaction sample tube module is uniformly stirred under the action of the magnetic lines provided by the vertical magnetic lines generating module, and the electrode module controls the sample in the electrochemical reaction sample tube module to perform a high-throughput chemical reaction. The photochemical reaction module is arranged on the temperature control module, and includes a light source module and a photoreaction sample tube module. The photoreaction sample tube module is uniformly stirred under the action of the magnetic lines provided by the vertical magnetic line generating module, and the light source module controls the sample in the photoreaction sample tube module to perform a photochemical reaction.

2. The modular high-throughput parallel chemical reaction device according to claim 1, characterized in that: The electrode module includes an electrode, an electrode mounting substrate and an electrode control bus; The electrochemical reaction sample tube module comprises a metal heat conductive block base; The metal heat-conducting block base is arranged on the temperature control module, and a plurality of first reaction bottles are placed on the metal heat-conducting block base, and a strong magnetic stirring bar 1 is placed in each of the first reaction bottles; The electrode mounting substrate is arranged on the top of the first reaction bottle corresponding to the metal heat conductive block base, one end of each of the electrodes is mounted on the electrode mounting substrate, and the other end extends into the corresponding first reaction bottle respectively, and the electrodes are energized through the electrode control bus.

3. The modular high-throughput parallel chemical reaction device according to claim 2, characterized in that: The light source module includes a dot matrix light source board, a light source control bus and light source lamp beads; The photoreaction sample tube module comprises a metal base; The metal base is arranged on the dot matrix light source board, and a plurality of second reaction bottles are placed on the metal base. A strong magnetic stirrer 2 is placed in each of the second reaction bottles. A light source lamp bead is arranged on the dot matrix light source board at a position corresponding to each of the second reaction bottles, and the light source lamp bead is used to illuminate the chemical reagents in the second reaction bottles.

4. The modular high-throughput parallel chemical reaction device according to claim 3, characterized in that: The metal base has a built-in microporous channel 1, and a cooling liquid inlet and outlet are provided on the side wall of the metal base, and the cooling liquid inlet and outlet are used to pass a heat-conducting or cooling-conducting fluid, and the heat-conducting or cooling-conducting fluid controls the temperature of the photochemical reaction in the second reaction bottle through the microporous channel 1; The dot matrix light source board has a built-in microporous channel 2, and a cooling liquid inlet and outlet are arranged on the side wall of the dot matrix light source board. The cooling liquid inlet and outlet are used to pass cooling liquid, and the cooling liquid enters the microporous channel 2 to cool the light source lamp beads.

5. The high-throughput parallel chemical reaction device with modular design according to any one of claims 1 to 4, characterized in that: The temperature control module includes a temperature control base, and a plurality of the temperature control bases are located directly above the vertical magnetic line generating module and are arranged in sequence along the direction of the vertical magnetic line generating module. The temperature control bases are connected to a temperature controller.

6. The modular high-throughput parallel chemical reaction device according to claim 3 or 4, characterized in that: The outer dimensions of the sample reaction tube module, the metal heat conductive block base and the metal base are consistent with the SLAS / SBS ​​standard well plate dimensions, and the interiors are designed to be 96 wells 1 ml, 48 wells 2 ml, 24 wells 4 ml or 8 ml.

7. The modular high-throughput parallel chemical reaction device according to claim 5, characterized in that: The vertical magnetic field line generating module also includes a fixing frame; The fixing frame is arranged outside the magnetic pole group and is used for fixing the magnetic pole group; The magnetic pole set includes a connecting frame and one or more magnets; The connecting frame is arranged inside the fixing frame and is parallel to the plane where the bottom surface of the temperature control module is located; One magnet is fixed on the connecting frame alone; or a plurality of magnets are evenly and evenly fixed on the connecting frame at equal intervals, and a line connecting two magnetic poles of each magnet is perpendicular to the bottom surface of the temperature control module.

8. The modular high-throughput parallel chemical reaction device according to claim 7, characterized in that: A driving module is also provided in the vertical magnetic stirring mixing platform. The driving module is connected to the vertical magnetic force line generating module and is used to drive the vertical magnetic force line generating module to rotate in a plane perpendicular to the bottom surface of the temperature control module.

9. The modular high-throughput parallel chemical reaction device according to claim 8, characterized in that: The driving module includes a driving motor, a coupling and a speed controller; The output shaft of the driving motor is connected to the connecting frame, the speed controller is connected to the driving motor, and the connecting frame is connected to the output end of the driving motor through the coupling.

10. The modular high-throughput parallel chemical reaction device according to any one of claims 7 to 9, characterized in that: The vertical magnetic stirring mixing platform also includes a host control screen, which is arranged on the front of the vertical magnetic stirring mixing platform; The magnet is a neodymium iron boron magnet.

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